AU2001261171A1 - Compounds and methods for the treatment and prevention of bacterial infection - Google Patents
Compounds and methods for the treatment and prevention of bacterial infectionInfo
- Publication number
- AU2001261171A1 AU2001261171A1 AU2001261171A AU6117101A AU2001261171A1 AU 2001261171 A1 AU2001261171 A1 AU 2001261171A1 AU 2001261171 A AU2001261171 A AU 2001261171A AU 6117101 A AU6117101 A AU 6117101A AU 2001261171 A1 AU2001261171 A1 AU 2001261171A1
- Authority
- AU
- Australia
- Prior art keywords
- moiety
- mutant
- pore
- mutation
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000036541 health Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- ZKVLEFBKBNUQHK-UHFFFAOYSA-N helium;molecular nitrogen;molecular oxygen Chemical compound [He].N#N.O=O ZKVLEFBKBNUQHK-UHFFFAOYSA-N 0.000 description 1
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- 238000002955 isolation Methods 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
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- 229930182817 methionine Natural products 0.000 description 1
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- 239000013612 plasmid Substances 0.000 description 1
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- 239000002157 polynucleotide Substances 0.000 description 1
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- 150000003109 potassium Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
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- FGDZQCVHDSGLHJ-UHFFFAOYSA-M rubidium chloride Inorganic materials [Cl-].[Rb+] FGDZQCVHDSGLHJ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20180000P | 2000-05-04 | 2000-05-04 | |
| US60201800 | 2000-05-04 | ||
| PCT/US2001/014372 WO2001082788A2 (fr) | 2000-05-04 | 2001-05-04 | Traitement et prevention d'infections bacteriennes et composes a cet effet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001261171A1 true AU2001261171A1 (en) | 2001-11-12 |
Family
ID=22747352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001261171A Abandoned AU2001261171A1 (en) | 2000-05-04 | 2001-05-04 | Compounds and methods for the treatment and prevention of bacterial infection |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7037503B2 (fr) |
| EP (1) | EP1278764A4 (fr) |
| JP (1) | JP2003531841A (fr) |
| KR (1) | KR20030019366A (fr) |
| CN (1) | CN1440419A (fr) |
| AU (1) | AU2001261171A1 (fr) |
| CA (1) | CA2407443A1 (fr) |
| CZ (1) | CZ20023662A3 (fr) |
| HU (1) | HUP0301658A2 (fr) |
| IL (1) | IL152553A0 (fr) |
| MX (1) | MXPA02010826A (fr) |
| NO (1) | NO20025204L (fr) |
| PL (1) | PL365453A1 (fr) |
| WO (1) | WO2001082788A2 (fr) |
| ZA (1) | ZA200208835B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455673B1 (en) * | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| AU2002239229A1 (en) | 2000-12-05 | 2002-06-18 | Wisconsin Alumni Research Foundation | Receptor for b. anthracis toxin |
| US7763451B2 (en) | 2001-11-09 | 2010-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for preparing Bacillus anthracis protective antigen for use in vaccines |
| JP2005511059A (ja) * | 2001-12-05 | 2005-04-28 | バートナガー ラケシュ | 非毒性炭疽ワクチンの調製のためのプロセス |
| AU2003213022A1 (en) * | 2002-02-11 | 2003-09-22 | Alexion Pharmaceuticals, Inc. | Immunotherapeutics for biodefense |
| US20040258699A1 (en) * | 2002-02-11 | 2004-12-23 | Bowdish Katherine S. | Immunotherapeutics for biodefense |
| US7201912B2 (en) * | 2002-04-12 | 2007-04-10 | Emergent Biodefense Operation Lansing Inc. | Recombinant immunogenic compositions and methods for protecting against lethal infections from Bacillus anthracis |
| EP1530634A4 (fr) | 2002-06-26 | 2005-11-02 | Human Genome Sciences Inc | Sequences shine-dalgarno et procedes d'utilisation |
| US7601351B1 (en) | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
| AU2003278776A1 (en) * | 2002-09-10 | 2004-04-30 | Vical Incorporated | Codon-optimized polynucleotide-based vaccines against bacillus anthracis infection |
| AU2003304316A1 (en) * | 2002-11-08 | 2005-01-28 | President And Fellows Of Harvard College | Compounds and methods for the treatment and prevention of bacterial infection |
| US20060014248A1 (en) * | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
| US20050130892A1 (en) * | 2003-03-07 | 2005-06-16 | Xencor, Inc. | BAFF variants and methods thereof |
| US20050221443A1 (en) * | 2003-01-06 | 2005-10-06 | Xencor, Inc. | Tumor necrosis factor super family agonists |
| US7553930B2 (en) * | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| JP4545151B2 (ja) * | 2003-02-06 | 2010-09-15 | シーラス コーポレイション | 非食細胞中への侵入について減弱化されているリステリア、そのリステリアを含むワクチン、およびそれらの使用法 |
| US7695725B2 (en) * | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| KR101173871B1 (ko) * | 2003-02-06 | 2012-08-16 | 앤저 테라퓨틱스 인코퍼레이티드 | 변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법 |
| US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| US20100003276A1 (en) * | 2004-12-07 | 2010-01-07 | Hermes Jeffery D | Methods for treating anthrax and inhibiting lethal factor |
| US20080206276A1 (en) * | 2005-07-08 | 2008-08-28 | Michael Otto | Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections |
| AU2007259329A1 (en) * | 2006-05-12 | 2007-12-21 | Farris, Darise | Anthrax compositions and methods of use and production |
| WO2009126355A2 (fr) * | 2008-01-28 | 2009-10-15 | Baxter International, Inc. | Procédés d’augmentation de la production recombinante de l’antigène protecteur de bacillus anthracis |
| US20110110968A1 (en) * | 2009-11-12 | 2011-05-12 | Stanley Goldman | Human optimized Bacillus anthracis protective antigen |
| DK3549949T5 (da) | 2011-04-22 | 2024-09-02 | Wyeth Llc | Sammensætninger vedrørende et mutant Clostridium-difficile-toksin og fremgangsmåder dertil |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792458A (en) * | 1987-10-05 | 1998-08-11 | The United States Of America As Represented By The Department Of Health And Human Services | Mutant diphtheria toxin conjugates |
| US5591631A (en) | 1993-02-12 | 1997-01-07 | The United States Of America As Represented By The Department Of Health And Human Services | Anthrax toxin fusion proteins, nucleic acid encoding same |
| US5677274A (en) * | 1993-02-12 | 1997-10-14 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Anthrax toxin fusion proteins and related methods |
| US5917017A (en) * | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| US6455673B1 (en) * | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| EP0866718A1 (fr) | 1995-12-13 | 1998-09-30 | President And Fellows Of Harvard College | Utilisation de peptides de toxine et/ou de marqueurs d'affinite pour l'introduction de composes dans des cellules |
| GB9618107D0 (en) * | 1996-08-30 | 1996-10-09 | Secr Defence | Vaccine production |
| AU2771099A (en) | 1998-02-18 | 1999-09-06 | President And Fellows Of Harvard College | Inhibition of toxin translocation |
| US6426231B1 (en) * | 1998-11-18 | 2002-07-30 | The Texas A&M University System | Analyte sensing mediated by adapter/carrier molecules |
| US6413768B1 (en) * | 1998-12-02 | 2002-07-02 | University Of Maryland | Expression plasmids |
| US6329156B1 (en) * | 1999-03-22 | 2001-12-11 | The Regents Of The University Of California | Method for screening inhibitors of the toxicity of Bacillus anthracis |
-
2001
- 2001-05-04 IL IL15255301A patent/IL152553A0/xx unknown
- 2001-05-04 WO PCT/US2001/014372 patent/WO2001082788A2/fr not_active Application Discontinuation
- 2001-05-04 CN CN01812400A patent/CN1440419A/zh active Pending
- 2001-05-04 EP EP01935043A patent/EP1278764A4/fr not_active Withdrawn
- 2001-05-04 JP JP2001579671A patent/JP2003531841A/ja active Pending
- 2001-05-04 HU HU0301658A patent/HUP0301658A2/hu unknown
- 2001-05-04 MX MXPA02010826A patent/MXPA02010826A/es unknown
- 2001-05-04 US US09/848,909 patent/US7037503B2/en not_active Expired - Fee Related
- 2001-05-04 KR KR1020027014690A patent/KR20030019366A/ko not_active Application Discontinuation
- 2001-05-04 AU AU2001261171A patent/AU2001261171A1/en not_active Abandoned
- 2001-05-04 PL PL01365453A patent/PL365453A1/xx unknown
- 2001-05-04 CA CA002407443A patent/CA2407443A1/fr not_active Abandoned
- 2001-05-04 CZ CZ20023662A patent/CZ20023662A3/cs unknown
-
2002
- 2002-10-30 NO NO20025204A patent/NO20025204L/no not_active Application Discontinuation
- 2002-10-31 ZA ZA200208835A patent/ZA200208835B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200208835B (en) | 2004-02-09 |
| CZ20023662A3 (cs) | 2003-04-16 |
| EP1278764A2 (fr) | 2003-01-29 |
| CN1440419A (zh) | 2003-09-03 |
| HUP0301658A2 (hu) | 2003-08-28 |
| NO20025204D0 (no) | 2002-10-30 |
| WO2001082788A2 (fr) | 2001-11-08 |
| US20020039588A1 (en) | 2002-04-04 |
| PL365453A1 (en) | 2005-01-10 |
| WO2001082788A3 (fr) | 2002-07-25 |
| KR20030019366A (ko) | 2003-03-06 |
| WO2001082788A9 (fr) | 2002-12-19 |
| NO20025204L (no) | 2002-12-16 |
| IL152553A0 (en) | 2003-05-29 |
| EP1278764A4 (fr) | 2004-05-19 |
| CA2407443A1 (fr) | 2001-11-08 |
| JP2003531841A (ja) | 2003-10-28 |
| US7037503B2 (en) | 2006-05-02 |
| MXPA02010826A (es) | 2006-03-09 |
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