AU2005231687B2 - New free-radical scavenger containing viscoelastic composition, methods of use and package - Google Patents
New free-radical scavenger containing viscoelastic composition, methods of use and package Download PDFInfo
- Publication number
- AU2005231687B2 AU2005231687B2 AU2005231687A AU2005231687A AU2005231687B2 AU 2005231687 B2 AU2005231687 B2 AU 2005231687B2 AU 2005231687 A AU2005231687 A AU 2005231687A AU 2005231687 A AU2005231687 A AU 2005231687A AU 2005231687 B2 AU2005231687 B2 AU 2005231687B2
- Authority
- AU
- Australia
- Prior art keywords
- composition
- viscoelastic
- viscoelastic composition
- maximum
- minimum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 177
- 238000000034 method Methods 0.000 title claims abstract description 37
- 239000002516 radical scavenger Substances 0.000 title description 6
- 229940123457 Free radical scavenger Drugs 0.000 title description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 23
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 22
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 20
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 19
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 19
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- 210000002159 anterior chamber Anatomy 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 23
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 20
- 239000000600 sorbitol Substances 0.000 claims description 20
- 229920005862 polyol Polymers 0.000 claims description 19
- 150000003077 polyols Chemical class 0.000 claims description 19
- 150000001298 alcohols Chemical class 0.000 claims description 15
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 14
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
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- 239000000594 mannitol Substances 0.000 claims description 5
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
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- 229920002125 Sokalan® Polymers 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 210000001742 aqueous humor Anatomy 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
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- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
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- 229920001277 pectin Polymers 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims description 2
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- 239000000230 xanthan gum Substances 0.000 claims description 2
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- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- MMVYPOCJESWGTC-UHFFFAOYSA-N Molybdenum(2+) Chemical compound [Mo+2] MMVYPOCJESWGTC-UHFFFAOYSA-N 0.000 claims 1
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- -1 polyvinylalchol Polymers 0.000 claims 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000008213 purified water Substances 0.000 description 12
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- 239000007983 Tris buffer Substances 0.000 description 8
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- 150000004676 glycans Chemical class 0.000 description 6
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- RVBUGGBMJDPOST-UHFFFAOYSA-N 2-thiobarbituric acid Chemical compound O=C1CC(=O)NC(=S)N1 RVBUGGBMJDPOST-UHFFFAOYSA-N 0.000 description 5
- 208000002177 Cataract Diseases 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 210000004087 cornea Anatomy 0.000 description 4
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- 239000007800 oxidant agent Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
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- 229940118019 malondialdehyde Drugs 0.000 description 3
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- 239000000047 product Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
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- 239000000463 material Substances 0.000 description 2
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- 229910001220 stainless steel Inorganic materials 0.000 description 2
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- 238000002604 ultrasonography Methods 0.000 description 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-threitol Chemical compound OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
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- 108010067787 Proteoglycans Proteins 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
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- 239000012634 fragment Substances 0.000 description 1
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- 229960003180 glutathione Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- 238000012423 maintenance Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- IZXGZAJMDLJLMF-UHFFFAOYSA-N methylaminomethanol Chemical compound CNCO IZXGZAJMDLJLMF-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
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- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940032362 superoxide dismutase Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- 150000003568 thioethers Chemical class 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 235000019263 trisodium citrate Nutrition 0.000 description 1
- 229940042596 viscoat Drugs 0.000 description 1
- 229940006076 viscoelastic substance Drugs 0.000 description 1
- 239000003190 viscoelastic substance Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/143—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/812,551 US20050215516A1 (en) | 2004-03-29 | 2004-03-29 | New free-radical scavenger containing viscoelastic composition, methods of use and package |
| US10/812,551 | 2004-03-29 | ||
| PCT/US2005/009512 WO2005097226A1 (en) | 2004-03-29 | 2005-03-22 | New free-radical scavenger containing viscoelastic composition, methods of use and package |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005231687A1 AU2005231687A1 (en) | 2005-10-20 |
| AU2005231687B2 true AU2005231687B2 (en) | 2007-08-16 |
Family
ID=34963427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005231687A Ceased AU2005231687B2 (en) | 2004-03-29 | 2005-03-22 | New free-radical scavenger containing viscoelastic composition, methods of use and package |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20050215516A1 (https=) |
| EP (1) | EP1732620B1 (https=) |
| JP (1) | JP2007530226A (https=) |
| KR (1) | KR20060131938A (https=) |
| CN (2) | CN101485906A (https=) |
| AT (1) | ATE401915T1 (https=) |
| AU (1) | AU2005231687B2 (https=) |
| CA (1) | CA2560943C (https=) |
| DE (1) | DE602005008413D1 (https=) |
| ES (1) | ES2309735T3 (https=) |
| WO (1) | WO2005097226A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2918276B1 (fr) | 2007-07-02 | 2010-01-22 | Anteis Sa | "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires" |
| US10028976B2 (en) | 2007-07-02 | 2018-07-24 | Aptissen Sa | Injectable formulation of natural polysaccharide and polyol for treatment of osteoarthritis |
| GB2501943B (en) * | 2012-05-10 | 2020-09-23 | Zeiss Carl Meditec Ag | Ophthalmic viscoelastic device |
| AT514540A1 (de) | 2013-06-18 | 2015-01-15 | Apomedica Pharmazeutische Produkte Gmbh | Ophthalmische Zusammensetzung |
| PL3193832T3 (pl) * | 2015-06-17 | 2019-12-31 | Al.Chi.Mi.A. S.R.L. | Lepkosprężysty preparat do stosowania w metodach chirurgicznych w chirurgii ocznej |
| WO2017131130A1 (ja) * | 2016-01-29 | 2017-08-03 | 生化学工業株式会社 | コンドロイチン硫酸及びヒアルロン酸を含有する安定化された水性組成物 |
| EP3713617A1 (en) * | 2017-11-22 | 2020-09-30 | Bausch & Lomb Incorporated | Ophthalmic viscoelastic compositions |
| CN108371729A (zh) * | 2018-05-22 | 2018-08-07 | 上海建华精细生物制品有限公司 | 有自由基清除功能的眼科手术粘弹剂及其制备方法和应用 |
| WO2020005416A1 (en) | 2018-06-27 | 2020-01-02 | Bausch & Lomb Incorporated | Packaging solutions |
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| US5631243A (en) * | 1990-07-03 | 1997-05-20 | Collagenesis Inc. | Collagen-based viscoelastic solution for visco-surgery |
| EP0781547A1 (en) * | 1995-12-22 | 1997-07-02 | Chemedica S.A. | Sodium hyaluronate based ophthalmic formulation for use in eye surgery |
| WO2003072081A1 (en) * | 2002-02-22 | 2003-09-04 | Pharmacia Corporation | Ophthalmic formulation with gum system |
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| US4287175A (en) * | 1978-06-22 | 1981-09-01 | Merck & Co., Inc. | Contact lens wetting agents |
| US4713375A (en) * | 1985-08-01 | 1987-12-15 | Lindstrom Richard L | Viscoelastic solution |
| CA1284250C (en) * | 1985-09-06 | 1991-05-14 | Dale P. Devore | Viscoelastic collagen solution for ophthalmic use and method of preparation |
| US4819617A (en) * | 1986-09-04 | 1989-04-11 | University Of Florida | Viscoelastic material for ophthalmic surgery |
| JPS6419024A (en) * | 1987-07-15 | 1989-01-23 | Tosoh Corp | Separation of immunoglobulin g subclass |
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| US5368585A (en) * | 1992-04-07 | 1994-11-29 | Dokken; Glenda K. | Reusable diaper and cover combination |
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-
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- 2004-03-29 US US10/812,551 patent/US20050215516A1/en not_active Abandoned
-
2005
- 2005-03-22 JP JP2007506237A patent/JP2007530226A/ja active Pending
- 2005-03-22 CN CNA2009100083060A patent/CN101485906A/zh active Pending
- 2005-03-22 KR KR1020067020196A patent/KR20060131938A/ko not_active Ceased
- 2005-03-22 CN CNB2005800102038A patent/CN100525847C/zh not_active Expired - Fee Related
- 2005-03-22 ES ES05726035T patent/ES2309735T3/es not_active Expired - Lifetime
- 2005-03-22 AU AU2005231687A patent/AU2005231687B2/en not_active Ceased
- 2005-03-22 AT AT05726035T patent/ATE401915T1/de not_active IP Right Cessation
- 2005-03-22 WO PCT/US2005/009512 patent/WO2005097226A1/en not_active Ceased
- 2005-03-22 EP EP05726035A patent/EP1732620B1/en not_active Expired - Lifetime
- 2005-03-22 DE DE602005008413T patent/DE602005008413D1/de not_active Expired - Lifetime
- 2005-03-22 CA CA2560943A patent/CA2560943C/en not_active Expired - Fee Related
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2009
- 2009-10-19 US US12/581,242 patent/US20100036387A1/en not_active Abandoned
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|---|---|---|---|---|
| US5631243A (en) * | 1990-07-03 | 1997-05-20 | Collagenesis Inc. | Collagen-based viscoelastic solution for visco-surgery |
| EP0781547A1 (en) * | 1995-12-22 | 1997-07-02 | Chemedica S.A. | Sodium hyaluronate based ophthalmic formulation for use in eye surgery |
| WO2003072081A1 (en) * | 2002-02-22 | 2003-09-04 | Pharmacia Corporation | Ophthalmic formulation with gum system |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2560943A1 (en) | 2005-10-20 |
| CA2560943C (en) | 2011-01-04 |
| JP2007530226A (ja) | 2007-11-01 |
| AU2005231687A1 (en) | 2005-10-20 |
| US20050215516A1 (en) | 2005-09-29 |
| WO2005097226A1 (en) | 2005-10-20 |
| KR20060131938A (ko) | 2006-12-20 |
| DE602005008413D1 (de) | 2008-09-04 |
| ATE401915T1 (de) | 2008-08-15 |
| CN1938056A (zh) | 2007-03-28 |
| EP1732620B1 (en) | 2008-07-23 |
| CN101485906A (zh) | 2009-07-22 |
| ES2309735T3 (es) | 2008-12-16 |
| EP1732620A1 (en) | 2006-12-20 |
| US20100036387A1 (en) | 2010-02-11 |
| CN100525847C (zh) | 2009-08-12 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |