AU2003259352A1 - Labelled nucleotides - Google Patents

Labelled nucleotides

Info

Publication number
AU2003259352A1
AU2003259352A1 AU2003259352A AU2003259352A AU2003259352A1 AU 2003259352 A1 AU2003259352 A1 AU 2003259352A1 AU 2003259352 A AU2003259352 A AU 2003259352A AU 2003259352 A AU2003259352 A AU 2003259352A AU 2003259352 A1 AU2003259352 A1 AU 2003259352A1
Authority
AU
Australia
Prior art keywords
labelled nucleotides
labelled
nucleotides
nucleoside
linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003259352A
Other languages
English (en)
Inventor
Xiaohai Liu
John Milton
Silke Ruediger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solexa Ltd Great Britain
Original Assignee
Solexa Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31946334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2003259352(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/227,131 external-priority patent/US7057026B2/en
Application filed by Solexa Ltd Great Britain filed Critical Solexa Ltd Great Britain
Publication of AU2003259352A1 publication Critical patent/AU2003259352A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2003259352A 2002-08-23 2003-08-22 Labelled nucleotides Abandoned AU2003259352A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/227,131 2002-08-23
US10/227,131 US7057026B2 (en) 2001-12-04 2002-08-23 Labelled nucleotides
PCT/GB2003/003690 WO2004018493A1 (fr) 2002-08-23 2003-08-22 Nucleotides marques

Publications (1)

Publication Number Publication Date
AU2003259352A1 true AU2003259352A1 (en) 2004-03-11

Family

ID=31946334

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003259352A Abandoned AU2003259352A1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Country Status (12)

Country Link
EP (5) EP3438116B1 (fr)
AT (1) ATE431354T1 (fr)
AU (1) AU2003259352A1 (fr)
CY (3) CY1118471T1 (fr)
DE (1) DE60327649D1 (fr)
DK (4) DK3438116T3 (fr)
ES (4) ES2604951T3 (fr)
GB (1) GB2395953A (fr)
HU (2) HUE032483T2 (fr)
PT (3) PT2119722T (fr)
SI (3) SI2119722T1 (fr)
WO (1) WO2004018493A1 (fr)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
CA2425112C (fr) 2000-10-06 2011-09-27 The Trustees Of Columbia University In The City Of New York Methode d'analyse massivement parallele destinee a decoder l'adn et l'arn
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
HUE032483T2 (en) 2002-08-23 2017-09-28 Illumina Cambridge Ltd Marked nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
JP2006509040A (ja) 2002-08-23 2006-03-16 ソレックサ リミテッド 修飾されたヌクレオチド
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
EP1730307A4 (fr) 2004-03-03 2008-11-05 Univ Columbia Nucleotides fluorescents photoclivables destines a sequencer de l'adn sur une puce construite par chimie de couplage specifique au site
GB0427236D0 (en) * 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
WO2006064199A1 (fr) * 2004-12-13 2006-06-22 Solexa Limited Procede ameliore de detection de nucleotides
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
WO2007002204A2 (fr) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Procedes de pyrosequencage et compositions associees
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0517097D0 (en) * 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7982029B2 (en) 2005-10-31 2011-07-19 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
WO2007053719A2 (fr) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Analogues nucleotidiques fluorescents de 3'-o-allyl-dntp-allyl-fluorophore chimiquement clivables et procedes associes
CN101460953B (zh) 2006-03-31 2012-05-30 索雷克萨公司 用于合成分析的序列的系统和装置
US20090253581A1 (en) 2006-04-04 2009-10-08 Keygene N.V. High Throughput Detection of Molecular Markers Based on AFLP and High Throughput Sequencing
EP2021415B1 (fr) 2006-05-18 2017-03-15 Illumina Cambridge Limited Composes de type teinte et application de leurs conjugues marques
EP2032686B1 (fr) 2006-06-23 2022-01-12 Illumina, Inc. Dispositif et méthode pour la création d'amas ordonnés d'adn
DK2038425T3 (da) 2006-07-12 2010-12-06 Keygene Nv Fysisk kortlægning med høj kapacitet ved anvendelse af AFLP
US8399188B2 (en) 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
CN102443030B (zh) 2006-12-05 2015-12-16 激光基因公司 光可断裂的标记核苷酸和核苷与标记的核苷酸和核苷以及其在dna测序中的使用方法
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US9163053B2 (en) 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
EP4310194A2 (fr) 2007-10-19 2024-01-24 The Trustees of Columbia University in the City of New York Conception et synthèse de nucléotides fluorescents clivables en tant que terminateurs réversibles pour le séquençage d'adn par synthèse
EP2209911B1 (fr) 2007-10-19 2013-10-16 The Trustees of Columbia University in the City of New York Séquençage d'adn avec des terminateurs réversibles nucléotidiques non fluorescents et des terminateurs nucléotidiques modifiés par un marqueur séparable et un composé de déoxyinosine contenant un terminateur réversible
WO2009097368A2 (fr) 2008-01-28 2009-08-06 Complete Genomics, Inc. Procédés et compositions pour un appel de base efficace dans des réactions de séquençage
NZ588112A (en) 2008-03-17 2013-04-26 Expressive Res Bv Expression-linked gene discovery
CN102124018A (zh) 2008-04-29 2011-07-13 生命科技公司 可维持从核苷酸模板酶促合成双链核苷酸的非天然聚合酶底物及其使用的方法
CN102264917B (zh) 2008-06-11 2015-06-10 激光基因公司 核苷酸和核苷以及将其用于dna测序的方法
EP2379751B1 (fr) 2009-01-13 2013-03-20 Keygene N.V. Nouvelles stratégies de séquençage du génome
US9315860B2 (en) 2009-10-26 2016-04-19 Genovoxx Gmbh Conjugates of nucleotides and method for the application thereof
EP2614159B1 (fr) 2010-09-10 2017-11-08 Bio-Rad Laboratories, Inc. Choix de la taille de l'adn pour l'analyse de la chromatine
CN103403188B (zh) 2011-01-31 2016-03-30 伊鲁米那股份有限公司 用于降低核酸损伤的方法
US9994894B2 (en) 2011-04-27 2018-06-12 Agct Gmbh Method and components for detecting nucleic acid chains
EP2705161A1 (fr) 2011-05-04 2014-03-12 Genovoxx GmbH Conjugués nucléoside-triphosphate et procédés d'utilisation de ceux-ci
WO2012162429A2 (fr) 2011-05-23 2012-11-29 The Trustees Of Columbia University In The City Of New York Séquençage de l'adn par synthèse utilisant la détection par spectroscopie raman et infrarouge
JP6028025B2 (ja) 2011-07-08 2016-11-16 キージーン・エン・フェー オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定
CN104024269B (zh) 2011-09-13 2017-05-24 激光基因公司 5‑甲氧基，3’‑oh未阻断，可快速光切割的终止核苷酸以及用于核酸测序的方法
EP2768972B2 (fr) * 2011-09-23 2020-07-22 Illumina, Inc. Procédés et compositions de séquençage d'acides nucléiques
US8754244B1 (en) 2013-03-08 2014-06-17 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
WO2014135221A1 (fr) 2013-03-08 2014-09-12 Illumina Cambridge Ltd Composés de polyméthine et leur utilisation comme marqueurs fluorescents
CN105263918B (zh) 2013-03-08 2018-05-18 伊鲁米纳剑桥有限公司 罗丹明化合物及其作为荧光标记物的用途
CA2902099C (fr) 2013-03-08 2020-06-02 F. Hoffmann-La Roche Ag Analyse de sang destinee a mettre en evidence des mutations de l'egfr
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
WO2014144883A1 (fr) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Molecules marquees par des amas de raman destinees a l'imagerie biologique
BR112015022448B1 (pt) 2013-03-15 2020-12-08 Illumina Cambridge Limited molécula de nucleotídeo ou nucleosídeo modificado, métodos para preparar o crescimento de polinucleotídeo complementar a polinucleotídeo alvo de fita simples em reação de sequenciação e para determinar a sequência de polinucleotídeo alvo de fita simples e kit
JP6151360B2 (ja) 2013-07-31 2017-06-21 株式会社日立ハイテクノロジーズ 核酸分析用フローセル、及び核酸分析装置
CN103667469A (zh) * 2013-11-29 2014-03-26 武汉科技大学 一种基于万能碱基的dna测序方法
WO2015103225A1 (fr) 2013-12-31 2015-07-09 Illumina, Inc. Cuve à circulation adressable utilisant des électrodes à motif
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
US10190162B2 (en) 2014-10-23 2019-01-29 Complete Genomics, Inc. Signal confinement sequencing (SCS) and nucleotide analogues for signal confinement sequencing
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
EP3363898B1 (fr) 2015-10-13 2022-11-30 Japan Agency for Marine-Earth Science and Technology Procédé de fragmentation d'arn double brin et son utilisation
US10988501B2 (en) * 2016-04-22 2021-04-27 Mgi Tech Co., Ltd. Reversibly blocked nucleoside analogues and their use
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
EP4257596A3 (fr) 2016-12-22 2023-12-06 Illumina Cambridge Limited Composés coumarines et leurs utilisations en tant que marqueurs fluorescents
GB2567124A (en) 2017-05-08 2019-04-10 Vysoka Akola Chemicko Tech V Praze Imaging agents and methods
GB2577020B (en) 2017-05-26 2020-09-16 Nuclera Nucleics Ltd Use of terminal transferase enzyme in nucleic acid synthesis
FI3663407T3 (fi) 2017-08-01 2023-04-18 Mgi Tech Co Ltd Nukleiinihapon sekvensointimenetelmä
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11390753B2 (en) 2019-03-01 2022-07-19 Illumina Cambridge Limited Exocyclic amine substituted coumarin compounds and uses as fluorescent labels
WO2020178231A1 (fr) 2019-03-01 2020-09-10 Illumina, Inc. Détection fluorescente multiplexée d'analytes
JP2022521866A (ja) 2019-03-01 2022-04-13 イルミナ ケンブリッジ リミテッド 第三級アミン置換クマリン化合物およびそれらの蛍光標識としての使用
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
CA3157457A1 (fr) 2019-11-27 2021-06-03 Xiaolin Wu Compositions et colorants contenant du cyclooctatetraene
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
BR112022026056A2 (pt) 2020-06-22 2023-03-07 Illumina Cambridge Ltd Nucleosídeos e nucleotídeos com grupo bloqueador 3? acetal
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
CN116615560A (zh) 2020-10-30 2023-08-18 元素生物科学公司 用于大规模平行核酸测序的试剂
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4334327A1 (fr) 2021-05-05 2024-03-13 Illumina Cambridge Limited Colorants fluorescents contenant des hétérocycles fusionnés contenant du bis-bore et leurs utilisations dans le séquençage
CA3216735A1 (fr) 2021-05-20 2022-11-24 Patrizia IAVICOLI Compositions et procedes de sequencage par synthese
CA3224382A1 (fr) 2021-06-29 2023-01-05 Amirali Kia Organe d'appel de base auto-appris, entraine a l'aide d'oligo-sequences
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023003757A1 (fr) 2021-07-19 2023-01-26 Illumina Software, Inc. Extraction d'intensité avec interpolation et adaptation pour appel de base
CA3223746A1 (fr) 2021-07-28 2023-02-02 Rohan PAUL Etalonnage de score de qualite de systemes d'appel de bases
WO2023014741A1 (fr) 2021-08-03 2023-02-09 Illumina Software, Inc. Assignation de bases utilisant de multiples modèles de systèmes d'assignation de bases
US20230047225A1 (en) 2021-08-14 2023-02-16 Illumina, Inc. Polymerases, compositions, and methods of use
CA3223115A1 (fr) 2022-03-28 2023-10-05 Xiaolin Wu Avidine marquee et procedes de sequencage
WO2023186819A1 (fr) 2022-03-29 2023-10-05 Illumina Cambridge Limited Colorants de chroménoquinoléine et leurs utilisations dans le séquencage
US20230357845A1 (en) 2022-03-31 2023-11-09 Illumina, Inc. Compositions and methods for improving sequencing signals
AU2023244351A1 (en) 2022-03-31 2024-01-18 Illumina, Inc. Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis
WO2023232829A1 (fr) 2022-05-31 2023-12-07 Illumina, Inc Compositions et procédés de séquençage d'acides nucléiques
WO2024003087A1 (fr) 2022-06-28 2024-01-04 Illumina, Inc. Colorants fluorescents contenant un hétérocycle de bore bis tétracyclique fusionné et leurs utilisations dans le séquençage
WO2024059852A1 (fr) 2022-09-16 2024-03-21 Illumina, Inc. Segmentation de grappes et appel de bases conditionnel
WO2024068889A2 (fr) 2022-09-30 2024-04-04 Illumina, Inc. Compositions et procédés de réduction de photolésions pendant le séquençage
WO2024123866A1 (fr) 2022-12-09 2024-06-13 Illumina, Inc. Nucléosides et nucléotides à groupes bloquants 3´ et lieurs clivables

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US227131A (en) 1880-05-04 Heney o
DE3906357A1 (de) 1989-03-01 1990-09-06 Boehringer Mannheim Gmbh Neue acyclische nucleosid-analoga, verfahren zu ihrer herstellung und verwendung dieser verbindungen als antivirale arzneimittel
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP0450060A1 (fr) 1989-10-26 1991-10-09 Sri International Sequen age d'adn
CA2159356A1 (fr) 1993-04-13 1994-10-27 Michael L. Wood Derives non nucleosidiques de la coumarine , agents de reticulation de polynucleotides
AU5171696A (en) 1995-02-27 1996-09-18 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
JP3813818B2 (ja) 1998-05-01 2006-08-23 アリゾナ ボード オブ リージェンツ オリゴヌクレオチドおよびｄｎａ分子のヌクレオチド配列の決定方法
EP1105529B2 (fr) 1998-07-30 2013-05-29 Illumina Cambridge Limited Biomolecules en rangees et leur utilisation dans une procedure de sequencage
AU3498900A (en) 1999-02-23 2000-09-14 Caliper Technologies Corporation Sequencing by incorporation
PT1159453E (pt) 1999-03-10 2008-08-29 Asm Scient Inc Processo para sequenciação directa de ácidos nucleicos
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
GB0013276D0 (en) 2000-06-01 2000-07-26 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
CA2425112C (fr) * 2000-10-06 2011-09-27 The Trustees Of Columbia University In The City Of New York Methode d'analyse massivement parallele destinee a decoder l'adn et l'arn
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
US6753449B2 (en) 2001-10-09 2004-06-22 Arqule, Inc. Cleavable linker for solid phase synthesis
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
JP2006509040A (ja) 2002-08-23 2006-03-16 ソレックサ リミテッド 修飾されたヌクレオチド
HUE032483T2 (en) 2002-08-23 2017-09-28 Illumina Cambridge Ltd Marked nucleotides
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays

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EP1560838B1 (fr) 2009-05-13
SI3438116T1 (sl) 2021-07-30
EP3438116A1 (fr) 2019-02-06
PT3147292T (pt) 2018-11-22
CY1123971T1 (el) 2022-05-27
GB2395953A (en) 2004-06-09
HUE055068T2 (hu) 2021-10-28
ES2694651T3 (es) 2018-12-26
CY1118471T1 (el) 2017-07-12
EP2119722A1 (fr) 2009-11-18
ES2864086T3 (es) 2021-10-13
EP3147292A1 (fr) 2017-03-29
PT2119722T (pt) 2016-12-12
PT3438116T (pt) 2021-03-23
DK2119722T3 (en) 2016-12-12
GB0405882D0 (en) 2004-04-21
DK3147292T3 (en) 2018-12-03
EP1560838A1 (fr) 2005-08-10
EP2119722B1 (fr) 2016-10-26
DK1560838T3 (da) 2009-09-07
ES2604951T3 (es) 2017-03-10
EP3147292B1 (fr) 2018-09-26
ATE431354T1 (de) 2009-05-15
DE60327649D1 (de) 2009-06-25
SI2119722T1 (sl) 2017-03-31
SI3147292T1 (sl) 2019-01-31
EP3438116B1 (fr) 2021-02-17
CY1120882T1 (el) 2019-12-11
EP3848380A1 (fr) 2021-07-14
ES2326077T3 (es) 2009-09-30
WO2004018493A1 (fr) 2004-03-04
HUE032483T2 (en) 2017-09-28
DK3438116T3 (da) 2021-03-22

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