DE2139183A1 - Sustained action cosmetic and/or pharm compsns - contg addns of cyclic adenosine-monophosphoric acid - Google Patents

Abstract

The activity of title compsns. contg. hormones, anabolic steroids, vitamins et al. is protracted by the addn. of cyclic adenosine-monophosphoric acid (c-AMP) and derivs. including the cyclic guanosine-monophosphoric acid which exhibit a strictly local effect e.g. on the skin.

Description

Description Cosmetic and pharmaceutical accessories The cosmetic (and pharmaceutical) preparations containing u.s. Hormones (estrogens, progestins, androgens etc.), anabolic steroids and / or vitamins and vitaminoids are often used an uncertain effect. It has now been found that the effect of the substance mentioned The cosmetic and pharmaceutical preproteins can be significantly protahed "cyclic adenosine monophosphoric acid" (adenosine-3.54 monophosphoric acid cyclic; c-AMP) or their derivatives or related compounds, for example cycl. Dibutyryl-3,5'-adanosine phosphoric acid, Dibutyryl-gunanesin-3,5-monophosphoric acid cyclic or the monobutyryl compounds in. -orm of the acids or their salts. The butyryl groups increase the Ed @@ solubility and they can be replaced by valeryl groups or other groups will.

Since the c-2MP is hardly permeable and the alkali salts are just as little so remarkable that the alkylolamine salts are appreciably parpeable, which is one of them Continuing in the application means.

The composition of cosmetics is the usual, they can be smooth bi be creamy.

The wise physiological effects of c-AMP are known and the adenosine triphosphates or salts have already been recommended for cosmetics; they are not permeable and do not have the broad effect of c-AMP or its derivatives.

as a so-called secondary masseger (@second messenger ") leads en Cell-specific hormonal information, presumably want @@ for suitable receptors the cell membrane continued to grow inside the cell. Le can, for example, the Effect of the adreaccorticotropic norm (ACTI) on the adrenal cortex (e.g. cortiostaroid secretion) Replace with local application of c-AMP.

de many studies in the last few years have shown that @@ c-AMP plays an important role in enzyme activation and changes in cellular wound permeability in cell metabolism. The c-AMP request enables the vital transpcription (@ NA- <R @ A) and thus also the translation (@@@ - <Prot @ in).

Experiments on the dehumidified flanks of McPigs with an O / W emulsion with c-AMP (colamine salt) and c-dibutyryl-AMP resulted in acanthosis of the skin and similar Proliferation. The findings were improved with the addition of anabolic steroids and these could be reduced in quantity. There is a considerable technical in it Advantage to see, as many anabolic steroids are physiologically not like that harmless than presented in the literature (hub effects), such as ethisterone, api-Androsterdn.

There is also a considerable advantage in the fact that the c-AMP and D-derivatives Strictly develop local effects on the target organ, i.e. on the skin. She cannot possibly interfering adversely with the overall metabolism, as is the case with estrogens is to be feared.

The c-AMT or derivatives enable the energy metabolism to influence the cell externally significantly.

These properties make the c-AMP and derivatives also important Component of numerous cosmetic and / or pharmaceutical preparations.

Examples: Hasr water: 55.0 ethanol or Igopropanol 44.0 water, distilled 0.2 panthenol 0.2 salicylic acid 0.05 laurylpyridinium chloride 0.1 camphoric acid 0.2 dipropylene glycol 01 polyvinylpyrrolidone pure 0r25 fragrances 5 - 50 mg dibutyrul-adenosine-3,5-monophesphate-colamine salt cycl.

+ 10 -100 mg c-AMP -alkylolamine salt per 1000 ml Bautoremo: 10.0 paraffin oil, Low viscosity 5.0 Peanut oil, preserved 8.0 Miglyol 812 (a triglyceride) 7.0 Ischexadecyl isostcarate 2.0 Lanolin oil, light 9.0 Axial emulsifier with surfactants 3.0 Glycerin IAB 7 0.2 Chloracetamide 0.5 magnesium sulfate crystallizes 53.0 @@ sser, desstillier56t 2.0 citrate buffer (pH 5.5-6.5); 1.10-3 molar 5 - 50 mg c-dibutyl-AMP-amine salt + (or) 10-100 mg c- AMP per 1 kg of emulsion Production: The emulsion is at around 75-80 ° Considered Literature: I. Karlson: mechanisms of action of the hormones. 18.Coll.d.Ges.

f. Physiol. Chemistry. Mosbach 1967. Springer-Verlag, Berlin 1967 W. Blech: The biochem. How the hormones work. Natural science

Rdsch. 11, 459 (1968) E.J.V.J. Christ: Fette-Soap-Paint 10, 849 (14. Tausk: Pharmakologie der Hormone. Georg Thieme Verlag (1970) J. Pastan u. R.L. Perlmann: Cyclic AMP in Metabolism.

Nature New Biology Vol. 229 Jan.6; p.5 (1971) R.C. Haymes, S.B. Koritz u.F.O. Peron: J.Biol.Chem. 234, 1421 (1959) @. @. Sutherland, R.W. Butcher, G.A. Robison, I.G. Hardman: The role of adenosine-3,5'-monophosphate in hormone action. From: (1) .S.1 Y. Oshima, T. Horiuchi, Y.Iida & T. Kameyama. Mol. Gen. Genetics 106, 307 (1970) E. Böhme, K. Munske and G. Schulz. Nannyn-Schmiedeberg's Arch.

Pbarmakol. 264, 220 (1969) J.F. Kuo, J. Sanes, and P. Greengard. Federation Proceedings 29, 1990 (1970)

Claims (1)

Claim: Cosmetic and / or pharmaceutical preparations characterized in that they cyclic adenosine monophosphoric acid and their Derivatives including cyclic guanosine monophosphoric acid and the like Derivatives are added.