AU2002220596A1 - Synthesis of r(+)alpha-lipoic acid - Google Patents

Synthesis of r(+)alpha-lipoic acid

Info

Publication number
AU2002220596A1
AU2002220596A1 AU2002220596A AU2059602A AU2002220596A1 AU 2002220596 A1 AU2002220596 A1 AU 2002220596A1 AU 2002220596 A AU2002220596 A AU 2002220596A AU 2059602 A AU2059602 A AU 2059602A AU 2002220596 A1 AU2002220596 A1 AU 2002220596A1
Authority
AU
Australia
Prior art keywords
alpha
halo
octanoic acid
methylbenzylamine
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002220596A
Other languages
English (en)
Inventor
Giovanna Falabella
Antonio Nardi
Annibale Salvi
Flavio Villani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorio Chimico Internazionale SpA
Original Assignee
Laboratorio Chimico Internazionale SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Internazionale SpA filed Critical Laboratorio Chimico Internazionale SpA
Publication of AU2002220596A1 publication Critical patent/AU2002220596A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
AU2002220596A 2000-10-10 2001-10-08 Synthesis of r(+)alpha-lipoic acid Abandoned AU2002220596A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI00A2188 2000-10-10
IT2000MI002188A IT1319196B1 (it) 2000-10-10 2000-10-10 Sintesi dell'acido r(+)alfa-lipoico.
PCT/EP2001/011576 WO2002030919A1 (en) 2000-10-10 2001-10-08 SYNTHESIS OF R(+)α-LIPOIC ACID

Publications (1)

Publication Number Publication Date
AU2002220596A1 true AU2002220596A1 (en) 2002-04-22

Family

ID=11445937

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002220596A Abandoned AU2002220596A1 (en) 2000-10-10 2001-10-08 Synthesis of r(+)alpha-lipoic acid

Country Status (11)

Country Link
US (1) US6864374B2 (cs)
EP (1) EP1335911B1 (cs)
JP (1) JP4257574B2 (cs)
KR (1) KR100822532B1 (cs)
AT (1) ATE266020T1 (cs)
AU (1) AU2002220596A1 (cs)
CZ (1) CZ301710B6 (cs)
DE (1) DE60103179T2 (cs)
ES (1) ES2219577T3 (cs)
IT (1) IT1319196B1 (cs)
WO (1) WO2002030919A1 (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10201464B4 (de) * 2002-01-16 2005-06-16 Viatris Gmbh & Co. Kg Verfahren zur Herstellung reiner Thioctsäure
ITMI20030831A1 (it) 2003-04-22 2004-10-23 Laboratorio Chimico Int Spa Sale basico dell'acido tiottico con la l-carnitina.
CN100387593C (zh) * 2006-01-26 2008-05-14 南京师范大学 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法
ITMI20061024A1 (it) 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
EP2349322A4 (en) * 2008-10-24 2011-11-23 Biolink Life Sciences Inc SALT OF R - (+) - ALPHA-LIPOIC ACID STABLE AND INSOLUBLE IN WATER USEFUL FOR THE TREATMENT OF SWEET DIABETES AND ITS CO-MORBIDITIES
KR20110103987A (ko) * 2008-12-01 2011-09-21 인베이스크 테라퓨틱, 인크. 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도
CN101880224B (zh) * 2009-05-08 2013-02-20 上海医药工业研究院 一种6,8-二氯辛酸的拆分方法
US8080674B2 (en) * 2009-06-12 2011-12-20 Ampac Fine Chemicals Llc. Preparation of polymer-free R-(+)-α-lipoic acid magnesium salt
DE102012109704A1 (de) * 2012-10-11 2014-04-17 Epcos Ag Keramisches Bauelement mit Schutzschicht und Verfahren zu dessen Herstellung
CN109942426B (zh) * 2019-04-02 2022-03-22 福建科宏生物工程股份有限公司 一种s-(-)-硫辛酸循环利用的处理方法
CN116496245B (zh) * 2023-03-01 2024-10-01 杭州新曦科技有限公司 用于制备R-α-硫辛酸及其相关中间体的方法
CN116925035A (zh) * 2023-07-27 2023-10-24 风火轮(上海)生物科技有限公司 一种硫辛酸的纯化方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
DE3814163A1 (de) * 1988-04-27 1989-11-09 Rhein Chemie Rheinau Gmbh Verfahren zur herstellung von disulfiden
DE4137773A1 (de) 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
DE4342619A1 (de) * 1993-12-14 1995-06-22 Bayer Ag Verbessertes Verfahren zur Herstellung von 2,2'-Dinitrodiphenyldisulfid
DE19510130C1 (de) * 1995-03-21 1996-11-21 Asta Medica Ag Verfahren zur Herstellung rieselfähiger R,S-Thioctsäure, R,S-Thioctsäure sowie deren Verwendung
GB9510858D0 (en) * 1995-05-30 1995-07-26 Chiroscience Ltd Process for preparing lipoic acid
DE19533881A1 (de) * 1995-09-13 1997-03-20 Dresden Arzneimittel Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester
CZ96798A3 (cs) * 1997-04-02 1998-10-14 Sankyo Company Limited Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky
EP2145883A1 (en) * 1998-10-26 2010-01-20 The Research Foundation Of The State University Of New York Dibenzyl lipoic acid derivatives and their use in treatment of disease
AR042572A1 (es) * 1999-04-02 2005-06-29 Sod Conseils Rech Applic Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos
DE19938621A1 (de) * 1999-08-14 2001-02-22 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von lösemittelfreier alpha-Liponsäure
IT1319195B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Processo per la produzione dell'acido r(+)alfa-lipoico.

Also Published As

Publication number Publication date
US20040002610A1 (en) 2004-01-01
ES2219577T3 (es) 2004-12-01
DE60103179T2 (de) 2005-05-04
JP2004511477A (ja) 2004-04-15
US6864374B2 (en) 2005-03-08
IT1319196B1 (it) 2003-09-26
DE60103179D1 (en) 2004-06-09
CZ301710B6 (cs) 2010-06-02
KR20030070001A (ko) 2003-08-27
EP1335911B1 (en) 2004-05-06
ATE266020T1 (de) 2004-05-15
EP1335911A1 (en) 2003-08-20
KR100822532B1 (ko) 2008-04-16
WO2002030919A1 (en) 2002-04-18
JP4257574B2 (ja) 2009-04-22
ITMI20002188A1 (it) 2002-04-10
ITMI20002188A0 (it) 2000-10-10

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