DE1910561A1 - Hair loss prevention agents - Google Patents
Hair loss prevention agentsInfo
- Publication number
- DE1910561A1 DE1910561A1 DE19691910561 DE1910561A DE1910561A1 DE 1910561 A1 DE1910561 A1 DE 1910561A1 DE 19691910561 DE19691910561 DE 19691910561 DE 1910561 A DE1910561 A DE 1910561A DE 1910561 A1 DE1910561 A1 DE 1910561A1
- Authority
- DE
- Germany
- Prior art keywords
- hair loss
- loss according
- preventing
- salts
- exist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
PATENTANWÄLTE -j Q -j Q C β A PATENTANWÄLTE -j Q -j QC β A
Krefeld - Moerser Straße \HO · Fernruf CO 21 51) 2 Oit- 69Krefeld - Moerser Straße \ HO · Fernruf CO 21 51) 2 Oit- 69
Datum: 28.2.1969Date: 28.2.1969
Unser Zeichen: o pt ccs UC Di?Our reference : o pt ccs UC Di?
Ihr Zeichen:Your sign:
Dr. med. Kurt Herten, 415 Kreield, Jentgesallee 11 Mittel zur Verhütung von HaarausfallDr. med. Kurt Herten, 415 Kreield, Jentgesallee 11 Preparations for preventing hair loss
Die Erfindung bezieht sich auf ein Mittel zur Verhütung von Haarausxall.The invention relates to an agent for preventing Hair removal.
Die Ursache des allgemeinen Haarausfalles und der G-iatzenbiiduiig bei Männern und Frauen konnte bisher nicht ausreichend geklärt v/erden. Der bisherige Stand der 'Technik in der Verhütung des Haarausfalles stützt sich auf die Erfahrungstatsachen der Alterungserscheinungen, der meist örtlichen Begrenzung im Schädeldachbereich und der gelegentlichen Folge nach Stoffwechselbelastungen wie Schv/angerschaft, fieberhaften Erkrankungen, Vergiftungen oder Arzneimittelbehandlung.The cause of general hair loss and g-iatzenbiiduiig in men and women has so far not been adequately clarified. The current state of the art in contraception the hair loss is based on the facts of experience of the signs of aging, the mostly local limitation in the roof of the skull and the occasional consequence of metabolic stress such as pregnancy, feverish Illness, poisoning, or drug treatment.
Ausgehend von diesen Erfahrungen wurde versucht, den Haarausfall durch Stoffwechselverbesserungen des Haarbodens mit Sexualhormonen, Schiladrüsenhormonen, Vitaminen und Extrakten pflanzlicher Herkunft zu verhüten. Man hat auch schon versucht, mit einem örtlichen Angebot von Aulbaustoffen, besonders Aminosäuren und deren Abkömmlingen, dein Haarausfall zuBased on these experiences, attempts were made to reduce hair loss by using metabolic improvements in the scalp To prevent sex hormones, shila gland hormones, vitamins and extracts of vegetable origin. One has already tried with a local supply of building materials, especially amino acids and their derivatives, to prevent your hair loss
009837/2185 Bad original009837/2185 original bathroom
Deutsche Bank AG 1O3/1525 Krefeld · Stadt-Sparkasse Krefeld 3O5 722 - Postscheck Essen 4O55Deutsche Bank AG 1O3 / 1525 Krefeld · Stadt-Sparkasse Krefeld 3O5 722 - Postal check Essen 4O55
begegnen. Schließlich sind auch kapillarerweiternde Mittel verwendet worden. Allgemein befriedigende und sichere Erfolge sind bishex- jedoch nicht erzielt worden.to encounter. Finally, there are also capillary dilators been used. Generally satisfactory and certain successes have not yet been achieved.
Diese Überlegungen,"* die zur Erfindung führen, gehen davon aus, daß mögliche Störfaktoren der Haarernahrung nur an der Kopfhaut zur Auswirkung kommen, infolge der ungünstigen anatomischen Lage bezüglich des Blutkreislauf es. Ais I'Olge tritt eine Verlangsamung der Gewebedurchspülung mit Serum und eine Durchlässigkeifcsverminderung der Zellwände der Koruhaut ein. Eine weitere Überlegung geht dahin, daß eine Weiterstellung (Hyperämie) der Kapillaren ein Absinken des inneren Wanddruckes im arteriellen und einem Anstieg im venösen Kapillax'bex'eich bewirkt. Dem loigx eine verminderte Abpressung von G-ewebeserum im arteriellen und eine verringerte liückilutung im venösen Kapiiiarbereich.These considerations, "* which lead to the invention, are based on this from that possible disruptive factors of the hair nutrition only at the Scalp come into play, as a result of the unfavorable anatomical Location related to the blood circulation it. Ais I'Olge kicks a slowing down of the tissue flushing with serum and a reduction in the permeability of the cell walls of the coral skin. Another consideration is that a continuation (Hyperemia) of the capillaries a decrease in the internal wall pressure in the arterial and an increase in the venous capillax'bex'eich causes. The loigx shows a reduced pressure of G-ewebeserum in the arterial and a reduced bleeding in the venous Capillary area.
Aus diesen Gründen könnten auch die bisherigen Maßnahmen zur Verhütung von Haarausfall, die auf eine Gei'äßerweiterung abzielten, keinen Erfolg haben. Nur eine vermehrte Durchsoülung des Gewebes mix Serum, das ja alle nötigen Sxoi-'e enthält sowie eine Wiederhersteilung der Zellvanddurchlässigkeit kann das Haar richtig ernähren.For these reasons, the previous measures to prevent hair loss, which aimed at dilatation of the blood vessels, could also have no success. Just an increased soaking of the tissue mix serum, which contains all the necessary Sxoi-'e as well as a restoration of the cell wall permeability nourishing the hair properly.
ITach diesen Erkenntnissen müssen deshalb kapiliarrisistenssteigernde bzw. kapillarabdichtende Mittel zur Anwendung kommen, unter Einhaltung eines normalen Kapillarkreislaufes. DieseAccording to these findings, therefore, capillary risk increasing or capillary sealing agents are used, while maintaining a normal capillary circuit. These
009837/2185009837/2185
badbath
sorgen für die Aufrechterhaltung des arteriellen Abpreßdruckes durch verminderte Durchlässigkeit für höhermolekulare Substanzen und Eiweiße.ensure that the arterial pressure is maintained through reduced permeability for higher molecular weight Substances and proteins.
Di e Erfindung schlägt deshalb alt' Mittel zur "Verhütung von Haarausfall eine Substanz vor, die im direkten Gegensatz zum Stande der Technik keine kapillarerweiternden sondern kapillarabdichtende Mittel enthält. Desweiteren soll das erfindungsgemäße Mittel Mineralsalze sowie calciummobilisierende Paktoren M wie z.P. Hebenschilddrüsenhormon oder Dihydrotachysterin aufweisen.The invention therefore proposes a substance for preventing hair loss which, in direct contrast to the state of the art, does not contain capillary-widening but capillary-sealing agents. Furthermore, the inventive agent should contain mineral salts and calcium-mobilizing factors M such as thyroid hormone or dihydrotachysterin.
Die neben den I'apillarabdichtungsmitteln der Substanz zugefügten Mineralsalze und calciuimnobilisierenden Paktoren dienen dazu, die Durchlässigkeit der Zellvände des Haarbodens für die Nährstoffe zu erhöhen.Those added to the substance in addition to the apillary sealants Mineral salts and calcium immobilizing factors serve to to increase the permeability of the cell walls of the scalp for nutrients.
Nach einem weiteren Merkmal der Erfindung ist vorgesehen, daßAccording to a further feature of the invention it is provided that
die Mineralsalze? aus Salzen des Calcium und/oder Kalium bestehen. ™ Gegebenenfalls können daneben auch Magnesiumsalze verwendet werden.the mineral salts? consist of salts of calcium and / or potassium. ™ If necessary, magnesium salts can also be used.
Schließlich sieht iie Erfindung vor, daß die Säurerestionen der f>alsr aup ualo?enionen und/oder PC,-Ionen und/oder SQ^- Ionen best^en.Finally, the invention provides that the acid residues of the f> alsr aup u alo? Enions and / or PC, ions and / or SQ ^ ions exist.
Die '"irkFarskeit des erfindungsgemäßen Kittels läßt sich weiterhin i?d\ir.%>: frhC:h =■£.,· -äaS dem T*ittel "το-ff-^echselentelfter ausThe '' irkFarskeit the coat according to the invention can furthermore i d \ ir%>:. FRHC. H = ■ £, · -äaS the T * edium "το-ff ^ echselentelfter from
00 9 8 337./;2 1 8 5.00 9 8 3 3 7. / ; 2 1 8 5.
V' ' ' ' BAD ORIGINAL V ' ''' BAD ORIGINAL
aus Methioninabkömmlingen, insbesondere Acethylmethionin zugesetzt wird.from methionine derivatives, especially acetyl methionine is added.
Nach einem weiteren Merkmal der Erfindung sollen in "bevorzugter Weise die Kapillarabdichtungsmittel aus Rutinabkömmlingen, insbesondere Trihydrooxaethylrutosidura oder aus HesperidinabkömmlIngen wie beispielsweise Hesperidinmythylchalkon bestehen.According to a further feature of the invention, "should be more preferred Make the capillary sealing means from rutin derivatives, in particular trihydrooxaethylrutosidura or from hesperidin derivatives such as hesperidin methyl chalcone exist.
Schließlich sieht die Erfindung vor, daß das Mittel in flüssiger Form hergestellt ist.Finally, the invention provides that the agent is produced in liquid form.
Ferner können dem Mittel haut^ffine Substanzen, insbesondere Glyzerin zum Transport des Mittels in tiefere Hautschichten zugesetzt sein.Furthermore, skin-affine substances, in particular Glycerine can be added to transport the agent into the deeper layers of the skin.
Beispiel; Zur Verhütung von weiterem Haarausfall wurden mehrere Patienten mit einem Mittel folgender Zusammensetzung behandelt: Example; To prevent further hair loss, several patients were treated with an agent of the following composition:
Nebenschilddrüsenhormon 20 Oollip EinheitenParathyroid hormone 20 oollip units
Kaliumchlorid 50,0 mgPotassium Chloride 50.0 mg
Magnesiumchlorid 38,1 mgMagnesium chloride 38.1 mg
Calciumchlorid - 44,4 mgCalcium chloride - 44.4 mg
d,l- Acethylmethionin 500,0 mgd, l-Acethyl methionine 500.0 mg
Trihydrooxyaethylrutosidum 500,0 mgTrihydrooxyaethylrutosidum 500.0 mg
aqua destillata 15,0 gaqua destillata 15.0 g
Glyzerin ad 50 gGlycerine ad 50 g
^erandlunp· erfol<?tp durch Auftragen des T-ittels auf die^ erandlunp · success <? tp by applying the title to the
009837/2 185009837/2 185
BAD ORIGINALBATH ORIGINAL
Kopfhaut j wobei regelmäßig sofort der Haarausfall gestoppt wurde. Gelegentlich sind v/eitere Behandlungen in Abständen von etwa Ή Tagen efforderlich gewesen.Scalp j being regularly stopped immediately the hair loss became. Further treatments at intervals of about 3/4 days have occasionally been necessary.
Claims (9)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691910561 DE1910561A1 (en) | 1969-03-01 | 1969-03-01 | Hair loss prevention agents |
IT481470A IT1036504B (en) | 1969-03-01 | 1970-02-27 | LOTION TO PREVENT HAIR LOSS |
FR7007313A FR2060316A1 (en) | 1969-03-01 | 1970-02-27 | Hair loss prevention agent |
BE746615D BE746615A (en) | 1969-03-01 | 1970-02-27 | MEANS OF PREVENTING HAIR LOSS |
NL7002875A NL7002875A (en) | 1969-03-01 | 1970-02-27 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691910561 DE1910561A1 (en) | 1969-03-01 | 1969-03-01 | Hair loss prevention agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DE1910561A1 true DE1910561A1 (en) | 1970-09-10 |
Family
ID=5726863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19691910561 Pending DE1910561A1 (en) | 1969-03-01 | 1969-03-01 | Hair loss prevention agents |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE746615A (en) |
DE (1) | DE1910561A1 (en) |
FR (1) | FR2060316A1 (en) |
IT (1) | IT1036504B (en) |
NL (1) | NL7002875A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0216084A2 (en) * | 1985-08-23 | 1987-04-01 | Richardson-Vicks, Inc. | Improved sunscreen and moisturizer |
FR2604088A1 (en) * | 1986-09-22 | 1988-03-25 | Oreal | PHOTOSTABLE COSMETIC COMPOSITION CONTAINING TRIHYDROXYETHYLRUTIN IN COMBINATION WITH WATER-SOLUBLE FILTERS DERIVED FROM BENZYLIDENECAMPHRE AND USE THEREOF FOR THE PROTECTION OF SKIN AND HAIR |
EP0415598A1 (en) * | 1989-08-16 | 1991-03-06 | Unilever Plc | Cosmetic composition |
EP0461827A2 (en) * | 1990-06-11 | 1991-12-18 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Hair restorer |
FR2719468A1 (en) * | 1994-05-05 | 1995-11-10 | Oreal | Cosmetic compositions based on certain bioflavonoids and uses in particular in the hair field. |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1159266B1 (en) | 1999-03-05 | 2004-11-03 | Duke University | C-16 unsaturated fp-selective prostaglandins analogs |
US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
-
1969
- 1969-03-01 DE DE19691910561 patent/DE1910561A1/en active Pending
-
1970
- 1970-02-27 FR FR7007313A patent/FR2060316A1/en not_active Withdrawn
- 1970-02-27 IT IT481470A patent/IT1036504B/en active
- 1970-02-27 BE BE746615D patent/BE746615A/en unknown
- 1970-02-27 NL NL7002875A patent/NL7002875A/xx unknown
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0216084A2 (en) * | 1985-08-23 | 1987-04-01 | Richardson-Vicks, Inc. | Improved sunscreen and moisturizer |
EP0216084A3 (en) * | 1985-08-23 | 1987-06-16 | Charles Of The Ritz Group Ltd. | Improved sunscreen and moisturizer |
FR2604088A1 (en) * | 1986-09-22 | 1988-03-25 | Oreal | PHOTOSTABLE COSMETIC COMPOSITION CONTAINING TRIHYDROXYETHYLRUTIN IN COMBINATION WITH WATER-SOLUBLE FILTERS DERIVED FROM BENZYLIDENECAMPHRE AND USE THEREOF FOR THE PROTECTION OF SKIN AND HAIR |
FR2604089A1 (en) * | 1986-09-22 | 1988-03-25 | Oreal | PHOTOSTABLE COSMETIC COMPOSITION CONTAINING ETHYLRUTIN DERIVATIVE AS PROTECTIVE AGENT AGAINST SOLAR LIGHT AND ITS USE FOR THE PROTECTION OF SKIN AND HAIR |
BE1000404A3 (en) * | 1986-09-22 | 1988-11-22 | Oreal | COSMETIC COMPOSITION CONTAINING photostable TRIHYDROXYETHYLRUTINE IN ASSOCIATION WITH FILTER HYDROSOLUBLE benzylidenecamphor DERIVATIVES AND USE FOR SKIN AND HAIR. |
BE1000405A3 (en) * | 1986-09-22 | 1988-11-22 | Oreal | COSMETIC COMPOSITION CONTAINING DERIVATIVE photostable ETHYLRUTINE AS AN AGENT OF PROTECTION FROM SUNLIGHT AND USE FOR SKIN PROTECTION AND HAIR. |
US4837006A (en) * | 1986-09-22 | 1989-06-06 | L'oreal | Photostable cosmetic composition containing trihydroxyethylrutin in combination with water-soluble sunscreens derived from benzylidenecamphor and its use in the protection of the skin and the hair |
EP0415598A1 (en) * | 1989-08-16 | 1991-03-06 | Unilever Plc | Cosmetic composition |
EP0461827A2 (en) * | 1990-06-11 | 1991-12-18 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Hair restorer |
EP0461827A3 (en) * | 1990-06-11 | 1994-01-05 | Hayashibara Biochem Lab | |
FR2719468A1 (en) * | 1994-05-05 | 1995-11-10 | Oreal | Cosmetic compositions based on certain bioflavonoids and uses in particular in the hair field. |
EP0681827A1 (en) * | 1994-05-05 | 1995-11-15 | L'oreal | Use of bioflavonoids as keratineous phaners protection agent |
US5660818A (en) * | 1994-05-05 | 1997-08-26 | L'oreal | Bioflavonoids as agents for protecting the physical and/or cosmetic properties of keratinous superficial body growths |
Also Published As
Publication number | Publication date |
---|---|
IT1036504B (en) | 1979-10-30 |
BE746615A (en) | 1970-07-31 |
NL7002875A (en) | 1970-09-03 |
FR2060316A1 (en) | 1971-06-18 |
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