AU2007215218B2 - Variants in complement regulatory genes predict age-related macular degeneration - Google Patents

Variants in complement regulatory genes predict age-related macular degeneration Download PDF

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Publication number
AU2007215218B2
AU2007215218B2 AU2007215218A AU2007215218A AU2007215218B2 AU 2007215218 B2 AU2007215218 B2 AU 2007215218B2 AU 2007215218 A AU2007215218 A AU 2007215218A AU 2007215218 A AU2007215218 A AU 2007215218A AU 2007215218 B2 AU2007215218 B2 AU 2007215218B2
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gene
protein
cfh
amd
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AU2007215218A1 (en
Inventor
Rando L. Allikmets
Michael C. Dean
Albert M. Gold
Gregory S. Hageman
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University of Iowa Research Foundation UIRF
Columbia University in the City of New York
National Institutes of Health NIH
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University of Iowa Research Foundation UIRF
Columbia University in the City of New York
National Institutes of Health NIH
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2007215218A 2006-02-13 2007-02-13 Variants in complement regulatory genes predict age-related macular degeneration Ceased AU2007215218B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77298906P 2006-02-13 2006-02-13
US60/772,989 2006-02-13
PCT/US2007/003696 WO2007095185A2 (fr) 2006-02-13 2007-02-13 Variants de genes de regulation du complement permettant de predire la degenerescence maculaire liee a l'age

Publications (2)

Publication Number Publication Date
AU2007215218A1 AU2007215218A1 (en) 2007-08-23
AU2007215218B2 true AU2007215218B2 (en) 2013-09-19

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AU2007215218A Ceased AU2007215218B2 (en) 2006-02-13 2007-02-13 Variants in complement regulatory genes predict age-related macular degeneration

Country Status (8)

Country Link
EP (1) EP1989319A4 (fr)
JP (1) JP5290772B2 (fr)
CN (1) CN101421409A (fr)
AU (1) AU2007215218B2 (fr)
CA (1) CA2638916A1 (fr)
IL (1) IL193396A (fr)
NZ (1) NZ570431A (fr)
WO (1) WO2007095185A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8012683B2 (en) 2006-02-13 2011-09-06 University Of Iowa Research Foundation Variants in complement regulatory genes predict age-related macular degeneration
US20120141994A1 (en) * 2009-04-29 2012-06-07 Deangelis Margaret M Methods and compositions for prognosing and detecting age-related macular degeneration
EP2963128A1 (fr) * 2009-07-10 2016-01-06 The Regents of the University of Michigan Compositions et procédés pour le diagnostic et le traitement de la dégénérescence maculaire
WO2011053774A1 (fr) * 2009-10-30 2011-05-05 Alcon Research, Ltd. Polymorphismes simple nucléotide et gènes associés à la dégénérescence maculaire liée à l'âge
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
CN102707068B (zh) * 2012-05-31 2015-03-18 北京大学 补体h因子用作甲基苯丙胺成瘾患者的基因表达产物中的应用
JP6387391B2 (ja) 2013-03-14 2018-09-05 ノバルティス アーゲー 眼科疾患の処置に有用な補体因子B阻害剤としての2−(1H−インドール−4−イルメチル)−3H−イミダゾ[4,5−b]ピリジン−6−カルボニトリル誘導体
US9676728B2 (en) 2013-10-30 2017-06-13 Novartis Ag 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof
US20170073754A1 (en) * 2014-02-07 2017-03-16 Novartis Ag Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy
CN106999559A (zh) * 2014-12-19 2017-08-01 儿童医院医疗中心 与移植相关血栓性微血管病相关的方法和组合物
CN109082460B (zh) * 2018-09-27 2021-07-13 领航基因科技(杭州)有限公司 应用于snp分型的非竞争性探针设计方法、检测方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001051A1 (fr) 1983-09-02 1985-03-14 Molecular Biosystems, Inc. Systeme de support polymere d'oligonucleotides
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
DE69503126T2 (de) 1994-05-05 1998-11-12 Beckman Instruments Inc Repetitive oligonukleotide matrix
US5985567A (en) 1997-08-15 1999-11-16 Beckman Coulter, Inc. Hybridization detection by pretreating bound single-stranded probes
US6013789A (en) 1998-02-20 2000-01-11 Beckman Coulter, Inc. Covalent attachment of biomolecules to derivatized polypropylene supports
WO2006062716A2 (fr) * 2004-11-18 2006-06-15 Yale University Methodes et preparations pour le traitement de troubles oculaires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hageman et al, (2005) PNAS v102 p7227-32 *

Also Published As

Publication number Publication date
CN101421409A (zh) 2009-04-29
JP5290772B2 (ja) 2013-09-18
IL193396A0 (en) 2009-05-04
NZ570431A (en) 2011-12-22
EP1989319A2 (fr) 2008-11-12
CA2638916A1 (fr) 2007-08-23
AU2007215218A1 (en) 2007-08-23
JP2009526524A (ja) 2009-07-23
WO2007095185A3 (fr) 2008-09-25
EP1989319A4 (fr) 2009-11-11
WO2007095185A2 (fr) 2007-08-23
IL193396A (en) 2013-03-24

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