AU2003234186B2 - Peptide inhibitors of protein kinase C Gamma for pain management - Google Patents

Peptide inhibitors of protein kinase C Gamma for pain management Download PDF

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Publication number
AU2003234186B2
AU2003234186B2 AU2003234186A AU2003234186A AU2003234186B2 AU 2003234186 B2 AU2003234186 B2 AU 2003234186B2 AU 2003234186 A AU2003234186 A AU 2003234186A AU 2003234186 A AU2003234186 A AU 2003234186A AU 2003234186 B2 AU2003234186 B2 AU 2003234186B2
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AU
Australia
Prior art keywords
peptide
pain
seq
domain
ypkc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003234186A
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English (en)
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AU2003234186A1 (en
Inventor
Joan J. Kendig
Daria Mochly-Rosen
Sarah M. Sweitzer
David C. Yeomans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
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Leland Stanford Junior University
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Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of AU2003234186A1 publication Critical patent/AU2003234186A1/en
Application granted granted Critical
Publication of AU2003234186B2 publication Critical patent/AU2003234186B2/en
Priority to AU2009201593A priority Critical patent/AU2009201593B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
AU2003234186A 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C Gamma for pain management Ceased AU2003234186B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009201593A AU2009201593B2 (en) 2002-04-22 2009-04-22 Peptide inhibitors of protein kinase C y for pain management

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37453002P 2002-04-22 2002-04-22
US60/374,530 2002-04-22
PCT/US2003/012542 WO2003089457A2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase c ϝ for pain management

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009201593A Division AU2009201593B2 (en) 2002-04-22 2009-04-22 Peptide inhibitors of protein kinase C y for pain management

Publications (2)

Publication Number Publication Date
AU2003234186A1 AU2003234186A1 (en) 2003-11-03
AU2003234186B2 true AU2003234186B2 (en) 2009-01-22

Family

ID=29251202

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2003234186A Ceased AU2003234186B2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C Gamma for pain management
AU2003234185A Ceased AU2003234185C1 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C
AU2009201593A Ceased AU2009201593B2 (en) 2002-04-22 2009-04-22 Peptide inhibitors of protein kinase C y for pain management
AU2009201760A Ceased AU2009201760B2 (en) 2002-04-22 2009-05-04 Peptide inhibitors of protein kinase C

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2003234185A Ceased AU2003234185C1 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C
AU2009201593A Ceased AU2009201593B2 (en) 2002-04-22 2009-04-22 Peptide inhibitors of protein kinase C y for pain management
AU2009201760A Ceased AU2009201760B2 (en) 2002-04-22 2009-05-04 Peptide inhibitors of protein kinase C

Country Status (6)

Country Link
US (8) US7393835B2 (enExample)
EP (3) EP1501533A4 (enExample)
JP (5) JP2005527209A (enExample)
AU (4) AU2003234186B2 (enExample)
CA (3) CA2481512C (enExample)
WO (2) WO2003089457A2 (enExample)

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US8507277B2 (en) * 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
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Also Published As

Publication number Publication date
WO2003089457A3 (en) 2004-01-22
CA2785889A1 (en) 2003-10-30
AU2009201593A1 (en) 2009-05-21
US7459424B2 (en) 2008-12-02
EP1501532A2 (en) 2005-02-02
JP2009091372A (ja) 2009-04-30
US20090143293A1 (en) 2009-06-04
US7393835B2 (en) 2008-07-01
US9365837B2 (en) 2016-06-14
JP2005523326A (ja) 2005-08-04
EP1501532A4 (en) 2007-11-14
JP2012176978A (ja) 2012-09-13
AU2003234186A1 (en) 2003-11-03
AU2003234185B2 (en) 2009-02-05
AU2009201760A1 (en) 2009-05-28
CA2481512C (en) 2013-06-18
US20080167247A1 (en) 2008-07-10
US20030223981A1 (en) 2003-12-04
US20140178352A1 (en) 2014-06-26
CA2482598A1 (en) 2003-10-30
AU2003234185C1 (en) 2009-11-19
WO2003089456A2 (en) 2003-10-30
US20050215483A1 (en) 2005-09-29
WO2003089456A3 (en) 2004-02-12
CA2481512A1 (en) 2003-10-30
EP2332559A1 (en) 2011-06-15
WO2003089457B1 (en) 2004-04-15
US20110275575A1 (en) 2011-11-10
AU2009201760B2 (en) 2011-03-17
JP2009102392A (ja) 2009-05-14
US7833984B2 (en) 2010-11-16
CA2482598C (en) 2012-09-25
AU2003234185A1 (en) 2003-11-03
EP1501533A4 (en) 2007-10-31
JP2005527209A (ja) 2005-09-15
US20040009922A1 (en) 2004-01-15
US8658594B2 (en) 2014-02-25
US7939493B2 (en) 2011-05-10
AU2009201593B2 (en) 2012-05-24
WO2003089457A2 (en) 2003-10-30
US20090192091A1 (en) 2009-07-30
EP1501533A2 (en) 2005-02-02
US7507711B2 (en) 2009-03-24

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