AU2007214468B2 - Methods and compositions for enhancing engraftment of hematopoietic stem cells - Google Patents

Methods and compositions for enhancing engraftment of hematopoietic stem cells Download PDF

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Publication number
AU2007214468B2
AU2007214468B2 AU2007214468A AU2007214468A AU2007214468B2 AU 2007214468 B2 AU2007214468 B2 AU 2007214468B2 AU 2007214468 A AU2007214468 A AU 2007214468A AU 2007214468 A AU2007214468 A AU 2007214468A AU 2007214468 B2 AU2007214468 B2 AU 2007214468B2
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AU
Australia
Prior art keywords
cells
graft
cell
patient
hsc
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2007214468A
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English (en)
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AU2007214468A1 (en
Inventor
Julie Lynn Christensen
Holger Karsunky
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Cellerant Therapeutics Inc
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Cellerant Therapeutics Inc
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Publication of AU2007214468A1 publication Critical patent/AU2007214468A1/en
Assigned to CELLERANT THERAPEUTICS, INC. reassignment CELLERANT THERAPEUTICS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: CELLERANT THERAPEUTICS, INC., CHRISTENSEN, JULIE LYNN, KARSUNKY, HOLGER
Application granted granted Critical
Publication of AU2007214468B2 publication Critical patent/AU2007214468B2/en
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2007214468A 2006-02-14 2007-02-14 Methods and compositions for enhancing engraftment of hematopoietic stem cells Ceased AU2007214468B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77340506P 2006-02-14 2006-02-14
US60/773,405 2006-02-14
PCT/US2007/062163 WO2007095594A2 (en) 2006-02-14 2007-02-14 Methods and compositions for enhancing engraftment of hematopoietic stem cells

Publications (2)

Publication Number Publication Date
AU2007214468A1 AU2007214468A1 (en) 2007-08-23
AU2007214468B2 true AU2007214468B2 (en) 2013-04-04

Family

ID=38372250

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007214468A Ceased AU2007214468B2 (en) 2006-02-14 2007-02-14 Methods and compositions for enhancing engraftment of hematopoietic stem cells

Country Status (8)

Country Link
US (1) US8383095B2 (https=)
EP (1) EP1984491B1 (https=)
JP (1) JP5341525B2 (https=)
CN (1) CN101421393B (https=)
AU (1) AU2007214468B2 (https=)
CA (1) CA2642020C (https=)
IL (1) IL193345A (https=)
WO (1) WO2007095594A2 (https=)

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CN105168250B (zh) 2004-10-25 2019-02-05 塞勒兰特治疗公司 增殖骨髓细胞群体的方法及其应用
WO2008137901A2 (en) 2007-05-06 2008-11-13 Sloan Kettering Institute For Cancer Research Methods for treating and preventing gi syndrome and graft versus host disease
CN102802686A (zh) * 2009-06-18 2012-11-28 Mc2细胞有限责任公司 骨髓胞外基质提取物及其治疗用途
US20130287750A1 (en) * 2009-10-14 2013-10-31 Cellect Biotechnology Ltd. Method of selecting stem cells and uses thereof
US20130095080A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Reserach Center Compositions and methods for providing hematopoietic function
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US20140205582A1 (en) * 2011-07-06 2014-07-24 Cellerant Therapeutics, Inc. Megakaryocyte progenitor cells for production of platelets
CA2858069C (en) 2011-12-08 2020-02-11 Novartis Ag Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2013130499A1 (en) * 2012-02-29 2013-09-06 University Of Virginia Patent Foundation Compositions and methods for cxcr4 signaling and umbilical cord blood stem cell engraftment
ES2681050T3 (es) 2012-04-11 2018-09-11 Acerta Pharma B.V. Inhibidores de la tirosina quinasa de Bruton para la movilización hematopoyética
US10722577B2 (en) * 2012-05-25 2020-07-28 Sloan Kettering Institute For Cancer Research Methods for treating GI syndrome and graft versus host disease
EP2943566A1 (en) 2013-01-08 2015-11-18 Fred Hutchinson Cancer Research Center Compositions and methods for expansion of embryonic hematopoietic stem cells
JP2016538253A (ja) * 2013-10-09 2016-12-08 セレクト バイオセラピューティクス リミテッド デスリガンドへの移植前曝露による造血前駆細胞の活性化
WO2015057992A1 (en) 2013-10-16 2015-04-23 Izumi Raquel Btk inhibitors for hematopoietic mobilization
MX389160B (es) 2013-10-31 2025-03-20 Hutchinson Fred Cancer Res Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas.
US10350245B2 (en) 2015-01-21 2019-07-16 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
EP3288570A4 (en) 2015-04-29 2018-11-21 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
WO2016176651A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
MX2018006828A (es) 2015-12-04 2018-08-09 Hutchinson Fred Cancer Res Usos de poblaciones expandidas de celulas madre/progenitoras hematopoyeticas.
WO2017203520A1 (en) * 2016-05-22 2017-11-30 Yeda Research And Development Co. Ltd. Methods of using pulmonary cells for transplantation and induction of tolerance
EP3595683A1 (en) * 2017-03-15 2020-01-22 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants
MX392743B (es) 2017-04-12 2025-03-12 Magenta Therapeutics Inc Antagonistas del receptor de hidrocarburo de arilo y sus usos.
WO2019089833A1 (en) * 2017-10-31 2019-05-09 Magenta Therapeutics Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
US11285177B2 (en) 2018-01-03 2022-03-29 Globus Medical, Inc. Allografts containing viable cells and methods thereof
EP3849565A4 (en) 2018-09-12 2022-12-28 Fred Hutchinson Cancer Research Center REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS
EP4476331A2 (en) 2022-02-07 2024-12-18 Ensoma, Inc. Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids
EP4338745A1 (en) * 2022-09-14 2024-03-20 Technische Universität Dresden Allogeneic human macrophages for cell therapy

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Also Published As

Publication number Publication date
EP1984491A2 (en) 2008-10-29
JP5341525B2 (ja) 2013-11-13
WO2007095594A2 (en) 2007-08-23
EP1984491A4 (en) 2010-03-24
CN101421393A (zh) 2009-04-29
EP1984491B1 (en) 2016-12-07
US20070237752A1 (en) 2007-10-11
WO2007095594A3 (en) 2008-07-31
IL193345A0 (en) 2011-08-01
JP2009526784A (ja) 2009-07-23
IL193345A (en) 2012-10-31
US8383095B2 (en) 2013-02-26
CA2642020A1 (en) 2007-08-23
CN101421393B (zh) 2013-08-14
CA2642020C (en) 2014-10-07
AU2007214468A1 (en) 2007-08-23

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired