AU2002330273A1 - Liposome-encapsulated insulin formulations - Google Patents
Liposome-encapsulated insulin formulationsInfo
- Publication number
- AU2002330273A1 AU2002330273A1 AU2002330273A AU2002330273A AU2002330273A1 AU 2002330273 A1 AU2002330273 A1 AU 2002330273A1 AU 2002330273 A AU2002330273 A AU 2002330273A AU 2002330273 A AU2002330273 A AU 2002330273A AU 2002330273 A1 AU2002330273 A1 AU 2002330273A1
- Authority
- AU
- Australia
- Prior art keywords
- liposome
- insulin formulations
- encapsulated insulin
- encapsulated
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/975,752 US20030068361A1 (en) | 2001-10-09 | 2001-10-09 | Liposome-encapsulated insulin formulations |
| US09/975,752 | 2001-10-09 | ||
| PCT/US2002/032201 WO2003030829A2 (en) | 2001-10-09 | 2002-10-07 | Liposome-encapsulated insulin formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002330273A1 true AU2002330273A1 (en) | 2003-04-22 |
Family
ID=25523349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002330273A Abandoned AU2002330273A1 (en) | 2001-10-09 | 2002-10-07 | Liposome-encapsulated insulin formulations |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20030068361A1 (https=) |
| EP (1) | EP1434601A4 (https=) |
| JP (1) | JP2005536442A (https=) |
| AU (1) | AU2002330273A1 (https=) |
| CA (1) | CA2461048A1 (https=) |
| WO (1) | WO2003030829A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050147566A1 (en) * | 2002-03-12 | 2005-07-07 | Scott Fleming | Site specific delivery of co-administered drugs via inhalation |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| EP1525890A1 (en) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophore complexes |
| US20060135906A1 (en) * | 2004-11-16 | 2006-06-22 | Akihiko Matsumura | Iontophoretic device and method for administering immune response-enhancing agents and compositions |
| IL174387A0 (en) * | 2005-03-31 | 2008-01-20 | Dexcel Pharma Technologies Ltd | A solid composition for intra-oral delivery of insulin |
| US20110135725A1 (en) * | 2005-05-23 | 2011-06-09 | Sdg, Inc. | Lipid Construct for Delivery of Insulin to a Mammal |
| JP2009509676A (ja) * | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | ナノ粒子と接合された活性物質のイオントフォレーシス送達 |
| JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| US7848801B2 (en) | 2005-12-30 | 2010-12-07 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
| AU2007243370A1 (en) * | 2006-04-24 | 2007-11-08 | The Cbr Institute For Biomedical Research, Inc. | Method of producing immunoliposomes and compositions thereof |
| US20080193514A1 (en) * | 2006-11-02 | 2008-08-14 | Transcu Ltd. | Compostions and methods for iontophoresis delivery of active ingredients through hair follicles |
| EP2123259A1 (en) * | 2007-01-16 | 2009-11-25 | Hokkaido University | Liposome preparation for iontophoresis having antioxidant component encapsulated therein |
| JP5489988B2 (ja) * | 2007-05-18 | 2014-05-14 | Ｔｔｉ・エルビュー株式会社 | 有効成分の生体界面への改善された放出を確保する経皮送達装置 |
| JP2010187707A (ja) * | 2007-06-12 | 2010-09-02 | Hokkaido Univ | インスリンを封入したイオントフォレーシス用リポソーム製剤 |
| US8962015B2 (en) | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
| AR073575A1 (es) * | 2008-09-10 | 2010-11-17 | Transcu Ltd | Aparato y metodo para dispensar basados en hpc liquidos viscosos en sustratos porosos por ejemplo proceso continuo basado en bandas |
| AU2009309623B9 (en) | 2008-10-30 | 2014-10-02 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| JP5638204B2 (ja) * | 2009-05-29 | 2014-12-10 | 国立大学法人 岡山大学 | 経口投与用リポソーム製剤およびその製造方法 |
| ES2702753T3 (es) * | 2010-01-05 | 2019-03-05 | Microdose Therapeutx Inc | Dispositivo de inhalación |
| US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
| US10525214B2 (en) | 2010-01-12 | 2020-01-07 | Dance Biopharm Inc. | Preservative-free single dose inhaler system |
| US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
| US8950394B2 (en) | 2010-01-12 | 2015-02-10 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| US9545488B2 (en) | 2010-01-12 | 2017-01-17 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| US9180261B2 (en) * | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| US20150072929A1 (en) * | 2011-02-01 | 2015-03-12 | Artur Martynov | Pharmaceutical composition comprising a mixture of carboxylated oligopeptides |
| US20140205671A1 (en) * | 2013-01-18 | 2014-07-24 | Nano And Advanced Materials Institute Limited | Synthesis and use of polyhydroxyalkanoate (pha) nanocapsules as a protein carrier |
| JP2016519127A (ja) | 2013-04-30 | 2016-06-30 | ノヴォ ノルディスク アー／エス | 新規投与レジメン |
| US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
| US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
| US10471222B2 (en) | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
| EP3261648B1 (en) | 2015-02-25 | 2023-12-06 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
| KR101764388B1 (ko) * | 2016-03-17 | 2017-08-02 | 한국화학연구원 | 피하주사용 인슐린 함유 리포솜 조성물 |
| US11077173B2 (en) | 2017-03-13 | 2021-08-03 | Sdg, Inc. | Lipid-based nanoparticles and methods using same |
| WO2018169954A1 (en) | 2017-03-13 | 2018-09-20 | Sdg, Inc. | Lipid-based nanoparticles with enhanced stability |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
| CA3162617A1 (en) * | 2019-11-22 | 2021-05-27 | The Research Foundation For The State University Of New York | Compositions and methods for use in type 1 diabetes |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH624011A5 (https=) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| JPS55153713A (en) * | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
| NL193099C (nl) * | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
| US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| US5545618A (en) * | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5970973A (en) * | 1993-01-29 | 1999-10-26 | Aradigm Corporation | Method of delivering insulin lispro |
| US5672581A (en) * | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
| US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5824638A (en) * | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| ZA984697B (en) * | 1997-06-13 | 1999-12-01 | Lilly Co Eli | Stable insulin formulations. |
-
2001
- 2001-10-09 US US09/975,752 patent/US20030068361A1/en not_active Abandoned
-
2002
- 2002-10-07 CA CA002461048A patent/CA2461048A1/en not_active Abandoned
- 2002-10-07 JP JP2003533863A patent/JP2005536442A/ja active Pending
- 2002-10-07 AU AU2002330273A patent/AU2002330273A1/en not_active Abandoned
- 2002-10-07 WO PCT/US2002/032201 patent/WO2003030829A2/en not_active Ceased
- 2002-10-07 EP EP02766540A patent/EP1434601A4/en not_active Withdrawn
-
2003
- 2003-08-15 US US10/641,953 patent/US20040033256A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1434601A4 (en) | 2009-08-19 |
| JP2005536442A (ja) | 2005-12-02 |
| EP1434601A2 (en) | 2004-07-07 |
| US20030068361A1 (en) | 2003-04-10 |
| CA2461048A1 (en) | 2003-04-17 |
| US20040033256A1 (en) | 2004-02-19 |
| WO2003030829A2 (en) | 2003-04-17 |
| WO2003030829A3 (en) | 2003-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |