AU2004288715A1

AU2004288715A1 - Methods of using and compositions comprising a JNK inhibitor for the treatment and management of asbestos-related diseases and disorders

Methods of using and compositions comprising a JNK inhibitor for the treatment and management of asbestos-related diseases and disorders Download PDF

Info

Publication number: AU2004288715A1
Authority: AU; Australia
Prior art keywords: heterocycle; alkyl; aryl; arylalkyl; independently selected
Prior art date: 2003-11-06
Legal status : Abandoned

Application number

AU2004288715A

Other languages

English (en)

Inventor

Jerome B. Zeldis

Current Assignee

Celgene Corp

Original Assignee

Celgene Corp

Priority date

2003-11-06

Filing date

2004-11-04

Publication date

2005-05-26

2004-11-04 Application filed by Celgene Corp filed Critical Celgene Corp

2005-05-26 Publication of AU2004288715A1 publication Critical patent/AU2004288715A1/en

Status Abandoned legal-status Critical Current

Links

239000012825 JNK inhibitor Substances 0.000 title claims description 144
229940118135 JNK inhibitor Drugs 0.000 title claims description 130
239000010425 asbestos Substances 0.000 title claims description 80
229910052895 riebeckite Inorganic materials 0.000 title claims description 80
238000000034 method Methods 0.000 title claims description 77
238000011282 treatment Methods 0.000 title claims description 29
239000000203 mixture Substances 0.000 title description 36
208000037765 diseases and disorders Diseases 0.000 title description 3
125000000217 alkyl group Chemical group 0.000 claims description 143
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 142
-1 hydroxy, carboxy Chemical group 0.000 claims description 132
125000001424 substituent group Chemical group 0.000 claims description 104
125000003118 aryl group Chemical group 0.000 claims description 87
201000010099 disease Diseases 0.000 claims description 77
125000000623 heterocyclic group Chemical group 0.000 claims description 76
150000001875 compounds Chemical class 0.000 claims description 69
208000035475 disorder Diseases 0.000 claims description 64
125000003710 aryl alkyl group Chemical group 0.000 claims description 63
239000013543 active substance Substances 0.000 claims description 61
239000001257 hydrogen Substances 0.000 claims description 50
229910052739 hydrogen Inorganic materials 0.000 claims description 50
125000003545 alkoxy group Chemical group 0.000 claims description 43
150000002431 hydrogen Chemical class 0.000 claims description 39
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 38
229910052736 halogen Inorganic materials 0.000 claims description 37
150000002367 halogens Chemical class 0.000 claims description 37
125000000753 cycloalkyl group Chemical group 0.000 claims description 36
150000003839 salts Chemical class 0.000 claims description 33
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 29
125000004183 alkoxy alkyl group Chemical group 0.000 claims description 28
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 28
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 24
125000004103 aminoalkyl group Chemical group 0.000 claims description 20
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238000001959 radiotherapy Methods 0.000 claims description 17
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