AU2004287440A1 - Dialysates and methods and systems related thereto - Google Patents
Dialysates and methods and systems related thereto Download PDFInfo
- Publication number
- AU2004287440A1 AU2004287440A1 AU2004287440A AU2004287440A AU2004287440A1 AU 2004287440 A1 AU2004287440 A1 AU 2004287440A1 AU 2004287440 A AU2004287440 A AU 2004287440A AU 2004287440 A AU2004287440 A AU 2004287440A AU 2004287440 A1 AU2004287440 A1 AU 2004287440A1
- Authority
- AU
- Australia
- Prior art keywords
- pyrophosphate
- type compound
- dialysate
- groups
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims description 44
- 239000000385 dialysis solution Substances 0.000 title description 8
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 124
- 150000001875 compounds Chemical class 0.000 claims description 90
- 235000011180 diphosphates Nutrition 0.000 claims description 83
- 238000001631 haemodialysis Methods 0.000 claims description 53
- 230000000322 hemodialysis Effects 0.000 claims description 53
- 208000005475 Vascular calcification Diseases 0.000 claims description 51
- -1 alkali metal pyrophosphate Chemical class 0.000 claims description 37
- 238000000502 dialysis Methods 0.000 claims description 36
- 239000012141 concentrate Substances 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 32
- 210000004369 blood Anatomy 0.000 claims description 27
- 239000008280 blood Substances 0.000 claims description 27
- 229940002612 prodrug Drugs 0.000 claims description 26
- 239000000651 prodrug Substances 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000011575 calcium Substances 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 21
- 229910052791 calcium Inorganic materials 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 18
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 16
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000003937 drug carrier Substances 0.000 claims description 10
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 9
- 125000003368 amide group Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 150000001768 cations Chemical class 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- 125000000524 functional group Chemical group 0.000 claims description 6
- 150000002430 hydrocarbons Chemical class 0.000 claims description 6
- 208000017169 kidney disease Diseases 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 201000006370 kidney failure Diseases 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 239000005864 Sulphur Substances 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000003282 alkyl amino group Chemical group 0.000 claims description 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 2
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 claims description 2
- 235000019820 disodium diphosphate Nutrition 0.000 claims description 2
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 150000003957 organoselenium compounds Chemical class 0.000 claims description 2
- WRMXOVHLRUVREB-UHFFFAOYSA-N phosphono phosphate;tributylazanium Chemical compound OP(O)(=O)OP([O-])([O-])=O.CCCC[NH+](CCCC)CCCC.CCCC[NH+](CCCC)CCCC WRMXOVHLRUVREB-UHFFFAOYSA-N 0.000 claims description 2
- 235000011007 phosphoric acid Nutrition 0.000 claims description 2
- 125000000565 sulfonamide group Chemical group 0.000 claims description 2
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 3
- 229910004856 P—O—P Inorganic materials 0.000 claims 3
- 239000011591 potassium Substances 0.000 claims 3
- 239000003513 alkali Substances 0.000 claims 1
- 229940048084 pyrophosphate Drugs 0.000 description 73
- 208000004434 Calcinosis Diseases 0.000 description 28
- 230000002308 calcification Effects 0.000 description 28
- 239000003795 chemical substances by application Substances 0.000 description 26
- 210000000709 aorta Anatomy 0.000 description 22
- 239000012636 effector Substances 0.000 description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 229910019142 PO4 Inorganic materials 0.000 description 13
- 241000700159 Rattus Species 0.000 description 13
- 239000002253 acid Substances 0.000 description 13
- 229960005069 calcium Drugs 0.000 description 13
- 229940079593 drug Drugs 0.000 description 13
- 239000003814 drug Substances 0.000 description 13
- 125000000623 heterocyclic group Chemical group 0.000 description 13
- 230000002829 reductive effect Effects 0.000 description 13
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 201000010099 disease Diseases 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 9
- 239000002609 medium Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 8
- 230000008901 benefit Effects 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 235000021317 phosphate Nutrition 0.000 description 8
- 229940048086 sodium pyrophosphate Drugs 0.000 description 8
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 8
- 230000002378 acidificating effect Effects 0.000 description 7
- 125000001589 carboacyl group Chemical group 0.000 description 7
- 238000013461 design Methods 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 7
- 239000010452 phosphate Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 6
- 102000009617 Inorganic Pyrophosphatase Human genes 0.000 description 6
- 108010009595 Inorganic Pyrophosphatase Proteins 0.000 description 6
- 125000005907 alkyl ester group Chemical group 0.000 description 6
- 150000007860 aryl ester derivatives Chemical class 0.000 description 6
- 125000004104 aryloxy group Chemical group 0.000 description 6
- 239000004202 carbamide Substances 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 208000020832 chronic kidney disease Diseases 0.000 description 6
- 125000000392 cycloalkenyl group Chemical group 0.000 description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 6
- 150000003951 lactams Chemical class 0.000 description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 125000003107 substituted aryl group Chemical group 0.000 description 6
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 125000002837 carbocyclic group Chemical group 0.000 description 5
- 201000000523 end stage renal failure Diseases 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
- 125000001424 substituent group Chemical group 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 229940122361 Bisphosphonate Drugs 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 150000004663 bisphosphonates Chemical class 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
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- 238000012377 drug delivery Methods 0.000 description 4
- 208000028208 end stage renal disease Diseases 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 3
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- 208000026935 allergic disease Diseases 0.000 description 3
- 125000003435 aroyl group Chemical group 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000011161 development Methods 0.000 description 3
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
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- XPPKVPWEQAFLFU-VJJZLTLGSA-N dihydroxyphosphoryl dihydrogen phosphate Chemical compound OP(O)(=O)O[32P](O)(O)=O XPPKVPWEQAFLFU-VJJZLTLGSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
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- 230000008034 disappearance Effects 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
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- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 description 2
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- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical class CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 125000004934 phenanthridinyl group Chemical group C1(=CC=CC2=NC=C3C=CC=CC3=C12)* 0.000 description 1
- 125000004625 phenanthrolinyl group Chemical group N1=C(C=CC2=CC=C3C=CC=NC3=C12)* 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000005547 pivalate group Chemical group 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000006085 pyrrolopyridyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- 125000004426 substituted alkynyl group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 125000006092 tetrahydro-1,1-dioxothienyl group Chemical group 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000006090 thiamorpholinyl sulfone group Chemical group 0.000 description 1
- 125000006089 thiamorpholinyl sulfoxide group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
- 125000005490 tosylate group Chemical group 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical class CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51517403P | 2003-10-28 | 2003-10-28 | |
| US60/515,174 | 2003-10-28 | ||
| PCT/US2004/035541 WO2005044189A2 (en) | 2003-10-28 | 2004-10-27 | Dialysates and methods and systems related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2004287440A1 true AU2004287440A1 (en) | 2005-05-19 |
Family
ID=34572815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004287440A Abandoned AU2004287440A1 (en) | 2003-10-28 | 2004-10-27 | Dialysates and methods and systems related thereto |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070148258A1 (https=) |
| EP (1) | EP1682077A4 (https=) |
| JP (1) | JP4838139B2 (https=) |
| KR (1) | KR101249707B1 (https=) |
| CN (2) | CN101094681A (https=) |
| AU (1) | AU2004287440A1 (https=) |
| BR (1) | BRPI0416088A (https=) |
| CA (1) | CA2544235C (https=) |
| WO (1) | WO2005044189A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8187467B2 (en) | 2003-12-30 | 2012-05-29 | Ajay Gupta | Parenteral administration of pyrophosphate for prevention or treatment of phosphate or pyrophosphate depletion |
| US8771749B2 (en) | 2007-10-05 | 2014-07-08 | National University Corporation Chiba University | Stable bicarbonate ion-containing drug solution |
| US7658952B2 (en) | 2007-10-11 | 2010-02-09 | Baxter International Inc. | Dialysis solutions containing pyrophosphates |
| ES2332636B1 (es) * | 2008-08-06 | 2011-02-10 | Universitat De Les Illes Balears | Composicion de liquido de dialisis. |
| JP5258448B2 (ja) * | 2008-08-12 | 2013-08-07 | 扶桑薬品工業株式会社 | 透析用製剤 |
| AU2015200995B2 (en) * | 2010-04-23 | 2016-09-08 | Vantive Health Gmbh | Methods and compositions for reducing or preventing vascular calcification during peritoneal dialysis therapy |
| WO2011133855A1 (en) * | 2010-04-23 | 2011-10-27 | Baxter International Inc. | Methods and compositions for reducing or preventing vascular calcification during peritoneal dialysis therapy |
| CN102517635B (zh) * | 2012-01-12 | 2014-12-24 | 中国科学院新疆理化技术研究所 | 化合物锂钾磷氧和锂钾磷氧晶体及其制备方法 |
| EP2862583A1 (en) * | 2013-10-17 | 2015-04-22 | Gambro Lundia AB | Perm selective membrane for treating vascular calcification in chronic hemodialysis patients |
| DE102015007842A1 (de) * | 2015-06-18 | 2016-12-22 | Fresenius Medical Care Deutschland Gmbh | Dialyselösung |
| WO2018165132A1 (en) * | 2017-03-06 | 2018-09-13 | University Of Houston System | Polyphosphates as inhibitors of calcium crystallization |
| IT201700085412A1 (it) * | 2017-07-26 | 2019-01-26 | Pharmanutra S P A | Composizione per uso nella prevenzione e nel trattamento di patologie dell'apparato cardiovascolare |
| IT201700089258A1 (it) | 2017-08-02 | 2019-02-02 | Pharmanutra S P A | Composizione per uso nella prevenzione e nel trattamento di carenza di ferro |
| AU2018445164B2 (en) | 2018-10-11 | 2025-05-29 | Vifor (International) Ltd. | Inositol phosphates for the treatment of ectopic calcification |
| IT201900007326A1 (it) | 2019-05-27 | 2020-11-27 | Alesco Srl | Composizioni comprendenti acidi grassi cetilati e loro uso nel trattamento di artriti e stati infiammatori articolari |
| IT201900007311A1 (it) | 2019-05-27 | 2020-11-27 | Alesco Srl | Procedimento per la preparazione di una composizione comprendente acidi grassi cetilati |
| CN118416279B (zh) * | 2024-04-23 | 2025-09-02 | 大连医科大学附属第二医院 | 一种预防血管钙化的动静脉内瘘外用敷料及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE216217T1 (de) * | 1996-02-08 | 2002-05-15 | Warner Lambert Co | Zahnpflegemittel gegen zahnsteinbildung enthaltend hochlösliche pyrophosphate |
| US6689275B1 (en) * | 1996-12-31 | 2004-02-10 | Ajay Gupta | Method and pharmaceutical composition for replacing iron losses in dialysis patients |
| US6779468B1 (en) * | 1997-08-07 | 2004-08-24 | Ajay Gupta | Method and pharmaceutical composition for iron delivery in hemodialysis and peritoneal dialysis patients |
| DE69734781T2 (de) * | 1996-12-31 | 2006-07-20 | Gupta, Ajay, Cerritos | Verfahren und pharmazeutische zusammensetzung zum zuführen von eisen bei hämodialyse-und peritonealdialysepatienten |
| EP1009452A4 (en) * | 1997-08-07 | 2004-03-31 | Ajay Gupta | WATER-SOLUBLE VITAMINS AND DIALYSIS SOLUTION CONTAINING NUTRIENTS |
| JP2003519183A (ja) * | 2000-01-04 | 2003-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用 |
| JP2002249433A (ja) * | 2000-12-19 | 2002-09-06 | Sumitomo Pharmaceut Co Ltd | 血管石灰化抑制剤 |
| DK1406641T3 (da) | 2001-06-18 | 2009-05-04 | Neptune Technologies & Bioress | Krillekstrakter til forebyggelse og/eller behandling af cardiovaskulære sygdomme |
| US6524788B1 (en) * | 2001-11-02 | 2003-02-25 | Thomas L. Cantor | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| US8187467B2 (en) * | 2003-12-30 | 2012-05-29 | Ajay Gupta | Parenteral administration of pyrophosphate for prevention or treatment of phosphate or pyrophosphate depletion |
-
2004
- 2004-10-27 CN CNA2004800390401A patent/CN101094681A/zh active Pending
- 2004-10-27 JP JP2006538192A patent/JP4838139B2/ja not_active Expired - Fee Related
- 2004-10-27 US US10/577,607 patent/US20070148258A1/en not_active Abandoned
- 2004-10-27 BR BRPI0416088-6A patent/BRPI0416088A/pt not_active IP Right Cessation
- 2004-10-27 AU AU2004287440A patent/AU2004287440A1/en not_active Abandoned
- 2004-10-27 CA CA2544235A patent/CA2544235C/en not_active Expired - Fee Related
- 2004-10-27 CN CN2012105744771A patent/CN103054901A/zh active Pending
- 2004-10-27 KR KR1020067010395A patent/KR101249707B1/ko not_active Expired - Fee Related
- 2004-10-27 WO PCT/US2004/035541 patent/WO2005044189A2/en not_active Ceased
- 2004-10-27 EP EP04818294A patent/EP1682077A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2544235C (en) | 2013-12-10 |
| BRPI0416088A (pt) | 2007-01-02 |
| KR101249707B1 (ko) | 2013-04-05 |
| EP1682077A4 (en) | 2009-07-01 |
| KR20070014110A (ko) | 2007-01-31 |
| WO2005044189A2 (en) | 2005-05-19 |
| CN103054901A (zh) | 2013-04-24 |
| JP4838139B2 (ja) | 2011-12-14 |
| EP1682077A2 (en) | 2006-07-26 |
| WO2005044189A3 (en) | 2007-06-14 |
| CA2544235A1 (en) | 2005-05-19 |
| US20070148258A1 (en) | 2007-06-28 |
| JP2007523056A (ja) | 2007-08-16 |
| CN101094681A (zh) | 2007-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK3 | Application lapsed section 142(2)(c) - examination deferred under section 46 no request for examination |