AU2002219707A1 - Testing endosymbiont cellular organelles and compounds identifiable therewith - Google Patents
Testing endosymbiont cellular organelles and compounds identifiable therewithInfo
- Publication number
- AU2002219707A1 AU2002219707A1 AU2002219707A AU1970702A AU2002219707A1 AU 2002219707 A1 AU2002219707 A1 AU 2002219707A1 AU 2002219707 A AU2002219707 A AU 2002219707A AU 1970702 A AU1970702 A AU 1970702A AU 2002219707 A1 AU2002219707 A1 AU 2002219707A1
- Authority
- AU
- Australia
- Prior art keywords
- nucleic acid
- organism
- dna
- gene product
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000003463 organelle Anatomy 0.000 title claims description 80
- 230000001413 cellular effect Effects 0.000 title claims description 53
- 150000001875 compounds Chemical class 0.000 title claims description 49
- 238000012360 testing method Methods 0.000 title description 18
- 150000007523 nucleic acids Chemical class 0.000 claims description 128
- 108020004707 nucleic acids Proteins 0.000 claims description 120
- 102000039446 nucleic acids Human genes 0.000 claims description 120
- 238000000034 method Methods 0.000 claims description 110
- 239000000523 sample Substances 0.000 claims description 76
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 59
- 201000010099 disease Diseases 0.000 claims description 53
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 53
- 108090000623 proteins and genes Proteins 0.000 claims description 51
- 230000003321 amplification Effects 0.000 claims description 44
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 44
- 239000003814 drug Substances 0.000 claims description 38
- 230000000694 effects Effects 0.000 claims description 38
- 210000002950 fibroblast Anatomy 0.000 claims description 24
- 238000003556 assay Methods 0.000 claims description 18
- 238000013518 transcription Methods 0.000 claims description 16
- 230000035897 transcription Effects 0.000 claims description 16
- 241000902900 cellular organisms Species 0.000 claims description 15
- 230000001225 therapeutic effect Effects 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 12
- 230000002588 toxic effect Effects 0.000 claims description 10
- 239000004009 herbicide Substances 0.000 claims description 9
- 239000000824 cytostatic agent Substances 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 230000002363 herbicidal effect Effects 0.000 claims description 6
- 239000002777 nucleoside Substances 0.000 claims description 6
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 102000004598 Small Nuclear Ribonucleoproteins Human genes 0.000 claims description 5
- 108010003165 Small Nuclear Ribonucleoproteins Proteins 0.000 claims description 5
- 239000002917 insecticide Substances 0.000 claims description 5
- 208000017667 Chronic Disease Diseases 0.000 claims description 4
- 238000009007 Diagnostic Kit Methods 0.000 claims description 3
- WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims description 2
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 2
- 244000038559 crop plants Species 0.000 claims description 2
- 229960000684 cytarabine Drugs 0.000 claims description 2
- 229960000390 fludarabine Drugs 0.000 claims description 2
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 2
- 229960002949 fluorouracil Drugs 0.000 claims description 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 2
- 229960001428 mercaptopurine Drugs 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 229960003087 tioguanine Drugs 0.000 claims description 2
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 108020005196 Mitochondrial DNA Proteins 0.000 description 75
- 210000004027 cell Anatomy 0.000 description 57
- 108020004414 DNA Proteins 0.000 description 52
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 48
- 108091064355 mitochondrial RNA Proteins 0.000 description 42
- 239000013611 chromosomal DNA Substances 0.000 description 37
- 238000006243 chemical reaction Methods 0.000 description 35
- 230000007423 decrease Effects 0.000 description 21
- 239000011541 reaction mixture Substances 0.000 description 19
- 229940079593 drug Drugs 0.000 description 18
- 238000002560 therapeutic procedure Methods 0.000 description 16
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 15
- 229960005542 ethidium bromide Drugs 0.000 description 15
