AU2002365036B2 - Prevention of flap necrosis in plastic surgery - Google Patents

Prevention of flap necrosis in plastic surgery Download PDF

Info

Publication number
AU2002365036B2
AU2002365036B2 AU2002365036A AU2002365036A AU2002365036B2 AU 2002365036 B2 AU2002365036 B2 AU 2002365036B2 AU 2002365036 A AU2002365036 A AU 2002365036A AU 2002365036 A AU2002365036 A AU 2002365036A AU 2002365036 B2 AU2002365036 B2 AU 2002365036B2
Authority
AU
Australia
Prior art keywords
pedicle
flap
drug
lidocaine
nitrosothiol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002365036A
Other languages
English (en)
Other versions
AU2002365036A1 (en
Inventor
Jonathan S Stamler
Eric J Toone
Michael R Zenn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of AU2002365036A1 publication Critical patent/AU2002365036A1/en
Application granted granted Critical
Publication of AU2002365036B2 publication Critical patent/AU2002365036B2/en
Priority to AU2006252204A priority Critical patent/AU2006252204B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002365036A 2001-12-06 2002-12-02 Prevention of flap necrosis in plastic surgery Ceased AU2002365036B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2006252204A AU2006252204B2 (en) 2001-12-06 2006-12-21 Prevention of Flap Necrosis in Plastic Surgery

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33617501P 2001-12-06 2001-12-06
US60/336,175 2001-12-06
PCT/US2002/036138 WO2003049593A2 (en) 2001-12-06 2002-12-02 Prevention of flap necrosis in plastic surgery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2006252204A Division AU2006252204B2 (en) 2001-12-06 2006-12-21 Prevention of Flap Necrosis in Plastic Surgery

Publications (2)

Publication Number Publication Date
AU2002365036A1 AU2002365036A1 (en) 2003-06-23
AU2002365036B2 true AU2002365036B2 (en) 2006-09-21

Family

ID=23314894

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002365036A Ceased AU2002365036B2 (en) 2001-12-06 2002-12-02 Prevention of flap necrosis in plastic surgery

Country Status (8)

Country Link
US (1) US20060153931A1 (enExample)
EP (1) EP1463440B1 (enExample)
JP (2) JP4563679B2 (enExample)
AT (1) ATE450187T1 (enExample)
AU (1) AU2002365036B2 (enExample)
CA (1) CA2467245A1 (enExample)
DE (1) DE60234642D1 (enExample)
WO (1) WO2003049593A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
JP2007532697A (ja) 2004-04-19 2007-11-15 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー 局所的血流増大の有益な効果
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
CN102481275B (zh) 2009-06-24 2014-07-23 战略科学技术有限公司 含有布洛芬的表面组合物
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
EP2445493A1 (en) 2009-06-24 2012-05-02 Strategic Science & Technologies, LLC Topical composition containing naproxen
CN103442723A (zh) 2010-12-29 2013-12-11 战略科学与技术有限责任公司 治疗变态反应和其它适应症的系统和方法
EP2658551B1 (en) 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
WO2020185674A1 (en) * 2019-03-08 2020-09-17 South Dakota Board Of Regents A vasoactive topical compound to affect tissue blood flow, reduce tissue necrosis and promote healing
CN112843241B (zh) * 2021-01-14 2023-07-25 中国药科大学 可生物响应的一氧化氮供体型聚合物前药及其制备方法
EP4536264A4 (en) * 2022-06-08 2026-08-05 Univ Virginia Commonwealth Guest/host inclusion complexes containing S-nitrosoglutathione and their methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300302A (en) * 1990-10-04 1994-04-05 Nestec S.A. Pharmaceutical composition in gel form in a dispensing package
JP2599031B2 (ja) * 1990-11-30 1997-04-09 宇部興産株式会社 高純度亜硝酸アルキルエステルの製造法
PT719145E (pt) * 1994-05-27 2001-01-31 Cellegy Pharma Inc Composicao dadora de oxido nitrico para tratamento de desordens anais
US5770645A (en) * 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US6232434B1 (en) * 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5797887A (en) * 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
WO1998050430A2 (en) * 1997-05-02 1998-11-12 Somatogen, Inc. Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
US6395736B1 (en) * 1998-12-14 2002-05-28 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
AU3490300A (en) * 1999-03-12 2000-10-04 Nitromed, Inc. Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
US6359182B1 (en) * 2000-10-26 2002-03-19 Duke University C-nitroso compounds and use thereof

Also Published As

Publication number Publication date
US20060153931A1 (en) 2006-07-13
JP2010047619A (ja) 2010-03-04
WO2003049593A3 (en) 2004-02-19
JP5266191B2 (ja) 2013-08-21
EP1463440A2 (en) 2004-10-06
AU2002365036A1 (en) 2003-06-23
WO2003049593A2 (en) 2003-06-19
ATE450187T1 (de) 2009-12-15
JP2005511708A (ja) 2005-04-28
EP1463440B1 (en) 2009-12-02
DE60234642D1 (de) 2010-01-14
CA2467245A1 (en) 2003-06-19
EP1463440A4 (en) 2008-01-23
JP4563679B2 (ja) 2010-10-13

Similar Documents

Publication Publication Date Title
JP5266191B2 (ja) 形成外科における組織弁壊死の予防
TW570794B (en) Pharmaceutical composition for preventing and treating gastrointestinal damage and disorders, ethanol withdrawal syndrome, or pain
Kuczyńska et al. The comparison of dexketoprofen and other painkilling medications (review from 2018 to 2021)
CN110678166A (zh) 增强非手术医学治疗的方法
JP2004512318A (ja) Ｃ−ニトロソ化合物とその使用
JP2012255018A (ja) 感覚器官的に許容されるイブプロフェン経口投与用製剤、該製剤の製法並びに使用法
Werre et al. Isosorbide dinitrate in the treatment of anal fissure: a randomised, prospective, double blind, placebo‐controlled trial
Sharma et al. The effect of intravenous dexamethasone on intraoperative and early postoperative pain in lumbar spine surgery: a randomized double-blind placebo-controlled study
JP2022529661A (ja) ジスキネジア治療薬
JP2004515526A (ja) ロキソプロフェン含有筋肉注射用医薬組成物
AU2006252204B2 (en) Prevention of Flap Necrosis in Plastic Surgery
WO2003013548A1 (en) Medical composition for external use for dermatosis
CN112384197A (zh) 治疗与缺氧相关的组织损伤的给药方案
KR101008052B1 (ko) 경피흡수형 뇌 보호제
RU2432942C1 (ru) Композиция для приготовления обладающей пролонгированным действием лекарственной формы для лечения орофарингеальной зоны
US20040039042A1 (en) Method of transdermal drug delivery
CN1297264C (zh) 一种注射用洛索洛芬钠药物组合物
JPS6045161B2 (ja) 熱傷の治療剤
Cashman Non-steroidal anti-inflammatory drugs versus postoperative pain
ES2359910T3 (es) Composición medicinal para inhibir la expresión de atp-citrato liasa y su uso.
George et al. Analgesic effects of caudal versus intravenous dexamethasone on bupivacaine based caudal block for paediatric infraumbilical surgeries
Sharma et al. Efficacy and Safety of Transdermal versus Intravenous Diclofenac for Postoperative Analgesia in Pediatric Inguinal Surgeries: A Comparative Study
Karale et al. Study of intra operative haemodynamic stability of oral gabapentin to attenuate peri-operative pain.
ES2379829T3 (es) Cicatrización de heridas y úlceras mediada por isoniazida
WO2012131412A2 (en) Pharmaceutical composition containing no, process for the preparation and use thereof

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired