AU2001257174A1 - Integrin/adhesion antagonists - Google Patents

Integrin/adhesion antagonists

Info

Publication number
AU2001257174A1
AU2001257174A1 AU2001257174A AU5717401A AU2001257174A1 AU 2001257174 A1 AU2001257174 A1 AU 2001257174A1 AU 2001257174 A AU2001257174 A AU 2001257174A AU 5717401 A AU5717401 A AU 5717401A AU 2001257174 A1 AU2001257174 A1 AU 2001257174A1
Authority
AU
Australia
Prior art keywords
composition
matter
peptide
seq
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001257174A
Other languages
English (en)
Inventor
Thomas Charles Boone
Ulrich Feige
Tadahiko Kohno
David Lee Lacey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2001257174A1 publication Critical patent/AU2001257174A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2001257174A 2000-04-21 2001-04-23 Integrin/adhesion antagonists Abandoned AU2001257174A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19891900P 2000-04-21 2000-04-21
US60198919 2000-04-21
US20139400P 2000-05-03 2000-05-03
US60201394 2000-05-03
PCT/US2001/013069 WO2001081377A2 (fr) 2000-04-21 2001-04-23 Antagonistes d'integrine/d'adhesion

Publications (1)

Publication Number Publication Date
AU2001257174A1 true AU2001257174A1 (en) 2001-11-07

Family

ID=26894282

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001257174A Abandoned AU2001257174A1 (en) 2000-04-21 2001-04-23 Integrin/adhesion antagonists

Country Status (7)

Country Link
US (1) US20020168363A1 (fr)
EP (1) EP1274730A2 (fr)
JP (1) JP2003530871A (fr)
AU (1) AU2001257174A1 (fr)
CA (1) CA2407086A1 (fr)
MX (1) MXPA02010351A (fr)
WO (1) WO2001081377A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887674B1 (en) 1998-04-13 2005-05-03 California Institute Of Technology Artery- and vein-specific proteins and uses therefor
WO2004078137A2 (fr) * 2003-03-04 2004-09-16 Greenville Hospital System Agents antitumoraux comprenant une partie de ciblage et une partie de declenchement de reponse immunitaire
JP4762889B2 (ja) 2003-03-12 2011-08-31 バスジーン セラピューティクス,インコーポレイテッド 血管形成及び腫瘍成長を阻止するための核酸化合物
CN101072797B (zh) 2004-03-12 2012-05-09 瓦斯基因治疗公司 结合ephb4、抑制血管发生和肿瘤生长的抗体
ATE492564T1 (de) 2004-03-12 2011-01-15 Vasgene Therapeutics Inc Ephb4-bindende antikörper zur inhibierung von angiogenese und tumorwachstum
US20050220760A1 (en) * 2004-04-02 2005-10-06 Clemson University Novel immunotherapy
EP1799713B1 (fr) 2004-09-23 2014-11-05 VasGene Therapeutics, Inc. Composes de polypeptides pour l'inhibition de l'angiogenese et de croissance tumorale
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
EP2237797A4 (fr) 2008-01-03 2012-11-07 Scripps Research Inst Ciblage d'anticorps par domaine de reconnaissance modulaire
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
AU2012258637B2 (en) 2011-05-24 2017-07-20 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
CN105451767B (zh) 2013-03-15 2019-10-18 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
WO2017158168A1 (fr) * 2016-03-18 2017-09-21 Fundació Institut De Bioenginyeria De Catalunya (Ibec) Inhibiteurs de liaison taline-vinculine pour le traitement du cancer
JP7291624B2 (ja) * 2016-11-01 2023-06-15 アローヘッド ファーマシューティカルズ インコーポレイテッド アルファ-vベータ-6インテグリンリガンド及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981478A (en) * 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
US5510332A (en) * 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
EP0727225A3 (fr) * 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions et méthodes pour l'imagerie ultrasonique dirigée
EP0906419A2 (fr) * 1996-03-28 1999-04-07 Chiron Corporation Ligands peptidiques du recepteur de l'urokinase
PT954588E (pt) * 1996-12-20 2007-03-30 Amgen Inc Composições que contêm uma proteína de fusão ob e métodos para a sua preparação e utilização
ES2388341T3 (es) * 1998-10-23 2012-10-11 Kirin-Amgen Inc. Péptidos miméticos de trombopoyetina diméricos que se unen al receptor MPL y que tienen actividad trombopoyética
DE60127656T2 (de) * 2000-02-25 2007-12-20 Immunex Corp., Seattle Integrin antagonisten
ES2260219T3 (es) * 2000-04-21 2006-11-01 Amgen Inc. Derivados de peptidos apo-ai/aii.

Also Published As

Publication number Publication date
EP1274730A2 (fr) 2003-01-15
WO2001081377A2 (fr) 2001-11-01
CA2407086A1 (fr) 2001-11-01
MXPA02010351A (es) 2003-04-25
US20020168363A1 (en) 2002-11-14
WO2001081377A3 (fr) 2002-07-18
JP2003530871A (ja) 2003-10-21

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