- 210000003470 mitochondria Anatomy 0.000 description 15
- 239000000203 mixture Substances 0.000 description 14
- 239000013612 plasmid Substances 0.000 description 13
- 238000011002 quantification Methods 0.000 description 13
- 230000007480 spreading Effects 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 13
- 239000003443 antiviral agent Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 210000000349 chromosome Anatomy 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 238000004113 cell culture Methods 0.000 description 11
- VXUGVISSBXKUEL-UHFFFAOYSA-N 2-hydroxypropanoic acid;2-oxopropanoic acid Chemical compound CC(O)C(O)=O.CC(=O)C(O)=O VXUGVISSBXKUEL-UHFFFAOYSA-N 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 230000008859 change Effects 0.000 description 9
- 230000002438 mitochondrial effect Effects 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 7
- 108091093105 Nuclear DNA Proteins 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 230000000996 additive effect Effects 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 108091008146 restriction endonucleases Proteins 0.000 description 7
- 231100000331 toxic Toxicity 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 238000011088 calibration curve Methods 0.000 description 6
- 238000013519 translation Methods 0.000 description 6
- 241000725303 Human immunodeficiency virus Species 0.000 description 5
- 230000000798 anti-retroviral effect Effects 0.000 description 5
- 210000003763 chloroplast Anatomy 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 210000003527 eukaryotic cell Anatomy 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 206010053961 Mitochondrial toxicity Diseases 0.000 description 4
- 241000209094 Oryza Species 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 230000001085 cytostatic effect Effects 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 238000001976 enzyme digestion Methods 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 231100000296 mitochondrial toxicity Toxicity 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- 238000011225 antiretroviral therapy Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000002759 chromosomal effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 101150017854 petB gene Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- VHJLVAABSRFDPM-UHFFFAOYSA-N 1,4-dithiothreitol Chemical compound SCC(O)C(O)CS VHJLVAABSRFDPM-UHFFFAOYSA-N 0.000 description 2
- NOVZFMNCTCKLPF-UHFFFAOYSA-N 2,5-bis(aziridin-1-yl)-3,6-dipropoxycyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C(OCCC)=C(N2CC2)C(=O)C(OCCC)=C1N1CC1 NOVZFMNCTCKLPF-UHFFFAOYSA-N 0.000 description 2
- 108020004998 Chloroplast DNA Proteins 0.000 description 2
- 108020005133 Chloroplast RNA Proteins 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 108091028733 RNTP Proteins 0.000 description 2
- 101710137500 T7 RNA polymerase Proteins 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000002141 anti-parasite Effects 0.000 description 2
- -1 anti-parasiticum Substances 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000003096 antiparasitic agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000003255 drug test Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 208000006443 lactic acidosis Diseases 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 210000002706 plastid Anatomy 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000005758 transcription activity Effects 0.000 description 2
- 230000002103 transcriptional effect Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
- WCKQPPQRFNHPRJ-UHFFFAOYSA-N 4-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid Chemical compound C1=CC(N(C)C)=CC=C1N=NC1=CC=C(C(O)=O)C=C1 WCKQPPQRFNHPRJ-UHFFFAOYSA-N 0.000 description 1
- BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 241000413244 Ascochilopsis Species 0.000 description 1
- 102000015790 Asparaginase Human genes 0.000 description 1
- 108010024976 Asparaginase Proteins 0.000 description 1
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 206010022714 Intestinal ulcer Diseases 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- 102000043276 Oncogene Human genes 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
- IVTVGDXNLFLDRM-HNNXBMFYSA-N Tomudex Chemical compound C=1C=C2NC(C)=NC(=O)C2=CC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)S1 IVTVGDXNLFLDRM-HNNXBMFYSA-N 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- 229960001220 amsacrine Drugs 0.000 description 1
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229960003272 asparaginase Drugs 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
- BHKICZDKIIDMNR-UHFFFAOYSA-L azane;cyclobutane-1,1-dicarboxylate;platinum(4+) Chemical compound N.N.[Pt+4].[O-]C(=O)C1(C([O-])=O)CCC1 BHKICZDKIIDMNR-UHFFFAOYSA-L 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229960002436 cladribine Drugs 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 210000001840 diploid cell Anatomy 0.000 description 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 229960001842 estramustine Drugs 0.000 description 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960001330 hydroxycarbamide Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 229940127073 nucleoside analogue Drugs 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
- 229960000624 procarbazine Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229960004432 raltitrexed Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00204322A EP1211323A1 (de) | 2000-12-04 | 2000-12-04 | Auf endosymbiotischen Zellorganellnukleinsäuren basierende Tests |
| EP00204322.2 | 2000-12-04 | ||
| EP01202168.9 | 2001-06-06 | ||
| EP01202168 | 2001-06-06 | ||
| PCT/NL2001/000883 WO2002046470A2 (en) | 2000-12-04 | 2001-12-04 | Testing endosymbiont cellular organelles and compounds identifiable therewith |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002219707A1 true AU2002219707A1 (en) | 2002-06-18 |
Family
ID=26072883
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002219707A Abandoned AU2002219707A1 (en) | 2000-12-04 | 2001-12-04 | Testing endosymbiont cellular organelles and compounds identifiable therewith |
| AU2008200491A Expired AU2008200491B8 (en) | 2000-12-04 | 2008-02-01 | Testing endosymbiont cellular organelles and compounds identifiable therewith |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008200491A Expired AU2008200491B8 (en) | 2000-12-04 | 2008-02-01 | Testing endosymbiont cellular organelles and compounds identifiable therewith |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6967016B2 (de) |
| EP (1) | EP1229130B1 (de) |
| JP (1) | JP4472253B2 (de) |
| KR (1) | KR20040034582A (de) |
| CN (1) | CN1322143C (de) |
| AU (2) | AU2002219707A1 (de) |
| CA (1) | CA2364294C (de) |
| DK (1) | DK1229130T3 (de) |
| ES (1) | ES2445748T3 (de) |
| HK (1) | HK1069189A1 (de) |
| IL (1) | IL156286A0 (de) |
| NZ (2) | NZ543940A (de) |
| WO (1) | WO2002046470A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2180064A3 (de) * | 2000-10-18 | 2010-08-11 | Pharmasset, Inc. | Multiplex Quantifizierung von Nukleinsäuren in erkrankten Zellen |
| DK1229130T3 (en) * | 2000-12-04 | 2014-02-24 | Primagen B V | TEST BASED ON nucleic acids OF ENDOSYMBIONTISKE, cellular organelles |
| US20050153381A1 (en) * | 2002-02-14 | 2005-07-14 | Marusich Michael F. | Immunocapture of mitochondrial protein complexes |
| EP1418242A1 (de) * | 2002-11-08 | 2004-05-12 | PrimaGen Holding B.V. | Verfahren zur Quantifizierung des Verhältnisses von mindestens zwei Nukleinsäuresequenzen |
| AU2003279621A1 (en) * | 2002-11-08 | 2004-06-07 | Primagen Holding B.V. | Method for quantifying a ratio between at least two nucleic acid sequences |
| EP1418241A1 (de) * | 2002-11-08 | 2004-05-12 | PrimaGen Holding B.V. | Methode zur Quantifizierung des Verhältnisses zweier Nukleinsäuresequenzen |
| US20040110241A1 (en) * | 2002-12-06 | 2004-06-10 | Segal Mark S. | Materials and methods for monitoring vascular endothelial function |
| SI2368553T1 (sl) | 2003-04-08 | 2015-05-29 | Progenics Pharmaceuticals, Inc. | Farmacevtske formulacije, vsebujoče metilnatrekson |
| MXPA05012620A (es) | 2003-05-21 | 2006-05-25 | Bios Chile I G S A | Marcadores para celulas precancerosas y cancerosas y metodo para interferir con la proliferacion celular. |
| EP1493823A1 (de) * | 2003-07-02 | 2005-01-05 | PrimaGen Holding B.V. | Inhibitoren der HMG-CoA Reduktase beeinflussen den DNA-Gehalt der Mitochondrien von Zellen |
| EP1571225A1 (de) * | 2004-03-02 | 2005-09-07 | PrimaGen Holding B.V. | Diagnose von Krankheiten und Überwachung einer Therapie unter Verwendung des AC133 Gens |
| US20070077578A1 (en) * | 2004-03-02 | 2007-04-05 | Primagen Holding B.V. | Diagnosis of (a risk of ) disease and monitoring of therapy |
| EP2471923B1 (de) | 2004-05-28 | 2014-08-20 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit microRNA |
| EP1652935A1 (de) * | 2004-10-29 | 2006-05-03 | PrimaGen Holding B.V. | Verfahren zur Bestimmung des Gesundheitsstatus eines Individuums durch die Verwendung von mitochondrialen Nukleinsäuren |
| WO2006062389A2 (en) | 2004-10-29 | 2006-06-15 | Primagen Holding B.V. | Methods using mitochondrial nucleic acid for determining a health status of an individual |
| ES2503765T3 (es) | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| US7465561B2 (en) | 2005-06-30 | 2008-12-16 | Roche Molecular Systems, Inc. | Probes and methods for hepatitis C virus typing using single probe analysis |
| US20070134678A1 (en) * | 2005-12-12 | 2007-06-14 | Rees Dianne M | Comparative genome hybridization of organelle genomes |
| US20090131348A1 (en) * | 2006-09-19 | 2009-05-21 | Emmanuel Labourier | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| EP3064503A1 (de) | 2007-03-29 | 2016-09-07 | Progenics Pharmaceuticals, Inc. | Antagonisten der peripheren opioidrezeptoren und ihre verwendung |
| PT2139890E (pt) | 2007-03-29 | 2014-09-03 | Wyeth Llc | Antagonistas do receptor opióide periférico e respectivas utilizações |
| MX2009010550A (es) | 2007-03-29 | 2009-12-14 | Progenics Pharm Inc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| US20090024333A1 (en) * | 2007-07-19 | 2009-01-22 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems relating to mitochondrial DNA phenotypes |
| US20090024330A1 (en) * | 2007-07-19 | 2009-01-22 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems relating to epigenetic phenotypes |
| US20090022666A1 (en) * | 2007-07-19 | 2009-01-22 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems relating to mitochondrial DNA information |
| WO2009036332A1 (en) | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| CA2713568C (en) | 2008-02-06 | 2016-09-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| WO2009117669A2 (en) | 2008-03-21 | 2009-09-24 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| WO2012097849A2 (en) * | 2011-01-18 | 2012-07-26 | Merck Patent Gmbh | Mitochondrial genome-restricted dna sequences |
| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340807C (en) * | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5569754A (en) * | 1993-06-11 | 1996-10-29 | Board Of Regents, University Of Tx Systems | RNA import elements for transport into mitochondria |
| US5506101A (en) * | 1993-06-30 | 1996-04-09 | Cedars-Sinai Medical Center | Method for detection of susceptibility mutations for ototoxic deafness |
| US5840493A (en) | 1994-03-30 | 1998-11-24 | Mitokor | Mitochondrial DNA mutations that segregate with late onset diabetes mellitus |
| CA2186636A1 (en) * | 1994-03-30 | 1995-10-12 | Corinna Herrnstadt | Diagnosis, therapy and cellular and animal models for diseases associated with mitochondrial defects |
| KR100399715B1 (ko) | 1994-08-18 | 2003-12-18 | 악조 노벨 엔.브이. | Cmv핵산증폭 및 검출용 프라이머와 프로브 |
| AU705377B2 (en) * | 1995-07-03 | 1999-05-20 | Akzo Nobel N.V. | A method for determining the integrity of nucleic acid |
| AU2803397A (en) | 1996-04-17 | 1997-11-07 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Method and kit for detecting genomic instability |
| US6232065B1 (en) * | 1998-05-06 | 2001-05-15 | Case Western Reserve University | Analysis of gene family expression |
| US6441149B1 (en) | 1998-06-15 | 2002-08-27 | Mitokor | Diagnostic method based on quantification of extramitochondrial DNA |
| JP2003521879A (ja) * | 1999-04-20 | 2003-07-22 | マイトコー | アルツハイマー病とともに分離するミトコンドリア遺伝子における一塩基多型 |
| US6221600B1 (en) * | 1999-10-08 | 2001-04-24 | Board Of Regents, The University Of Texas System | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis |
| US20020049176A1 (en) * | 1999-11-10 | 2002-04-25 | Anderson Christen M. | Modulation of mitochondrial mass and function for the treatment of diseases and for target and drug discovery |
| EP1242581A2 (de) * | 1999-12-08 | 2002-09-25 | Bayer Aktiengesellschaft | Regulation der humanen mitochondrialen deformylase |
| US20020048763A1 (en) * | 2000-02-04 | 2002-04-25 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis |
| DK1229130T3 (en) * | 2000-12-04 | 2014-02-24 | Primagen B V | TEST BASED ON nucleic acids OF ENDOSYMBIONTISKE, cellular organelles |
| US20020169562A1 (en) * | 2001-01-29 | 2002-11-14 | Gregory Stephanopoulos | Defining biological states and related genes, proteins and patterns |
| JP4105626B2 (ja) * | 2001-05-29 | 2008-06-25 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | ミトコンドリアｄｎａアッセイの薬理学的応用 |
-
2001
- 2001-12-04 DK DK01204688.4T patent/DK1229130T3/en active
- 2001-12-04 CN CNB018224776A patent/CN1322143C/zh not_active Expired - Lifetime
- 2001-12-04 KR KR10-2003-7007424A patent/KR20040034582A/ko not_active Application Discontinuation
- 2001-12-04 IL IL15628601A patent/IL156286A0/xx unknown
- 2001-12-04 CA CA2364294A patent/CA2364294C/en not_active Expired - Lifetime
- 2001-12-04 NZ NZ543940A patent/NZ543940A/en not_active IP Right Cessation
- 2001-12-04 EP EP01204688.4A patent/EP1229130B1/de not_active Expired - Lifetime
- 2001-12-04 AU AU2002219707A patent/AU2002219707A1/en not_active Abandoned
- 2001-12-04 NZ NZ526519A patent/NZ526519A/en not_active IP Right Cessation
- 2001-12-04 WO PCT/NL2001/000883 patent/WO2002046470A2/en active Application Filing
- 2001-12-04 JP JP2002548186A patent/JP4472253B2/ja not_active Expired - Lifetime
- 2001-12-04 US US10/006,009 patent/US6967016B2/en not_active Expired - Lifetime
- 2001-12-04 ES ES01204688.4T patent/ES2445748T3/es not_active Expired - Lifetime
-
2005
- 2005-02-15 US US11/058,105 patent/US20050208549A1/en not_active Abandoned
- 2005-03-01 HK HK05101744A patent/HK1069189A1/xx not_active IP Right Cessation
-
2008
- 2008-02-01 AU AU2008200491A patent/AU2008200491B8/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HK1069189A1 (en) | 2005-05-13 |
| AU2008200491B8 (en) | 2011-05-26 |
| CA2364294A1 (en) | 2002-06-04 |
| NZ543940A (en) | 2008-04-30 |
| ES2445748T3 (es) | 2014-03-05 |
| CA2364294C (en) | 2013-04-02 |
| CN1322143C (zh) | 2007-06-20 |
| AU2008200491B2 (en) | 2011-04-28 |
| WO2002046470A2 (en) | 2002-06-13 |
| US20020164612A1 (en) | 2002-11-07 |
| KR20040034582A (ko) | 2004-04-28 |
| IL156286A0 (en) | 2004-01-04 |
| EP1229130A3 (de) | 2003-10-22 |
| JP2004530416A (ja) | 2004-10-07 |
| EP1229130B1 (de) | 2013-11-20 |
| DK1229130T3 (en) | 2014-02-24 |
| US6967016B2 (en) | 2005-11-22 |
| US20050208549A1 (en) | 2005-09-22 |
| NZ526519A (en) | 2006-08-31 |
| EP1229130A2 (de) | 2002-08-07 |
| WO2002046470A3 (en) | 2004-01-15 |
| CN1526022A (zh) | 2004-09-01 |
| AU2008200491A8 (en) | 2011-05-26 |
| JP4472253B2 (ja) | 2010-06-02 |
| AU2008200491A1 (en) | 2008-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2008200491B8 (en) | Testing endosymbiont cellular organelles and compounds identifiable therewith | |
| US8623602B2 (en) | Lysis and reverse transcription for MRNA quantification | |
| JP6840207B2 (ja) | マイコバクテリウム・ツベルクロシスの検出および分析のための組成物および方法 | |
| EP1418241A1 (de) | Methode zur Quantifizierung des Verhältnisses zweier Nukleinsäuresequenzen | |
| WO2018065830A1 (en) | Multiplex realtime pcr kit for diagnosing multidrug resistance (mdr) and extensively drug resistance (xdr) tuberculosis | |
| JP2015513921A (ja) | 任意のポリメラーゼ伸長活性の高感度定量的測定と生細胞存在の決定とに有用なポリメラーゼ活性測定方法 | |
| JP2018166410A (ja) | 生体試料中の核酸の長期保存方法 | |
| JP2013538585A (ja) | Ｒｔ−ｐｃｒ反応緩衝液中での細胞溶解のための方法 | |
| KR20200048076A (ko) | 중증 열성 혈소판 감소 증후군(sfts) 바이러스 감염 질환 진단용 키트 | |
| US20120082995A1 (en) | Method for quantitative pcr amplification of deoxyribonucleic acids from a sample containing pcr inhibitors | |
| CN111712583A (zh) | 使用多拷贝基因诊断恙虫病的方法 | |
| US20230094433A1 (en) | Methods and kits for the detection of sars-cov-2 | |
| CN101314792A (zh) | 肾移植免疫排斥三联基因尿检法及试剂盒和诊断试剂 | |
| RU2699180C1 (ru) | Набор олигонуклеотидных праймеров и флуоресцентно-меченого зонда для идентификации рнк возбудителей сапа burkholderia mallei и мелиоидоза burkholderia pseudomallei на основе транскрипционной амплификации (nasba) в режиме "реального времени" | |
| EP1211323A1 (de) | Auf endosymbiotischen Zellorganellnukleinsäuren basierende Tests | |
| WO2004042085A2 (en) | Method for quantifying a ratio between at least two nucleic acid sequences | |
| EP1418242A1 (de) | Verfahren zur Quantifizierung des Verhältnisses von mindestens zwei Nukleinsäuresequenzen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |