AU2002212541A1 - Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections - Google Patents

Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections

Info

Publication number
AU2002212541A1
AU2002212541A1 AU2002212541A AU1254102A AU2002212541A1 AU 2002212541 A1 AU2002212541 A1 AU 2002212541A1 AU 2002212541 A AU2002212541 A AU 2002212541A AU 1254102 A AU1254102 A AU 1254102A AU 2002212541 A1 AU2002212541 A1 AU 2002212541A1
Authority
AU
Australia
Prior art keywords
ydroxamic
bakterial
inhibitors
acid
microbial infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002212541A
Other languages
English (en)
Inventor
Paul Raymond Beckett
Steven Launchbury
Gilles Pain
Lisa Marie Pratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0028519A external-priority patent/GB0028519D0/en
Priority claimed from GB0116864A external-priority patent/GB0116864D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of AU2002212541A1 publication Critical patent/AU2002212541A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2002212541A 2000-11-23 2001-11-08 Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections Abandoned AU2002212541A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0028519A GB0028519D0 (en) 2000-11-23 2000-11-23 Antimicrobial agents
GB0028519 2000-11-23
GB0116864A GB0116864D0 (en) 2001-07-11 2001-07-11 Antimicrobial agents
GB0116864 2001-07-11
PCT/GB2001/004965 WO2002041886A1 (en) 2000-11-23 2001-11-08 Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections

Publications (1)

Publication Number Publication Date
AU2002212541A1 true AU2002212541A1 (en) 2002-06-03

Family

ID=26245320

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002212541A Abandoned AU2002212541A1 (en) 2000-11-23 2001-11-08 Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections

Country Status (6)

Country Link
US (2) US7173053B2 (de)
EP (1) EP1339400B1 (de)
AT (1) ATE298565T1 (de)
AU (1) AU2002212541A1 (de)
DE (1) DE60111768T2 (de)
WO (1) WO2002041886A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1339400B1 (de) * 2000-11-23 2005-06-29 Vernalis (Oxford) Ltd N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
JP2007509082A (ja) * 2003-10-22 2007-04-12 アルピダ エー／エス ペプチドデホルミラーゼ阻害剤としてのベンゾイミダゾール誘導体類およびそれらの使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733882A (en) * 1994-01-17 1998-03-31 Smithkline Beecham Corporation Retroviral protease inhibitors
GB9404046D0 (en) * 1994-03-03 1994-04-20 Smithkline Beecham Corp Novel compounds
US5665753A (en) * 1994-03-03 1997-09-09 Smithkline Beecham Corporation Cytokine inhibiting imidazole substituted hydroxamic acid derivatives
US5703092A (en) * 1995-04-18 1997-12-30 The Dupont Merck Pharmaceutical Company Hydroxamic acid compounds as metalloprotease and TNF inhibitors
ES2212142T3 (es) * 1996-12-17 2004-07-16 Warner-Lambert Company Llc Uso de inhibidores de metaloproteinasas de la matriz para promover la curacion de heridas.
BR9907689A (pt) * 1998-02-07 2000-11-14 British Biotech Pharm Agentes antibacterianos
GB9810464D0 (en) 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
EP1169031A1 (de) * 1999-04-09 2002-01-09 British Biotech Pharmaceuticals Limited Antimikrobielles mittel
EP1339400B1 (de) * 2000-11-23 2005-06-29 Vernalis (Oxford) Ltd N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen

Also Published As

Publication number Publication date
WO2002041886A1 (en) 2002-05-30
EP1339400A1 (de) 2003-09-03
EP1339400B1 (de) 2005-06-29
US7173053B2 (en) 2007-02-06
US20040106666A1 (en) 2004-06-03
ATE298565T1 (de) 2005-07-15
US20090069322A1 (en) 2009-03-12
DE60111768T2 (de) 2006-04-27
DE60111768D1 (de) 2005-08-04

Similar Documents

Publication Publication Date Title
NZ506679A (en) HIV inhibiting pyrimidine derivatives
MXPA04009497A (es) Piridinoilpiperidinas como antagonistas de 5-ht1f.
NZ505675A (en) N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
DE69628466D1 (de) Zwischenverbindungen zur Herstellung von neunen Pyridoncarbonsäurederivate oder deren Salzen
MY133572A (en) Gyrase inhibitors and uses thereof
YU55902A (sh) 3-aminohinazolin-2,4-dioni kao antibakterijska sredstva
TW200740775A (en) Macrocylic inhibitors of hepatitis C virus
NZ510369A (en) Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection
PT1044186E (pt) Composto 2-benzilamino-2-fenil-acetamida substituidos
AU2002212541A1 (en) Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections
NO942748L (no) Pyrroloimidazolyl- og imidazopyridinylsubstituerte 1H-benzimidazolderivater som aromatasehemmere
WO2003022797A1 (fr) Derives de carba-sucres amine et traitements du trouble du metabolisme des glycolipides les contenant en tant qu'ingredient actif
ATE299701T1 (de) Antibakteriell wirksame hydroxamsäure-derivate
ATE397609T1 (de) Corticotropinfreisetzungsfaktor antagonisten
AP2002002708A0 (en) 2-Aminothiazoline derivatives and their use as no-synthase inhibitors.
WO2002050081A3 (en) Antimicrobial agents
NZ335859A (en) Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
DE60006368D1 (de) Hsv primase-inhibitoren
MXPA02011966A (es) Derivados de higromicina a para el el tratamiento de infecciones bacterianas y por protozoarios.
AU2002365650A8 (en) Bacterial enzyme inhibitors