AU2003205963A1 - Azaphenylalanine derivatives and their use as antithrombotic agents - Google Patents

Azaphenylalanine derivatives and their use as antithrombotic agents

Info

Publication number
AU2003205963A1
AU2003205963A1 AU2003205963A AU2003205963A AU2003205963A1 AU 2003205963 A1 AU2003205963 A1 AU 2003205963A1 AU 2003205963 A AU2003205963 A AU 2003205963A AU 2003205963 A AU2003205963 A AU 2003205963A AU 2003205963 A1 AU2003205963 A1 AU 2003205963A1
Authority
AU
Australia
Prior art keywords
azaphenylalanine
derivatives
antithrombotic agents
antithrombotic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003205963A
Other languages
English (en)
Other versions
AU2003205963A8 (en
Inventor
Ales Obreza
Mojca Stegnar
Alenka Trampus Bakija
Uros Urleb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Univerza v Ljubljani
Original Assignee
Lek Pharmaceuticals dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals dd filed Critical Lek Pharmaceuticals dd
Publication of AU2003205963A8 publication Critical patent/AU2003205963A8/xx
Publication of AU2003205963A1 publication Critical patent/AU2003205963A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003205963A 2002-01-24 2003-01-27 Azaphenylalanine derivatives and their use as antithrombotic agents Abandoned AU2003205963A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200200013A SI21137A (sl) 2002-01-24 2002-01-24 Derivati azafenilalanina
PCT/IB2003/000403 WO2004067522A1 (en) 2002-01-24 2003-01-27 Azaphenylalanine derivatives and their use as antithrombotic agents

Publications (2)

Publication Number Publication Date
AU2003205963A8 AU2003205963A8 (en) 2004-08-23
AU2003205963A1 true AU2003205963A1 (en) 2004-08-23

Family

ID=39522234

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003205963A Abandoned AU2003205963A1 (en) 2002-01-24 2003-01-27 Azaphenylalanine derivatives and their use as antithrombotic agents

Country Status (6)

Country Link
AT (1) AT503355A2 (sl)
AU (1) AU2003205963A1 (sl)
CH (1) CH696724A5 (sl)
DE (1) DE10392134T5 (sl)
SI (1) SI21137A (sl)
WO (1) WO2004067522A1 (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042678A1 (de) * 2004-10-14 2006-04-27 Wilex Ag Verfahren zur reinigung von 3-hydroxy-amidino-phenylalanin-derivaten durch ausfällung und umkristallisation eines salzes mit einer aromatischen sulfonsäure
DE102004057195A1 (de) 2004-11-26 2006-06-01 Wilex Ag Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon
GB0523539D0 (en) * 2005-11-18 2005-12-28 Lek Tovarna Farmacevtskih New use of organic compounds
AU2008235089B8 (en) 2007-04-10 2014-04-10 Bayer Intellectual Property Gmbh Insecticidal aryl isoxazoline derivatives
JP7238123B2 (ja) * 2019-06-28 2023-03-13 富士フイルム株式会社 ペプチド化合物の製造方法、保護基形成用試薬、及び、縮合多環芳香族炭化水素化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2073776A1 (en) * 1990-11-15 1992-05-16 Joerg Stuerzebecher Meta-substituted phenyl alanine derivatives
DE4111394A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
GB9322976D0 (en) * 1993-11-08 1994-01-05 Pfizer Ltd Therapeutic agents
ATE386029T1 (de) * 2001-03-21 2008-03-15 Wilex Ag Urokinase-inhibitoren

Also Published As

Publication number Publication date
AT503355A2 (de) 2007-09-15
AU2003205963A8 (en) 2004-08-23
SI21137A (sl) 2003-08-31
DE10392134T5 (de) 2005-10-13
WO2004067522A1 (en) 2004-08-12
CH696724A5 (de) 2007-10-31

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 18, NO 37, PAGE(S) 9225 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME LEK PHARMACEUTICALS D.D., APPLICATION NO. 2003205963, UNDER INID (71) CORRECT THE NAME TO READ LEK PHARMACEUTICALS D.D.; UNIVERSITY OF LJUBLJANA

MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase