AU2003298868B2 - Compositions comprising a combination of diphenyl ura IMPDH inhibitors and apoptosis-inducing anti-cancer agents - Google Patents
Compositions comprising a combination of diphenyl ura IMPDH inhibitors and apoptosis-inducing anti-cancer agents Download PDFInfo
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- AU2003298868B2 AU2003298868B2 AU2003298868A AU2003298868A AU2003298868B2 AU 2003298868 B2 AU2003298868 B2 AU 2003298868B2 AU 2003298868 A AU2003298868 A AU 2003298868A AU 2003298868 A AU2003298868 A AU 2003298868A AU 2003298868 B2 AU2003298868 B2 AU 2003298868B2
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43155502P | 2002-12-06 | 2002-12-06 | |
| US60/431,555 | 2002-12-06 | ||
| US49626103P | 2003-08-19 | 2003-08-19 | |
| US60/496,261 | 2003-08-19 | ||
| PCT/US2003/038523 WO2004052349A2 (en) | 2002-12-06 | 2003-12-04 | Compositions comprising a combination of diphenyl ura impdh inhibitors and apoptosis-inducing anti-cancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003298868A1 AU2003298868A1 (en) | 2004-06-30 |
| AU2003298868B2 true AU2003298868B2 (en) | 2009-09-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003298868A Ceased AU2003298868B2 (en) | 2002-12-06 | 2003-12-04 | Compositions comprising a combination of diphenyl ura IMPDH inhibitors and apoptosis-inducing anti-cancer agents |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7943593B2 (enExample) |
| EP (1) | EP1575579B1 (enExample) |
| JP (1) | JP4789621B2 (enExample) |
| AT (1) | ATE424198T1 (enExample) |
| AU (1) | AU2003298868B2 (enExample) |
| CA (1) | CA2510006C (enExample) |
| DE (1) | DE60326488D1 (enExample) |
| WO (1) | WO2004052349A2 (enExample) |
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| JP2009505945A (ja) * | 2005-05-26 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | （ｓ）−１−シアノブタン−２−イル（ｓ）−１−（３−（３−（３−メトキシ−４−（オキサゾール−５−イル）フェニル）ウレイド）フェニル）エチルカルバメートの多形形態 |
| AU2020253560A1 (en) * | 2019-04-05 | 2021-11-25 | Prolynx Llc | Improved conjugation linkers |
| JP2022136035A (ja) * | 2021-03-04 | 2022-09-15 | 国立大学法人東京農工大学 | 化合物、該化合物を用いた金属ナノ粒子複合体、及び標的分子の検出方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040029A1 (en) * | 1996-04-22 | 1997-10-30 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| WO2000056331A1 (en) * | 1999-03-19 | 2000-09-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210745A (en) * | 1978-01-04 | 1980-07-01 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine |
| US4357324A (en) * | 1981-02-24 | 1982-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| AU723730B2 (en) | 1996-04-23 | 2000-09-07 | Vertex Pharmaceuticals Incorporated | Urea derivatives as inhibitors of IMPDH enzyme |
-
2003
- 2003-12-04 CA CA2510006A patent/CA2510006C/en not_active Expired - Fee Related
- 2003-12-04 DE DE60326488T patent/DE60326488D1/de not_active Expired - Lifetime
- 2003-12-04 AU AU2003298868A patent/AU2003298868B2/en not_active Ceased
- 2003-12-04 WO PCT/US2003/038523 patent/WO2004052349A2/en not_active Ceased
- 2003-12-04 US US10/728,114 patent/US7943593B2/en not_active Expired - Fee Related
- 2003-12-04 JP JP2005508461A patent/JP4789621B2/ja not_active Expired - Fee Related
- 2003-12-04 EP EP03796628A patent/EP1575579B1/en not_active Expired - Lifetime
- 2003-12-04 AT AT03796628T patent/ATE424198T1/de not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040029A1 (en) * | 1996-04-22 | 1997-10-30 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| WO2000056331A1 (en) * | 1999-03-19 | 2000-09-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
Non-Patent Citations (1)
| Title |
|---|
| Kaufmann et al. Exper. Cell Reserach (2000) vol. 256, pages 42-49 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4789621B2 (ja) | 2011-10-12 |
| WO2004052349A3 (en) | 2004-07-29 |
| JP2006524186A (ja) | 2006-10-26 |
| AU2003298868A1 (en) | 2004-06-30 |
| US7943593B2 (en) | 2011-05-17 |
| ATE424198T1 (de) | 2009-03-15 |
| DE60326488D1 (de) | 2009-04-16 |
| EP1575579B1 (en) | 2009-03-04 |
| WO2004052349A2 (en) | 2004-06-24 |
| EP1575579A2 (en) | 2005-09-21 |
| US20050059734A1 (en) | 2005-03-17 |
| CA2510006C (en) | 2012-02-07 |
| CA2510006A1 (en) | 2004-06-24 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| GM | Mortgages registered |
Name of requester: MACQUARIE US TRADING LLC |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |