AU2001253038A1 - Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives - Google Patents

Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Info

Publication number
AU2001253038A1
AU2001253038A1 AU2001253038A AU5303801A AU2001253038A1 AU 2001253038 A1 AU2001253038 A1 AU 2001253038A1 AU 2001253038 A AU2001253038 A AU 2001253038A AU 5303801 A AU5303801 A AU 5303801A AU 2001253038 A1 AU2001253038 A1 AU 2001253038A1
Authority
AU
Australia
Prior art keywords
decarboxy
cosmetic
methods
pharmaceutical compositions
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001253038A
Inventor
Mitchell Anthony Delong
John Mcmillan Mciver
Robert Scott Youngquist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of AU2001253038A1 publication Critical patent/AU2001253038A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
    • A61Q5/065—Preparations for temporary colouring the hair, e.g. direct dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/304—Aromatic acids (P-C aromatic linkage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and treat bone disorders.
AU2001253038A 2000-03-31 2001-03-30 Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives Abandoned AU2001253038A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19384500P 2000-03-31 2000-03-31
US60193845 2000-03-31
PCT/US2001/010369 WO2001074314A2 (en) 2000-03-31 2001-03-30 Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Publications (1)

Publication Number Publication Date
AU2001253038A1 true AU2001253038A1 (en) 2001-10-15

Family

ID=22715254

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001253038A Abandoned AU2001253038A1 (en) 2000-03-31 2001-03-30 Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Country Status (10)

Country Link
US (5) US20020013294A1 (en)
EP (1) EP1267806B1 (en)
JP (1) JP2003528898A (en)
CN (1) CN1419438A (en)
AT (1) ATE311849T1 (en)
AU (1) AU2001253038A1 (en)
CA (1) CA2401888A1 (en)
DE (1) DE60115618T2 (en)
ES (1) ES2254401T3 (en)
WO (1) WO2001074314A2 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4834224B2 (en) 1999-03-05 2011-12-14 デューク ユニバーシティ C16 unsaturated FP-selective prostaglandin analogs
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US6696466B1 (en) * 2000-09-07 2004-02-24 Leslie Joe Dunaway Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines
US6765001B2 (en) * 2001-12-21 2004-07-20 Medicis Pharmaceutical Corporation Compositions and methods for enhancing corticosteroid delivery
SE0104421D0 (en) 2001-12-21 2001-12-21 Ponsus Pharma Ab New composition
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
US7326717B2 (en) 2003-05-06 2008-02-05 L'oreal Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof
CA2536281C (en) * 2003-08-21 2012-05-15 Sucampo Ag Ophthalmic composition comprising a 15-keto-prostaglandin compound
ES2331313T3 (en) * 2003-11-07 2009-12-29 Senju Pharmaceutical Co., Ltd. PHARMACEUTICAL COMPOSITION CONTAINING PROSTAGLANDIN.
WO2006047466A2 (en) * 2004-10-21 2006-05-04 Duke University Ophthamological drugs
JP4892483B2 (en) * 2004-12-29 2012-03-07 株式会社アールテック・ウエノ Compositions and methods for the treatment of the scalp and hair
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
WO2010102078A1 (en) * 2009-03-04 2010-09-10 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
EP2094839B1 (en) 2006-12-08 2020-02-05 University of Rochester Expansion of hematopoietic stem cells
US20090018204A1 (en) * 2007-07-13 2009-01-15 Brinkenhoff Michael C Composition and method for enhancing hair growth
FR2920309B1 (en) 2007-08-28 2010-05-28 Galderma Res & Dev USE OF TRAVOPROST TO TREAT THE FALL OF HAIR
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
WO2010064203A1 (en) 2008-12-02 2010-06-10 L'oreal Combination of reduced glutathione and amino acids for improving the quality of the hair in women
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
EP3533445A1 (en) 2009-03-19 2019-09-04 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
FR2949052B1 (en) 2009-08-13 2015-03-27 Oreal PROCESS FOR COSMETIC TREATMENT OF SCALP.
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
CA2807944C (en) 2010-08-12 2020-02-18 Fate Therapeutics, Inc. Improved hematopoietic stem and progenitor cell therapy
KR102011532B1 (en) 2011-09-30 2019-08-16 블루버드 바이오, 인코포레이티드. Compounds for improved viral transduction
EP3381456A1 (en) 2011-12-02 2018-10-03 Fate Therapeutics, Inc. Improved methods for treating ischemia
CA2857640C (en) 2011-12-02 2021-11-16 Fate Therapeutics, Inc. Enhanced stem cell composition
US9790233B2 (en) 2012-04-16 2017-10-17 Case Western Reserve University Compositions and methods of modulating 15-PGDH activity
WO2014150602A1 (en) 2013-03-15 2014-09-25 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
KR102061716B1 (en) * 2013-08-30 2020-01-02 (주)아모레퍼시픽 Composition for promoting hair growth or restoration containing 21-o-angeloyltheasapogenol e3
EP3057973B1 (en) 2013-10-15 2019-09-04 Case Western Reserve University Compositions comprising a 15-pgdh inhibitor for the healing of wounds
EP3250682A4 (en) 2015-01-26 2018-08-01 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
EP3324982A4 (en) 2015-07-21 2019-01-09 The Children's Medical Center Corporation Pd-l1 expressing hematopoietic stem cells and uses
CA3010236A1 (en) 2016-01-20 2017-07-27 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
JP2019502725A (en) 2016-01-20 2019-01-31 フェイト セラピューティクス，インコーポレイテッド Compositions and methods for immune cell regulation in adoptive immunotherapy
WO2017139561A1 (en) 2016-02-12 2017-08-17 Bluebird Bio, Inc. Vcn enhancer compositions and methods of using the same
AU2017217813B2 (en) 2016-02-12 2023-08-03 Bluebird Bio, Inc. VCN enhancer compositions and methods of using the same
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
WO2018106595A1 (en) 2016-12-05 2018-06-14 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
AU2018215678A1 (en) 2017-02-06 2019-08-22 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
JOP20210115A1 (en) 2018-11-21 2023-01-30 Univ Texas Compositions and methods of modulating short-chain dehydrogenase activity
US20230193212A1 (en) 2020-05-06 2023-06-22 Orchard Therapeutics (Europe) Limited Treatment for neurodegenerative diseases
CA3183262A1 (en) 2020-05-20 2021-11-25 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity

Family Cites Families (329)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US146439A (en) * 1874-01-13 Improvement in pruning-shears
US37913A (en) * 1863-03-17 Improvement in sewing-machines
US37914A (en) * 1863-03-17 Improved automatic nose-bag
DE1617477U (en) 1950-09-27 1950-12-14 Heinrich Dressel WHEEL HOLDER FOR BIKES, FOR EXAMPLE FOR BABY CARRIAGES AND SMALL VEHICLES.
US3776939A (en) * 1958-05-28 1973-12-04 S Bergstrom Dihydro-pgf1a
US3776938A (en) * 1958-05-28 1973-12-04 S Bergstrom Dihydro-pge1
US3069322A (en) * 1958-05-28 1962-12-18 Bergstrom Sune Pge and pgf
US3839409A (en) * 1958-05-28 1974-10-01 Kemiska Inst Karolinska I Pge3 esters and alkanoates
US3461461A (en) * 1965-11-01 1969-08-12 Upjohn Co 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines
US3524867A (en) * 1966-06-06 1970-08-18 Upjohn Co Process for producing cyclopenta (b)pyrans
US3435053A (en) * 1966-06-06 1969-03-25 Upjohn Co Cyclopenta(b)pyrans
US3538120A (en) 1967-05-22 1970-11-03 Ciba Geigy Corp Cyclopentyl-alkanoic acids
DE1617477A1 (en) 1967-06-22 1970-01-08 Fischer Geb Beutelschiess Alwi Organic hair growth tonic with guarantee
US3636120A (en) * 1967-10-09 1972-01-18 Upjohn Co Prostaglandin e primary alcohols
GB1285371A (en) 1968-08-29 1972-08-16 Upjohn Co Improvements in or relating to therapeutic methods using prostaglandins
GB1251750A (en) 1968-11-12 1971-10-27
DE1910561A1 (en) 1969-03-01 1970-09-10 Herten Dr Med Kurt Hair loss prevention agents
BE755555A (en) * 1969-09-02 1971-03-01 Richardson Merrell Inc QUINOXALINE DERIVATIVES
US3882241A (en) * 1969-12-01 1975-05-06 Upjohn Co Use of prostaglandins E and F for prevention of pregnancy in humans
US3896156A (en) * 1970-06-30 1975-07-22 Upjohn Co Dihydroprostaglandin e, analogs
IT1012505B (en) 1970-09-28 1977-03-10 Imes C Spa SEA URCHIN EXTRACT
GB1324737A (en) 1970-11-02 1973-07-25 Upjohn Co Prostaglandins and the preparation thereof
JPS5212919Y2 (en) 1971-06-14 1977-03-23
BE791369A (en) 1971-11-16 1973-05-14 American Cyanamid Co TRIS- (META-HYDROXYBENZYL) CYANURATES SUBJECT TO STERIC PREVENTION AND USE AS ANTI-OXIDANTS
JPS525744Y2 (en) 1972-03-18 1977-02-05
US3798275A (en) * 1972-04-05 1974-03-19 Ciba Geigy Corp Etherified mercapto-methoxyamines
GB1386146A (en) 1972-05-03 1975-03-05 Ici Ltd Cyclopentane derivatives
US4304907A (en) 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
US3974213A (en) 1972-07-13 1976-08-10 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
GB1428137A (en) 1972-09-27 1976-03-17 Ici Ltd Prostanoic acid derivatives
JPS4969636U (en) 1972-09-29 1974-06-18
JPS5220141Y2 (en) 1972-10-13 1977-05-10
US3882245A (en) * 1972-11-01 1975-05-06 Upjohn Co Use of prostaglandins in combating shock
JPS4969636A (en) 1972-11-07 1974-07-05
US3984424A (en) 1972-11-08 1976-10-05 Pfizer Inc. P-biphenyl esters of 15-substituted-ω-pentanorprostaglandins
US4152527A (en) * 1972-11-08 1979-05-01 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
DD118856A5 (en) 1972-11-08 1976-03-20
US4024179A (en) * 1972-11-08 1977-05-17 Pfizer Inc. Substituted ω-pentanorprostaglandins
IL43571A (en) 1972-11-08 1977-08-31 Pfizer Omega-pentanorprostaglandins and their preparation
JPS4993342U (en) 1972-12-05 1974-08-13
JPS5253841Y2 (en) 1972-12-12 1977-12-07
JPS49101356U (en) 1972-12-20 1974-08-31
JPS49100071U (en) 1972-12-20 1974-08-28
JPS5320995Y2 (en) 1972-12-23 1978-06-02
JPS49101356A (en) 1973-02-07 1974-09-25
JPS49102647A (en) 1973-02-14 1974-09-27
JPS5720305B2 (en) 1973-02-28 1982-04-27
US3984455A (en) * 1973-07-16 1976-10-05 The Upjohn Company Prostaglandin E1 analogs
JPS5118118Y2 (en) 1973-07-17 1976-05-14
FR2239458A1 (en) 1973-07-31 1975-02-28 Aries Robert Prostaglandin amides - with antilipolytic, gonadotrophic, luteolytic, hypotensive and other activities associated with prostaglandins
DE2365101A1 (en) 1973-12-21 1975-07-10 Schering Ag NEW PROSTANIC ACID DERIVATIVES AND METHOD FOR THEIR PRODUCTION
US3931282A (en) 1974-02-21 1976-01-06 Syntex (U.S.A.) Inc. 11α-Hydroxymethyl prostaglandins
US3928588A (en) * 1974-02-22 1975-12-23 Upjohn Co Method of reducing the undesirable gastrointestinal effects of prostaglandin synthetase inhibitors
JPS50157344A (en) 1974-03-20 1975-12-19
DE2416193C2 (en) * 1974-04-03 1985-08-14 Hoechst Ag, 6230 Frankfurt Prostaglandin analogs, processes for their preparation and their use as cytoprotective agents
GB1458315A (en) 1974-04-22 1976-12-15 Ici Ltd Prostanoic acid derivatives
JPS50142539U (en) 1974-05-13 1975-11-25
JPS50157344U (en) 1974-06-12 1975-12-26
US3964455A (en) * 1974-12-19 1976-06-22 General Motors Corporation Valve control mechanism
DE2460990A1 (en) 1974-12-21 1976-07-01 Hoechst Ag NEW PROSTAGLANDIN ANALOGS AND PROCEDURES FOR THEIR PRODUCTION
JPS5186449U (en) 1974-12-30 1976-07-10
GB1507211A (en) * 1975-02-14 1978-04-12 Ono Pharmaceutical Co Prostaglandin analogues
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition
US4217360A (en) * 1975-02-27 1980-08-12 Schering Aktiengesellschaft Novel 1,3-benzodioxaneprostanoic acid derivatives and process for the preparation thereof
GB1506817A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
DE2517771A1 (en) * 1975-04-18 1976-10-28 Schering Ag NEW PROSTAGLANDIN ACETYLENE ANALOGS AND METHOD FOR THEIR PRODUCTION
JPS5328160Y2 (en) 1975-05-16 1978-07-15
GB1517562A (en) 1975-06-13 1978-07-12 Ici Ltd Prostane derivatives
GB1520522A (en) 1975-06-16 1978-08-09 Ono Pharmaceutical Co 16-methyleneprostaglandins
ES449162A1 (en) 1975-06-23 1977-12-16 Syntex Inc 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
JPS582925B2 (en) 1975-07-21 1983-01-19 カケンカガク カブシキガイシヤ Anteina prostaglandin F2 alpha
US4005133A (en) 1975-10-14 1977-01-25 The Upjohn Company PGF2.sub.α, L-Arginine salt
US4128577A (en) 1975-12-29 1978-12-05 The Upjohn Company 15-Methyl- and 16-phenoxy-PGF2 α, amides
US4158667A (en) * 1976-02-04 1979-06-19 The Upjohn Company 6-Keto PGF analogs
US4596812A (en) * 1976-05-24 1986-06-24 The Upjohn Company Methods and solutions for treating male pattern alopecia
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4051238A (en) 1976-06-03 1977-09-27 The Upjohn Company Treatment of genital tract diseases of domestic animals with prostaglandins
US4268522A (en) * 1976-06-14 1981-05-19 Pfizer Inc. 13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof
DE2635985A1 (en) * 1976-08-06 1978-02-09 Schering Ag PROSTANIC ACID DERIVATIVE AND PROCESS FOR THEIR PRODUCTION
DE2737808A1 (en) 1976-08-27 1978-03-16 Pfizer 2-SUBSTITUTED ARYL HETEROCYCLIC OMEGA PENTANOR PROSTAGLANDIN
DE2737807A1 (en) 1976-08-27 1978-03-09 Pfizer C LOW 1 -P-BIPHENYLESTER OF OMEGA-PENTANORPROSTAGLANDINES
US4499293A (en) * 1976-09-22 1985-02-12 The Upjohn Company PGI2 Salts
US4123441A (en) * 1976-09-22 1978-10-31 The Upjohn Company Enlarged-hetero-ring prostacyclin analogs
US4089885A (en) * 1976-11-05 1978-05-16 American Home Products Corporation Prostaglandin derivatives
US4171331A (en) 1978-06-05 1979-10-16 Miles Laboratories, Inc. 1 And 2-substituted analogues of certain prostaglandins
US4178457A (en) 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
US4206151A (en) * 1978-12-21 1980-06-03 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl or cyclopropyl prostan-1-ols of the E, A and F series
US4311707A (en) * 1979-02-12 1982-01-19 American Cyanamid Company Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions
GB2048254B (en) 1979-04-02 1983-05-25 Upjohn Co 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives
JPS5829710Y2 (en) 1979-05-25 1983-06-29 スガツネ工業株式会社 lock
US4225508A (en) * 1979-07-05 1980-09-30 The Upjohn Company 19-Hydroxy-PGI2 compounds
US4225507A (en) * 1979-07-05 1980-09-30 The Upjohn Company 19-Hydroxy-19-methyl-PGI2 compounds
US4296504A (en) 1980-07-07 1981-10-27 Lawson Daniel C Toilet seat lock
JPS6032763Y2 (en) 1980-09-06 1985-09-30 日興エンジニアリング株式会社 liquid filling equipment
JPH0222226Y2 (en) 1981-02-04 1990-06-14
JPS5829710A (en) 1981-03-25 1983-02-22 ジ・アツプジヨン・カンパニ− Remedy for osteoporosis by prostaglandins
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
US4543353A (en) 1981-11-27 1985-09-24 Farmitalia Carlo Erba S.P.A. Ester and amide derivatives of 13,14-didehydro prostaglandins
US4599353A (en) 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
JPS6032763A (en) 1983-07-29 1985-02-19 Nippon Iyakuhin Kogyo Kk Novel 11-oxoprostanoic acid derivative and its use
US4912235A (en) 1983-12-22 1990-03-27 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers
EP0187854A4 (en) 1984-07-13 1987-01-22 Gail S Bazzano Substituted pyrimidine oxides useful for hair growth promotion.
NZ212914A (en) 1984-07-31 1988-08-30 Syntex Inc Tetranorprostaglandin derivatives and pharmaceutical compositions
JPS6134778U (en) 1984-07-31 1986-03-03 株式会社明電舎 electrical equipment storage box
JPS61126069A (en) * 1984-11-21 1986-06-13 Res Dev Corp Of Japan Prostaglandin derivative
JPS61218510A (en) 1985-03-22 1986-09-29 Dai Ichi Seiyaku Co Ltd Agent for hair
US4757089A (en) 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
US5863948A (en) * 1985-06-14 1999-01-26 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
US4704386A (en) * 1985-08-29 1987-11-03 G. D. Searle & Co. 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides
US4883819A (en) 1986-07-31 1989-11-28 The Trustees Of Columbia University In The City Of New York Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
FI872552A (en) * 1986-06-09 1987-12-10 American Cyanamid Co PROSTAGLANDINKOMPOSITION FOER LOKALT BRUK.
US4889845A (en) * 1986-06-09 1989-12-26 American Cyanamid Company Vehicle for topical application of pharmaceuticals
US5041439A (en) 1986-06-13 1991-08-20 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US5663203A (en) * 1986-09-11 1997-09-02 Schering Aktiengesellschaft Agents containing prostacyclin derivatives for topical application
US5500230A (en) * 1987-01-23 1996-03-19 The General Hospital Corporation Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators
US5219885A (en) * 1987-02-16 1993-06-15 Froelich Juergen Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration
JPS63211231A (en) 1987-02-27 1988-09-02 Sumitomo Pharmaceut Co Ltd Remedy for male infertile animal
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
GB8713747D0 (en) 1987-06-12 1987-07-15 Unilever Plc Skin treatment composition
US5166178B1 (en) 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
GB2209939B (en) 1987-09-18 1992-01-02 R Tech Ueno Ltd The use of 13,14-dihydro-15-keto-prostaglandins as ocular hypotensive agents
SE8703854D0 (en) 1987-10-07 1987-10-07 Pharmacia Ab PROSTAGLAND INGREDIENTS FOR TREATMENT OF GLAUCOME OR OCULAR HYPERTENSION
AU619543B2 (en) 1988-05-11 1992-01-30 Sucampo Ag Use of 15-ketoprostaglandin e or f compounds for uterine contraction
JPH0222226A (en) 1988-07-12 1990-01-25 Ono Pharmaceut Co Ltd Remedy for osteopathic disease containing pgd analog compound as active ingredient
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP0569046B1 (en) * 1988-09-06 2002-11-13 Pharmacia Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5194429A (en) * 1988-10-01 1993-03-16 K.K. Ueno Seiyaku Oyo Kenkyujo Ocular hypotensive agents
FR2647675B1 (en) 1989-06-05 1994-05-20 Sanofi USE OF A STATINE DERIVATIVE IN THE TREATMENT OF EYE CONDITIONS
US4968812A (en) 1989-06-23 1990-11-06 Shell Oil Company Spirolactonelactams
JPH0737390B2 (en) 1989-08-29 1995-04-26 久光製薬株式会社 Ointment composition
JPH0737389B2 (en) 1989-08-29 1995-04-26 久光製薬株式会社 Ointment containing prostaglandin E1
CA1339132C (en) 1989-09-12 1997-07-29 Johan W. Stjernschantz Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
JPH0627942Y2 (en) 1989-12-14 1994-07-27 松下電器産業株式会社 Condenser with fuse holder
JPH0720909Y2 (en) 1989-12-14 1995-05-15 松下電器産業株式会社 condenser
CA2039420C (en) * 1990-04-04 1996-12-10 Ryuji Ueno Treatment of cataract with 15-keto-prostaglandin compounds
US5063057A (en) * 1990-09-26 1991-11-05 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic capsules
US5302617A (en) * 1990-04-27 1994-04-12 Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
DE4024347A1 (en) 1990-07-27 1992-01-30 Schering Ag CYCLOPENTANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL USE
JPH04300833A (en) 1991-03-29 1992-10-23 Green Cross Corp:The Prostaglandin e1-containing fat emulsion-loaded aerosol
US5378840A (en) * 1992-04-16 1995-01-03 G. D. Searle & Co. Substituted dibenzoxazepine compounds
US5312832A (en) * 1991-05-17 1994-05-17 Allergan, Inc. Ocular hypotensive 2-decarboxyl-2-acylthioalkyl prostaglandin derivatives
US5288754A (en) * 1992-02-04 1994-02-22 Allergan, Inc. Polar C-1 esters of prostaglandins
US5641494A (en) * 1992-03-20 1997-06-24 Janssen Pharmaceutica N.V. Agent for regulating the greasiness of the skin
US5578643A (en) * 1992-05-20 1996-11-26 Loyola University Of Chicago Protective prostaglandins for use in conjunction with chemotherapeutic agents
US5422371A (en) * 1992-05-27 1995-06-06 Arch Development Corp. Methods and compositions for inhibiting 5α-reductase activity
JP3102141B2 (en) * 1992-05-29 2000-10-23 東レ株式会社 Hair restorer
US5817694A (en) * 1992-06-08 1998-10-06 New Pharma International Corp. 16-methyl-11,16-dihydroxy-9-oxoprost-2,13-dien-1-oic acid and derivatives
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
US5972991A (en) * 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5688819A (en) 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
CA2146127C (en) * 1992-10-13 2000-06-13 Louis Desantis, Jr. Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma
US5332730A (en) 1992-10-16 1994-07-26 Allergan, Inc. Azido derivatives of cyclopentane heptanoic or heptenoic acid
US5340813A (en) * 1992-11-09 1994-08-23 Cell Therapeutics, Inc. Substituted aminoalkyl xanthine compounds
DE4238830A1 (en) * 1992-11-17 1994-05-19 Anton Felder Process for hydraulically branching an open flow and hydraulically operating channel branching
US5670506A (en) * 1993-04-05 1997-09-23 Cell Therapeutics, Inc. Halogen, isothiocyanate or azide substituted xanthines
US5395932A (en) * 1993-04-30 1995-03-07 G. D. Searle & Co. 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5985597A (en) * 1993-05-26 1999-11-16 Merck Frosst Canada, Inc. DNA encoding prostaglandin receptor EP1
CA2165953C (en) 1993-06-25 2003-08-19 Mark Abramovitz Prostaglandin receptor ep3 and dna encoding it
US5869281A (en) * 1993-06-25 1999-02-09 Merck Frosst Canada Inc. DNA encoding prostaglandin receptor FP
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5605814A (en) * 1993-08-31 1997-02-25 Merck Frosst Canada Inc. DNA encoding human prostaglandin receptor EP2
US5516652A (en) * 1993-10-06 1996-05-14 Merck Frosst Canada Inc. DNA encoding prostaglandin receptor IP
FR2711060B1 (en) 1993-10-13 1995-11-17 Oreal Method for modifying the growth of hair and / or hair and compositions which can be used for this purpose.
SE9303444D0 (en) 1993-10-20 1993-10-20 Kabi Pharmacia Ab New use of prostaglandins
WO1995011033A1 (en) 1993-10-22 1995-04-27 Commonwealth Scientific And Industrial Research Organisation Polyoxometallates in the treatment of flavivirus infections
SE9303627D0 (en) * 1993-11-03 1993-11-03 Kabi Pharmacia Ab Method and means for the prevention of cataract
US5431881A (en) 1993-12-10 1995-07-11 Palacios; Henry J. Treatment of hair loss and dermatological problems
CA2179399A1 (en) * 1993-12-20 1995-06-29 Kiyoshi Taniguchi 4,5-diaryloxazole derivatives
US6124344A (en) 1993-12-28 2000-09-26 Allergan Sales, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US5458883A (en) 1994-01-12 1995-10-17 Duke University Method of treating disorders of the eye
US5462968A (en) 1994-01-19 1995-10-31 Allergan, Inc. EP2 -receptor agonists as agents for lowering intraocular pressure
SE9403158D0 (en) * 1994-09-21 1994-09-21 Pharmacia Ab New use of prostaglandins
US5698733A (en) 1994-09-30 1997-12-16 Alcon Laboratories, Inc. Use of 9-deoxy prostaglandin derivatives to treat glaucoma
US5885974A (en) * 1994-12-06 1999-03-23 Michael M. Danielov Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor
AU714054B2 (en) * 1995-01-06 1999-12-16 Toray Industries, Inc. Benzene-fused heterocyclic derivatives and use of the same
JP3064015B2 (en) * 1995-01-26 2000-07-12 メルク フロスト カナダ アンド カンパニー Prostaglandin receptor DP
US5885766A (en) * 1995-02-17 1999-03-23 Societe L'oreal S.A. Method of screening of substances for their effect on the expression of mediators of inflammation in a hair follicle
FR2730811B1 (en) 1995-02-17 1997-03-21 Oreal METHOD FOR DIAGNOSING AND / OR MONITORING THE EVOLUTION OF A HAIR DISORDER AND / OR MEASURING THE EFFECTIVENESS OF A TREATMENT APPLIED TO COMBAT A HAIR DISORDER
EP0825980B1 (en) 1995-05-18 2001-07-04 Allergan Sales, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylakenyl derivatives as therapeutic agents for the treatment of ocular hypertension
WO1998021180A1 (en) 1995-06-07 1998-05-22 Alcon Laboratories, Inc. Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
DE69610481T2 (en) * 1995-06-26 2001-04-26 Teijin Ltd PROSTAGLANDINE AND METHOD FOR THE PRODUCTION THEREOF
TW401408B (en) * 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
HUP9601442A3 (en) * 1995-07-25 1999-03-29 Panacea Biotec Ltd Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
US5661178A (en) 1995-09-01 1997-08-26 Allergan Method for effecting vasodilation with (1,5-inter)aryl prostaglandin derivatives
US6251436B1 (en) 1995-09-29 2001-06-26 L.A.M. Pharmaceutical Corporation Drug preparations for treating sexual dysfunction
WO1997015319A1 (en) 1995-10-23 1997-05-01 Queen's University At Kingston Method and pharmaceutical composition for chondrostimulation with a prostaglandin (e.g. misoprostol) and tgf-beta, optionally in combination with igf-1
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO1997023226A1 (en) 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of prostaglandins and miotics for lowering intraocular pressure
US5866602A (en) 1995-12-22 1999-02-02 Alcon Laboratories, Inc. Keto-substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
US5814660A (en) 1995-12-22 1998-09-29 Alcon Laboratories, Inc. 9-oxa prostaglandin analogs as ocular hypotensives
AU7680096A (en) 1995-12-22 1997-07-17 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
CA2236582C (en) * 1995-12-22 2004-08-17 Alcon Laboratories, Inc. Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
US5741810A (en) 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
US5658897A (en) * 1996-04-08 1997-08-19 Allergan Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents
US5990168A (en) 1996-04-18 1999-11-23 Alberta Cancer Board Methods and compositions for the treatment of ataxia telangiectasia
JP3049593B2 (en) 1996-05-01 2000-06-05 株式会社ビメーク Hair restorer
US6242485B1 (en) 1996-06-10 2001-06-05 R-Tech Ueno Endothelin antagonist
AU3588797A (en) 1996-07-03 1998-01-21 Board Of Regents Of The University Of Oklahoma, The Enhancement of skin pigmentation by prostaglandins
US5792851A (en) * 1996-09-03 1998-08-11 Albert Einstin College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Human prostaglandin transporter
EP0930296B2 (en) 1996-09-17 2005-11-02 Asahi Glass Company Ltd. Fluorinated prostaglandin derivatives and medicines
JP4004109B2 (en) 1996-09-17 2007-11-07 参天製薬株式会社 Fluorine-containing prostaglandin derivatives and pharmaceuticals
US5827508A (en) 1996-09-27 1998-10-27 The Procter & Gamble Company Stable photoprotective compositions
WO1998019680A1 (en) 1996-11-01 1998-05-14 Alcon Laboratories, Inc. Use of a combination of carbonic anhydrase inhibitors and prostaglandins for treating glaucoma
WO1998020880A2 (en) 1996-11-12 1998-05-22 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
JP2001504122A (en) 1996-11-12 2001-03-27 アルコン ラボラトリーズ，インコーポレイテッド CIS-Δ ▲ 4４ analogs of prostaglandins as intraocular pressure lowering agents
JP4248022B2 (en) 1996-11-12 2009-04-02 アルコン ラボラトリーズ，インコーポレイテッド 15-Fluoroprostaglandin as an intraocular pressure-lowering agent
US6353014B1 (en) 1996-11-12 2002-03-05 Alcon Laboratories, Inc. 15-ketal postaglandins for the treatment of glaucoma or ocular hypertension
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
IL130333A0 (en) 1996-12-20 2000-06-01 Pfizer Prevention and treatment of skeletal disorder with EP2 receptor subtype selective prostaglandin E2 agonists
UA59384C2 (en) 1996-12-20 2003-09-15 Пфайзер, Інк. Preventing bone mass loss and recovery thereof by means of prostaglandin agonists
JPH10265454A (en) * 1997-01-27 1998-10-06 Ono Pharmaceut Co Ltd 3,7dithiaprostanoic acid derivative, its production and medicine containing the same derivative as active ingredient
NO317155B1 (en) 1997-02-04 2004-08-30 Ono Pharmaceutical Co <Omega> -cycloalkyl-prostaglandin-E <N> 2 </ N> derivatives
DE69823852T2 (en) 1997-02-04 2005-05-19 Johnstone, Murray A., Seattle PROCESS FOR PROMOTING HAIR GROWTH AND DEVELOPING THE HAIR SYSTEM
KR20000070903A (en) 1997-02-10 2000-11-25 오노 야꾸힝 고교 가부시키가이샤 11,15-o-dialkylprostagladin e derivatives, process for producing the same, and drugs containing the same as the active ingredient
WO1998037895A1 (en) 1997-02-27 1998-09-03 Toray Industries, Inc. Drugs for ameliorating pulmonary circulation
WO1998039293A2 (en) 1997-03-07 1998-09-11 Alcon Laboratories, Inc. 13-thia prostaglandins for use in glaucoma therapy
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs
JP3217293B2 (en) * 1997-04-17 2001-10-09 株式会社アールテック・ウエノ Hair growth / hair restorer
IT1291633B1 (en) 1997-04-22 1999-01-11 Pharmaconsult S A S USE OF ALPHA-METHYL-P-THYROSINE TO INHIBIT THE PRODUCTION OF MELANIN IN THE MELANOCYTES OF THE IRIS
EP1007028A4 (en) 1997-05-09 2002-06-05 8-iso-prostaglandins for glaucoma therapy
JP2002501533A (en) 1997-05-30 2002-01-15 メルク エンド カンパニー インコーポレーテッド Ophthalmic composition for the treatment of ocular hypertension
AU7349298A (en) 1997-06-23 1999-01-04 Pfizer Inc. Prostaglandin agonists
SE9702706D0 (en) 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side effects for the treatment of glaucoma
WO1999012556A1 (en) 1997-09-08 1999-03-18 The Public Health Research Institute Of The City Of New York, Inc. HIV-1 gp120 V1/V2 DOMAIN EPITOPES CAPABLE OF GENERATING NEUTRALIZING ANTIBODIES
WO1999012553A1 (en) 1997-09-08 1999-03-18 Idec Pharmaceuticals Corporation Methods for producing human antibodies in scid mice using dendritic cells
WO1999012899A1 (en) 1997-09-09 1999-03-18 The Procter & Gamble Company A process for making prostaglandin f analogs
AUPO907697A0 (en) 1997-09-09 1997-10-02 Day, Robert Edward Chemical supplementation of bone
DE69824966T2 (en) * 1997-09-09 2005-04-07 Duke University AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO-PROSTAGLANDINE USES AS FP AGONISTE
EP1035853A1 (en) 1997-09-09 2000-09-20 The Procter & Gamble Company Use of f prostanoid receptor agonists for treating a bone disorder
RS49707B (en) 1997-09-09 2007-12-31 F.Hoffmann-La Roche Ag., Application of a polypeptide analog of parathyroid hormone related peptide (pthrp) and salts thereof for the preparation of a medicament for the treatment of bone healing
CN1269785A (en) 1997-09-09 2000-10-11 普罗克特和甘保尔公司 Aromatic C16-C20 substituted tetrahydro prostaglandius useful as EP agonists
WO1999012898A1 (en) * 1997-09-09 1999-03-18 The Procter & Gamble Company Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
KR20010023840A (en) 1997-09-09 2001-03-26 데이비드 엠 모이어 Method of increasing bone volume using non-naturally-occurring fp selective agonists
ATE363914T1 (en) 1997-09-09 2007-06-15 Curis Inc SYNERGISTIC EFFECT OF THE OB/BMP MORPHOGEN AND GDNF/NGF NEUROTROPHIC FACTORS
ID24840A (en) 1997-09-09 2000-08-24 Procter & Gamble PROCESS TO MAKE INGREDIENTS BETWEEN EPOXIDE
EP1011709A4 (en) 1997-09-09 2003-06-18 Univ California Inhibition of apoptotis using prosaposin receptor agonists
AU9312598A (en) 1997-09-10 1999-03-29 Allegheny University Of The Health Sciences Inhibitors of collagen assembly
WO1999012552A1 (en) 1997-09-10 1999-03-18 Merck & Co., Inc. 9a-AZALIDES AS VETERINARY ANTIMICROBIAL AGENTS
WO1999012563A2 (en) 1997-09-11 1999-03-18 The Governemnt Of The United States Of America, Represented By The Department Of Health And Human Services Mucosal cytotoxic t lymphocyte responses
US6331319B1 (en) 1997-09-11 2001-12-18 Purdue Research Foundation Galactosidase modified submucosal tissue
US6326170B1 (en) 1997-09-12 2001-12-04 Smithkline Beecham Corp. Prokaryotic polynucleotides, polypeptides and their uses
EP0970697A4 (en) 1997-09-17 2001-02-21 Toray Industries Cervical maturing agent
ATE253047T1 (en) 1997-09-19 2003-11-15 Shionogi & Co COMPOUNDS WITH (2.2.1)BICYCLIC MOLECULAR STRUCTURE
UA67754C2 (en) 1997-10-10 2004-07-15 Пфайзер, Інк. Prostaglandin agonists and use thereof for the treatment of bone disorders
US6124314A (en) 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
JP2001520999A (en) 1997-10-28 2001-11-06 アシビ， エルエルシー Treatment of sexual dysfunction in women
AUPP010397A0 (en) 1997-10-30 1997-11-20 Vaisman, Jakov Method and composition for treatment of sexual dysfunction
AU1373499A (en) 1997-11-14 1999-06-07 United Therapeutics Corporation Use of 9-deoxy-2', 9-alpha-methano-3- oxa-4,5,6- trinor-3, 7-(1',3'-interphenylene) -13,14-dihydro- prostaglandin f1 to treat peripheral vascular disease
US5877211A (en) * 1997-11-21 1999-03-02 Allergan EP2 receptor agonists as neuroprotective agents for the eye
CA2314369A1 (en) 1997-12-18 1999-06-24 Nathan Earl Scott Prostaglandin e2/f2.alpha. combination for treating impotence and enhancing sexual arousal
US6099870A (en) 1997-12-18 2000-08-08 Johnson & Johnson Consumer Companies, Inc. Methods for improving the health of hair and scalp
WO1999032441A1 (en) 1997-12-22 1999-07-01 Alcon Laboratories, Inc. 13-oxa prostaglandins for the treatment of glaucoma and ocular hypertension
WO1999032641A1 (en) 1997-12-22 1999-07-01 Unilever N.V. A process for site-directed integration of multiple copies of a gene in a mould
US5955575A (en) 1997-12-22 1999-09-21 Hopital Sainte-Justine Antagonists of G-protein-coupled receptor
KR20010033538A (en) 1997-12-25 2001-04-25 오노 야꾸힝 고교 가부시키가이샤 ω-CYCLOALKYL-PROSTAGLANDIN E2 DERIVATIVES
GB2330307A (en) 1998-02-07 1999-04-21 Glaxo Group Ltd EP4 Receptor antagonists as bone resorption inhibitors
EP1071648A2 (en) 1998-03-13 2001-01-31 Merck Frosst Canada &amp; Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
ES2244208T3 (en) 1998-03-31 2005-12-01 Duke University OXIMIL AND HYDROXYLAMINE C11 PROSTAGLANDINAS USED AS ANTAGONISTAS FP.
TR200002808T2 (en) * 1998-03-31 2001-01-22 The Procter & Gamble Company C11 oximyl and hydroxylamino prostaglandins useful as medicines
US6444840B1 (en) 1998-03-31 2002-09-03 The Procter & Gamble Co. C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists
EP1083168B1 (en) 1998-05-25 2003-10-22 Taisho Pharmaceutical Co., Ltd Prostaglandin derivative
US6458549B2 (en) 1998-06-11 2002-10-01 Winthrop-University Hospital Methods of diagnosing renal salt wasting syndrome and Alzheimer's disease and methods of treating the same
US5942545A (en) 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
US6187818B1 (en) 1998-06-17 2001-02-13 Pharmacia & Upjohn Company Prostaglandins formulation and process
WO2000002450A1 (en) 1998-07-08 2000-01-20 Fibrogen, Inc. Method for treatment of fibrosis related diseases by the administration of prostacyclin derivatives
CN1146423C (en) 1998-07-14 2004-04-21 阿尔康实验室公司 Prostaglandin product
TWI249520B (en) 1998-07-15 2006-02-21 Ono Pharmaceutical Co 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient
JP2002521332A (en) 1998-07-21 2002-07-16 メルク エンド カムパニー インコーポレーテッド Ophthalmic composition for the treatment of high intraocular pressure
AU5114499A (en) 1998-07-21 2000-02-14 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US6284234B1 (en) * 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
WO2000009557A1 (en) 1998-08-12 2000-02-24 Kazusa Dna Research Institute Foundation Novel gene and protein pgth encoded thereby
US6586468B1 (en) 1998-09-14 2003-07-01 Ono Pharmaceutical Co., Ltd. ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
AUPP608898A0 (en) 1998-09-23 1998-10-15 Fujisawa Pharmaceutical Co., Ltd. New use of prostaglandin E2 antagonists
US6121253A (en) 1998-11-20 2000-09-19 Merck Frosst Canada & Co. Prostaglandin conjugates for treating or preventing bone disease
CZ20013117A3 (en) 1999-03-01 2002-06-12 Pfizer Products Inc. Oxamic acids and derivatives as thyroid receptor ligands
JP4834224B2 (en) 1999-03-05 2011-12-14 デューク ユニバーシティ C16 unsaturated FP-selective prostaglandin analogs
CN1382121A (en) 1999-03-05 2002-11-27 宝洁公司 C16 unsaturated FP-selective prostaglandins analogs
AU3082999A (en) 1999-03-12 2000-10-04 Alcon Laboratories, Inc. Combination therapy for treating glaucoma
US6894175B1 (en) * 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
IL147771A0 (en) * 1999-08-04 2002-08-14 Procter & Gamble Novel 2-decarboxy-2-phosphinico prostaglandin f analogs
US6548535B2 (en) * 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
IL143477A (en) 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
US20020146439A1 (en) 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
EP1186287A1 (en) * 2000-03-31 2002-03-13 Toray Industries, Inc. Hair growth or hair formation controlling agents
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
FR2812193B1 (en) 2000-07-28 2003-10-24 Oreal USE OF AN ANTAGONIST OF PROSTAGLANDIN EP-2 AND / OR EP-4 RECEPTORS TO ATTENUATE, DECREASE OR STOP HAIR AND HAIR GROWTH IN COSMETIC PREPARATIONS
FR2812191B1 (en) 2000-07-28 2003-10-17 Oreal USE OF PROSTAGLANDIN E2 RECEPTOR AGONISTS (EP-3) TO ATTENUATE, DECREASE OR STOP HAIR AND HAIR GROWTH IN COSMETIC PREPARATIONS
FR2812190B1 (en) * 2000-07-28 2003-01-31 Oreal USE OF NON-PROSTANOIC AGONISTS OF EP-2 AND / OR EP-4 PROSTAGLANDIN RECEPTORS AS A COSMETIC AGENT FOR MITIGATING, DECREASING OR STOPPING HAIR AND HAIR LOSS
EP1361867B1 (en) 2001-02-22 2007-03-21 Jagotec AG Fibrate-statin combinations with reduced fed-fasted effects
EP1298223A3 (en) 2001-09-28 2003-07-23 Pfizer Products Inc. Methods related to the A-C repeat Z-sequence upstream from the aldose reductase gene
SE0104334D0 (en) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
US20040082013A1 (en) 2002-01-24 2004-04-29 Regan John W Methods for screening for substances which inhibit fp prostanoid receptor interaction with a compound having pgf2alpha activity and methods of treating cancer
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
DE60307607T2 (en) 2002-03-18 2007-08-09 Pfizer Products Inc., Groton USE OF SELECTIVE EP4 RECEPTOR AGONISTS FOR THE TREATMENT OF DISEASES
US7186707B2 (en) 2002-04-01 2007-03-06 University Of Florida Prodrugs for use as ophthalmic agents
GB0208785D0 (en) 2002-04-17 2002-05-29 Medical Res Council Treatment methtods
US7320967B2 (en) * 2002-04-23 2008-01-22 L'oreal Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
US6573294B1 (en) 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
US7521530B2 (en) 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
US20030199590A1 (en) 2002-07-25 2003-10-23 Cagle Gerald D Prostaglandin analogues for promotion of hair growth
US7589233B2 (en) 2003-07-29 2009-09-15 Signature R&D Holdings, Llc L-Threonine derivatives of high therapeutic index
US7045634B2 (en) 2003-09-05 2006-05-16 Allergan, Inc. Prostamide receptor antagonists
US20050058614A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods for the treatment of gray hair using cyclopentane(ene) heptan(en)oic acid amides
US7070768B2 (en) 2003-09-25 2006-07-04 Allergan, Inc. Method for imparting artificial tan to human skin
US20050112075A1 (en) 2003-11-25 2005-05-26 Hwang Cheng S. Reduction of hair growth
WO2005053683A1 (en) 2003-11-26 2005-06-16 Duke University A method of preventing or treating glaucoma
US7288029B1 (en) 2005-01-19 2007-10-30 Gkn Driveline North America, Inc. Propshaft with crash-worthiness
WO2006047466A2 (en) 2004-10-21 2006-05-04 Duke University Ophthamological drugs
GB0506759D0 (en) 2005-04-02 2005-05-11 Medical Res Council Combination treatment methods
WO2007123818A2 (en) 2006-04-18 2007-11-01 Nitromed, Inc. Organic nitric oxide enhancing salts of prostaglandins, compositions and methods of use
US20070254920A1 (en) 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US7868032B2 (en) 2006-10-18 2011-01-11 Allergan, Inc. Prostamide receptor antagonists
US20090018204A1 (en) 2007-07-13 2009-01-15 Brinkenhoff Michael C Composition and method for enhancing hair growth
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) * 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
JP2012507552A (en) 2008-10-29 2012-03-29 アエリエ・ファーマシューティカルズ・インコーポレーテッド Amino acid salt of prostaglandin
WO2010108012A1 (en) 2009-03-18 2010-09-23 Duke University Compositions and methods for promoting nasal patency and treating neurogenic bladder using prostaglandins

Also Published As

Publication number Publication date
US9346837B2 (en) 2016-05-24
DE60115618T2 (en) 2006-06-22
US9877908B2 (en) 2018-01-30
WO2001074314A2 (en) 2001-10-11
US20020013294A1 (en) 2002-01-31
JP2003528898A (en) 2003-09-30
WO2001074314A3 (en) 2002-02-21
ES2254401T3 (en) 2006-06-16
ATE311849T1 (en) 2005-12-15
CN1419438A (en) 2003-05-21
US20160220467A1 (en) 2016-08-04
US20170239160A1 (en) 2017-08-24
DE60115618D1 (en) 2006-01-12
CA2401888A1 (en) 2001-10-11
US20060247214A1 (en) 2006-11-02
US9675539B2 (en) 2017-06-13
EP1267806B1 (en) 2005-12-07
EP1267806A2 (en) 2003-01-02
US20140099268A1 (en) 2014-04-10

Similar Documents

Publication Publication Date Title
AU2001253038A1 (en) Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
AU2001253039A1 (en) Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
WO2001074307A3 (en) Compositions and methods for treating hair loss using oximyl- and hydroxylamino- prostaglandins
AU2001251166A1 (en) Compositions and methods for treating hair loss using c16 - c20 aromatic tetrahydro prostaglandins
WO2004066899A3 (en) System and method for face and body treatment
WO2003104443A3 (en) Hair follicle mesenchymal stem cells and use thereof
EP1179334A3 (en) Hair tonic for preventing or treating hair loss
AU2001270554A1 (en) Use of an (r)-enantiomer of lipoic acid in cosmetics and dermatologicals
AU2002366280A1 (en) Skin/hair equivalent with reconstructed papillae
BR0204596A (en) Topical composition, and methods for improving the aesthetic appearance of the skin, for enhancing the therapeutic efficacy of a topical composition for the skin, nail, lips and / or hair, and for enhancing the production of a predetermined plant cell constituent.
ES2127490T3 (en) USE OF AN OIL RICH IN PETROSELENIC ACID AS A MOISTURIZING AGENT.
AU2003274052A1 (en) Use of cellulose microbeads to make the skin matt
PL370795A1 (en) Composition based on etyllinoleate and triethylcitrate for the treatment of seborrhea and acne
AU2001240940A1 (en) Cosmetic and dermatological composition for psoriatic skin, scalp treatment and care
AU2838101A (en) Use of melatonin for treating androgenetic and diffuse alopecia
EP1911494A3 (en) Use of oligosaccharides to stimulate beta-endorphin production
MXPA02004701A (en) Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders.
GEP20063828B (en) Methods for Treating or Preventing Skin Disorders Using CD2-Binding Agents
CA2157836A1 (en) L-carnitine salt and cosmetic and pharmaceutical compositions containing same for treating dermatoses
MXPA02010957A (en) Reducing composition for treating keratin fibres, comprising a particular aminosilicone.
WO2003039453A3 (en) Novel benzoyl peroxide compositions for the treatment of dermatological disorders and methods for their use
GB0027769D0 (en) Cosmetic method of treating skin
EP1465577A4 (en) Methods for improving the aesthetic appearance of skin
CA2148305A1 (en) Ceramid and Vinylpyrrolidone Polymer Composition Useful for the Treatment and the Protection of Superficial Body Growths
WO2002096369A3 (en) Haircare agent comprising natural oils