AU2003218600C1 - ERBB3 based methods and compositions for treating neoplasms - Google Patents

ERBB3 based methods and compositions for treating neoplasms Download PDF

Info

Publication number
AU2003218600C1
AU2003218600C1 AU2003218600A AU2003218600A AU2003218600C1 AU 2003218600 C1 AU2003218600 C1 AU 2003218600C1 AU 2003218600 A AU2003218600 A AU 2003218600A AU 2003218600 A AU2003218600 A AU 2003218600A AU 2003218600 C1 AU2003218600 C1 AU 2003218600C1
Authority
AU
Australia
Prior art keywords
amino acid
protein
erbb
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003218600A
Other languages
English (en)
Other versions
AU2003218600B2 (en
AU2003218600A1 (en
Inventor
Mingdong Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zensun Shanghai Science and Technology Ltd
Original Assignee
Zensun Shanghai Science and Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CNB02116259XA external-priority patent/CN1219882C/zh
Application filed by Zensun Shanghai Science and Technology Ltd filed Critical Zensun Shanghai Science and Technology Ltd
Publication of AU2003218600A1 publication Critical patent/AU2003218600A1/en
Publication of AU2003218600B2 publication Critical patent/AU2003218600B2/en
Application granted granted Critical
Publication of AU2003218600C1 publication Critical patent/AU2003218600C1/en
Assigned to ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY CO., LTD. reassignment ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY CO., LTD. Request to Amend Deed and Register Assignors: ZENSUN (SHANGHAI) SCI-TECH. LTD.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2003218600A 2002-03-26 2003-03-26 ERBB3 based methods and compositions for treating neoplasms Ceased AU2003218600C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN02116259.X 2002-03-26
CNB02116259XA CN1219882C (zh) 2002-03-18 2002-03-26 以erbb－3为基础的用于肿瘤治疗的方法和组合物
PCT/CN2003/000217 WO2003080835A1 (en) 2002-03-26 2003-03-26 Erbb3 based methods and compositions for treating neoplasms

Publications (3)

Publication Number Publication Date
AU2003218600A1 AU2003218600A1 (en) 2003-10-08
AU2003218600B2 AU2003218600B2 (en) 2009-05-21
AU2003218600C1 true AU2003218600C1 (en) 2009-12-17

Family

ID=28048642

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003218600A Ceased AU2003218600C1 (en) 2002-03-26 2003-03-26 ERBB3 based methods and compositions for treating neoplasms

Country Status (7)

Country Link
US (2) US7919098B2 (https=)
EP (2) EP2400021B1 (https=)
JP (2) JP4660094B2 (https=)
CN (1) CN100424175C (https=)
AU (1) AU2003218600C1 (https=)
CA (1) CA2480099C (https=)
WO (1) WO2003080835A1 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ105799A0 (en) 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
RU2473560C2 (ru) * 2005-11-02 2013-01-27 Дьюк Юниверсити Совместная химиотерапия и иммунотерапия
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
JP5738516B2 (ja) 2005-12-30 2015-06-24 ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド 心機能改善のためのニューレグリンの徐放
SG178789A1 (en) * 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
US20090156488A1 (en) * 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
WO2009157919A1 (en) * 2008-06-23 2009-12-30 Tumor Biology Investment Group, Inc. SOLUBLE ErbB3 DETECTION, REGULATION AND TREATMENT OF CANCER
UA104868C2 (uk) * 2008-08-15 2014-03-25 Меррімак Фармасьютікалз, Інк. Спосіб лікування пацієнта, що має неопластичну пухлину, відповідно до спрогнозованої реакції
JP5743898B2 (ja) * 2008-11-28 2015-07-01 ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド ニューレグリンペプチド及びその使用
JP2012509908A (ja) * 2008-11-28 2012-04-26 ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド ニューレグリン及び心臓幹細胞
MX358013B (es) 2009-11-13 2018-08-01 Amgen Inc Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
MA33892B1 (fr) 2009-12-22 2013-01-02 Roche Glycart Ag Anticorps anti-her3, et leurs utilisations
CA2792327C (en) 2010-03-11 2019-09-24 Merrimack Pharmaceuticals, Inc. Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
IT1402149B1 (it) * 2010-10-04 2013-08-28 Ist Fisioterap Ospitalroma Uso di un fosfopeptide in grado di bloccare l interazione her3/p85 per il trattamento dei tumori iperesprimenti her2.
ITRM20100577A1 (it) 2010-11-02 2012-05-03 Takis Srl Immunoterapia contro il recettore erbb-3
TWI418362B (zh) * 2010-11-19 2013-12-11 Univ Nat Pingtung Sci & Tech 溶血性巴斯德桿菌重組外膜脂蛋白e及含此之疫苗組成物
US20140134170A1 (en) 2011-03-11 2014-05-15 Merrimack Pharmaceuticals, Inc. Use of inhibitors of egfr-family receptors in the treatment of hormone refractory breast cancers
SG192775A1 (en) 2011-03-15 2013-09-30 Merrimack Pharmaceuticals Inc Overcoming resistance to erbb pathway inhibitors
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
JP6180425B2 (ja) 2011-11-23 2017-08-23 メディミューン，エルエルシー Ｈｅｒ３に特異的な結合分子及びそれらの使用
WO2013110030A2 (en) * 2012-01-19 2013-07-25 Duke University Vaccines against antigens involved in therapy resistance and methods of using same
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
US11305012B2 (en) 2013-09-24 2022-04-19 Medimmune, Llc Binding molecules specific for HER3 and uses thereof
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
US10745490B2 (en) 2014-04-11 2020-08-18 Celldex Therapeutics, Inc. Anti-ErbB antibodies and methods of use thereof
US20170196953A1 (en) 2014-07-07 2017-07-13 Duke University VACCINES AGAINST AN ONCOGENIC ISOFORM OF HER2 (ErbB2) AND METHODS OF USING THE SAME
EP3166630A4 (en) 2014-07-07 2018-03-28 Duke University Vaccines against an oncogenic isoform of esr1 and methods of using the same
EP3169354A4 (en) * 2014-07-17 2018-06-13 Brian J. Czerniecki Identification of immunogenic mhc class ii peptides for immune-based therapy
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
EP3325005A4 (en) * 2015-07-17 2019-03-27 Brian J. Czerniecki IDENTIFICATION OF IMMUNOGENIC MHC CLASS II PEPTIDES FOR IMMUNO-BASED THERAPY
EP3785729B1 (en) * 2015-09-02 2024-03-13 The Cleveland Clinic Foundation Ovarian cancer vaccines
WO2017120576A1 (en) 2016-01-07 2017-07-13 Duke University Cancer vaccines and methods of delivery
CN110167968B (zh) * 2016-09-15 2023-11-28 斯图加特大学 针对her3的抗原结合蛋白
US11224665B2 (en) 2016-10-05 2022-01-18 Duke University Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same
US10487143B2 (en) 2016-10-05 2019-11-26 Duke University Vaccines against HER3 antigens and methods of using the same
CA3076012A1 (en) * 2017-09-27 2019-04-04 L2 Diagnostics, Llc Erbb peptide pharmaceutical and vaccine compositions and therapeutics uses thereof for cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008214A1 (en) * 1989-12-01 1991-06-13 The United States Of America, Represented By The Secretary, United States Department Of Commerce Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
CA2042064C (en) 1989-08-04 2008-10-21 Susan G. Stuart C-erbb-2 external domain:gp75
US5578482A (en) 1990-05-25 1996-11-26 Georgetown University Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
DE4221256C2 (de) 1992-06-26 1997-07-10 Lancaster Group Ag Galenische Zusammensetzung für die topische Anwendung
US5869305A (en) 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US5741511A (en) 1995-04-12 1998-04-21 Sam Yang Co., Ltd. Transdermal drug delivery device for treating erectile dysfunction
US5888767A (en) 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
JP2000502682A (ja) 1995-12-22 2000-03-07 ローカルメッド インコーポレイテッド 血管新生を促進する成長因子の局所的血管内デリバリー
US5736154A (en) 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
IL126303A (en) 1996-03-27 2002-05-23 Genentech Inc ErbB3 ANTIBODIES
WO1998002540A1 (en) * 1996-07-12 1998-01-22 Genentech, Inc. Chimeric heteromultimer adhesins
CN101412758A (zh) 1996-10-18 2009-04-22 基因技术股份有限公司 抗ErbB2抗体
US5981201A (en) 1997-01-08 1999-11-09 Beth Israel Deaconess Medical Center Methods of detection and treatment of breast cancer
WO1998035036A1 (en) 1997-02-10 1998-08-13 Genentech, Inc. Heregulin variants
SE9703226D0 (sv) 1997-09-08 1997-09-08 Astra Ab New pharmaceutical composition
US6197801B1 (en) 1998-01-14 2001-03-06 Usa Doctors Products, Inc. Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction
US5962274A (en) 1998-03-13 1999-10-05 Wake Forest University Viral vector directed to predetermined target cells
AUPQ105799A0 (en) 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
GB2368641B (en) 1999-07-06 2004-10-06 Gen Atomics Methods and compositions for assaying analytes
KR20030014223A (ko) 2000-05-15 2003-02-15 파마시아 이탈리아 에스.피.에이. 항종양제로서의 아로마타제 억제제 및 모노클로날항-ｈｅｒ2 항체
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity
CA2599606A1 (en) 2005-02-23 2006-08-31 Merrimack Pharmaceuticals, Inc. Bispecific binding agents for modulating biological activity
SG178789A1 (en) 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008214A1 (en) * 1989-12-01 1991-06-13 The United States Of America, Represented By The Secretary, United States Department Of Commerce Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US5480968A (en) * 1989-12-01 1996-01-02 The United States Of America As Represented By The Department Of Health And Human Services Isolated polypeptide erbB-3, related to the epidermal growth factor receptor and antibody thereto
US5820859A (en) * 1989-12-01 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Method of targeting a therapeutic agent to cells expressing the erb B-3 receptor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bei R et al. Immune responses to all ErbB family receptors detectable in serum of cancer patients. Oncogene. 18(6):1267-75, 1999. *
Kraus MH et al. Proc. Natl. Acad. Sci. U.S.A. 86 (23), 9193-9197, 1989. *

Also Published As

Publication number Publication date
EP1495123B1 (en) 2013-10-30
EP2400021A2 (en) 2011-12-28
JP2005533488A (ja) 2005-11-10
EP2400021B1 (en) 2016-11-30
EP2400021A3 (en) 2012-03-21
AU2003218600B2 (en) 2009-05-21
CA2480099C (en) 2019-01-08
AU2003218600A1 (en) 2003-10-08
US7919098B2 (en) 2011-04-05
WO2003080835A1 (en) 2003-10-02
JP4660094B2 (ja) 2011-03-30
JP2010213710A (ja) 2010-09-30
EP1495123A1 (en) 2005-01-12
US20110229478A1 (en) 2011-09-22
EP1495123A4 (en) 2009-06-24
US20080057064A1 (en) 2008-03-06
CN1650011A (zh) 2005-08-03
CA2480099A1 (en) 2003-10-02
CN100424175C (zh) 2008-10-08
JP5249282B2 (ja) 2013-07-31

Similar Documents

Publication Publication Date Title
AU2003218600B2 (en) ERBB3 based methods and compositions for treating neoplasms
US11235043B2 (en) Vaccines against antigens involved in therapy resistance and methods of using same
CN109071678B (zh) 神经生长因子融合蛋白、制备方法及其用途
WO2010105573A1 (zh) 抗血管新生融合蛋白
JPH01502669A (ja) 精製された血小板由来の成長因子及びその精製方法
WO2023077924A1 (zh) 一种抗胰腺癌的疫苗、及其医药用途
WO2022100585A1 (zh) 抗Her-2抗体-趋化因子融合蛋白及其制法和应用
AU766898B2 (en) Tumor associated antigen 791Tgp72
US20250188182A1 (en) Triple combination drug dosing therapy for head and neck cancer treatment
AU2022325383B2 (en) GPC3-TARGETED ANTIBODY INTERFERON α FUSION PROTEIN AND USE THEREOF
JP2007537143A (ja) アンジオモチンまたはアンジオモチンをコードするポリヌクレオチドを含むワクチン組成物、および、ワクチン組成物の血管新生に関連した病気の治療のための使用
CA2541840C (en) P185neu-encoding dna and therapeutical uses thereof
KR102829639B1 (ko) c-Met의 에피토프를 포함하는 암 백신 및 이의 용도
JP2008526686A (ja) インターロイキン−２の中和能を有する免疫治療用製剤
RU2836245C2 (ru) БЕЛОК СЛИЯНИЯ НАЦЕЛЕННОГО НА GPC3 АНТИТЕЛА И ИНТЕРФЕРОНА α И ЕГО ПРИМЕНЕНИЕ
CN121824722A (zh) 一种肿瘤免疫治疗多肽及其应用

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 17 JUL 2009.

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 17 JUL 2009

FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY CO., LTD.

Free format text: FORMER NAME(S): ZENSUN (SHANGHAI) SCI-TECH. LTD.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired