AU2007202359B2 - Tartrate salt of isofagomine and methods of use - Google Patents
Tartrate salt of isofagomine and methods of use Download PDFInfo
- Publication number
- AU2007202359B2 AU2007202359B2 AU2007202359A AU2007202359A AU2007202359B2 AU 2007202359 B2 AU2007202359 B2 AU 2007202359B2 AU 2007202359 A AU2007202359 A AU 2007202359A AU 2007202359 A AU2007202359 A AU 2007202359A AU 2007202359 B2 AU2007202359 B2 AU 2007202359B2
- Authority
- AU
- Australia
- Prior art keywords
- isofagomine
- tartrate
- isofagomine tartrate
- tartaric acid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- QPYJXFZUIJOGNX-HSUXUTPPSA-N afegostat Chemical compound OC[C@H]1CNC[C@@H](O)[C@@H]1O QPYJXFZUIJOGNX-HSUXUTPPSA-N 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims abstract description 49
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- ULBPPCHRAVUQMC-MUMXBIPUSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;(3r,4r,5r)-5-(hydroxymethyl)piperidine-3,4-diol Chemical compound OC[C@H]1CNC[C@@H](O)[C@@H]1O.OC(=O)[C@H](O)[C@@H](O)C(O)=O ULBPPCHRAVUQMC-MUMXBIPUSA-N 0.000 claims abstract 31
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 32
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- 238000005481 NMR spectroscopy Methods 0.000 description 17
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 15
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
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- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 description 7
- 150000002825 nitriles Chemical class 0.000 description 7
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
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|---|---|---|---|
| US80802006P | 2006-05-24 | 2006-05-24 | |
| US60/808,020 | 2006-05-24 | ||
| US89071907P | 2007-02-20 | 2007-02-20 | |
| US60/890,719 | 2007-02-20 |
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| AU2007202359A1 AU2007202359A1 (en) | 2007-12-13 |
| AU2007202359B2 true AU2007202359B2 (en) | 2012-02-16 |
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|---|---|---|---|
| AU2007202359A Ceased AU2007202359B2 (en) | 2006-05-24 | 2007-05-24 | Tartrate salt of isofagomine and methods of use |
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|---|---|
| US (2) | US7501439B2 (enExample) |
| EP (1) | EP1860101B1 (enExample) |
| JP (1) | JP5292605B2 (enExample) |
| AT (1) | ATE504570T1 (enExample) |
| AU (1) | AU2007202359B2 (enExample) |
| BR (1) | BRPI0706114A2 (enExample) |
| CA (1) | CA2590122C (enExample) |
| DE (1) | DE602007013648D1 (enExample) |
| DK (1) | DK1860101T3 (enExample) |
| IL (1) | IL183415A (enExample) |
| MX (1) | MX2007006175A (enExample) |
| PL (1) | PL1860101T3 (enExample) |
| PT (1) | PT1860101E (enExample) |
| WO (1) | WO2007140212A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006254796B2 (en) * | 2005-06-08 | 2012-08-16 | Amicus Therapeutics, Inc. | Treatment of CNS disorders associated with mutations in genes encoding lysosomal enzymes |
| BRPI0713442A2 (pt) | 2006-06-23 | 2012-03-06 | Amicus Therapeutics, Inc. | Método para o tratamento de desrodens neurológicas, pelo aumento da atividade de b-glicocerebrosidase |
| WO2008144773A1 (en) | 2007-05-22 | 2008-11-27 | Amicus Therapeutics, Inc. | New method for preparing isofagomine and its derivatives |
| WO2009102895A2 (en) | 2008-02-12 | 2009-08-20 | Amicus Therapeutics, Inc. | Method to predict response to pharmacological chaperone treatment of diseases |
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|---|---|---|---|---|
| US5844102A (en) * | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
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| US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5844102A (en) * | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
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| US20070281975A1 (en) | 2007-12-06 |
| EP1860101B1 (en) | 2011-04-06 |
| WO2007140212A2 (en) | 2007-12-06 |
| JP5292605B2 (ja) | 2013-09-18 |
| IL183415A0 (en) | 2007-09-20 |
| US7863453B2 (en) | 2011-01-04 |
| CA2590122A1 (en) | 2007-11-24 |
| BRPI0706114A2 (pt) | 2008-11-18 |
| US20090176830A1 (en) | 2009-07-09 |
| DE602007013648D1 (de) | 2011-05-19 |
| CA2590122C (en) | 2015-03-31 |
| MX2007006175A (es) | 2009-02-16 |
| US7501439B2 (en) | 2009-03-10 |
| PT1860101E (pt) | 2011-07-12 |
| ATE504570T1 (de) | 2011-04-15 |
| EP1860101A1 (en) | 2007-11-28 |
| JP2007314540A (ja) | 2007-12-06 |
| IL183415A (en) | 2012-03-29 |
| DK1860101T3 (da) | 2011-07-25 |
| PL1860101T3 (pl) | 2011-10-31 |
| WO2007140212A3 (en) | 2008-12-24 |
| AU2007202359A1 (en) | 2007-12-13 |
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