AU2002226330A1 - Triazole derivatives and pharmaceutical compositions comprising them - Google Patents
Triazole derivatives and pharmaceutical compositions comprising themInfo
- Publication number
- AU2002226330A1 AU2002226330A1 AU2002226330A AU2633002A AU2002226330A1 AU 2002226330 A1 AU2002226330 A1 AU 2002226330A1 AU 2002226330 A AU2002226330 A AU 2002226330A AU 2633002 A AU2633002 A AU 2633002A AU 2002226330 A1 AU2002226330 A1 AU 2002226330A1
- Authority
- AU
- Australia
- Prior art keywords
- formula
- acid
- compound
- methoxy
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 46
- 239000002253 acid Substances 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- 239000012453 solvate Substances 0.000 claims description 22
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 16
- 101800001982 Cholecystokinin Proteins 0.000 claims description 12
- 102100025841 Cholecystokinin Human genes 0.000 claims description 12
- 229940107137 cholecystokinin Drugs 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 11
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 8
- 229960003805 amantadine Drugs 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 6
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- MPSUGQWRVNRJEE-UHFFFAOYSA-N triazol-1-amine Chemical class NN1C=CN=N1 MPSUGQWRVNRJEE-UHFFFAOYSA-N 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
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- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 4
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- UXTMROKLAAOEQO-UHFFFAOYSA-N chloroform;ethanol Chemical compound CCO.ClC(Cl)Cl UXTMROKLAAOEQO-UHFFFAOYSA-N 0.000 description 1
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- SXZIXHOMFPUIRK-UHFFFAOYSA-N diphenylmethanimine Chemical compound C=1C=CC=CC=1C(=N)C1=CC=CC=C1 SXZIXHOMFPUIRK-UHFFFAOYSA-N 0.000 description 1
- 235000014632 disordered eating Nutrition 0.000 description 1
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- 229940126534 drug product Drugs 0.000 description 1
- 230000008918 emotional behaviour Effects 0.000 description 1
- HVJJYOAPXBPQQV-UHFFFAOYSA-N ethyl 2-azidoacetate Chemical compound CCOC(=O)CN=[N+]=[N-] HVJJYOAPXBPQQV-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
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- YFHXZQPUBCBNIP-UHFFFAOYSA-N fura-2 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=3OC(=CC=3C=2)C=2OC(=CN=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 YFHXZQPUBCBNIP-UHFFFAOYSA-N 0.000 description 1
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- JPZYUHLBRMMAPC-UHFFFAOYSA-N methyl 3-[2-[[1-(2-cyclohexylethyl)-5-(2,5-dimethoxy-4-methylphenyl)-1,2,4-triazol-3-yl]carbamoyl]-6-methoxy-4,5-dimethylindol-1-yl]propanoate Chemical compound C=1C2=C(C)C(C)=C(OC)C=C2N(CCC(=O)OC)C=1C(=O)NC(=NN1CCC2CCCCC2)N=C1C1=CC(OC)=C(C)C=C1OC JPZYUHLBRMMAPC-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- UVEWQKMPXAHFST-UHFFFAOYSA-N n,1-diphenylmethanimine Chemical group C=1C=CC=CC=1C=NC1=CC=CC=C1 UVEWQKMPXAHFST-UHFFFAOYSA-N 0.000 description 1
- ALIRAGZUFDQVEN-UHFFFAOYSA-N n-(diaminomethylideneamino)-2,5-dimethoxy-4-methylbenzamide Chemical compound COC1=CC(C(=O)NNC(N)=N)=C(OC)C=C1C ALIRAGZUFDQVEN-UHFFFAOYSA-N 0.000 description 1
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- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0004153A HUP0004153A3 (en) | 2000-10-26 | 2000-10-26 | 3-amino-triazole derivatives with medicinal applicability, process for their preparation and pharmaceutical compositions containing them and their use |
| HU0004153 | 2000-10-26 | ||
| FR0013728 | 2000-10-26 | ||
| FR0013728A FR2815963B1 (fr) | 2000-10-26 | 2000-10-26 | Nouveaux derives du triazole et les compositions pharmaceutiques les contenant |
| PCT/EP2001/012984 WO2002034743A1 (en) | 2000-10-26 | 2001-10-25 | Triazole derivatives and pharmaceutical compositions comprising them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002226330A1 true AU2002226330A1 (en) | 2002-05-06 |
Family
ID=89978697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002226330A Abandoned AU2002226330A1 (en) | 2000-10-26 | 2001-10-25 | Triazole derivatives and pharmaceutical compositions comprising them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20040019091A1 (xx) |
| EP (1) | EP1335914A1 (xx) |
| JP (1) | JP2004512334A (xx) |
| KR (1) | KR20030042035A (xx) |
| CN (1) | CN1471525A (xx) |
| AR (1) | AR031042A1 (xx) |
| AU (1) | AU2002226330A1 (xx) |
| BG (1) | BG107642A (xx) |
| BR (1) | BR0114888A (xx) |
| CA (1) | CA2420727A1 (xx) |
| EA (1) | EA200300238A1 (xx) |
| EE (1) | EE200300161A (xx) |
| HR (1) | HRP20030330A2 (xx) |
| IL (1) | IL155055A0 (xx) |
| IS (1) | IS6734A (xx) |
| NO (1) | NO20031841L (xx) |
| NZ (1) | NZ524437A (xx) |
| PL (1) | PL365328A1 (xx) |
| SK (1) | SK5172003A3 (xx) |
| WO (1) | WO2002034743A1 (xx) |
| YU (1) | YU18803A (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005035793A2 (en) * | 2003-10-09 | 2005-04-21 | Decode Genetics Ehf. | Cckar markers and haplotypes associated with extreme weight conditions |
| JP4892915B2 (ja) * | 2005-10-04 | 2012-03-07 | 大日本印刷株式会社 | エパルレスタット製造法 |
| EA201100189A1 (ru) * | 2008-07-15 | 2011-08-30 | Новартис Аг | Гетероарильные производные в качестве ингибиторов dgat1 |
| US20130179356A1 (en) * | 2012-01-05 | 2013-07-11 | General Electric Company | Method and system for maintenance of turbomachinery |
| CN104130243B (zh) * | 2014-07-08 | 2016-05-25 | 河北美星化工有限公司 | 取代对卤苯基三唑环取代氟化烟酰胺化合物及合成方法 |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2701708B1 (fr) * | 1993-02-19 | 1995-05-19 | Sanofi Elf | Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament. |
| FR2703995B1 (fr) * | 1993-04-16 | 1995-07-21 | Sanofi Elf | 5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant. |
| FR2763337B1 (fr) * | 1997-05-13 | 1999-08-20 | Sanofi Sa | Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant |
-
2001
- 2001-10-25 KR KR10-2003-7005772A patent/KR20030042035A/ko not_active Application Discontinuation
- 2001-10-25 AU AU2002226330A patent/AU2002226330A1/en not_active Abandoned
- 2001-10-25 SK SK517-2003A patent/SK5172003A3/sk unknown
- 2001-10-25 IL IL15505501A patent/IL155055A0/xx unknown
- 2001-10-25 EA EA200300238A patent/EA200300238A1/ru unknown
- 2001-10-25 WO PCT/EP2001/012984 patent/WO2002034743A1/en not_active Application Discontinuation
- 2001-10-25 CN CNA018181236A patent/CN1471525A/zh active Pending
- 2001-10-25 PL PL01365328A patent/PL365328A1/xx not_active Application Discontinuation
- 2001-10-25 YU YU18803A patent/YU18803A/sh unknown
- 2001-10-25 BR BR0114888-5A patent/BR0114888A/pt not_active Application Discontinuation
- 2001-10-25 NZ NZ524437A patent/NZ524437A/en not_active Application Discontinuation
- 2001-10-25 EE EEP200300161A patent/EE200300161A/xx unknown
- 2001-10-25 US US10/398,858 patent/US20040019091A1/en not_active Abandoned
- 2001-10-25 JP JP2002537734A patent/JP2004512334A/ja not_active Withdrawn
- 2001-10-25 AR ARP010104990A patent/AR031042A1/es unknown
- 2001-10-25 EP EP01988716A patent/EP1335914A1/en not_active Withdrawn
- 2001-10-25 CA CA002420727A patent/CA2420727A1/en not_active Abandoned
-
2003
- 2003-02-28 IS IS6734A patent/IS6734A/is unknown
- 2003-03-18 BG BG107642A patent/BG107642A/xx unknown
- 2003-04-24 NO NO20031841A patent/NO20031841L/no not_active Application Discontinuation
- 2003-04-28 HR HR20030330A patent/HRP20030330A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EE200300161A (et) | 2003-06-16 |
| KR20030042035A (ko) | 2003-05-27 |
| IS6734A (is) | 2003-02-28 |
| CN1471525A (zh) | 2004-01-28 |
| EA200300238A1 (ru) | 2003-10-30 |
| JP2004512334A (ja) | 2004-04-22 |
| YU18803A (sh) | 2006-05-25 |
| AR031042A1 (es) | 2003-09-03 |
| NZ524437A (en) | 2004-10-29 |
| HRP20030330A2 (en) | 2003-06-30 |
| BG107642A (en) | 2003-11-28 |
| CA2420727A1 (en) | 2002-05-02 |
| US20040019091A1 (en) | 2004-01-29 |
| PL365328A1 (en) | 2004-12-27 |
| EP1335914A1 (en) | 2003-08-20 |
| IL155055A0 (en) | 2003-10-31 |
| NO20031841D0 (no) | 2003-04-24 |
| NO20031841L (no) | 2003-06-19 |
| SK5172003A3 (en) | 2003-10-07 |
| BR0114888A (pt) | 2003-12-09 |
| WO2002034743A1 (en) | 2002-05-02 |
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