AU2003303714B2 - Improved linkers for radiopharmaceutical compounds - Google Patents

Improved linkers for radiopharmaceutical compounds Download PDF

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Publication number
AU2003303714B2
AU2003303714B2 AU2003303714A AU2003303714A AU2003303714B2 AU 2003303714 B2 AU2003303714 B2 AU 2003303714B2 AU 2003303714 A AU2003303714 A AU 2003303714A AU 2003303714 A AU2003303714 A AU 2003303714A AU 2003303714 B2 AU2003303714 B2 AU 2003303714B2
Authority
AU
Australia
Prior art keywords
acid
amino
compound
substituted bile
bile acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003303714A
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English (en)
Other versions
AU2003303714A1 (en
Inventor
Christoph De Haen
Adrian Nunn
Rolf E. Swenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of AU2003303714A1 publication Critical patent/AU2003303714A1/en
Application granted granted Critical
Publication of AU2003303714B2 publication Critical patent/AU2003303714B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2003303714A 2003-01-13 2003-12-24 Improved linkers for radiopharmaceutical compounds Ceased AU2003303714B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43972203P 2003-01-13 2003-01-13
US60/439,722 2003-01-13
PCT/US2003/041656 WO2004062574A2 (en) 2003-01-13 2003-12-24 Improved linkers for radiopharmaceutical compounds

Publications (2)

Publication Number Publication Date
AU2003303714A1 AU2003303714A1 (en) 2004-08-10
AU2003303714B2 true AU2003303714B2 (en) 2009-02-19

Family

ID=32713508

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003303714A Ceased AU2003303714B2 (en) 2003-01-13 2003-12-24 Improved linkers for radiopharmaceutical compounds

Country Status (9)

Country Link
US (2) US7989417B2 (enExample)
EP (1) EP1583564B1 (enExample)
JP (1) JP4610345B2 (enExample)
CN (1) CN100534535C (enExample)
AT (1) ATE435035T1 (enExample)
AU (1) AU2003303714B2 (enExample)
CA (1) CA2512310C (enExample)
DE (1) DE60328226D1 (enExample)
WO (1) WO2004062574A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
ATE435035T1 (de) * 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
AU2004314112A1 (en) * 2003-12-24 2005-07-28 Bracco Imaging S.P.A. Improved gastrin releasing peptide compounds
EP2438847A3 (en) * 2004-06-18 2012-11-07 David R. Elmaleh Contrast medium and its use in intravascular imaging device
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
DK2013221T3 (en) * 2006-04-19 2015-09-28 Univ Texas Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
EP2606911A1 (en) * 2007-02-16 2013-06-26 KTB Tumorforschungsgesellschaft mbH Receptor And Antigen Targeted Prodrug
WO2008144728A1 (en) * 2007-05-21 2008-11-27 Bracco Imaging S.P.A. Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications
WO2014040192A1 (en) 2012-09-13 2014-03-20 British Columbia Cancer Agency Branch Compositions targeting bradykinin receptor b1 for medical imaging of cancer and other disorders
CN104744568B (zh) * 2013-12-25 2018-02-23 华东理工大学 对神经激肽‑1受体蛋白特异性识别的p物质多肽探针及其制备与应用
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
WO2017132642A1 (en) * 2016-01-29 2017-08-03 The Regents Of The University Of California A wearable sensor, and method, to monitor anti-coagulation therapy
CN109970834A (zh) * 2019-02-27 2019-07-05 郑州明泽医药科技有限公司 一种氢化可的松琥珀酸钠的制备方法
CN112067556B (zh) * 2020-09-29 2021-08-17 湖北鑫英泰系统技术股份有限公司 一种油浸式设备油气检测方法及装置
JP2024115570A (ja) * 2023-02-15 2024-08-27 Ｊｆｅエンジニアリング株式会社 放射性核種標識薬剤
CN121627612A (zh) * 2025-11-28 2026-03-10 拓及鼎(嘉兴)医药科技有限公司 一种偶联药物用自带双连接子的螯合剂及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646272A (en) * 1989-09-14 1997-07-08 Hoechst Aktiengesellschaft Bile acid conjugates of proline hydroxylase inhibitors
US6153729A (en) * 1997-06-20 2000-11-28 St. Jude's Children's Research Hospital Isolated nuclear matrix targeting peptide
WO2001009163A2 (en) * 1999-07-30 2001-02-08 The University Court Of The University Of Glasgow Improvement of peptide transport by conjugation with bile acids
WO2001064708A1 (en) * 2000-02-29 2001-09-07 Bracco Imaging S.P.A. Bile acids conjugates with metal ion chelates and the use thereof
US6461588B1 (en) * 1998-12-23 2002-10-08 Bracco Imaging S.P.A. Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics
WO2002087597A1 (en) * 2001-04-30 2002-11-07 Mediplex Corporation Oral delivery of macromolecules

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US5534497A (en) * 1986-05-28 1996-07-09 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
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US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
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US5217955A (en) * 1989-09-15 1993-06-08 Biomeasure, Inc. Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
US5811387A (en) * 1990-05-15 1998-09-22 Chiron Corporation Peptoid mixtures
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
US5620959A (en) * 1990-07-31 1997-04-15 Glaxo Wellcome Inc. Bombesin antagonists
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists
US5369094A (en) * 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
DK0585397T3 (da) * 1991-05-23 1997-08-25 Merrell Pharma Inc Bombesinanaloger
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US5620955A (en) * 1993-06-18 1997-04-15 Peptide Technologies Corporation Bombesin receptor antagonists and uses thereof
US5410018A (en) * 1994-02-25 1995-04-25 Oregon Regional Primate Research Center Bombesin-related peptides
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US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
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WO2001076531A2 (en) * 2000-04-07 2001-10-18 University Of Maryland, Baltimore Bile acid containing prodrugs with enhanced bioavailability
ATE435035T1 (de) * 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646272A (en) * 1989-09-14 1997-07-08 Hoechst Aktiengesellschaft Bile acid conjugates of proline hydroxylase inhibitors
US6153729A (en) * 1997-06-20 2000-11-28 St. Jude's Children's Research Hospital Isolated nuclear matrix targeting peptide
US6461588B1 (en) * 1998-12-23 2002-10-08 Bracco Imaging S.P.A. Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics
WO2001009163A2 (en) * 1999-07-30 2001-02-08 The University Court Of The University Of Glasgow Improvement of peptide transport by conjugation with bile acids
WO2001064708A1 (en) * 2000-02-29 2001-09-07 Bracco Imaging S.P.A. Bile acids conjugates with metal ion chelates and the use thereof
WO2002087597A1 (en) * 2001-04-30 2002-11-07 Mediplex Corporation Oral delivery of macromolecules

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Bioconjugate Chemistry, 1991, 2(2), pp 117-23 *

Also Published As

Publication number Publication date
WO2004062574A9 (en) 2005-05-26
US20060241018A1 (en) 2006-10-26
JP4610345B2 (ja) 2011-01-12
AU2003303714A1 (en) 2004-08-10
CA2512310C (en) 2012-09-25
ATE435035T1 (de) 2009-07-15
JP2006513247A (ja) 2006-04-20
CN1738652A (zh) 2006-02-22
WO2004062574A3 (en) 2005-04-14
DE60328226D1 (de) 2009-08-13
US20110280802A1 (en) 2011-11-17
CA2512310A1 (en) 2004-07-29
WO2004062574A2 (en) 2004-07-29
EP1583564A2 (en) 2005-10-12
EP1583564B1 (en) 2009-07-01
CN100534535C (zh) 2009-09-02
US7989417B2 (en) 2011-08-02
EP1583564A4 (en) 2007-06-13

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired