AU2005233591B2 - Thioamide derivatives as progesterone receptor modulators - Google Patents

Thioamide derivatives as progesterone receptor modulators Download PDF

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Publication number
AU2005233591B2
AU2005233591B2 AU2005233591A AU2005233591A AU2005233591B2 AU 2005233591 B2 AU2005233591 B2 AU 2005233591B2 AU 2005233591 A AU2005233591 A AU 2005233591A AU 2005233591 A AU2005233591 A AU 2005233591A AU 2005233591 B2 AU2005233591 B2 AU 2005233591B2
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AU
Australia
Prior art keywords
compound
formula
treating
alkyl
compounds
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005233591A
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English (en)
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AU2005233591A1 (en
Inventor
Bogdan Kazimierz Wilk
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Wyeth LLC
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Wyeth LLC
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Publication of AU2005233591A1 publication Critical patent/AU2005233591A1/en
Application granted granted Critical
Publication of AU2005233591B2 publication Critical patent/AU2005233591B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ink Jet (AREA)
AU2005233591A 2004-04-08 2005-04-07 Thioamide derivatives as progesterone receptor modulators Ceased AU2005233591B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56056904P 2004-04-08 2004-04-08
US60/560,569 2004-04-08
PCT/US2005/011757 WO2005100346A1 (en) 2004-04-08 2005-04-07 Thioamide derivatives as progesterone receptor modulators

Publications (2)

Publication Number Publication Date
AU2005233591A1 AU2005233591A1 (en) 2005-10-27
AU2005233591B2 true AU2005233591B2 (en) 2011-10-27

Family

ID=34965700

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005233591A Ceased AU2005233591B2 (en) 2004-04-08 2005-04-07 Thioamide derivatives as progesterone receptor modulators

Country Status (14)

Country Link
US (4) US7358246B2 (enExample)
EP (1) EP1732921B1 (enExample)
JP (1) JP4869221B2 (enExample)
CN (1) CN100522960C (enExample)
AT (1) ATE413398T1 (enExample)
AU (1) AU2005233591B2 (enExample)
BR (1) BRPI0509209A (enExample)
CA (1) CA2561014C (enExample)
DE (1) DE602005010840D1 (enExample)
DK (1) DK1732921T3 (enExample)
ES (1) ES2317223T3 (enExample)
MX (1) MXPA06011696A (enExample)
PL (1) PL1732921T3 (enExample)
WO (1) WO2005100346A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409699T1 (de) * 2004-04-08 2008-10-15 Wyeth Corp Verfahren zur minimierung von thioamidverunreinigungen
CA2561014C (en) * 2004-04-08 2013-09-10 Wyeth Thioamide derivatives as progesterone receptor modulators
GT200500185A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
US20070093548A1 (en) * 2005-10-25 2007-04-26 Wyeth Use of progesterone receptor modulators
US7618989B2 (en) * 2006-08-15 2009-11-17 Wyeth Tricyclic oxazolidone derivatives useful as PR modulators
EA201070715A1 (ru) * 2007-12-20 2011-02-28 Тева Вимен'С Хелс, Инк. Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции
CN107281215A (zh) * 2016-04-01 2017-10-24 复旦大学附属妇产科医院 硫化氢供体硫氢化钠在制药中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066581A1 (en) * 1999-05-04 2000-11-09 American Home Products Corporation Cyanopyrroles as progesterone receptor agonists
US6436929B1 (en) * 1999-05-04 2002-08-20 Wyeth Cyclothiocarbamate derivatives as progesterone receptor modulators

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US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4295987A (en) * 1979-12-26 1981-10-20 The Procter & Gamble Company Cross-linked sodium polyacrylate absorbent
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
AU608891B2 (en) 1987-09-24 1991-04-18 Merck & Co., Inc. Solubility modulated drug delivery device
US5273752A (en) * 1989-07-18 1993-12-28 Alza Corporation Controlled release dispenser comprising beneficial agent
US5124455A (en) * 1990-08-08 1992-06-23 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
US5459151A (en) * 1993-04-30 1995-10-17 American Home Products Corporation N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents
US5854388A (en) * 1993-06-24 1998-12-29 Washington State University Research Foundation Angiotensin IV peptides and receptor
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5756127A (en) * 1996-10-29 1998-05-26 Wright Medical Technology, Inc. Implantable bioresorbable string of calcium sulfate beads
FI971385A0 (fi) 1997-04-04 1997-04-04 Bioxid Oy Biokompatibel komposition, metoder foer dess framstaellning samt anvaendning daerav
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6417214B1 (en) * 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6509334B1 (en) * 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
BR0010216A (pt) * 1999-05-04 2002-03-19 American Home Prod Derivados de tio-oxindol
HUP0203332A3 (en) * 1999-05-04 2004-12-28 Wyeth Corp Cyclothiocarbamate derivatives, their use as progesterone receptor modulators and pharmaceutical compositions containing them
EP1202955A4 (en) * 1999-08-10 2004-02-11 Smithkline Beecham Corp 1,4-SUBSTITUTED 4,4-DIARYLCYCLOHEXANES
US6258833B1 (en) * 1999-12-23 2001-07-10 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
JP4716547B2 (ja) * 2000-08-10 2011-07-06 住友精化株式会社 ２−フェニルチアゾール類の製造方法
US20030225273A1 (en) * 2002-03-21 2003-12-04 Michaelides Michael R. Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
US20060100199A1 (en) 2002-06-06 2006-05-11 Seiji Yoshikawa Novel condensed imidazole derivatives
TW200407124A (en) * 2002-06-25 2004-05-16 Wyeth Corp Use of thio-oxindole derivatives in treatment of hormone-related conditions
RU2005101624A (ru) * 2002-06-25 2005-06-27 Уайт (Us) Применение производных тиооксиндола в терапии кожных нарушений
CN1665510A (zh) * 2002-06-25 2005-09-07 惠氏公司 作为pr调节剂的环硫代氨基甲酸酯衍生物的衍生物和其用于治疗皮肤病的用途
CN1662241A (zh) * 2002-06-25 2005-08-31 惠氏公司 环硫代氨基甲酸酯衍生物在治疗与激素有关的病症中的用途
CA2561014C (en) * 2004-04-08 2013-09-10 Wyeth Thioamide derivatives as progesterone receptor modulators
BRPI0509159B1 (pt) 2004-04-08 2014-08-26 Wyeth Llc Processo para preparar um composto de fenoxicicloalquila
ATE409699T1 (de) 2004-04-08 2008-10-15 Wyeth Corp Verfahren zur minimierung von thioamidverunreinigungen
CA2563063C (en) 2004-04-27 2014-06-03 Wyeth Purification of progesterone receptor modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066581A1 (en) * 1999-05-04 2000-11-09 American Home Products Corporation Cyanopyrroles as progesterone receptor agonists
US6436929B1 (en) * 1999-05-04 2002-08-20 Wyeth Cyclothiocarbamate derivatives as progesterone receptor modulators

Also Published As

Publication number Publication date
CA2561014C (en) 2013-09-10
PL1732921T3 (pl) 2009-04-30
JP4869221B2 (ja) 2012-02-08
US7358246B2 (en) 2008-04-15
AU2005233591A1 (en) 2005-10-27
US8168672B2 (en) 2012-05-01
US7511071B2 (en) 2009-03-31
WO2005100346A1 (en) 2005-10-27
BRPI0509209A (pt) 2007-08-28
CN1938299A (zh) 2007-03-28
ATE413398T1 (de) 2008-11-15
CA2561014A1 (en) 2005-10-27
US20100197645A1 (en) 2010-08-05
ES2317223T3 (es) 2009-04-16
DE602005010840D1 (de) 2008-12-18
DK1732921T3 (da) 2009-02-23
EP1732921B1 (en) 2008-11-05
CN100522960C (zh) 2009-08-05
US20080167299A1 (en) 2008-07-10
EP1732921A1 (en) 2006-12-20
US20050227971A1 (en) 2005-10-13
MXPA06011696A (es) 2006-12-14
US20090143345A1 (en) 2009-06-04
JP2007532564A (ja) 2007-11-15
US7659265B2 (en) 2010-02-09

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired