AU2005277601B2 - Crystalline form of a biphenyl compound - Google Patents

Crystalline form of a biphenyl compound Download PDF

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Publication number
AU2005277601B2
AU2005277601B2 AU2005277601A AU2005277601A AU2005277601B2 AU 2005277601 B2 AU2005277601 B2 AU 2005277601B2 AU 2005277601 A AU2005277601 A AU 2005277601A AU 2005277601 A AU2005277601 A AU 2005277601A AU 2005277601 B2 AU2005277601 B2 AU 2005277601B2
Authority
AU
Australia
Prior art keywords
hydroxy
compound
ester
methyl
biphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005277601A
Other languages
English (en)
Other versions
AU2005277601A1 (en
Inventor
Robert S. Chao
Pierre-Jean Colson
Miroslav Rapta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theravance Biopharma R&D IP LLC
Original Assignee
Theravance Biopharma R&D IP LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D IP LLC filed Critical Theravance Biopharma R&D IP LLC
Publication of AU2005277601A1 publication Critical patent/AU2005277601A1/en
Application granted granted Critical
Publication of AU2005277601B2 publication Critical patent/AU2005277601B2/en
Assigned to THERAVANCE RESPIRATORY COMPANY, LLC reassignment THERAVANCE RESPIRATORY COMPANY, LLC Request for Assignment Assignors: THERAVANCE, INC.
Assigned to THERAVANCE BIOPHARMA R&D IP, LLC reassignment THERAVANCE BIOPHARMA R&D IP, LLC Request for Assignment Assignors: THERAVANCE RESPIRATORY COMPANY, LLC
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2005277601A 2004-08-16 2005-08-15 Crystalline form of a biphenyl compound Ceased AU2005277601B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60180504P 2004-08-16 2004-08-16
US60/601,805 2004-08-16
PCT/US2005/029013 WO2006023454A1 (en) 2004-08-16 2005-08-15 Crystalline form of a biphenyl compound

Publications (2)

Publication Number Publication Date
AU2005277601A1 AU2005277601A1 (en) 2006-03-02
AU2005277601B2 true AU2005277601B2 (en) 2011-10-27

Family

ID=35687428

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005277601A Ceased AU2005277601B2 (en) 2004-08-16 2005-08-15 Crystalline form of a biphenyl compound

Country Status (25)

Country Link
US (4) US7521558B2 (https=)
EP (1) EP1778672B1 (https=)
JP (2) JP5032990B2 (https=)
KR (1) KR101363352B1 (https=)
CN (1) CN101006077B (https=)
AR (1) AR051003A1 (https=)
AU (1) AU2005277601B2 (https=)
BR (1) BRPI0514413C1 (https=)
CA (1) CA2575874C (https=)
DK (1) DK1778672T3 (https=)
ES (1) ES2400958T3 (https=)
HR (1) HRP20130192T1 (https=)
IL (1) IL180853A (https=)
MA (1) MA28825B1 (https=)
MX (1) MX2007001688A (https=)
MY (1) MY141224A (https=)
NO (1) NO338770B1 (https=)
NZ (1) NZ552796A (https=)
PL (1) PL1778672T3 (https=)
PT (1) PT1778672E (https=)
RU (1) RU2381223C2 (https=)
SI (1) SI1778672T1 (https=)
TW (1) TWI374883B (https=)
WO (1) WO2006023454A1 (https=)
ZA (1) ZA200701057B (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
US8429052B2 (en) * 2005-07-19 2013-04-23 Lincoln National Life Insurance Company Method and system for providing employer-sponsored retirement plan
GB0602778D0 (en) * 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
TW200811105A (en) * 2006-04-25 2008-03-01 Theravance Inc Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
TW200811104A (en) * 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound
AP2009004791A0 (en) * 2006-10-04 2009-04-30 Pfizer Ltd Sulfonamide derivatives as adrenergic agonists andmuscarinic antagonists
ES2302447B1 (es) * 2006-10-20 2009-06-12 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2306595B1 (es) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320961B1 (es) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
SG175023A1 (en) * 2009-04-14 2011-11-28 Glaxo Group Ltd Process for the preparation of a biphenyl-2-ylcarbamic acid ester
AU2015234331B2 (en) * 2009-04-23 2017-08-03 Theravance Biopharma R&D Ip, Llc Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
SG175330A1 (en) 2009-04-23 2011-11-28 Theravance Inc DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND ß2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
GB201009801D0 (en) 2010-06-11 2010-07-21 Astrazeneca Ab Compounds 950
AR083115A1 (es) 2010-09-30 2013-01-30 Theravance Inc Sales oxalato cristalinas de un compuesto diamida
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
CA2852912A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Intellectual Property Limited Pazopanib formulation
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
ES2750523T3 (es) 2012-12-18 2020-03-26 Almirall Sa Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
TW201835041A (zh) 2017-02-17 2018-10-01 印度商托仁特生技有限公司 具β-腎上腺素促效劑及抗蕈毒活性化合物
WO2020047225A1 (en) 2018-08-30 2020-03-05 Theravance Biopharma R&D Ip, Llc Methods for treating chronic obstructive pulmonary disease
US20240300919A1 (en) * 2021-02-19 2024-09-12 Gbr Laboratories Private Limited A process for preparing batefenterol and intermediates thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042212A1 (en) * 1999-12-07 2001-06-14 Theravance, Inc. Carbamate derivatives having muscarinic receptor antagonist activity
US6653323B2 (en) * 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS596860B2 (ja) * 1975-05-19 1984-02-15 オオツカセイヤク カブシキガイシヤ ５−〔（２−アルキルアミノ−１−ヒドロキシ）アルキル〕カルボスチリル誘導体の製造法
TW297025B (https=) * 1992-02-14 1997-02-01 Squibb & Sons Inc
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
UA73543C2 (uk) 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
US20030018019A1 (en) 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP2004356517A (ja) 2003-05-30 2004-12-16 Ebara Corp 基板洗浄装置及び基板洗浄方法
US20050025718A1 (en) 2003-07-31 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
US7320990B2 (en) 2004-02-13 2008-01-22 Theravance, Inc. Crystalline form of a biphenyl compound
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042212A1 (en) * 1999-12-07 2001-06-14 Theravance, Inc. Carbamate derivatives having muscarinic receptor antagonist activity
US6653323B2 (en) * 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists

Also Published As

Publication number Publication date
US20120283289A1 (en) 2012-11-08
IL180853A (en) 2014-03-31
NO338770B1 (no) 2016-10-17
BRPI0514413C1 (pt) 2021-05-25
PT1778672E (pt) 2013-02-25
US20090221638A1 (en) 2009-09-03
PL1778672T3 (pl) 2013-05-31
WO2006023454A1 (en) 2006-03-02
HRP20130192T1 (hr) 2013-04-30
AR051003A1 (es) 2006-12-13
SI1778672T1 (sl) 2013-04-30
JP2012121929A (ja) 2012-06-28
NO20071307L (no) 2007-04-11
CA2575874A1 (en) 2006-03-02
US20130289281A1 (en) 2013-10-31
US7521558B2 (en) 2009-04-21
ZA200701057B (en) 2008-08-27
JP5032990B2 (ja) 2012-09-26
US8101766B2 (en) 2012-01-24
TW200613296A (en) 2006-05-01
RU2381223C2 (ru) 2010-02-10
KR20070057832A (ko) 2007-06-07
MY141224A (en) 2010-03-31
CN101006077A (zh) 2007-07-25
DK1778672T3 (da) 2013-03-25
EP1778672A1 (en) 2007-05-02
IL180853A0 (en) 2007-07-04
BRPI0514413B1 (pt) 2019-04-16
CA2575874C (en) 2012-10-09
US20060035931A1 (en) 2006-02-16
BRPI0514413A (pt) 2008-06-10
EP1778672B1 (en) 2012-12-19
MA28825B1 (fr) 2007-08-01
MX2007001688A (es) 2007-04-23
JP2008513358A (ja) 2008-05-01
TWI374883B (en) 2012-10-21
AU2005277601A1 (en) 2006-03-02
HK1106227A1 (en) 2008-03-07
CN101006077B (zh) 2012-04-25
US8754223B2 (en) 2014-06-17
KR101363352B1 (ko) 2014-02-14
NZ552796A (en) 2010-09-30
US8476299B2 (en) 2013-07-02
ES2400958T3 (es) 2013-04-15
RU2007109598A (ru) 2008-09-27

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: THERAVANCE RESPIRATORY COMPANY, LLC

Free format text: FORMER OWNER WAS: THERAVANCE, INC.

PC Assignment registered

Owner name: THERAVANCE BIOPHARMA R&D IP, LLC

Free format text: FORMER OWNER(S): THERAVANCE RESPIRATORY COMPANY, LLC

MK14 Patent ceased section 143(a) (annual fees not paid) or expired