AU2004236573B2 - Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues - Google Patents

Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues Download PDF

Info

Publication number
AU2004236573B2
AU2004236573B2 AU2004236573A AU2004236573A AU2004236573B2 AU 2004236573 B2 AU2004236573 B2 AU 2004236573B2 AU 2004236573 A AU2004236573 A AU 2004236573A AU 2004236573 A AU2004236573 A AU 2004236573A AU 2004236573 B2 AU2004236573 B2 AU 2004236573B2
Authority
AU
Australia
Prior art keywords
pdx
cell
pancreatic
expression
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2004236573A
Other languages
English (en)
Other versions
AU2004236573A1 (en
Inventor
Sarah Ferber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU2004236573A1 publication Critical patent/AU2004236573A1/en
Application granted granted Critical
Publication of AU2004236573B2 publication Critical patent/AU2004236573B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2004236573A 2003-05-12 2004-05-12 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues Expired AU2004236573B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46971503P 2003-05-12 2003-05-12
US60/469,715 2003-05-12
PCT/IB2004/001973 WO2004098646A1 (en) 2003-05-12 2004-05-12 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Publications (2)

Publication Number Publication Date
AU2004236573A1 AU2004236573A1 (en) 2004-11-18
AU2004236573B2 true AU2004236573B2 (en) 2009-10-22

Family

ID=33435254

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004236573A Expired AU2004236573B2 (en) 2003-05-12 2004-05-12 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Country Status (4)

Country Link
EP (1) EP1624898A1 (enExample)
JP (2) JP2006525994A (enExample)
AU (1) AU2004236573B2 (enExample)
WO (1) WO2004098646A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
CA2634510C (en) 2005-12-21 2018-01-09 Universite Catholique De Louvain Isolated liver stem cells
CN101573445A (zh) * 2006-09-22 2009-11-04 贝勒研究院 由胰腺腺泡细胞向胰岛素生成细胞的体内转化
CA2904198A1 (en) * 2013-03-15 2014-09-18 Universite De Geneve Use of insulin signaling antagonists, optionally in combination of transfection of non-beta cells, for inducing insulin production
KR102181336B1 (ko) 2013-06-13 2020-11-24 오르제네시스 엘티디. 세포 집단, 이의 전환분화 방법 및 이용 방법
JP6474394B2 (ja) 2013-07-05 2019-02-27 ユニベルシテ カトリック ドゥ ルーベン ヒト成体肝臓幹細胞由来の馴化培地および肝臓障害の治療におけるその使用
MA41296A (fr) * 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
US9957287B2 (en) 2016-05-26 2018-05-01 Cornell University Methods and compositions to treat type-1 and type-2 diabetes
WO2018044795A1 (en) 2016-08-29 2018-03-08 Yong Zhao Compositions and methods for programming adult cells with platelet rich fraction of blood containing platelet-like cells
AU2017321314A1 (en) 2016-08-29 2019-02-28 Hackensack University Medical Center Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans
WO2018207179A1 (en) 2017-05-08 2018-11-15 Orgenesis Ltd. Transdifferentiated cell populations and methods of use thereof
US11788062B2 (en) * 2017-07-27 2023-10-17 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Functional feline pancreatic cells from adipose tissue
CN112899351B (zh) * 2021-02-03 2022-08-26 东华大学 一种双重荧光定量pcr检测pdx模型小鼠细胞浸润状态试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072885A2 (en) * 1999-06-01 2000-12-07 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
WO2003033697A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0206357D0 (en) * 2002-03-18 2002-05-01 Univ Bath Cells
JP4136434B2 (ja) * 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072885A2 (en) * 1999-06-01 2000-12-07 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
WO2003033697A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERBER, S. et al., Nature Medicine, 2000, Vol. 6, No. 5, pages 568-72 (X) *
HORB, M.E. et al., CURRENT BIOLOGY, CURRENT SCIENCE, 2003, Vol. 13, No. 2, pages 105-15 (X) *
KOJIMA et al., Nature Medicine, 2003, Vol. 9, page 956 (X) *

Also Published As

Publication number Publication date
WO2004098646A1 (en) 2004-11-18
EP1624898A1 (en) 2006-02-15
AU2004236573A1 (en) 2004-11-18
JP2011068660A (ja) 2011-04-07
JP2006525994A (ja) 2006-11-16
WO2004098646B1 (en) 2005-04-28

Similar Documents

Publication Publication Date Title
US9481894B2 (en) Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8119405B2 (en) Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
JP2011068660A (ja) 非膵島組織における調節された膵ホルモンの産生を誘導する方法
JP2003500457A5 (enExample)
US11617769B2 (en) Methods of transdifferentiation and methods of use thereof
KR102181336B1 (ko) 세포 집단, 이의 전환분화 방법 및 이용 방법
Kaneto et al. Role of MafA in pancreatic β-cells
Zhang et al. Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired