AU2003259056B2 - Method of measuring molecular interactions - Google Patents

Method of measuring molecular interactions Download PDF

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Publication number
AU2003259056B2
AU2003259056B2 AU2003259056A AU2003259056A AU2003259056B2 AU 2003259056 B2 AU2003259056 B2 AU 2003259056B2 AU 2003259056 A AU2003259056 A AU 2003259056A AU 2003259056 A AU2003259056 A AU 2003259056A AU 2003259056 B2 AU2003259056 B2 AU 2003259056B2
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AU
Australia
Prior art keywords
sample
probe
fluorescence
detector
measured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2003259056A
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English (en)
Other versions
AU2003259056A1 (en
Inventor
Dylan A. Bulseco
David E. Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sensor Technologies LLC
Original Assignee
Sensor Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sensor Technologies LLC filed Critical Sensor Technologies LLC
Publication of AU2003259056A1 publication Critical patent/AU2003259056A1/en
Application granted granted Critical
Publication of AU2003259056B2 publication Critical patent/AU2003259056B2/en
Priority to AU2007249147A priority Critical patent/AU2007249147A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/457—Correlation spectrometry, e.g. of the intensity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AU2003259056A 2002-08-01 2003-08-01 Method of measuring molecular interactions Expired - Fee Related AU2003259056B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2007249147A AU2007249147A1 (en) 2002-08-01 2007-12-20 Method of measuring molecular interactions

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40050302P 2002-08-01 2002-08-01
US60/400,503 2002-08-01
US43027302P 2002-12-02 2002-12-02
US60/430,273 2002-12-02
US46139403P 2003-04-08 2003-04-08
US60/461,394 2003-04-08
PCT/US2003/024780 WO2004013610A2 (en) 2002-08-01 2003-08-01 Method of measuring molecular interactions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2007249147A Division AU2007249147A1 (en) 2002-08-01 2007-12-20 Method of measuring molecular interactions

Publications (2)

Publication Number Publication Date
AU2003259056A1 AU2003259056A1 (en) 2004-02-23
AU2003259056B2 true AU2003259056B2 (en) 2007-10-04

Family

ID=31499331

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2003259056A Expired - Fee Related AU2003259056B2 (en) 2002-08-01 2003-08-01 Method of measuring molecular interactions
AU2003261358A Abandoned AU2003261358A1 (en) 2002-08-01 2003-08-01 Fluorescence correlation spectroscopy instrument

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2003261358A Abandoned AU2003261358A1 (en) 2002-08-01 2003-08-01 Fluorescence correlation spectroscopy instrument

Country Status (6)

Country Link
US (3) US7268878B2 (https=)
EP (2) EP1527333A1 (https=)
JP (2) JP2005534945A (https=)
AU (2) AU2003259056B2 (https=)
CA (2) CA2494478A1 (https=)
WO (2) WO2004013610A2 (https=)

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IL157206A0 (en) * 2003-08-03 2004-02-19 Correlating spatial position of chemical species on a substrate with molecular weight, structure and chemical reactivity
JP4746276B2 (ja) * 2004-02-25 2011-08-10 オリンパス株式会社 膜構造を有する生体構造物の膜機能を解析する方法
US20050191705A1 (en) * 2004-03-01 2005-09-01 Werner James H. High throughput screening using fluorophore labeled lipid membranes and fluorescence correlation spectroscopy
WO2005089524A2 (en) * 2004-03-19 2005-09-29 U.S. Genomics, Inc. Compositions and methods for detection of single molecules
FR2869412B1 (fr) * 2004-04-27 2006-07-14 Centre Nat Rech Scient Cnrse Determination d'une fonction d'autocorrelation
JP4338590B2 (ja) 2004-06-03 2009-10-07 独立行政法人科学技術振興機構 蛍光相関分光法による抗原の迅速検出及び／又は測定法。
US7214927B2 (en) * 2004-10-08 2007-05-08 Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. Method and apparatus using liquid crystal light valve to filter incident light on a photodetector
EP1672353A1 (de) * 2004-12-16 2006-06-21 Evotec Technologies GmbH Verfahren zur Zustandserfassung eines biologischen Systems mit einem Lumineszenzsensor
FR2890446B1 (fr) * 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
DE102005062910A1 (de) * 2005-12-29 2007-07-05 Basf Ag Verfahren zur Bestimmung der Identität oder Nicht-Identität und Konzentration einer chemischen Verbindung in einem Medium
JP5473202B2 (ja) * 2006-10-13 2014-04-16 滋賀県 試料中の蛍光性物質を検出する方法およびシステム
US7916304B2 (en) * 2006-12-21 2011-03-29 Howard Hughes Medical Institute Systems and methods for 3-dimensional interferometric microscopy
JP5401115B2 (ja) * 2009-02-13 2014-01-29 興和株式会社 生物由来の生理活性物質の測定方法及び測定装置
US20120135874A1 (en) * 2009-05-08 2012-05-31 The Johns Hopkins University Single molecule spectroscopy for analysis of cell-free nucleic acid biomarkers
FR2949560A1 (fr) 2009-09-02 2011-03-04 Centre Nat Rech Scient Systeme de spectroscopie a guide d'onde pour l'analyse de particules dans un milieu
WO2011123092A1 (en) * 2010-03-29 2011-10-06 Analogic Corporation Optical detection system and/or method
US20130215426A1 (en) * 2010-08-04 2013-08-22 Nir Science Corporation Method and apparatus for analyte detection
EP3358387A1 (en) * 2010-08-27 2018-08-08 The Board of Trustees of The Leland Stanford Junior University Microscopy imaging device with advanced imaging properties
US20120184831A1 (en) * 2011-01-18 2012-07-19 Radiation Monitoring Devices, Inc. Systems, devices and methods for monitoring hemodynamics
IL234766A (en) * 2014-09-21 2015-09-24 Visionsense Ltd Fluorescent Imaging System
WO2017214730A1 (en) 2016-06-14 2017-12-21 Novadaq Technologies Inc. Methods and systems for adaptive imaging for low light signal enhancement in medical visualization
EP4242743A3 (en) * 2017-02-10 2023-10-18 Stryker European Operations Limited Open-field handheld fluorescence imaging systems and methods
CN109520982A (zh) * 2018-11-20 2019-03-26 东南大学 一种荧光相关光谱测量系统
CN113295662B (zh) * 2021-05-21 2022-04-12 上海交通大学 一种用于三种分子间结合作用解析的荧光三元相关光谱系统
EP4407295A4 (en) * 2022-01-21 2025-10-15 Horiba Ltd PARTICLE ANALYSIS DEVICE
GB202203238D0 (en) * 2022-03-09 2022-04-20 Renishaw Plc Optical apparatus

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US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6403313B1 (en) * 1999-12-21 2002-06-11 Ingeneus Corporation Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators
US6420115B1 (en) * 1999-12-21 2002-07-16 Ingeneus Corporation Cation mediated triplex hybridization assay

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Also Published As

Publication number Publication date
JP2005534945A (ja) 2005-11-17
CA2494478A1 (en) 2004-02-12
US7268878B2 (en) 2007-09-11
CA2493993A1 (en) 2004-02-12
AU2003259056A1 (en) 2004-02-23
US20040082080A1 (en) 2004-04-29
WO2004013610A2 (en) 2004-02-12
EP1527333A1 (en) 2005-05-04
EP1546675A4 (en) 2008-03-26
AU2003261358A1 (en) 2004-02-23
US20040080750A1 (en) 2004-04-29
WO2004013610A3 (en) 2004-05-21
JP2005534944A (ja) 2005-11-17
WO2004013620A1 (en) 2004-02-12
EP1546675A2 (en) 2005-06-29
US20070291254A1 (en) 2007-12-20

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Legal Events

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MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee