CA2510006C - Compositions comprising a combination of diphenyl urea impdh inhibitors and apoptosis-inducing anti-cancer agents - Google Patents
Compositions comprising a combination of diphenyl urea impdh inhibitors and apoptosis-inducing anti-cancer agents Download PDFInfo
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- CA2510006C CA2510006C CA2510006A CA2510006A CA2510006C CA 2510006 C CA2510006 C CA 2510006C CA 2510006 A CA2510006 A CA 2510006A CA 2510006 A CA2510006 A CA 2510006A CA 2510006 C CA2510006 C CA 2510006C
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- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43155502P | 2002-12-06 | 2002-12-06 | |
| US60/431,555 | 2002-12-06 | ||
| US49626103P | 2003-08-19 | 2003-08-19 | |
| US60/496,261 | 2003-08-19 | ||
| PCT/US2003/038523 WO2004052349A2 (en) | 2002-12-06 | 2003-12-04 | Compositions comprising a combination of diphenyl ura impdh inhibitors and apoptosis-inducing anti-cancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2510006A1 CA2510006A1 (en) | 2004-06-24 |
| CA2510006C true CA2510006C (en) | 2012-02-07 |
Family
ID=32511581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2510006A Expired - Fee Related CA2510006C (en) | 2002-12-06 | 2003-12-04 | Compositions comprising a combination of diphenyl urea impdh inhibitors and apoptosis-inducing anti-cancer agents |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7943593B2 (enExample) |
| EP (1) | EP1575579B1 (enExample) |
| JP (1) | JP4789621B2 (enExample) |
| AT (1) | ATE424198T1 (enExample) |
| AU (1) | AU2003298868B2 (enExample) |
| CA (1) | CA2510006C (enExample) |
| DE (1) | DE60326488D1 (enExample) |
| WO (1) | WO2004052349A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504515B2 (en) | 2005-05-26 | 2009-03-17 | Vertex Pharmaceuticals Incorporated | Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4- (oxazol-5-yl)phenyl) ureido)phenyl) ethylcarbamate |
| SG11202110436UA (en) * | 2019-04-05 | 2021-10-28 | Prolynx Llc | Improved conjugation linkers |
| JP2022136035A (ja) * | 2021-03-04 | 2022-09-15 | 国立大学法人東京農工大学 | 化合物、該化合物を用いた金属ナノ粒子複合体、及び標的分子の検出方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210745A (en) * | 1978-01-04 | 1980-07-01 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine |
| US4357324A (en) * | 1981-02-24 | 1982-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| TW409125B (en) * | 1996-04-22 | 2000-10-21 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| HUP0004421A3 (en) | 1996-04-23 | 2002-10-28 | Vertex Pharmaceuticals Inc Cam | Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme |
| AR029341A1 (es) * | 1999-03-19 | 2003-06-25 | Vertex Pharma | Inhibidores de la enzima impdh (inosina-5'-monofosfato dehidrogenasa) |
-
2003
- 2003-12-04 WO PCT/US2003/038523 patent/WO2004052349A2/en not_active Ceased
- 2003-12-04 DE DE60326488T patent/DE60326488D1/de not_active Expired - Lifetime
- 2003-12-04 US US10/728,114 patent/US7943593B2/en not_active Expired - Fee Related
- 2003-12-04 AU AU2003298868A patent/AU2003298868B2/en not_active Ceased
- 2003-12-04 JP JP2005508461A patent/JP4789621B2/ja not_active Expired - Fee Related
- 2003-12-04 AT AT03796628T patent/ATE424198T1/de not_active IP Right Cessation
- 2003-12-04 CA CA2510006A patent/CA2510006C/en not_active Expired - Fee Related
- 2003-12-04 EP EP03796628A patent/EP1575579B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE424198T1 (de) | 2009-03-15 |
| CA2510006A1 (en) | 2004-06-24 |
| AU2003298868A1 (en) | 2004-06-30 |
| JP2006524186A (ja) | 2006-10-26 |
| EP1575579A2 (en) | 2005-09-21 |
| US20050059734A1 (en) | 2005-03-17 |
| WO2004052349A3 (en) | 2004-07-29 |
| EP1575579B1 (en) | 2009-03-04 |
| DE60326488D1 (de) | 2009-04-16 |
| AU2003298868B2 (en) | 2009-09-17 |
| WO2004052349A2 (en) | 2004-06-24 |
| JP4789621B2 (ja) | 2011-10-12 |
| US7943593B2 (en) | 2011-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20151204 |