AU2002243878B8 - Methods for immuno-detection of epitopes on molecules and for detection of interactions of molecules via fluorescent dyes - Google Patents

Methods for immuno-detection of epitopes on molecules and for detection of interactions of molecules via fluorescent dyes Download PDF

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Publication number
AU2002243878B8
AU2002243878B8 AU2002243878A AU2002243878A AU2002243878B8 AU 2002243878 B8 AU2002243878 B8 AU 2002243878B8 AU 2002243878 A AU2002243878 A AU 2002243878A AU 2002243878 A AU2002243878 A AU 2002243878A AU 2002243878 B8 AU2002243878 B8 AU 2002243878B8
Authority
AU
Australia
Prior art keywords
epitope
rna
cdr
specifically binds
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002243878A
Other languages
English (en)
Other versions
AU2002243878B2 (en
AU2002243878A1 (en
Inventor
Mark I. Greene
Bin Li
Qingdu Liu
Ramachandran Murali
Hongtao Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/783,896 external-priority patent/US7045286B2/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of AU2002243878A1 publication Critical patent/AU2002243878A1/en
Application granted granted Critical
Publication of AU2002243878B2 publication Critical patent/AU2002243878B2/en
Publication of AU2002243878B8 publication Critical patent/AU2002243878B8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AU2002243878A 2001-02-15 2002-02-08 Methods for immuno-detection of epitopes on molecules and for detection of interactions of molecules via fluorescent dyes Ceased AU2002243878B8 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/783,896 US7045286B2 (en) 2000-07-25 2001-02-15 Methods of detecting molecules expressing selected epitopes via fluorescent dyes
US09/783,896 2001-02-15
US09/977,716 2001-10-15
US09/977,716 US7524628B2 (en) 2000-07-25 2001-10-15 Method for detecting molecules expressing a selected epitope via fluorescent dyes
PCT/US2002/003640 WO2002066980A1 (en) 2001-02-15 2002-02-08 Methods for immuno-detection of epitopes on molecules and for detection of interactions of molecules via fluorescent dyes

Publications (3)

Publication Number Publication Date
AU2002243878A1 AU2002243878A1 (en) 2003-02-27
AU2002243878B2 AU2002243878B2 (en) 2007-10-18
AU2002243878B8 true AU2002243878B8 (en) 2008-03-20

Family

ID=27120195

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002243878A Ceased AU2002243878B8 (en) 2001-02-15 2002-02-08 Methods for immuno-detection of epitopes on molecules and for detection of interactions of molecules via fluorescent dyes

Country Status (6)

Country Link
US (2) US7524628B2 (https=)
EP (2) EP1366363A4 (https=)
JP (1) JP4414138B2 (https=)
AU (1) AU2002243878B8 (https=)
CA (1) CA2439235A1 (https=)
WO (1) WO2002066980A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176037B2 (en) * 2000-07-13 2007-02-13 The Scripps Research Institute Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
US6951947B2 (en) * 2000-07-13 2005-10-04 The Scripps Research Institute Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
CA2490542C (en) 2002-05-23 2013-07-16 Mark I. Greene Fas peptide mimetics and uses thereof
CN101410530B (zh) 2003-04-18 2013-03-27 贝克顿·迪金森公司 免疫-扩增
WO2005054514A1 (en) * 2003-12-02 2005-06-16 Agency For Science, Technology And Research Immuno-amplification rna assay
AU2005216136A1 (en) * 2004-02-20 2005-09-09 The Trustees Of The University Of Pennsylvania Reagents, kits and methods for immunodetection of epitopes on molecules
EP1718323B1 (en) * 2004-02-20 2011-12-07 The Trustees of The University of Pennsylvania Binding peptidomimetics and uses of the same
JP2007529718A (ja) * 2004-03-12 2007-10-25 ザ スクリップス リサーチ インスティチュート 蛋白質活性の検出および定量のための蛍光シグナル発光型生細胞バイオセンサー分子ならびに色素
WO2010085548A2 (en) * 2009-01-22 2010-07-29 Li-Cor, Inc. Single molecule proteomics with dynamic probes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0544212A1 (en) * 1991-11-26 1993-06-02 Nisshin Flour Milling Co., Ltd. Method for the detection or quantitation of trace substances
US5922553A (en) * 1996-11-21 1999-07-13 Trustees Of The University Of Pennsylvania Method of detecting protein by immuno RNA

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2596413B1 (fr) 1986-03-27 1988-06-10 Merieux Inst Nouveaux milieux de culture de bacteries appartenant au genre bordetella, contenant des derives etherifies de polymeres de d-glucose, et leur application
US5627027A (en) * 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5631129A (en) * 1988-12-05 1997-05-20 The Salk Institute For Biological Studies Target nucleic acid amplification/detection systems and methods for the use thereof
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9206318D0 (en) 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
US5334702A (en) 1991-03-25 1994-08-02 University Of Illinois Compositions which are immunologically crossreactive with antibodies and preparative methods therefor
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
DE69230142T2 (de) 1991-05-15 2000-03-09 Cambridge Antibody Technology Ltd. Verfahren zur herstellung von spezifischen bindungspaargliedern
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
KR100249110B1 (ko) * 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
US5985548A (en) 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
US5879657A (en) 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5436134A (en) 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
WO1994026932A1 (en) 1993-05-13 1994-11-24 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nucleic acid tagged immunoassay
US5663144A (en) 1995-05-03 1997-09-02 The Trustees Of The University Of Pennsylvania Compounds that bind to p185 and methods of using the same
US5874226A (en) 1995-05-22 1999-02-23 H. Lee Browne In situ immunodetection of antigens
US6248527B1 (en) 1998-10-21 2001-06-19 Millennium Pharmaceuticals, Inc. Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
US7045286B2 (en) 2000-07-25 2006-05-16 The Trustees Of The University Of Pennsylvania Methods of detecting molecules expressing selected epitopes via fluorescent dyes
US6743592B1 (en) 2000-07-25 2004-06-01 The Trustees Of The University Of Pennsylvania Methods, systems and kits for immuno-detection of epitopes expressed on molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0544212A1 (en) * 1991-11-26 1993-06-02 Nisshin Flour Milling Co., Ltd. Method for the detection or quantitation of trace substances
US5922553A (en) * 1996-11-21 1999-07-13 Trustees Of The University Of Pennsylvania Method of detecting protein by immuno RNA

Also Published As

Publication number Publication date
EP2012124A3 (en) 2009-06-10
EP1366363A1 (en) 2003-12-03
JP4414138B2 (ja) 2010-02-10
US20020094534A1 (en) 2002-07-18
AU2002243878B2 (en) 2007-10-18
US7524628B2 (en) 2009-04-28
EP2012124A2 (en) 2009-01-07
US20090227468A1 (en) 2009-09-10
CA2439235A1 (en) 2002-08-29
JP2004532393A (ja) 2004-10-21
EP1366363A4 (en) 2006-06-21
WO2002066980A1 (en) 2002-08-29

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR FROM GREENE, MARK L., ZHANG, HONG TAO, LI, QINDU, MURALI, RAMCHANDRAN TO GREENE, MARK I., ZHANG, HONGTAO, LI, QINGDU, MURALI, RAMACHANDRAN

FGA Letters patent sealed or granted (standard patent)
TH Corrigenda

Free format text: IN VOL 21, NO 41, PAGE(S) 4760 UNDER THE HEADING APPLICATIONS ACCEPTED -NAME INDEX UNDER THE NAME THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, APPLICATION NUMBER 2002243878, UNDER INID (72), CORRECT THE CO-INVENTOR NAME TO READ LIU, QINGDU; GREENE, MARK I.

TH Corrigenda

Free format text: IN VOL 21, NO 41, PAGE(S) 4760 UNDER THE HEADING APPLICATIONS ACCEPTED -NAME INDEX UNDER THE NAME THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, APPLICATION NUMBER 2002243878, UNDER INID (72) CORRECT THE NAME OF THE INVENTOR FROM ZHANG, HONG TAO TO ZHANG, HONGTAO

MK14 Patent ceased section 143(a) (annual fees not paid) or expired