AU2006311826C1 - Hydrazone derivatives and uses thereof - Google Patents

Hydrazone derivatives and uses thereof Download PDF

Info

Publication number
AU2006311826C1
AU2006311826C1 AU2006311826A AU2006311826A AU2006311826C1 AU 2006311826 C1 AU2006311826 C1 AU 2006311826C1 AU 2006311826 A AU2006311826 A AU 2006311826A AU 2006311826 A AU2006311826 A AU 2006311826A AU 2006311826 C1 AU2006311826 C1 AU 2006311826C1
Authority
AU
Australia
Prior art keywords
optionally substituted
aryl
alkyl
formula
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006311826A
Other languages
English (en)
Other versions
AU2006311826B2 (en
AU2006311826A1 (en
Inventor
Karnail Atwal
Robert W. Bryant
Rok Cerne
Seunghun Paul Lee
Roy Kyle Palmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REDPOINT BIO Corp
Original Assignee
REDPOINT BIO CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REDPOINT BIO CORP filed Critical REDPOINT BIO CORP
Publication of AU2006311826A1 publication Critical patent/AU2006311826A1/en
Publication of AU2006311826B2 publication Critical patent/AU2006311826B2/en
Application granted granted Critical
Publication of AU2006311826C1 publication Critical patent/AU2006311826C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/84—Flavour masking or reducing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86—Addition of bitterness inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/415—Aminophenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
AU2006311826A 2005-11-03 2006-11-03 Hydrazone derivatives and uses thereof Ceased AU2006311826C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73263405P 2005-11-03 2005-11-03
US60/732,634 2005-11-03
PCT/US2006/042988 WO2007056159A2 (en) 2005-11-03 2006-11-03 Hydrazone derivatives and uses thereof

Publications (3)

Publication Number Publication Date
AU2006311826A1 AU2006311826A1 (en) 2007-05-18
AU2006311826B2 AU2006311826B2 (en) 2010-11-11
AU2006311826C1 true AU2006311826C1 (en) 2011-06-16

Family

ID=38023837

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006311826A Ceased AU2006311826C1 (en) 2005-11-03 2006-11-03 Hydrazone derivatives and uses thereof

Country Status (11)

Country Link
US (1) US20070207093A1 (enExample)
EP (1) EP1951215A4 (enExample)
JP (1) JP2009514878A (enExample)
KR (1) KR20080070848A (enExample)
CN (1) CN101541348A (enExample)
AU (1) AU2006311826C1 (enExample)
BR (1) BRPI0618224A2 (enExample)
CA (1) CA2626846A1 (enExample)
NO (1) NO20082346L (enExample)
RU (1) RU2008115539A (enExample)
WO (1) WO2007056159A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8871746B2 (en) 2006-03-02 2014-10-28 Kineta Four, LLC Antiviral drugs for treatment of arenavirus infection
EP1988884A4 (en) 2006-03-02 2009-09-30 Siga Technologies Inc ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENAVIRUS INFECTIONS
EP1988776B1 (en) 2006-03-02 2012-08-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CA2677230A1 (en) * 2007-02-02 2008-08-14 Redpoint Bio Corporation Use of a trpm5 inhibitor to regulate insulin and glp-1 release
US8609649B2 (en) * 2007-03-20 2013-12-17 Brandeis University Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases
US20090175848A1 (en) * 2007-09-17 2009-07-09 Lee S Paul Modulation of the Cooperativity Between the Ion Channels TRPM5 and TRPA1
WO2009065854A1 (en) * 2007-11-21 2009-05-28 Neurosearch A/S N-acylhydrazone derivatives useful as modulators of nicotinic acetylcholine receptors
US20110033393A1 (en) * 2009-05-12 2011-02-10 Stein Philip Hydrazone Compounds and Their Use
JP2014500229A (ja) * 2010-08-20 2014-01-09 ダウ アグロサイエンシィズ エルエルシー ７−ヒドロキシ−インダノンベンゾイルヒドラゾン及び銅を含む相乗的殺真菌及び殺藻組成物
CA2839613A1 (en) 2011-06-24 2012-12-27 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
AU2012296639B2 (en) 2011-08-15 2016-06-09 University Of Utah Research Foundation Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors
US9266838B2 (en) 2011-08-15 2016-02-23 University Of Utah Research Foundation Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
BRPI1106472A2 (pt) * 2011-11-29 2014-04-15 Univ Rio De Janeiro Compostos n-glicinil-n-acilidrazônicos heterocíclicos, processo de síntese, composições farmacêuticas e método de tratamento
HK1211426A1 (en) 2012-12-19 2016-05-27 美国陶氏益农公司 Pesticidal compositions and processes related thereto
WO2014100163A1 (en) * 2012-12-19 2014-06-26 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
TWI621604B (zh) 2012-12-19 2018-04-21 陶氏農業科學公司 殺蟲組成物及其相關之方法
TWI631098B (zh) 2012-12-19 2018-08-01 陶氏農業科學公司 殺蟲組成物及其相關方法（一）
WO2014100190A1 (en) 2012-12-19 2014-06-26 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
TWI667224B (zh) 2014-06-09 2019-08-01 美商陶氏農業科學公司 殺蟲組成物及與其相關之方法
AU2017212303B2 (en) 2016-01-25 2019-09-12 Corteva Agriscience Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
CN105732476B (zh) * 2016-02-04 2017-12-01 吉首大学 一种咔唑‑靛红型化合物及其制法和用途
RU2691454C2 (ru) * 2016-03-30 2019-06-14 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Использование 3,4,5-триметокси-N'(2,2,6,6-тетраметил-пиперидин-4-илиден)бензогидразида гидрохлорида в качестве анксиолитического средства
RU2699658C2 (ru) * 2016-08-19 2019-09-09 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Ацилгидразон (2,3,4-триметокси-N'-(8-метил-8-азабицикло[3.2.1.] октан-3-илиден) бензогидразид гидрохлорид), обладающий противомигреневой и анксиолитической активностью
TWI780112B (zh) 2017-03-31 2022-10-11 美商科迪華農業科技有限責任公司 具有殺蟲效用之分子，及其相關之中間物、組成物暨方法
KR102128509B1 (ko) 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
EP4651866A1 (en) * 2023-01-20 2025-11-26 The Research Foundation for The State University of New York Hydrazonyl sultones and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5072042A (en) * 1989-02-10 1991-12-10 Basf Aktiengesellschaft Phenylhydrazones, the manufacture thereof and therapeutic and cosmetic compositions prepared therefrom
WO1992019236A1 (en) * 1991-05-07 1992-11-12 The Rockefeller University 2-alkylidene-aminoguanidines for inhibiting advanced nonenzymaticglycosylation of proteins
WO1999040062A1 (en) * 1998-02-05 1999-08-12 Novo Nordisk A/S Hydrazone derivatives
WO2003049698A2 (en) * 2001-12-10 2003-06-19 Temple University - Of The Commonwealth System Of Higher Education Substituted hydrazones as inhibitors of cyclooxygenase-2
WO2004072183A1 (en) * 2003-02-17 2004-08-26 Ciba Specialty Chemicals Holding Inc. Cationic substituted hydrazone dyes
WO2004083312A2 (en) * 2003-03-18 2004-09-30 Ciba Specialty Chemicals Holding Inc. Cationic dimeric dyes

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684534A (en) * 1985-02-19 1987-08-04 Dynagram Corporation Of America Quick-liquifying, chewable tablet
US5011678A (en) * 1989-02-01 1991-04-30 California Biotechnology Inc. Composition and method for administration of pharmaceutically active substances
US6649186B1 (en) * 1996-09-20 2003-11-18 Ethypharm Effervescent granules and methods for their preparation
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
US6060078A (en) * 1998-09-28 2000-05-09 Sae Han Pharm Co., Ltd. Chewable tablet and process for preparation thereof
US6403142B1 (en) * 1998-12-11 2002-06-11 Ralston Purina Company Hypoallergenic pet food
AU2378600A (en) * 1998-12-23 2000-07-31 Mount Sinai School Of Medicine Of The City University Of New York, The Inhibitors of the bitter taste response
US6773716B2 (en) * 1999-04-06 2004-08-10 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
US6187332B1 (en) * 1999-06-14 2001-02-13 Wisconsin Alumni Research Foundation Acidic buffered nasal spray
AU8032400A (en) * 1999-10-27 2001-05-08 Zapata Technologies, Inc. Flavor protectant closure liner compositions
AU2001241042A1 (en) * 2000-03-08 2001-09-17 Takeda Chemical Industries Ltd. Process for the preparation of hydrazine derivatives
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6485709B2 (en) * 2001-01-23 2002-11-26 Addent Inc. Dental bleaching gel composition, activator system and method for activating a dental bleaching gel
US20030208067A1 (en) * 2001-05-30 2003-11-06 Cao Sheldon Xiaodong Inhibitors of protein kinase for the treatment of disease
WO2003011287A1 (en) * 2001-08-03 2003-02-13 Vertex Pharmaceuticals Incorporated Pyrazolon derivatives as inhibitors of gsk-3
GB0226724D0 (en) * 2002-11-15 2002-12-24 Merck Sharp & Dohme Therapeutic agents
CA2516651C (en) * 2003-02-21 2013-05-07 The Queen's Medical Center Methods of screening for trpm5 modulators
WO2004079372A1 (en) * 2003-03-05 2004-09-16 Metabolex Inc. Methods and compositions for treating and diagnosing diabetes and related diseases involving beta-trp
US20050244810A1 (en) * 2003-09-29 2005-11-03 Egan Josephine M Taste signaling in gastrointestinal cells
US20050182011A1 (en) * 2003-11-13 2005-08-18 Eric Olson Inhibition of TRP channels as a treatment for cardiac hypertrophy and heart failure
US20070161052A1 (en) * 2005-10-19 2007-07-12 Senomyx, Inc. TRPM5 based assays and the use thereof for the identification of modulators of sweet, bitter or umami (savory) taste
RU2008115455A (ru) * 2005-11-03 2009-12-10 Рэдпойнт Био Корпорэйшн (Us) Высокопроизводительный скрининг-анализ ионного канала trpm5

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5072042A (en) * 1989-02-10 1991-12-10 Basf Aktiengesellschaft Phenylhydrazones, the manufacture thereof and therapeutic and cosmetic compositions prepared therefrom
WO1992019236A1 (en) * 1991-05-07 1992-11-12 The Rockefeller University 2-alkylidene-aminoguanidines for inhibiting advanced nonenzymaticglycosylation of proteins
WO1999040062A1 (en) * 1998-02-05 1999-08-12 Novo Nordisk A/S Hydrazone derivatives
WO2003049698A2 (en) * 2001-12-10 2003-06-19 Temple University - Of The Commonwealth System Of Higher Education Substituted hydrazones as inhibitors of cyclooxygenase-2
WO2004072183A1 (en) * 2003-02-17 2004-08-26 Ciba Specialty Chemicals Holding Inc. Cationic substituted hydrazone dyes
WO2004083312A2 (en) * 2003-03-18 2004-09-30 Ciba Specialty Chemicals Holding Inc. Cationic dimeric dyes

Also Published As

Publication number Publication date
BRPI0618224A2 (pt) 2011-08-23
CN101541348A (zh) 2009-09-23
WO2007056159A3 (en) 2008-10-16
RU2008115539A (ru) 2009-12-10
JP2009514878A (ja) 2009-04-09
US20070207093A1 (en) 2007-09-06
NO20082346L (no) 2008-08-04
AU2006311826B2 (en) 2010-11-11
CA2626846A1 (en) 2007-05-18
KR20080070848A (ko) 2008-07-31
WO2007056159A2 (en) 2007-05-18
EP1951215A2 (en) 2008-08-06
AU2006311826A1 (en) 2007-05-18
EP1951215A4 (en) 2009-07-29

Similar Documents

Publication Publication Date Title
AU2006311826B2 (en) Hydrazone derivatives and uses thereof
US7674831B2 (en) Heterocyclic compounds as sweetener enhancers
EP1546114B1 (en) Tetrahydropyrimidine-2-one derivatives and their uses
US20080153845A1 (en) Trpv1 antagonists and uses thereof
US20070259875A1 (en) Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof
WO2014069660A1 (ja) 血流促進剤
EP2197851B1 (en) Derivatives of n-phenylacetamide as inhibitors of the enzyme soat1 for pharmaceutical and cosmetic use
JP2022128985A (ja) α－ジカルボニル化合物分解剤
KR20090047637A (ko) 커큐민 또는 이의 약학적으로 허용가능한 염을유효성분으로 함유하는 통증 예방 및 치료용 조성물
US20110033393A1 (en) Hydrazone Compounds and Their Use
MX2008005670A (en) Hydrazone derivatives and uses thereof
AU2019229433A1 (en) Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products
US20080070865A1 (en) Triphenylphosphine oxide derivatives and uses thereof
EP3279184B1 (en) Novel benzoic acid amide compound
CN105120857A (zh) 营养组合物
CN121568927A (zh) 作为生理清凉剂的杂环化合物
US20250066320A1 (en) Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT( S) FILED 03 FEB 2011.

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 03 FEB 2011

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired