AU2003291226B2 - Transcription factor modulating compounds and methods of use thereof - Google Patents
Transcription factor modulating compounds and methods of use thereof Download PDFInfo
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- AU2003291226B2 AU2003291226B2 AU2003291226A AU2003291226A AU2003291226B2 AU 2003291226 B2 AU2003291226 B2 AU 2003291226B2 AU 2003291226 A AU2003291226 A AU 2003291226A AU 2003291226 A AU2003291226 A AU 2003291226A AU 2003291226 B2 AU2003291226 B2 AU 2003291226B2
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- substituted
- unsubstituted
- straight
- branched alkyl
- phenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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PCT/US2003/035205 WO2004041209A2 (en) | 2002-11-01 | 2003-11-03 | Transcription factor modulating compounds and methods of use thereof |
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EP1462105A1 (de) * | 2003-03-28 | 2004-09-29 | Procorde GmbH | Aktivierungs-spezifische Inhibitoren von NF-kB und Methode zur Behandlung entzündlicher Prozesse be kardiovaskulären Erkrankungen |
EP1613313B1 (de) | 2003-04-17 | 2007-06-06 | Janssen Pharmaceutica N.V. | 2-phenyl-benzimidazol und 2-phenyl-imidazo-4,5]-pyridin-derivate als checkpoint-kinase-cds1 (chk2)-hemmer zur behandlung von krebs |
US20060160799A1 (en) * | 2004-04-23 | 2006-07-20 | Alekshun Michael N | Transcription factor modulating compounds and methods of use thereof |
WO2007016292A2 (en) * | 2005-07-27 | 2007-02-08 | Vertex Pharmaceuticals Incorporated | Heterocyclic amides as biofilm modulators |
AU2006345003A1 (en) * | 2005-08-12 | 2008-04-10 | United States Government As Represented By The Secretary Of The United States Army And The U.S. Army Medical Research & Materiel Command | Broad spectrum antibacterial compounds |
WO2007053945A1 (en) * | 2005-11-09 | 2007-05-18 | Kane Biotech Inc. | Oral anti-microbial composition comprising competence-stimulating peptide |
CN101626765B (zh) * | 2006-06-23 | 2012-12-26 | 帕拉特克药品公司 | 转录因子调节化合物及其使用方法 |
BRPI0719761A2 (pt) | 2006-12-01 | 2014-01-21 | Laclede Inc | Uso de enzimas hidrolíticas e oxidativas para dissolver biofilme nas orelhas |
EP2139474A2 (de) * | 2007-03-27 | 2010-01-06 | Paratek Pharmaceuticals, Inc. | Verbindungen zur transkriptionsfaktor-modulation und verfahren zu ihrer verwendung |
EP2000140A1 (de) | 2007-06-05 | 2008-12-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verwendung 3-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidinen oder 3-Oxo-2,3-dihydro-5H-imidazolo[3,2-a]pyrimidinen zur Herstellung pharmazeutischer Zubereitungen zur Behandlung von Krebs |
JP5552121B2 (ja) * | 2008-09-04 | 2014-07-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のインドリジン阻害剤 |
GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
US20110059962A1 (en) * | 2009-04-22 | 2011-03-10 | Alekshun Michael N | Transcription factor modulating compounds and methods of use thereof |
WO2011151620A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
WO2011151617A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
WO2011151618A2 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
WO2011151619A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
WO2011151621A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
WO2012012478A1 (en) * | 2010-07-21 | 2012-01-26 | Merck Sharp & Dohme Corp. | Aldosterone synthase inhibitors |
US9332757B2 (en) | 2010-10-25 | 2016-05-10 | Vanderbilt University | Composition for inhibition of insect host sensing |
PT2705345E (pt) * | 2011-05-02 | 2015-06-17 | Lapenna José Carlos | Utilização de halogeno-cianoacetamidas para fixação e preservação de amostras biológicas |
WO2012154403A2 (en) | 2011-05-06 | 2012-11-15 | Vanderbilt University | Composition for inhibition of insect sensing |
US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
ITMI20132192A1 (it) * | 2013-12-23 | 2015-06-24 | Purisa S R L | Composti antimicrobici |
US20180000793A1 (en) | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
CN113749102A (zh) | 2015-03-25 | 2021-12-07 | 范德比尔特大学 | 作为orco介导的气味感觉干扰剂的二元组合物 |
US10472687B2 (en) | 2016-01-08 | 2019-11-12 | Institute For Systems Biology | Methods to identify antituberculosis compounds |
PE20210340A1 (es) | 2017-09-15 | 2021-02-22 | Aduro Biotech Inc | Compuestos que contienen pirazolopirimidinona y sus usos |
WO2021009514A1 (en) | 2019-07-17 | 2021-01-21 | Summit (Oxford) Limited | Process for the preparation of ridinilazole and crystalline forms thereof |
JP7458622B2 (ja) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | 抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法 |
CN110840897B (zh) * | 2019-11-28 | 2023-08-08 | 河北旺发生物科技有限公司 | 金属β-内酰胺酶抑制剂 |
CN111166743B (zh) * | 2020-01-02 | 2022-03-22 | 中国医学科学院医药生物技术研究所 | 一类含噻唑结构化合物的抗感染用途 |
GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
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US3300505A (en) * | 1964-12-07 | 1967-01-24 | Ciba Geigy Corp | Ether-2-r-substituted benzimidazoles and derivatives and acid addition salts thereof |
US3429890A (en) * | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
US3325356A (en) * | 1965-08-20 | 1967-06-13 | Merck & Co Inc | Compositions and method for treating helminthiasis |
GB1141936A (en) * | 1966-03-26 | 1969-02-05 | Shionogi & Co | Improvements in or relating to benzimidazole derivatives |
DE1923481A1 (de) * | 1969-05-08 | 1970-11-12 | Hoechst Ag | Verfahren zur Herstellung von Amiden und Estern der 1-Hydroxy-benzimidazol-2-carbonsaeure |
US3686110A (en) * | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
US3873558A (en) * | 1970-03-05 | 1975-03-25 | Merck & Co Inc | Process for preparing 1,5-substituted or 1,6-substituted benzimidazoles |
CH556868A (de) * | 1970-03-05 | 1974-12-13 | Merck & Co Inc | Verfahren zur herstellung von 1-hydroxy-5-(oder 6-)-carbonyl-amino-2-(4'-thiazolyl)-benzimidazolen. |
US3646049A (en) * | 1970-03-05 | 1972-02-29 | Merck & Co Inc | Acylaminobenzimidazole derivatives |
NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
CA2002859C (en) * | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
AU4988997A (en) * | 1996-10-23 | 1998-05-15 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
WO2000012089A1 (en) * | 1998-08-31 | 2000-03-09 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
WO2004001058A2 (en) * | 2001-05-04 | 2003-12-31 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
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WO2004041209A2 (en) | 2004-05-21 |
EP1558341A2 (de) | 2005-08-03 |
EP1558341A4 (de) | 2010-09-08 |
CA2504448A1 (en) | 2004-05-21 |
JP2006513162A (ja) | 2006-04-20 |
JP5175316B2 (ja) | 2013-04-03 |
CA2504448C (en) | 2012-06-19 |
WO2004041209A3 (en) | 2004-09-30 |
JP2010235612A (ja) | 2010-10-21 |
JP2012131813A (ja) | 2012-07-12 |
AU2003291226A1 (en) | 2004-06-07 |
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