AU2003263878A1 - Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents - Google Patents

Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Info

Publication number
AU2003263878A1
AU2003263878A1 AU2003263878A AU2003263878A AU2003263878A1 AU 2003263878 A1 AU2003263878 A1 AU 2003263878A1 AU 2003263878 A AU2003263878 A AU 2003263878A AU 2003263878 A AU2003263878 A AU 2003263878A AU 2003263878 A1 AU2003263878 A1 AU 2003263878A1
Authority
AU
Australia
Prior art keywords
compounds
carbinol
chemotherapeutic
metabolites
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003263878A
Other languages
English (en)
Inventor
Wan-Ru Chao
Ling Jong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of AU2003263878A1 publication Critical patent/AU2003263878A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
AU2003263878A 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents Abandoned AU2003263878A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/224,979 US6800655B2 (en) 2002-08-20 2002-08-20 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US10/224,979 2002-08-20
PCT/US2003/025772 WO2004018475A2 (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Publications (1)

Publication Number Publication Date
AU2003263878A1 true AU2003263878A1 (en) 2004-03-11

Family

ID=31946289

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003263878A Abandoned AU2003263878A1 (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Country Status (8)

Country Link
US (4) US6800655B2 (US07666897-20100223-C00014.png)
EP (2) EP1623985B1 (US07666897-20100223-C00014.png)
JP (3) JP4764629B2 (US07666897-20100223-C00014.png)
AT (1) ATE411317T1 (US07666897-20100223-C00014.png)
AU (1) AU2003263878A1 (US07666897-20100223-C00014.png)
CA (1) CA2496203C (US07666897-20100223-C00014.png)
DE (1) DE60324155D1 (US07666897-20100223-C00014.png)
WO (1) WO2004018475A2 (US07666897-20100223-C00014.png)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US8080577B2 (en) * 2004-05-06 2011-12-20 Bioresponse, L.L.C. Diindolylmethane formulations for the treatment of leiomyomas
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
DE602005026328D1 (de) * 2004-12-30 2011-03-24 Bioresponse Llc Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
AU2006251832A1 (en) 2005-05-27 2006-11-30 Queen's University At Kingston Treatment of protein folding disorders
CN1807413B (zh) * 2005-09-28 2010-05-05 中国医学科学院医药生物技术研究所 咔唑磺酰胺衍生物及其制备方法
AU2007239283B2 (en) 2006-04-18 2013-02-07 Nippon Chemiphar Co., Ltd. Activating agent for peroxisome proliferator activated receptor delta
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
BRPI0717753B1 (pt) 2006-10-27 2022-04-12 Bioresponse, Llc Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
US7807705B2 (en) * 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US20100292316A1 (en) * 2007-07-18 2010-11-18 Research Development Foundation Improved therapeutic methods and compositions comprising chroman ring compounds
LT2277874T (lt) * 2008-04-15 2018-10-10 Nippon Chemiphar Co., Ltd. Peroksisomų proliferatoriaus aktyvuotų receptorių aktyvatorius
JP5550151B2 (ja) * 2008-09-17 2014-07-16 エスアールアイ インターナショナル インドール−３−カルビノール類似体およびその感染に対する薬剤としての使用
KR101477613B1 (ko) * 2009-03-31 2014-12-30 롬엔드하스전자재료코리아유한회사 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전자 소자
WO2010118339A2 (en) * 2009-04-09 2010-10-14 University Of Kansas Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability
CA2770494A1 (en) * 2009-08-14 2011-02-17 Ronald Barbaras Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases
US8153680B2 (en) * 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
DE102009052428A1 (de) * 2009-11-10 2011-05-12 Merck Patent Gmbh Verbindung für elektronische Vorrichtungen
EP2566481A4 (en) * 2010-05-06 2014-01-22 Merck Sharp & Dohme AS FAAH MODULATORS SUITABLE AZA-INDOL DERIVATIVES
CA2827214C (en) 2011-04-01 2017-07-18 Sri International Lipoxygenase inhibitors
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
US9969686B2 (en) * 2014-08-05 2018-05-15 Wisconsin Alumni Research Foundation Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
US10844051B2 (en) 2015-07-22 2020-11-24 The Royal Institution For The Advancement Of Learning/Mcgill University Substituted oxazoles for the treatment of cancer
CN105218552B (zh) * 2015-09-30 2018-02-27 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用
CN110698654B (zh) * 2018-07-10 2021-04-02 中国科学院长春应用化学研究所 基于三聚吲哚的超支化共轭聚电解质及其制备方法和用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1282451B (de) * 1965-09-01 1968-11-07 Kalle Ag Lichtempfindliche Schicht und Verfahren zur Herstellung fixierter Bilder
US4636820A (en) * 1980-03-06 1987-01-13 The Hilton-Davis Chemical Compositions, process and systems
ES2167303T3 (es) * 1986-10-28 2002-05-16 Ciba Sc Holding Ag Ftalidas cromogenas.
GB8713564D0 (en) 1987-06-10 1987-07-15 Kong Y C Synthesis
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5116978A (en) * 1989-03-08 1992-05-26 Appleton Papers Inc. Process for bis(indolyl)ethylene synthesis
US5086171A (en) * 1989-03-08 1992-02-04 Appleton Papers Inc. Bis-(indolyl)ethylenes
JP3038064B2 (ja) * 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
DE59207620D1 (de) * 1991-10-30 1997-01-16 Ciba Geigy Ag NIR-Farbstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5407102A (en) * 1994-02-15 1995-04-18 Freudinger; Mark J. Apparatus for dispensing a quantity of flowable material
US5948808A (en) * 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
US5942340A (en) * 1997-10-02 1999-08-24 Xerox Corporation Indolocarbazole electroluminescent devices
US5843607A (en) * 1997-10-02 1998-12-01 Xerox Corporation Indolocarbazole photoconductors
CA2330756C (en) 1998-05-04 2007-10-02 Asta Medica Aktiengesellschaft Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation
WO2000002857A1 (en) * 1998-07-08 2000-01-20 Harbor Branch Oceanographic Institution, Inc. Bis-indole derivatives and their use as antiinflammatory agents
IT1317925B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
IT1317926B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
JP2003346530A (ja) 2002-05-23 2003-12-05 Nippon Sheet Glass Co Ltd 面状光源装置および画像読み取り装置
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Also Published As

Publication number Publication date
US20040043965A1 (en) 2004-03-04
US20060128785A1 (en) 2006-06-15
JP4764629B2 (ja) 2011-09-07
EP1623985B1 (en) 2016-02-17
US6800655B2 (en) 2004-10-05
CA2496203C (en) 2012-03-27
EP1623985A3 (en) 2011-06-08
ATE411317T1 (de) 2008-10-15
US7078427B2 (en) 2006-07-18
JP5599236B2 (ja) 2014-10-01
EP1623985A2 (en) 2006-02-08
JP4699171B2 (ja) 2011-06-08
US20090023796A1 (en) 2009-01-22
EP1530572B1 (en) 2008-10-15
JP2006500379A (ja) 2006-01-05
CA2496203A1 (en) 2004-03-04
JP2010195840A (ja) 2010-09-09
EP1530572A2 (en) 2005-05-18
WO2004018475A3 (en) 2004-04-01
US7429610B2 (en) 2008-09-30
DE60324155D1 (de) 2008-11-27
JP2006036796A (ja) 2006-02-09
WO2004018475A2 (en) 2004-03-04
US20040157906A1 (en) 2004-08-12
US7666897B2 (en) 2010-02-23

Similar Documents

Publication Publication Date Title
AU2003263878A1 (en) Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
BR0211228A (pt) Composto, composição farmacêutica e seus usos
HK1088845A1 (en) Use of parthenolide derivatives as antileukemic and cytotoxic agents
AU2002218167A1 (en) N-phenyl-2-pyrimidine-amine derivatives
TW200621737A (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
NO20065904L (no) Terapeutiske forbindelser
AUPR213700A0 (en) Antiviral agents
MXPA04004601A (es) Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
TNSN04203A1 (en) Benzoxazinone-derived compounds, their preparation and use as medicaments
HK1084588A1 (en) Precutaneous absorption preparations containing 3-methyl-1-phenyl-2-pyrazolin-5-one
IL169184A0 (en) Aromatic compounds as anti-inflammatory, immunomdulatory and anti-proliferatory agents
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
BG106155A (en) Novel derivatives and analogues of galanthamin
MY133112A (en) 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use
ATE308969T1 (de) Kosmetische formulierung enthaltend dihydroxyaceton
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
MY139228A (en) Imidazolinylmethyl aralkylsulfonamides
WO2004048381A3 (en) Pyrazoloazepine compounds as pharmaceutical agents
AU2001266019A1 (en) 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivatives
EP2266566A3 (en) Nicotinamide derivatives and their use as therapeutic agents
WO2002065984A3 (en) Compounds having retinoid-like activity
HK1083839A1 (en) Indoline compound and medicinal use thereof
DE60309926D1 (de) Steroid-verbindungen mit anti-tumoraler wirkung
MXPA99003849A (es) Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina.
ATE461702T1 (de) Krebsmittel

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase