AU2006263669B9 - Inducing peripheral blood vessel vasodilation - Google Patents

Inducing peripheral blood vessel vasodilation Download PDF

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Publication number
AU2006263669B9
AU2006263669B9 AU2006263669A AU2006263669A AU2006263669B9 AU 2006263669 B9 AU2006263669 B9 AU 2006263669B9 AU 2006263669 A AU2006263669 A AU 2006263669A AU 2006263669 A AU2006263669 A AU 2006263669A AU 2006263669 B9 AU2006263669 B9 AU 2006263669B9
Authority
AU
Australia
Prior art keywords
compound
cocoa
disease
epicatechin
venous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2006263669A
Other languages
English (en)
Other versions
AU2006263669B2 (en
AU2006263669A1 (en
Inventor
John F. Hammerstone Jr.
Mark A. Kelm
Catherine L. Kwik-Uribe
Harold H. Schmitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mars Inc
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Publication of AU2006263669A1 publication Critical patent/AU2006263669A1/en
Publication of AU2006263669B2 publication Critical patent/AU2006263669B2/en
Application granted granted Critical
Publication of AU2006263669B9 publication Critical patent/AU2006263669B9/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
AU2006263669A 2005-06-29 2006-06-29 Inducing peripheral blood vessel vasodilation Active AU2006263669B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69555705P 2005-06-29 2005-06-29
US60/695,557 2005-06-29
PCT/US2006/025429 WO2007002854A2 (en) 2005-06-29 2006-06-29 Inducing peripheral blood vessel vasodilation

Publications (3)

Publication Number Publication Date
AU2006263669A1 AU2006263669A1 (en) 2007-01-04
AU2006263669B2 AU2006263669B2 (en) 2012-11-29
AU2006263669B9 true AU2006263669B9 (en) 2012-12-13

Family

ID=37596061

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006263669A Active AU2006263669B9 (en) 2005-06-29 2006-06-29 Inducing peripheral blood vessel vasodilation

Country Status (9)

Country Link
US (2) US20070037872A1 (https=)
EP (2) EP1896008A4 (https=)
JP (2) JP2009500411A (https=)
CN (1) CN101300007A (https=)
AU (1) AU2006263669B9 (https=)
CA (1) CA2611856C (https=)
MX (1) MX2007016120A (https=)
RU (2) RU2435578C2 (https=)
WO (1) WO2007002854A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100292280A1 (en) * 2007-04-15 2010-11-18 Oron Zachar Anti-pyretic vasodilators
JPWO2010092941A1 (ja) * 2009-02-16 2012-08-16 株式会社ブルボン 血管拡張作用を有する組成物、製造法および用途
CA2784788A1 (en) * 2009-12-18 2011-06-23 Exodos Life Sciences Limited Partnership Methods and compositions for treating peripheral vascular disease
RU2497200C1 (ru) * 2012-03-28 2013-10-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ фармакологической коррекции ишемии скелетной мышцы миноксидилом
JP2023522700A (ja) * 2020-04-24 2023-05-31 アボット・ラボラトリーズ 微小血管血流を増加させる方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2770228A1 (fr) * 1997-10-27 1999-04-30 Greentech Sa Procede d'obtention d'oligomeres de proanthocyanidines par biofermentation et leur utilisation dans des compositions cosmetiques, dietetiques, pharmaceutiques, chimiques et alimentaires
WO2001070214A2 (en) * 2000-03-22 2001-09-27 Mars, Incorporated The use of cocoa procyanidins combined with acetylsalicyclic acid as an anti-platelet therapy
WO2001080870A2 (en) * 2000-04-13 2001-11-01 Ocean Spray Cranberries, Inc. Compositions derived from cranberry and grapefruit and therapeutic uses therefor
WO2002081651A2 (en) * 2001-02-20 2002-10-17 Uab Research Foundation Polyphenolics for enhancing endothelial cell-mediated fibrinolysis
US20020165270A1 (en) * 1997-05-13 2002-11-07 Jose Remacle Use of a pharmaceutical composition for treating and/or preventing ischemia
US6610320B2 (en) * 2000-04-14 2003-08-26 Mars, Incorporated Compositions and methods for improving vascular health
US20040087516A1 (en) * 2002-11-06 2004-05-06 Rosenbloom Richard A.. Methods for the treatment of peripheral neural and vascular ailments
WO2005009452A1 (en) * 2003-07-31 2005-02-03 Pynogin Gmbh A composition for decreasing the risk of long-haul traveller’s syndrome comprising a mixture of pycnogenol and standardized giger root extract
WO2005034879A2 (en) * 2003-10-10 2005-04-21 Mars, Incorporated Treatment of diseases involving erbb2 kinase overexpression

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554645A (en) 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US6297273B1 (en) * 1996-04-02 2001-10-02 Mars, Inc. Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
US6015913A (en) * 1996-09-06 2000-01-18 Mars, Incorporated Method for producing fat and/or solids from cocoa beans
US6207842B1 (en) 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US5922756A (en) * 1998-02-14 1999-07-13 Chan; Marion Man-Ying Method of inhibiting nitric oxide synthase
US6156912A (en) 1999-04-09 2000-12-05 Mars, Incorporated 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation
US7015338B1 (en) 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US20020115603A1 (en) * 2000-06-22 2002-08-22 Chiron Corporation Methods and compositions for the treatment of peripheral artery disease
US6476241B1 (en) 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US7067679B2 (en) 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020165270A1 (en) * 1997-05-13 2002-11-07 Jose Remacle Use of a pharmaceutical composition for treating and/or preventing ischemia
FR2770228A1 (fr) * 1997-10-27 1999-04-30 Greentech Sa Procede d'obtention d'oligomeres de proanthocyanidines par biofermentation et leur utilisation dans des compositions cosmetiques, dietetiques, pharmaceutiques, chimiques et alimentaires
WO2001070214A2 (en) * 2000-03-22 2001-09-27 Mars, Incorporated The use of cocoa procyanidins combined with acetylsalicyclic acid as an anti-platelet therapy
WO2001080870A2 (en) * 2000-04-13 2001-11-01 Ocean Spray Cranberries, Inc. Compositions derived from cranberry and grapefruit and therapeutic uses therefor
US6610320B2 (en) * 2000-04-14 2003-08-26 Mars, Incorporated Compositions and methods for improving vascular health
WO2002081651A2 (en) * 2001-02-20 2002-10-17 Uab Research Foundation Polyphenolics for enhancing endothelial cell-mediated fibrinolysis
US20040087516A1 (en) * 2002-11-06 2004-05-06 Rosenbloom Richard A.. Methods for the treatment of peripheral neural and vascular ailments
WO2005009452A1 (en) * 2003-07-31 2005-02-03 Pynogin Gmbh A composition for decreasing the risk of long-haul traveller’s syndrome comprising a mixture of pycnogenol and standardized giger root extract
WO2005034879A2 (en) * 2003-10-10 2005-04-21 Mars, Incorporated Treatment of diseases involving erbb2 kinase overexpression

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Daroczy, J. et al, Orvosi Hetilap, 2004, 145(22):1177-1181 *
Henriet, J.P. Phlebologie, 1993, 46(2):313-325 *
Petrassi, C. et al, Phytomedicine, 2000, 7(5):383-388 *
Rohdewald, P. International Journal of Clinical Pharmacology and Therapeutics, 2002, 40(4):158-168 *

Also Published As

Publication number Publication date
JP2013136634A (ja) 2013-07-11
CA2611856C (en) 2018-02-27
US20070037872A1 (en) 2007-02-15
US20110257118A1 (en) 2011-10-20
EP1896008A2 (en) 2008-03-12
JP6149290B2 (ja) 2017-06-21
WO2007002854A2 (en) 2007-01-04
AU2006263669B2 (en) 2012-11-29
RU2435578C2 (ru) 2011-12-10
EP1896008A4 (en) 2010-04-07
AU2006263669A1 (en) 2007-01-04
CN101300007A (zh) 2008-11-05
EP2522347A1 (en) 2012-11-14
JP2009500411A (ja) 2009-01-08
CA2611856A1 (en) 2007-01-04
MX2007016120A (es) 2008-04-29
RU2587321C2 (ru) 2016-06-20
RU2011134621A (ru) 2013-02-27
WO2007002854A3 (en) 2007-07-26
RU2008103152A (ru) 2009-08-10

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