AU2001293788B2 - Quinazoline derivatives as alpha-1 adrenergic antagonists - Google Patents
Quinazoline derivatives as alpha-1 adrenergic antagonists Download PDFInfo
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- AU2001293788B2 AU2001293788B2 AU2001293788A AU2001293788A AU2001293788B2 AU 2001293788 B2 AU2001293788 B2 AU 2001293788B2 AU 2001293788 A AU2001293788 A AU 2001293788A AU 2001293788 A AU2001293788 A AU 2001293788A AU 2001293788 B2 AU2001293788 B2 AU 2001293788B2
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- Prior art keywords
- methyl
- amino
- dimethoxy
- compound
- phenyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
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- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22950300P | 2000-08-31 | 2000-08-31 | |
| US60/229,503 | 2000-08-31 | ||
| PCT/EP2001/009749 WO2002018348A2 (en) | 2000-08-31 | 2001-08-23 | Quinazoline derivatives as alpha-1 adrenergic antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
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| AU2001293788A Ceased AU2001293788B2 (en) | 2000-08-31 | 2001-08-23 | Quinazoline derivatives as alpha-1 adrenergic antagonists |
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| AU9378801A Pending AU9378801A (en) | 2000-08-31 | 2001-08-23 | Quinazoline derivatives as alpha-1 adrenergic antagonists |
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| EP (1) | EP1315714B1 (OSRAM) |
| JP (1) | JP3971299B2 (OSRAM) |
| KR (1) | KR100602929B1 (OSRAM) |
| CN (1) | CN1308324C (OSRAM) |
| AR (1) | AR032475A1 (OSRAM) |
| AT (1) | ATE309240T1 (OSRAM) |
| AU (2) | AU9378801A (OSRAM) |
| BR (1) | BR0113585A (OSRAM) |
| CA (1) | CA2420177C (OSRAM) |
| DE (1) | DE60114852T2 (OSRAM) |
| ES (1) | ES2251512T3 (OSRAM) |
| GT (1) | GT200100181A (OSRAM) |
| MX (1) | MXPA03001777A (OSRAM) |
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| PE (1) | PE20020407A1 (OSRAM) |
| UY (1) | UY26919A1 (OSRAM) |
| WO (1) | WO2002018348A2 (OSRAM) |
| ZA (1) | ZA200301082B (OSRAM) |
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| EP1423392B1 (en) * | 2001-08-10 | 2006-10-04 | Neuro Therapeutics Limited | Derivatives of morphine-like opioid compounds |
| AU2003219199A1 (en) * | 2002-04-03 | 2003-10-13 | Orion Corporation | Use of an alfa2-adrenoreceptor antagonist for cns-related diseases |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| ATE440825T1 (de) * | 2003-06-06 | 2009-09-15 | Vertex Pharma | Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern |
| PT1648878E (pt) | 2003-07-24 | 2009-07-23 | Euro Celtique Sa | Compostos de piperidina e composições farmacêuticas que os contêm |
| WO2006021345A2 (en) * | 2004-08-27 | 2006-03-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with adrenergic alpha-1b receptor (adra1b) |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| US7344583B2 (en) * | 2005-03-31 | 2008-03-18 | 3M Innovative Properties Company | Methods of making metal particles within cored dendrimers |
| US7413607B2 (en) * | 2005-03-31 | 2008-08-19 | 3M Innovative Properties Company | Templated semiconductor particles and methods of making |
| WO2006117305A1 (en) * | 2005-05-04 | 2006-11-09 | F. Hoffmann-La Roche Ag | (3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amines having an activity on the 5-ht receptor |
| US8796293B2 (en) | 2006-04-25 | 2014-08-05 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| US7956001B2 (en) * | 2006-09-19 | 2011-06-07 | 3M Innovative Properties Company | Templated metal oxide particles and methods of making |
| ES2522365T3 (es) | 2007-10-11 | 2014-11-14 | Astrazeneca Ab | Derivados de pirrolo [2,3-D] pirimidina como inhibidores de proteína quinasas B |
| TW200944526A (en) | 2008-04-22 | 2009-11-01 | Vitae Pharmaceuticals Inc | Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| MY169449A (en) | 2011-04-01 | 2019-04-11 | Astrazeneca Ab | Therapeutic treatment |
| US20140329786A1 (en) | 2011-11-30 | 2014-11-06 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| JP7376358B2 (ja) * | 2017-03-12 | 2023-11-08 | ワン，シャオドン | オピオイド受容体調節因子としての多環式アミン |
| WO2019088095A1 (ja) * | 2017-11-02 | 2019-05-09 | 国立大学法人九州大学 | 鎮痛剤及びその使用 |
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| JPH11512710A (ja) | 1995-09-29 | 1999-11-02 | メルク エンド カンパニー インコーポレーテッド | アルファ１ｂアドレナリンレセプターアンタゴニスト |
| NZ325248A (en) * | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
| GB9700504D0 (en) | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
| US6355641B1 (en) | 1999-03-17 | 2002-03-12 | Syntex (U.S.A.) Llc | Oxazolone derivatives and uses thereof |
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2001
- 2001-08-23 CN CNB018165958A patent/CN1308324C/zh not_active Expired - Fee Related
- 2001-08-23 AU AU9378801A patent/AU9378801A/xx active Pending
- 2001-08-23 DE DE60114852T patent/DE60114852T2/de not_active Expired - Fee Related
- 2001-08-23 EP EP01974210A patent/EP1315714B1/en not_active Expired - Lifetime
- 2001-08-23 KR KR1020037002933A patent/KR100602929B1/ko not_active Expired - Fee Related
- 2001-08-23 BR BR0113585-6A patent/BR0113585A/pt not_active IP Right Cessation
- 2001-08-23 JP JP2002523466A patent/JP3971299B2/ja not_active Expired - Fee Related
- 2001-08-23 AT AT01974210T patent/ATE309240T1/de not_active IP Right Cessation
- 2001-08-23 MX MXPA03001777A patent/MXPA03001777A/es active IP Right Grant
- 2001-08-23 CA CA002420177A patent/CA2420177C/en not_active Expired - Fee Related
- 2001-08-23 AU AU2001293788A patent/AU2001293788B2/en not_active Ceased
- 2001-08-23 ES ES01974210T patent/ES2251512T3/es not_active Expired - Lifetime
- 2001-08-23 WO PCT/EP2001/009749 patent/WO2002018348A2/en not_active Ceased
- 2001-08-29 US US09/942,385 patent/US6559153B2/en not_active Expired - Fee Related
- 2001-08-29 PE PE2001000870A patent/PE20020407A1/es not_active Application Discontinuation
- 2001-08-30 GT GT200100181A patent/GT200100181A/es unknown
- 2001-08-30 PA PA20018527901A patent/PA8527901A1/es unknown
- 2001-08-30 AR ARP010104130A patent/AR032475A1/es unknown
- 2001-08-30 UY UY26919A patent/UY26919A1/es not_active Application Discontinuation
-
2003
- 2003-02-07 ZA ZA200301082A patent/ZA200301082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2251512T3 (es) | 2006-05-01 |
| US20020045614A1 (en) | 2002-04-18 |
| WO2002018348A3 (en) | 2002-07-11 |
| KR100602929B1 (ko) | 2006-07-20 |
| WO2002018348A2 (en) | 2002-03-07 |
| PA8527901A1 (es) | 2002-07-30 |
| CN1545510A (zh) | 2004-11-10 |
| US6559153B2 (en) | 2003-05-06 |
| JP3971299B2 (ja) | 2007-09-05 |
| UY26919A1 (es) | 2002-02-28 |
| JP2004507527A (ja) | 2004-03-11 |
| AU9378801A (en) | 2002-03-13 |
| BR0113585A (pt) | 2003-07-29 |
| CA2420177A1 (en) | 2002-03-07 |
| EP1315714B1 (en) | 2005-11-09 |
| CN1308324C (zh) | 2007-04-04 |
| EP1315714A2 (en) | 2003-06-04 |
| KR20030022421A (ko) | 2003-03-15 |
| DE60114852D1 (de) | 2005-12-15 |
| AR032475A1 (es) | 2003-11-12 |
| CA2420177C (en) | 2008-07-08 |
| ATE309240T1 (de) | 2005-11-15 |
| GT200100181A (es) | 2002-05-23 |
| DE60114852T2 (de) | 2006-07-27 |
| PE20020407A1 (es) | 2002-05-21 |
| MXPA03001777A (es) | 2003-06-04 |
| ZA200301082B (en) | 2004-05-07 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |