AU2001283224B2 - Indole compounds useful for the treatment of cancer - Google Patents
Indole compounds useful for the treatment of cancer Download PDFInfo
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- AU2001283224B2 AU2001283224B2 AU2001283224A AU2001283224A AU2001283224B2 AU 2001283224 B2 AU2001283224 B2 AU 2001283224B2 AU 2001283224 A AU2001283224 A AU 2001283224A AU 2001283224 A AU2001283224 A AU 2001283224A AU 2001283224 B2 AU2001283224 B2 AU 2001283224B2
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- cancer
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/634,207 US7151100B1 (en) | 1999-07-23 | 2000-08-09 | Indole compounds useful for the treatment of cancer |
| US09/634,207 | 2000-08-09 | ||
| PCT/US2001/024978 WO2002012188A2 (fr) | 2000-08-09 | 2001-08-09 | Composes indoliques utilises dans le traitement du cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2001283224A1 AU2001283224A1 (en) | 2002-05-16 |
| AU2001283224B2 true AU2001283224B2 (en) | 2007-06-28 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001283224A Ceased AU2001283224B2 (en) | 2000-08-09 | 2001-08-09 | Indole compounds useful for the treatment of cancer |
| AU8322401A Pending AU8322401A (en) | 2000-08-09 | 2001-08-09 | Indole compounds useful for the treatment of cancer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU8322401A Pending AU8322401A (en) | 2000-08-09 | 2001-08-09 | Indole compounds useful for the treatment of cancer |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1307459A2 (fr) |
| JP (1) | JP2004518615A (fr) |
| AU (2) | AU2001283224B2 (fr) |
| CA (1) | CA2419060A1 (fr) |
| WO (1) | WO2002012188A2 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002520282A (ja) | 1998-07-09 | 2002-07-09 | フランシス エイ． ナーデラ， | 慢性リンパ性白血病の処置のための方法および組成物 |
| US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
| US7129262B2 (en) | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US7151100B1 (en) | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
| US7361680B2 (en) | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US20040152672A1 (en) * | 2000-08-09 | 2004-08-05 | Carson Dennis A. | Indole compounds useful for the treatment of cancer |
| US7211599B2 (en) | 2002-09-19 | 2007-05-01 | The Regents Of The University Of California | Use of etodolac to treat hyperplasia |
| US7314886B2 (en) | 2003-10-02 | 2008-01-01 | Cephalon, Inc. | Tetrahydropyrano-indole derivatives |
| FR2869231B1 (fr) * | 2004-04-27 | 2008-03-14 | Sod Conseils Rech Applic | Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine |
| EA031737B1 (ru) | 2010-06-03 | 2019-02-28 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) для лечения лейкоза и лимфомы |
| EP2771010A4 (fr) * | 2011-10-19 | 2015-04-01 | Pharmacyclics Inc | Utilisation d'inhibiteurs de la tyrosine kinase de bruton (btk) |
| JP6575950B2 (ja) | 2012-07-24 | 2019-09-18 | ファーマサイクリックス エルエルシー | Ｂｒｕｔｏｎ型チロシンキナーゼ（Ｂｔｋ）阻害剤に対する耐性を伴う変異 |
| JP2017509336A (ja) | 2014-03-20 | 2017-04-06 | ファーマサイクリックス エルエルシー | ホスホリパーゼｃガンマ２及び耐性に関連した変異 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3974179A (en) * | 1971-06-01 | 1976-08-10 | American Home Products Corporation | 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives |
| EP0289262A2 (fr) * | 1987-04-27 | 1988-11-02 | Syntex Pharmaceuticals International Limited | Alkylesters d'ammonium quaternaire-oméga et thioesters de médicaments antiinflammatoires acides non stéroiques |
| WO1998009603A2 (fr) * | 1996-09-06 | 1998-03-12 | Loma Linda University Medical Center | Compositions contenant des anti-inflammatoires non steroidiens a enantiomeres r et methodes therapeutiques et prophylactiques employant ces compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3843681A (en) * | 1971-06-01 | 1974-10-22 | American Home Prod | 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives |
| US4337760A (en) * | 1978-10-13 | 1982-07-06 | Adolf Schwimmer | Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals |
-
2001
- 2001-08-09 JP JP2002518166A patent/JP2004518615A/ja active Pending
- 2001-08-09 CA CA002419060A patent/CA2419060A1/fr not_active Abandoned
- 2001-08-09 AU AU2001283224A patent/AU2001283224B2/en not_active Ceased
- 2001-08-09 EP EP01962006A patent/EP1307459A2/fr not_active Withdrawn
- 2001-08-09 WO PCT/US2001/024978 patent/WO2002012188A2/fr active IP Right Grant
- 2001-08-09 AU AU8322401A patent/AU8322401A/xx active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3974179A (en) * | 1971-06-01 | 1976-08-10 | American Home Products Corporation | 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives |
| EP0289262A2 (fr) * | 1987-04-27 | 1988-11-02 | Syntex Pharmaceuticals International Limited | Alkylesters d'ammonium quaternaire-oméga et thioesters de médicaments antiinflammatoires acides non stéroiques |
| WO1998009603A2 (fr) * | 1996-09-06 | 1998-03-12 | Loma Linda University Medical Center | Compositions contenant des anti-inflammatoires non steroidiens a enantiomeres r et methodes therapeutiques et prophylactiques employant ces compositions |
Non-Patent Citations (3)
| Title |
|---|
| Chem. Abst. 112/13 (1990) 111681y. RN 125421-61-6. See generic formula RCOM(CH2)nN+R2R1 X- * |
| Chem. Abst. 126/16 (1997) 207064q * |
| Tetrahedron vol. 53, no. 52, 1997, pages 17769-17780, see example 6. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004518615A (ja) | 2004-06-24 |
| WO2002012188A3 (fr) | 2002-10-03 |
| AU8322401A (en) | 2002-02-18 |
| WO2002012188A2 (fr) | 2002-02-14 |
| CA2419060A1 (fr) | 2002-02-14 |
| WO2002012188B1 (fr) | 2003-03-20 |
| EP1307459A2 (fr) | 2003-05-07 |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |