CY1120882T1 - Επισημασμενα νουκλεοτιδια - Google Patents
Επισημασμενα νουκλεοτιδιαInfo
- Publication number
- CY1120882T1 CY1120882T1 CY181101161T CY181101161T CY1120882T1 CY 1120882 T1 CY1120882 T1 CY 1120882T1 CY 181101161 T CY181101161 T CY 181101161T CY 181101161 T CY181101161 T CY 181101161T CY 1120882 T1 CY1120882 T1 CY 1120882T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleotids
- labeled
- nucleoside
- linker
- nucleotide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Electrophonic Musical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η εφεύρεση παρέχει ένα νουκλεοτίδιο ή ένα νουκλεοσίδιο που έχει μια βάση προσκολλημένη σε έναν ανιχνεύσιμο επισημαντή μέσω ενός διασπάσιμου συνδέτη που χαρακτηρίζεται από το ότι ο διασπάσιμος συνδέτης περιλαμβάνει ένα τμήμα επιλεγμένο από την ομάδα που αποτελείται από: (όπου το Χ επιλέγεται από την ομάδα που περιλαμβάνει Ο, S, ΝΗ και NQ όπου το Q είναι μια C1-10 υποκατεστημένη ή μη αλκυλομάδα, το Υ επιλέγεται από την ομάδα που περιλαμβάνει Ο, S, ΝΗ και Ν(αλλύλιο), το Τ είναι υδρογόνο ή μια C1-10 υποκατεστημένη ή μη αλκυλομάδα και το * δείχνει ότι το τμήμα συνδέεται με το υπόλοιπο μέρος του νουκλεοτιδίου ή νουκλεοσιδίου).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/227,131 US7057026B2 (en) | 2001-12-04 | 2002-08-23 | Labelled nucleotides |
| EP09005942.9A EP2119722B1 (en) | 2002-08-23 | 2003-08-22 | Labelled nucleotides |
| EP03792520A EP1560838B1 (en) | 2002-08-23 | 2003-08-22 | Labelled nucleotides |
| PCT/GB2003/003690 WO2004018493A1 (en) | 2002-08-23 | 2003-08-22 | Labelled nucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120882T1 true CY1120882T1 (el) | 2019-12-11 |
Family
ID=31946334
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101200T CY1118471T1 (el) | 2002-08-23 | 2016-11-21 | Επισημασμενα νουκλεοτιδια |
| CY181101161T CY1120882T1 (el) | 2002-08-23 | 2018-11-06 | Επισημασμενα νουκλεοτιδια |
| CY20211100229T CY1123971T1 (el) | 2002-08-23 | 2021-03-17 | Επισημασμενα νουκλεοτιδια |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101200T CY1118471T1 (el) | 2002-08-23 | 2016-11-21 | Επισημασμενα νουκλεοτιδια |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100229T CY1123971T1 (el) | 2002-08-23 | 2021-03-17 | Επισημασμενα νουκλεοτιδια |
Country Status (12)
| Country | Link |
|---|---|
| EP (5) | EP3438116B1 (el) |
| AT (1) | ATE431354T1 (el) |
| AU (1) | AU2003259352A1 (el) |
| CY (3) | CY1118471T1 (el) |
| DE (1) | DE60327649D1 (el) |
| DK (4) | DK3438116T3 (el) |
| ES (4) | ES2604951T3 (el) |
| GB (1) | GB2395953A (el) |
| HU (2) | HUE032483T2 (el) |
| PT (3) | PT2119722T (el) |
| SI (3) | SI2119722T1 (el) |
| WO (1) | WO2004018493A1 (el) |
Families Citing this family (105)
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| US9708358B2 (en) | 2000-10-06 | 2017-07-18 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
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| GB0129012D0 (en) | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
| HUE032483T2 (en) | 2002-08-23 | 2017-09-28 | Illumina Cambridge Ltd | Marked nucleotides |
| US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
| JP2006509040A (ja) | 2002-08-23 | 2006-03-16 | ソレックサ リミテッド | 修飾されたヌクレオチド |
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
| EP1730307A4 (en) | 2004-03-03 | 2008-11-05 | Univ Columbia | PHOTOSPACTABLE FLUORESCENZ NUCLEOTIDES FOR DNA SEQUENCING ON A MEASUREMENT BASED BY STATION-SPECIFIC COUPLING SCHEME CONSTRUCTED CHIP |
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-
2003
- 2003-08-22 HU HUE09005942A patent/HUE032483T2/en unknown
- 2003-08-22 ES ES09005942.9T patent/ES2604951T3/es not_active Expired - Lifetime
- 2003-08-22 EP EP18195197.1A patent/EP3438116B1/en not_active Revoked
- 2003-08-22 DE DE60327649T patent/DE60327649D1/de not_active Expired - Lifetime
- 2003-08-22 PT PT90059429T patent/PT2119722T/pt unknown
- 2003-08-22 DK DK18195197.1T patent/DK3438116T3/da active
- 2003-08-22 PT PT181951971T patent/PT3438116T/pt unknown
- 2003-08-22 GB GB0405882A patent/GB2395953A/en not_active Withdrawn
- 2003-08-22 DK DK09005942.9T patent/DK2119722T3/en active
- 2003-08-22 AT AT03792520T patent/ATE431354T1/de not_active IP Right Cessation
- 2003-08-22 EP EP09005942.9A patent/EP2119722B1/en not_active Revoked
- 2003-08-22 ES ES03792520T patent/ES2326077T3/es not_active Expired - Lifetime
- 2003-08-22 DK DK16193088.8T patent/DK3147292T3/en active
- 2003-08-22 SI SI200332500A patent/SI2119722T1/sl unknown
- 2003-08-22 WO PCT/GB2003/003690 patent/WO2004018493A1/en not_active Application Discontinuation
- 2003-08-22 EP EP21156755.7A patent/EP3848380A1/en not_active Withdrawn
- 2003-08-22 ES ES18195197T patent/ES2864086T3/es not_active Expired - Lifetime
- 2003-08-22 SI SI200332583T patent/SI3147292T1/sl unknown
- 2003-08-22 DK DK03792520T patent/DK1560838T3/da active
- 2003-08-22 SI SI200332618T patent/SI3438116T1/sl unknown
- 2003-08-22 AU AU2003259352A patent/AU2003259352A1/en not_active Abandoned
- 2003-08-22 ES ES16193088.8T patent/ES2694651T3/es not_active Expired - Lifetime
- 2003-08-22 PT PT16193088T patent/PT3147292T/pt unknown
- 2003-08-22 EP EP03792520A patent/EP1560838B1/en not_active Expired - Lifetime
- 2003-08-22 EP EP16193088.8A patent/EP3147292B1/en not_active Revoked
- 2003-08-22 HU HUE18195197A patent/HUE055068T2/hu unknown
-
2016
- 2016-11-21 CY CY20161101200T patent/CY1118471T1/el unknown
-
2018
- 2018-11-06 CY CY181101161T patent/CY1120882T1/el unknown
-
2021
- 2021-03-17 CY CY20211100229T patent/CY1123971T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1560838B1 (en) | 2009-05-13 |
| SI3438116T1 (sl) | 2021-07-30 |
| EP3438116A1 (en) | 2019-02-06 |
| PT3147292T (pt) | 2018-11-22 |
| CY1123971T1 (el) | 2022-05-27 |
| GB2395953A (en) | 2004-06-09 |
| HUE055068T2 (hu) | 2021-10-28 |
| ES2694651T3 (es) | 2018-12-26 |
| CY1118471T1 (el) | 2017-07-12 |
| AU2003259352A1 (en) | 2004-03-11 |
| EP2119722A1 (en) | 2009-11-18 |
| ES2864086T3 (es) | 2021-10-13 |
| EP3147292A1 (en) | 2017-03-29 |
| PT2119722T (pt) | 2016-12-12 |
| PT3438116T (pt) | 2021-03-23 |
| DK2119722T3 (en) | 2016-12-12 |
| GB0405882D0 (en) | 2004-04-21 |
| DK3147292T3 (en) | 2018-12-03 |
| EP1560838A1 (en) | 2005-08-10 |
| EP2119722B1 (en) | 2016-10-26 |
| DK1560838T3 (da) | 2009-09-07 |
| ES2604951T3 (es) | 2017-03-10 |
| EP3147292B1 (en) | 2018-09-26 |
| ATE431354T1 (de) | 2009-05-15 |
| DE60327649D1 (de) | 2009-06-25 |
| SI2119722T1 (sl) | 2017-03-31 |
| SI3147292T1 (sl) | 2019-01-31 |
| EP3438116B1 (en) | 2021-02-17 |
| EP3848380A1 (en) | 2021-07-14 |
| ES2326077T3 (es) | 2009-09-30 |
| WO2004018493A1 (en) | 2004-03-04 |
| HUE032483T2 (en) | 2017-09-28 |
| DK3438116T3 (da) | 2021-03-22 |
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