AU2005227064A1 - Methods of protein fractionation using high performance tangential flow filtration - Google Patents

Methods of protein fractionation using high performance tangential flow filtration Download PDF

Info

Publication number
AU2005227064A1
AU2005227064A1 AU2005227064A AU2005227064A AU2005227064A1 AU 2005227064 A1 AU2005227064 A1 AU 2005227064A1 AU 2005227064 A AU2005227064 A AU 2005227064A AU 2005227064 A AU2005227064 A AU 2005227064A AU 2005227064 A1 AU2005227064 A1 AU 2005227064A1
Authority
AU
Australia
Prior art keywords
feedstream
protein
membrane
filtration
milk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2005227064A
Other languages
English (en)
Inventor
Mark Perrault
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
rEVO Biologics Inc
Original Assignee
GTC Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GTC Biotherapeutics Inc filed Critical GTC Biotherapeutics Inc
Publication of AU2005227064A1 publication Critical patent/AU2005227064A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/147—Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/024—Oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
AU2005227064A 2004-03-04 2005-02-08 Methods of protein fractionation using high performance tangential flow filtration Abandoned AU2005227064A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55013704P 2004-03-04 2004-03-04
US60/550,137 2004-03-04
US11/051,216 2005-02-04
US11/051,216 US20050197496A1 (en) 2004-03-04 2005-02-04 Methods of protein fractionation using high performance tangential flow filtration
PCT/US2005/004332 WO2005091801A2 (en) 2004-03-04 2005-02-08 Methods of protein fractionation using high performance tangential flow filtration

Publications (1)

Publication Number Publication Date
AU2005227064A1 true AU2005227064A1 (en) 2005-10-06

Family

ID=34914815

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005227064A Abandoned AU2005227064A1 (en) 2004-03-04 2005-02-08 Methods of protein fractionation using high performance tangential flow filtration

Country Status (8)

Country Link
US (1) US20050197496A1 (https=)
EP (1) EP1732587A4 (https=)
JP (1) JP2007526302A (https=)
KR (1) KR20060129530A (https=)
AU (1) AU2005227064A1 (https=)
CA (1) CA2560930A1 (https=)
IL (1) IL177877A0 (https=)
WO (1) WO2005091801A2 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030005468A1 (en) * 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
US20040226053A1 (en) * 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
PL1807101T3 (pl) 2004-09-30 2016-11-30 Urządzenia i sposoby do zintegrowanego wytwarzania cząsteczek biologicznych w sposób ciągły
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
US20080009443A1 (en) * 2006-03-07 2008-01-10 Throwleigh Technologies, L.L.C. Diafiltration system to fractionate protein mixtures
EP2014760A1 (en) * 2007-06-13 2009-01-14 CMC Biopharmaceuticals A/S A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
CN101754977B (zh) * 2007-07-17 2013-07-17 弗·哈夫曼-拉罗切有限公司 可变切向流过滤
BRPI0919998A2 (pt) * 2008-10-30 2017-06-06 Paques Ip Bv método para a filtração de um líquido de biorreator, módulo de membrana de fluxo cruzado, sistema de biorreator de membrana, e, uso de um fluxo descendente de líquido de um líquido de biorreator
US9055752B2 (en) 2008-11-06 2015-06-16 Intercontinental Great Brands Llc Shelf-stable concentrated dairy liquids and methods of forming thereof
US20120029165A1 (en) 2010-07-16 2012-02-02 Etzel Mark R Methods and Compositions Involving Whey Protein Isolates
UA112972C2 (uk) 2010-09-08 2016-11-25 Інтерконтінентал Грейт Брендс ЛЛС Рідкий молочний концентрат з високим вмістом сухих речовин
ES2811526T3 (es) 2010-12-30 2021-03-12 Lab Francais Du Fractionnement Glicoles como agentes de inactivación de patógenos
JP2012210187A (ja) * 2011-03-31 2012-11-01 Kaneka Corp 細胞懸濁液の濃縮方法
SG11201505715RA (en) * 2013-02-01 2015-08-28 Ampio Pharmaceuticals Inc Methods for producing diketopiperazines and compositions containing diketopiperazines
EP3594230A1 (en) 2013-02-13 2020-01-15 Laboratoire Français du Fractionnement et des Biotechnologies Highly galactosylated anti-tnf-alpha antibodies and uses thereof
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
ES2842350T3 (es) 2013-03-19 2021-07-13 Cmc Biologics As Un procedimiento para la producción de un producto (por ejemplo, polipéptido) en un proceso de fermentación de cultivo celular continuo
EP3016729B1 (fr) 2013-07-05 2020-03-25 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Matrice de chromatographie d'affinité
EP3113865A4 (en) * 2014-03-07 2017-11-01 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
EP4218991A1 (en) 2014-05-13 2023-08-02 Amgen Inc. Process control systems and methods for use with filters and filtration processes
AU2015264168B2 (en) * 2014-05-21 2020-03-12 Unchained Labs Systems and methods for exchange of buffer solutions
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
ES2742704T3 (es) 2014-06-25 2020-02-17 Emd Millipore Corp Elementos, módulos y sistemas de filtro compactos, enrollados en espiral
SG11201508664VA (en) 2014-08-29 2016-03-30 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
CN108325391B (zh) 2014-08-29 2021-05-18 Emd 密理博公司 过滤液体进料的方法
DE102015108501A1 (de) * 2015-05-29 2016-12-01 Sartorius Stedim Biotech Gmbh Verfahren und Filtrationsvorrichtung zur Herstellung einer konzentrierten Produktlösung
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
CA3023486C (en) 2016-06-09 2022-03-29 Emd Millipore Corporation Radial-path filter elements, systems and methods of using same
CN108017689A (zh) * 2016-11-04 2018-05-11 郑州伊美诺生物技术有限公司 一种离心管及使用该离心管获取抗体蛋白的方法
CN106474466B (zh) * 2016-12-07 2018-04-13 申联生物医药（上海）股份有限公司 一种口蹄疫疫苗的制备方法
SG11202005782UA (en) 2018-03-08 2020-09-29 Repligen Corp Tangential flow depth filtration systems and methods of filtration using same
KR20200141455A (ko) * 2018-05-25 2020-12-18 리플리겐 코포레이션 접선 유동 여과 시스템 및 방법
CN112236215A (zh) * 2018-06-21 2021-01-15 思拓凡瑞典有限公司 用于过滤的系统和相关联的方法
CA3147494A1 (en) * 2019-08-13 2021-02-18 Repligen Corporation Control systems and methods for automated clarification of cell culture with high solids content
CN113559712B (zh) * 2020-04-29 2026-04-21 上海药明生物技术有限公司 切向流过滤系统与方法
EP4149277A4 (en) 2021-05-21 2024-11-20 Cambridge Crops, Inc. d/b/a Mori SYSTEMS AND METHODS FOR MANUFACTURING SILK FIBROIN SOLUTION AND POWDERS CONTAINING SILK FIBROIN
US11864569B2 (en) 2021-08-16 2024-01-09 Cambridge Crops, Inc. Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin
EP4299156A1 (en) * 2022-06-29 2024-01-03 Sartorius Stedim Biotech GmbH Tangential flow filtration/chromatography systems, use thereof, and methods of separation
FR3139999A1 (fr) * 2022-09-22 2024-03-29 Bucher Vaslin Procédé de gestion du colmatage de membrane d’un dispositif de filtration tangentiel

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519558A (en) * 1968-02-15 1970-07-07 Abcor Inc Separation of similar solutes using a semipermeable membrane
BE759625A (fr) * 1969-12-10 1971-04-30 Molkereigenossenschaft Dahlenb Procede et dispositif pour la dialyse du lait, en particulier pour l'obtention de l'albumine du lait et du petit-lait
CH566798A5 (https=) * 1973-05-29 1975-09-30 Battelle Memorial Institute
SE396017B (sv) * 1974-12-23 1977-09-05 Alfa Laval Ab Filtreringsforfarande, serskilt for ultrafiltrering
US4351710A (en) * 1980-01-10 1982-09-28 Ionics, Incorporated Fractionation of protein mixtures
US4350156A (en) * 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
JPS583705B2 (ja) * 1980-07-18 1983-01-22 川澄化学工業株式会社 二重ロ過型血漿分離交換装置
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
US4888115A (en) * 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
DE3432718C1 (de) * 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
US4874516A (en) * 1984-12-29 1989-10-17 Ngk Insulators, Ltd. A ceramic filter for semi-ultrafiltration
US4789482A (en) * 1986-02-10 1988-12-06 Millipore Corporation Method for separating liquid compositions on the basis of molecular weight
ES2037273T3 (es) * 1987-04-11 1993-06-16 Ciba-Geigy Ag Proceso de focalizacion isoelectrica y medios para llevar a cabo dicho proceso.
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5750172A (en) * 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5356651A (en) * 1992-12-30 1994-10-18 Pall Corporation Manufacturing method for producing sterile milk using dynamic microfiltration
WO1994019935A1 (en) * 1993-03-09 1994-09-15 Genzyme Corporation Isolation of components of interest from milk
US5827690A (en) * 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5518624A (en) * 1994-05-06 1996-05-21 Illinois Water Treatment, Inc. Ultra pure water filtration
US5585466A (en) * 1994-12-06 1996-12-17 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Crystals of serum albumin for use in genetic engineering and rational drug design
US5843705A (en) * 1995-02-21 1998-12-01 Genzyme Transgenic Corporation Transgenically produced antithrombin III
US5597486A (en) * 1995-05-01 1997-01-28 Millipore Investment Holdings Limited Membrane filtration with optimized addition of second liquid to maximize flux
AU6884396A (en) * 1995-09-07 1997-03-27 Ppl Therapeutics (Scotland) Ltd Purification of alpha-1 proteinase inhibitor
US6054051A (en) * 1996-01-17 2000-04-25 Genentech, Inc. Tangential-flow filtration system
US6268487B1 (en) * 1996-05-13 2001-07-31 Genzyme Transgenics Corporation Purification of biologically active peptides from milk
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
EP1025244A2 (en) * 1997-10-20 2000-08-09 Genzyme Transgenics Corporation NOVEL MODIFIED MSP-1 NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS
FR2787465A1 (fr) * 1998-12-21 2000-06-23 Transgene Sa Procede d'inactivation des virus enveloppes dans une preparation virale de virus non enveloppes
US6984378B1 (en) * 1999-02-26 2006-01-10 Pfizer, Inc. Method for the purification, recovery, and sporulation of cysts and oocysts
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
WO2003102132A2 (en) * 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
US7264728B2 (en) * 2002-10-01 2007-09-04 Dow Corning Corporation Method of separating components in a sample using silane-treated silica filter media
US20040162414A1 (en) * 2002-11-22 2004-08-19 Santora Ling C. Method for reducing or preventing modification of a polypeptide in solution
AU2003261387A1 (en) * 2003-02-24 2004-09-17 Gtc Biotherapeutics, Inc. Methods of tangential flow filtration and an apparatus therefore
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum

Also Published As

Publication number Publication date
EP1732587A2 (en) 2006-12-20
WO2005091801A3 (en) 2006-06-15
WO2005091801A2 (en) 2005-10-06
CA2560930A1 (en) 2005-10-06
IL177877A0 (en) 2006-12-31
EP1732587A4 (en) 2007-09-05
KR20060129530A (ko) 2006-12-15
US20050197496A1 (en) 2005-09-08
JP2007526302A (ja) 2007-09-13

Similar Documents

Publication Publication Date Title
AU2005227064A1 (en) Methods of protein fractionation using high performance tangential flow filtration
US20040167320A1 (en) Methods of tangential flow filtration and an apparatus therefore
EP1991063B1 (en) Clarification of transgenic milk using depth filtration
CN101076347B (zh) 用于集成连续生产生物分子的装置和方法
CN101027080A (zh) 用高效切向流过滤进行蛋白质分级的方法
AU2011203578B2 (en) Devices and methods for integrated continuous manufacturing of biological molecules
HK1090670A (en) Methods of tangential flow filtration and an apparatus therefore
HK1208872B (zh) 使用双级切线流超滤纯化多肽

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application