AU2006336624B2 - Modulation of gene expression by oligomers targeted to chromosomal DNA - Google Patents

Modulation of gene expression by oligomers targeted to chromosomal DNA Download PDF

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Publication number
AU2006336624B2
AU2006336624B2 AU2006336624A AU2006336624A AU2006336624B2 AU 2006336624 B2 AU2006336624 B2 AU 2006336624B2 AU 2006336624 A AU2006336624 A AU 2006336624A AU 2006336624 A AU2006336624 A AU 2006336624A AU 2006336624 B2 AU2006336624 B2 AU 2006336624B2
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gene
oligomer
cell
target
target transcript
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AU2006336624A1 (en
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David Reid Corey
Bethany A. Janowski
John D. Minna
David S. Shames
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University of Texas System
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University of Texas System
University of Texas at Austin
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/331—Universal or degenerate base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2006336624A 2005-11-17 2006-11-13 Modulation of gene expression by oligomers targeted to chromosomal DNA Active AU2006336624B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011200554A AU2011200554B2 (en) 2005-11-17 2011-02-10 Modulation of gene expression by oligomers targeted to chromosomal DNA

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73810305P 2005-11-17 2005-11-17
US60/738,103 2005-11-17
PCT/US2006/044042 WO2007086990A2 (en) 2005-11-17 2006-11-13 Modulation of gene expression by oligomers targeted to chromosomal dna

Related Child Applications (1)

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AU2006336624A1 AU2006336624A1 (en) 2007-08-02
AU2006336624B2 true AU2006336624B2 (en) 2010-11-25

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AU2006336624A Active AU2006336624B2 (en) 2005-11-17 2006-11-13 Modulation of gene expression by oligomers targeted to chromosomal DNA
AU2011200554A Active AU2011200554B2 (en) 2005-11-17 2011-02-10 Modulation of gene expression by oligomers targeted to chromosomal DNA

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US (2) US7709456B2 (https=)
EP (3) EP1957648B1 (https=)
JP (2) JP5066095B2 (https=)
AU (2) AU2006336624B2 (https=)
CA (1) CA2629664A1 (https=)
DK (1) DK2641970T3 (https=)
WO (1) WO2007086990A2 (https=)

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JP5713377B2 (ja) 2005-12-28 2015-05-07 ザ スクリプス リサーチ インスティテュート 薬物標的としての天然アンチセンスおよび非コードｒｎａ転写物
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