AU2001289659A1 - Tocotrienolquinone cyclisation product with an anti-hypercholesterol effect - Google Patents

Tocotrienolquinone cyclisation product with an anti-hypercholesterol effect

Info

Publication number
AU2001289659A1
AU2001289659A1 AU2001289659A AU8965901A AU2001289659A1 AU 2001289659 A1 AU2001289659 A1 AU 2001289659A1 AU 2001289659 A AU2001289659 A AU 2001289659A AU 8965901 A AU8965901 A AU 8965901A AU 2001289659 A1 AU2001289659 A1 AU 2001289659A1
Authority
AU
Australia
Prior art keywords
tocotrienolquinone
hypercholesterol
effect
sup
cyclisation product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001289659A
Other languages
English (en)
Inventor
Kai-Uwe Baldenius
Klaus Kramer
Karin Schein
Dr. Hartwig Schroder
Rainer Sturmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of AU2001289659A1 publication Critical patent/AU2001289659A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AU2001289659A 2000-07-14 2001-07-13 Tocotrienolquinone cyclisation product with an anti-hypercholesterol effect Abandoned AU2001289659A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10034233A DE10034233A1 (de) 2000-07-14 2000-07-14 Tocotrienolchinon-Cyclisierungsprodukte
DE10034233 2000-07-14
PCT/EP2001/008163 WO2002006261A1 (de) 2000-07-14 2001-07-13 Tocotrienolchinon-zyklisierungsprodukte mit antihypercholesterin wirkung

Publications (1)

Publication Number Publication Date
AU2001289659A1 true AU2001289659A1 (en) 2002-01-30

Family

ID=7648895

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001289659A Abandoned AU2001289659A1 (en) 2000-07-14 2001-07-13 Tocotrienolquinone cyclisation product with an anti-hypercholesterol effect

Country Status (10)

Country Link
US (1) US6977270B2 (da)
EP (1) EP1301501B1 (da)
JP (1) JP2004504313A (da)
CN (1) CN1441793A (da)
AT (1) ATE263160T1 (da)
AU (1) AU2001289659A1 (da)
DE (2) DE10034233A1 (da)
DK (1) DK1301501T3 (da)
ES (1) ES2218448T3 (da)
WO (1) WO2002006261A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120046237A1 (en) * 1998-04-08 2012-02-23 Theoharides Theoharis C Compositions for protection against superficial vasodilator flush syndrome, and methods of use
EP2471530B1 (en) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
PT1933821T (pt) * 2005-09-15 2020-10-15 Ptc Therapeutics Inc Variantes de cauda de terapêuticos redox-ativos para tratamento de doenças mitocondriais e outras condições e modulação de biomarcadores energéticos
CA2635280C (en) 2006-02-22 2017-12-12 Edison Pharmaceuticals, Inc. Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
WO2010030607A1 (en) 2008-09-10 2010-03-18 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
SI2963006T1 (sl) * 2008-10-28 2019-01-31 Bioelectron Technology Corporation Sestavek vsebujoč alfa-tokotrienol kinon in njegove vmesne povezave
DK2424495T3 (da) 2009-04-28 2018-04-30 Bioelectron Tech Corp Behandling af lebers arvelig optisk neuropati og dominant optisk atrofi med tocotrienol-quinoner
CN102647981B (zh) * 2009-08-26 2016-09-28 爱迪生制药有限公司 预防和治疗脑缺血的方法
JP2014520894A (ja) 2011-07-19 2014-08-25 エジソン ファーマシューティカルズ， インコーポレイテッド 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
US10251861B2 (en) 2012-06-08 2019-04-09 Ohio State Innovation Foundation Methods for treating burn and scar injury using tocotrienol compositions
WO2017106786A1 (en) 2015-12-16 2017-06-22 Bioelectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910007523A (ko) * 1989-10-04 1991-05-30 브리스톨-마이어즈 스퀴브 컴페니 과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올
US5217992A (en) * 1989-10-04 1993-06-08 Bristol-Myers Squibb Company Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
CA2050514A1 (en) 1990-09-14 1992-03-15 Bradley C. Pearce Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
CA2096496A1 (en) 1992-05-29 1993-11-30 Bradley C. Pearce Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
US5318993A (en) * 1993-04-16 1994-06-07 Bristol-Myers Squibb Company Antihyperlipidemic benzoquinones
EP0669132A1 (en) * 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis
JP3926888B2 (ja) 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤

Also Published As

Publication number Publication date
EP1301501A1 (de) 2003-04-16
WO2002006261A1 (de) 2002-01-24
DE50101861D1 (de) 2004-05-06
CN1441793A (zh) 2003-09-10
ATE263160T1 (de) 2004-04-15
ES2218448T3 (es) 2004-11-16
DE10034233A1 (de) 2002-01-24
US20040116715A1 (en) 2004-06-17
US6977270B2 (en) 2005-12-20
JP2004504313A (ja) 2004-02-12
DK1301501T3 (da) 2004-07-19
EP1301501B1 (de) 2004-03-31

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