AU2007205065B2 - Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents - Google Patents
Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents Download PDFInfo
- Publication number
- AU2007205065B2 AU2007205065B2 AU2007205065A AU2007205065A AU2007205065B2 AU 2007205065 B2 AU2007205065 B2 AU 2007205065B2 AU 2007205065 A AU2007205065 A AU 2007205065A AU 2007205065 A AU2007205065 A AU 2007205065A AU 2007205065 B2 AU2007205065 B2 AU 2007205065B2
- Authority
- AU
- Australia
- Prior art keywords
- als
- mice
- candida
- protein
- albicans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013203750A AU2013203750B2 (en) | 2006-01-06 | 2013-04-11 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/327,197 | 2006-01-06 | ||
| US11/327,197 US20070077256A1 (en) | 1999-11-19 | 2006-01-06 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| PCT/US2007/000433 WO2007081896A2 (en) | 2006-01-06 | 2007-01-05 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013203750A Division AU2013203750B2 (en) | 2006-01-06 | 2013-04-11 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007205065A1 AU2007205065A1 (en) | 2007-07-19 |
| AU2007205065B2 true AU2007205065B2 (en) | 2013-10-31 |
Family
ID=38256965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007205065A Ceased AU2007205065B2 (en) | 2006-01-06 | 2007-01-05 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20070077256A1 (https=) |
| EP (4) | EP1982190B1 (https=) |
| JP (3) | JP5692963B2 (https=) |
| AU (1) | AU2007205065B2 (https=) |
| CA (2) | CA2636277C (https=) |
| CY (1) | CY1113693T1 (https=) |
| DK (1) | DK1982190T3 (https=) |
| ES (3) | ES2608354T3 (https=) |
| PT (1) | PT1982190E (https=) |
| WO (1) | WO2007081896A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077256A1 (en) * | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US20060083750A1 (en) * | 1999-11-19 | 2006-04-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US8541008B2 (en) * | 1999-11-19 | 2013-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| WO2011003085A1 (en) * | 2009-07-03 | 2011-01-06 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Hyr1 as a target for active and passive immunization against candida |
| WO2012163533A1 (en) | 2011-06-01 | 2012-12-06 | Eth Zurich | T cell epitope of candida albicans |
| GEP201706766B (en) * | 2011-07-22 | 2017-10-25 | Los Angeles Biomedical Res Center | Methods and compositions for vaccinating against staphylococcus aureus |
| US10130691B2 (en) | 2013-03-15 | 2018-11-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods for treating fungal and bacterial pathogens |
| JP6566616B2 (ja) * | 2014-08-19 | 2019-08-28 | キヤノン株式会社 | 通信装置、その制御方法、およびプログラム |
| US20200155449A1 (en) | 2015-11-16 | 2020-05-21 | Medincell | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| EP3426287A4 (en) * | 2016-03-09 | 2020-03-11 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Methods and kits for use in preventing and treating vulvovaginal candidiasis |
| US10308571B2 (en) * | 2017-10-11 | 2019-06-04 | Uop Llc | Process for minimizing benzene, toluene, and a recycle loop in a zero benzene aromatics complex |
| JP7439371B2 (ja) * | 2018-04-10 | 2024-02-28 | ロサンゼルス バイオメディカル リサーチ インスティテュート アット ハーバー- ユーシーエルエー メディカル センター | Candida auris感染症の治療方法 |
| EP3552620A1 (en) * | 2018-04-11 | 2019-10-16 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Methods of treatment for candida auris infections |
| US20220354935A1 (en) * | 2021-04-21 | 2022-11-10 | Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center | Vaccination against fungal epitopes to prevent inflammatory bowel diseases |
| WO2025248488A1 (en) * | 2024-05-29 | 2025-12-04 | Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center | Compositions and methods for preventing and treating healthcare-associated candida auris infections with dual antigen vaccine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030124134A1 (en) * | 1999-11-19 | 2003-07-03 | Harbor-Ucla Research And Education Institute | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| WO2006121895A2 (en) * | 2005-05-05 | 2006-11-16 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Family Cites Families (39)
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|---|---|---|---|---|
| US4346074A (en) | 1978-08-24 | 1982-08-24 | National Research Development Corp. | Pasteurellosis vaccines |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5622939A (en) | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| WO1995031998A1 (en) | 1994-05-23 | 1995-11-30 | The Research & Development Institute, Inc. | Candida albicans adhesin as a vaccine |
| US5668263A (en) | 1994-12-16 | 1997-09-16 | Smithkline Beecham Corporation | Conserved yeast nucleic acid sequences |
| US6500438B2 (en) | 1995-06-07 | 2002-12-31 | Pfizer Incorporated | In ovo vaccination against coccidiosis |
| DE69734601T2 (de) * | 1996-05-16 | 2006-08-03 | The Texas A & M University System, College Station | Zusammensetzung von kollagenbindungsprotein und verfahren zu deren verwendungen |
| US6747137B1 (en) | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| US6703025B1 (en) * | 1998-08-31 | 2004-03-09 | Inhibitex, Inc. | Multicomponent vaccines |
| US7067138B1 (en) | 1999-11-19 | 2006-06-27 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US20070077256A1 (en) | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| EP2319301B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
| AU2003231818B2 (en) | 2002-05-21 | 2007-04-19 | Intervet International B.V. | Methods for the in vitro culture of Sporozoea sp. and user thereof |
| US7241613B1 (en) | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| AU2003290867A1 (en) * | 2002-11-12 | 2004-06-03 | The Brigham And Women's Hospital, Inc. | Methods and products for treating staphylococcal infections |
| MXPA06005639A (es) | 2003-11-21 | 2006-08-17 | Pfizer Prod Inc | Adyuvante antimicrobiano. |
| US20050287146A1 (en) * | 2003-12-19 | 2005-12-29 | Joseph Patti | Method of inhibiting Candida-related infections using donor selected or donor stimulated immunoglobulin compositions |
| GB0420466D0 (en) | 2004-09-14 | 2004-10-20 | Cassone Antonio | Anti-glucan antibodies |
| WO2006036817A2 (en) | 2004-09-24 | 2006-04-06 | Microbia, Inc. | Fungal variants and uses thereof |
| CA2489194A1 (en) | 2004-12-03 | 2006-06-03 | Guilhem Janbon | Polypeptides involved in candida biofilm formation and uses thereof |
| WO2007126813A2 (en) | 2006-03-29 | 2007-11-08 | Inhibitex, Inc. | Cross-reactive monoclonal antibodies recognizing als family proteins |
| BRPI0711572A2 (pt) | 2006-04-17 | 2011-11-16 | Schering Plough Ltd | organismos recombinantes atenuados de clostridium e vacinas |
| EP2164511A1 (en) | 2007-05-22 | 2010-03-24 | Baylor College Of Medicine | Immune complex vaccination as a strategy to enhance immunity in the elderly and other immune compromised populations |
| US9050281B2 (en) | 2008-05-29 | 2015-06-09 | Intervet Inc. | Coccidiosis vaccines |
| US20100150942A1 (en) | 2008-12-03 | 2010-06-17 | Cantor Thomas L | Affinity purified human polyclonal antibodies and methods of making and using them |
| SA110310528B1 (ar) | 2009-06-22 | 2014-07-02 | Wyeth Llc | التركيبات المولدة للمناعة لأنتيجينات ستافيلوكوكس أوريس |
| WO2011003085A1 (en) | 2009-07-03 | 2011-01-06 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Hyr1 as a target for active and passive immunization against candida |
| WO2012163533A1 (en) | 2011-06-01 | 2012-12-06 | Eth Zurich | T cell epitope of candida albicans |
| GEP201706766B (en) * | 2011-07-22 | 2017-10-25 | Los Angeles Biomedical Res Center | Methods and compositions for vaccinating against staphylococcus aureus |
| BR112014005773A2 (pt) | 2011-09-14 | 2019-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | composições derivadas de hyr1 e métodos of tratamento usando as mesmas |
| WO2014144024A1 (en) | 2013-03-15 | 2014-09-18 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Hyr1 compositions and methods for treating fungal and bacterial pathogens |
| US20160030533A1 (en) | 2013-03-15 | 2016-02-04 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods of treating fungal and bacterial pathogens |
| US10130691B2 (en) | 2013-03-15 | 2018-11-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods for treating fungal and bacterial pathogens |
| GB201503812D0 (en) | 2015-03-06 | 2015-04-22 | Univ Aberdeen | Antibody molecules and uses thereof |
| EP3426287A4 (en) | 2016-03-09 | 2020-03-11 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Methods and kits for use in preventing and treating vulvovaginal candidiasis |
-
2006
- 2006-01-06 US US11/327,197 patent/US20070077256A1/en not_active Abandoned
-
2007
- 2007-01-05 EP EP07709622A patent/EP1982190B1/en not_active Not-in-force
- 2007-01-05 CA CA2636277A patent/CA2636277C/en not_active Expired - Fee Related
- 2007-01-05 WO PCT/US2007/000433 patent/WO2007081896A2/en not_active Ceased
- 2007-01-05 EP EP12001586.2A patent/EP2532360B1/en not_active Not-in-force
- 2007-01-05 ES ES12001586.2T patent/ES2608354T3/es active Active
- 2007-01-05 ES ES11008862.2T patent/ES2608309T3/es active Active
- 2007-01-05 JP JP2008549598A patent/JP5692963B2/ja not_active Expired - Fee Related
- 2007-01-05 ES ES07709622T patent/ES2391580T3/es active Active
- 2007-01-05 CA CA2948424A patent/CA2948424A1/en not_active Abandoned
- 2007-01-05 AU AU2007205065A patent/AU2007205065B2/en not_active Ceased
- 2007-01-05 EP EP12001595A patent/EP2532361A1/en not_active Withdrawn
- 2007-01-05 DK DK07709622.0T patent/DK1982190T3/da active
- 2007-01-05 PT PT07709622T patent/PT1982190E/pt unknown
- 2007-01-05 EP EP11008862.2A patent/EP2428800B1/en not_active Not-in-force
- 2007-01-05 US US12/160,073 patent/US20090297562A1/en not_active Abandoned
-
2011
- 2011-01-10 US US12/987,949 patent/US20120014995A1/en not_active Abandoned
-
2012
- 2012-09-21 JP JP2012207831A patent/JP5775044B2/ja not_active Expired - Fee Related
- 2012-10-18 CY CY20121100979T patent/CY1113693T1/el unknown
-
2013
- 2013-03-05 US US13/785,835 patent/US20140037689A1/en not_active Abandoned
-
2014
- 2014-05-22 JP JP2014105980A patent/JP2014148547A/ja not_active Withdrawn
-
2016
- 2016-02-03 US US15/014,440 patent/US10300120B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030124134A1 (en) * | 1999-11-19 | 2003-07-03 | Harbor-Ucla Research And Education Institute | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| WO2006121895A2 (en) * | 2005-05-05 | 2006-11-16 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Non-Patent Citations (1)
| Title |
|---|
| Sheppard et al. "Functional and Structural Diversity in the Als Protein Family of Candida albicans" J. Biol. Chem, 2004, vol. 279, pps 30480-30489 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2636277A1 (en) | 2007-07-19 |
| AU2007205065A1 (en) | 2007-07-19 |
| EP1982190A2 (en) | 2008-10-22 |
| JP2012255031A (ja) | 2012-12-27 |
| ES2608354T3 (es) | 2017-04-10 |
| US20120014995A1 (en) | 2012-01-19 |
| CA2948424A1 (en) | 2007-07-19 |
| JP2014148547A (ja) | 2014-08-21 |
| EP2428800B1 (en) | 2016-09-28 |
| US10300120B2 (en) | 2019-05-28 |
| DK1982190T3 (da) | 2012-10-22 |
| US20090297562A1 (en) | 2009-12-03 |
| EP2532360B1 (en) | 2016-09-28 |
| ES2391580T3 (es) | 2012-11-28 |
| WO2007081896A3 (en) | 2007-11-22 |
| ES2608309T3 (es) | 2017-04-07 |
| CA2636277C (en) | 2017-06-13 |
| JP2009524601A (ja) | 2009-07-02 |
| WO2007081896A2 (en) | 2007-07-19 |
| PT1982190E (pt) | 2012-10-22 |
| CY1113693T1 (el) | 2016-06-22 |
| EP2532361A1 (en) | 2012-12-12 |
| EP1982190A4 (en) | 2009-12-23 |
| JP5692963B2 (ja) | 2015-04-01 |
| US20140037689A1 (en) | 2014-02-06 |
| EP2532360A1 (en) | 2012-12-12 |
| EP1982190B1 (en) | 2012-07-18 |
| US20070077256A1 (en) | 2007-04-05 |
| EP2428800A1 (en) | 2012-03-14 |
| JP5775044B2 (ja) | 2015-09-09 |
| US20160220648A1 (en) | 2016-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |