DE2164052A1 - COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES - Google Patents

COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES

Info

Publication number
DE2164052A1
DE2164052A1 DE19712164052 DE2164052A DE2164052A1 DE 2164052 A1 DE2164052 A1 DE 2164052A1 DE 19712164052 DE19712164052 DE 19712164052 DE 2164052 A DE2164052 A DE 2164052A DE 2164052 A1 DE2164052 A1 DE 2164052A1
Authority
DE
Germany
Prior art keywords
cosmetic agents
skin
cytidine
uridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19712164052
Other languages
German (de)
Inventor
Rainer Dipl Chem Dr Klemm
Hans-Karl Dipl Chem Dr Maurer
Karl Dipl Chem Dr Rer Nat Seib
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PWA Papierwerke Waldhof Aschaffenburg AG
Original Assignee
Papierwerke Waldhof Aschaffenburg AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE793306D priority Critical patent/BE793306A/en
Application filed by Papierwerke Waldhof Aschaffenburg AG filed Critical Papierwerke Waldhof Aschaffenburg AG
Priority to DE19712164052 priority patent/DE2164052A1/en
Priority to GB5922072A priority patent/GB1422642A/en
Priority to IT3348972A priority patent/IT1054115B/en
Priority to FR7247088A priority patent/FR2164938A1/fr
Publication of DE2164052A1 publication Critical patent/DE2164052A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/002—Aftershave preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Description

PatentanwaltPatent attorney

HERMANN L. JUNG 757 baden-badenHERMANN L. JUNG 757 bathe-bathe

Dipl.-Chem. Ludwig-Wilhelm-Straße 12Dipl.-Chem. Ludwig-Wilhelm-Strasse 12

Telefon (072 21) 239 33 Telegramme: JUPAT Baden-BadenTelephone (072 21) 239 33 Telegrams: JUPAT Baden-Baden

Mein Zeichen TagMy sign day

Jg/Sch ON 758 W-81o 15.12.1971 Kosmetische Mittel mit NucleosidderivatenJg / Sch ON 758 W-81o December 15, 1971 Cosmetic agents with nucleoside derivatives

Es ist seit längerer Zeit bekannt, daß die Alterung der unbedeckten Haut überwiegend auf die UV-Strahlung zurückzuführen ist. Man könnte daher einen Alterungsschutz der Haut dadurch erreichen, daß man sie kontinuierlich mit Sonnenschutzmitteln, die UV-Lichtfiltersubstanz enthalten, abdeckt. Dies ist aber nicht möglich, da es sich bei allen bisher bekannten Lichtfiltersubstanzen um unphysiologische, chemische Substanzen handelt, die bei monatelanger, täglicher Anwendung die Haut reizen, allergisieren oder sensibilisieren können. Ebenso kannte man bisher keine physiologischen Substanzen, die eine so hohe Zellpermeabilität besitzen, daß sie bei bereits gealterter oder geschädigter Haut in die Zellen eindringen und eine Besserstellung des Hautgefüges zur Folge haben.It has long been known that the aging of the uncovered Skin is mainly due to UV radiation. One could therefore protect the skin from aging achieve that they are continuously covered with sunscreens that contain UV light filter substance. But this is not possible, since all previously known light filter substances are non-physiological, chemical substances that can irritate, allergize or sensitize the skin if used daily for months. as well So far no physiological substances have been known which have such a high cell permeability that they can be used when the patient is already aged or damaged skin penetrate the cells and improve the structure of the skin.

Überraschendervreise wurde nun gefunden, daß die Nucleoside Cytidin, Uridin, Cuanosin, Inosin und deren physiologische Derivate in Konzentrationen von mindestens 1% einen Lichtschutzfaktor von über 1,5 aufweisen und dabei durch die Zellpermeabilität zusätzlich eine Besserstellung des Hautgefüges erreichen. Diese Wirkung wird dabei durch einmaliges Auftragen des kosmetischen Mittels erzielt und hält durch das sofortige Eindringen der Substanzen ca. 24-48 Stunden an.Surprisingly, it has now been found that the nucleosides cytidine, uridine, cuanosine, inosine and their physiological Derivatives in concentrations of at least 1% have a sun protection factor of over 1.5 and thereby due to the cell permeability additionally achieve a better position of the skin structure. This effect is achieved through a single application of the cosmetic agent is achieved and lasts about 24-48 hours due to the immediate penetration of the substances.

~2~ 309830/1132~ 2 ~ 309830/1132

Postscheckkonto 2290 28 Frankfurt ,am MainPostal checking account 2290 28 Frankfurt, am Main

216405?'216405? '

Daß es sich hier nicht um einen oberflächlichen Abdeckeffekt handelt, wird dadurch bewiesen, daß die Wirkung auch bei häufigen Waschen oder Baden nicht verloren geht. Bei den Substanzen handelt es sich um physiologische Zellkernbausteine, die auch in extrem hohen Dosen und monatelanger Verabreichung auf die Haut keinen reizenden, allergisierenden oder sensibilisierenden Effekt zeigen. Eine Ausnahme bildet dabei das Adenosin und dessen Derivate, welche wegen ihrer gefäß-erweiternden-Wirkung in diesen Dosierungen nicht anwendbar ist. Einen ähnlich positiven Lichtschutzeffekt und Besserung der Hautstruktur zeigen auch die Desoxynucleoside und deren physiologische Derivate.That this is not a superficial covering effect acts, is proven by the fact that the effect is not lost even with frequent washing or bathing. Both Substances are physiological building blocks of the cell nucleus, which can also be administered in extremely high doses and for months show no irritating, allergic or sensitizing effect on the skin. An exception is made adenosine and its derivatives, which cannot be used in these dosages because of their vasodilating effect is. The deoxynucleosides also show a similarly positive light protection effect and improvement of the skin structure and their physiological derivatives.

Mit den erfindungsgemäß beanspruchten Substanzen ist es jetzt zum ersten Mal möglich, kosmetische Mittel herzustellen, die bei täglicher Anwendung einen Alterungsschutz für die Haut bieten, dabei noch eine Besserung des Hautzustandes bei bereits geschädigter Haut erziel-en und dies bei absoluter Verträglichkeit.With the substances claimed according to the invention, it is now possible for the first time to produce cosmetic agents which when used daily, they provide protection against aging for the skin while improving the condition of the skin Achieve damaged skin and this with absolute tolerance.

Besonders hervorzuheben ist die Mischung der Nucleoside Cytidin und Uridin in dem Verhältnis, wie sie als Inhaltsstoffe der Hefezellen vorkommen und über die Nucleinsäurespaltung gewonnen wird. Wie aus der Krebsforschung bekannt, besitzen diese beiden Nucleoside eine extrem hohe Zellpermeabilität und werden dadurch sehr schnell von den Zellen aufgenommen, wobei selbst in sehr hohen Dosierungen, sogar intravenös injiziert, bei Tierversuchen und bei Menschen keinerlei TOxiζitätserscheinungen festgestellt wurden.Particularly noteworthy is the mixture of the nucleosides cytidine and uridine in the ratio in which they occur as constituents of the yeast cells and obtained via nucleic acid cleavage will. As is known from cancer research, these two nucleosides have an extremely high cell permeability and are thereby absorbed very quickly by the cells, even in very high doses, even intravenously injected, no toxicity phenomena were found in animal experiments or in humans.

Demgemäß besteht die Erfindung darin, daß kosmetische Mittel durch einen Gehalt von mindestens 1% an Cytidin, Uridin, Guanosin, und/oder Inosin bzw. deren Derivate gekennzeichnet sind.Accordingly, the invention consists in that cosmetic agents by a content of at least 1% of cytidine, uridine, Guanosine and / or inosine or their derivatives are labeled.

Vorzugsweise wird eine bei der Spaltung von Hefennucleinsäure anfallende Mischung von Cytidin und uridin zugesetzt.A mixture of cytidine and uridine obtained during the cleavage of yeast nucleic acid is preferably added.

-3- 3 0 9 8 3 0/1132-3- 3 0 9 8 3 0/1132

In den nachfolgenden Beispielen ist die Erfindung dargestellt:The invention is illustrated in the following examples:

Beispiel 1:Example 1: TagescremeDay cream

Ammoniumstearat.Ammonium stearate.

GlycerinGlycerin

Stearinstearin

niedrig oxäthylierter Fettalkohollow oxyethylated fatty alcohol

hoch oxäthylierter Fettalkoholhighly oxethylated fatty alcohol

CarboxymethylcelluloseCarboxymethyl cellulose

Cytidin, üridin (aus HefenucleinsäurespaltungCytidine, uridine (from yeast nucleic acid cleavage

Wasser, demineralisiert ad 3,o 15,o 12,o o,5Water, demineralized to 3, o 15, o 12, o o, 5

0,60.6

5,o Ιοο,ο5, o Ιοο, ο

Beispiel 2;Example 2; Flüssige HautpflegeemulsionLiquid skin care emulsion

Glycerin-mono-di-fettsäureester Fettalkoholpolyglykoäther Octyldodecano1 Capryl-caprinsäuretriglycerid Paraffinöl Lanolin anhydr.Glycerol-mono-di-fatty acid ester fatty alcohol polyglycoether Octyldodecano1 caprylic capric acid triglyceride Paraffin oil Lanolin anhydr.

1.2-Propylenglykol Konservierungsmitte1 Cytidin-monophosphat-Na-Sa1ζ Wasser, demineralisiert ad 6 ,o 4,ο 4,ο 4,ο 2,ο 2,ο 3fo1.2-propylene glycol preservative agent1 cytidine monophosphate Na-Sa1ζ water, demineralised ad 6, o 4, ο 4, ο 4, ο 2, ο 2, ο 3 f o

3,ο Ιοο,ο3, ο Ιοο, ο

Beispiel 3Example 3

ffautcreme ö/w Typ Glycerin-mono-distearat Paraffin ffautcreme ö / w type glycerine-mono-distearate paraffin

Lanolin anhydr.Lanolin anhydr.

Paraffinöl Octyldodecano1 SorbitParaffin oil Octyldodecano1 Sorbitol

GuanosinGuanosine

Konservierungsmitte1 Wasser, demineralisiert ad 12,ο 6 ,o 4,ο 7,ο 6,ο 3,οPreservative1 water, demineralised ad 12, ο 6, o 4, ο 7, ο 6, ο 3, ο

3 0 9 8 3■ 0 / T 1 3 23 0 9 8 3 ■ 0 / T 1 3 2

71B405271B4052

Beispiel 4: Hautcreme ö/w Typ Example 4: skin cream ö / w type

Sorbitansesguüeat CeresinSorbitan sesguueate ceresin

BienenwachsBeeswax

Vaselinevaseline

ParaffinölParaffin oil

Ribonucleinsäure Wasser, demineralisiert ad 5,oRibonucleic acid water, demineralized ad 5, o

6 ,o6, o

7,ο7, ο

6 ,o6, o

5o,o5o, o

4,04.0

Ιοο,οΙοο, ο

Beispiel 5: Gesichtswasser Example 5: facial toner

Äthylalkohol 94 VoI % SorbitlösungEthyl alcohol 94% by volume sorbitol solution

Hammamelisdestillat Ei-weiß-Fettsäurekondensat InosinHammamelis distillate egg-white fatty acid condensate inosine

Wasser, demineralisiert ad 18,ο o,5 I/O 2,o 2,5 Ιοο,οWater, demineralized ad 18, ο o, 5 I / O 2, o 2.5 Ιοο, ο

Beispiel 6: Haarwasser Example 6: hair lotion

Isopropylalkohol Diisopropyladipat ■Calciumpantothenat RibonucIe insäure Wasser, demineralisiertIsopropyl alcohol diisopropyl adipate ■ calcium pantothenate RibonucIe in acid water, demineralized

adad

Beispiel 7: Rasierwasser Example 7: aftershave

Äthylalkohol 94 Vol% Lanolin flüssig
1.2-Propylenglykol HexachlorophenEthyl alcohol 94 vol% lanolin liquid
1,2-propylene glycol hexachlorophene

Cytidin, Uridin
(aus Hefenucleinsäurespaltung)Cytidine, uridine
(from yeast nucleic acid cleavage)

Wasser, demineralisiert ad 5o,o 2,o I/O I/O Water, demineralized to 50, o 2, o I / O I / O

Ιοο,οΙοο, ο

4o,o l,o 2,o o,24o, o l, o 2, o o, 2

2,o Ιοο,ο2, o Ιοο, ο

309830/1132309830/1132

-S--S-

Es sind selbstverständlich auch noch andere Zusammensetzungen von kosmetischen Mitteln möglich, wobei das wesentliche die Tatsache ist, daß Nucleoside darin enthalten sind. Der Vorteil dieser Mittel liegt vor allem darin, daß auch nach monatelanger täglicher Anwendung die Haut weder gerei-zt wird noch in irgendeiner anderen Form angegriffen wird. Dies erscheint vor allem deswegen wesentlich, v/eil bei allen sehr bekannten Mitteln zum Schutz der Haut nach längerer Zeit eine Reizung aufgetreten ist, welche nur durch Absetzen der Mittel behoben werden konnte. Auch ist kein Mittel bekannt, was durch direkte Beeinflussung der Zellen deren Schädigung durch Licht mindern kann. Alle bisher bekannten Lichtschutzmittel wirken als Filter und sind deshalb auch abwaschbar. Die neuen Mittel brauchen nicht dauernd neu aufgetragen zu werden, sondern wirken über längere Dauer hinweg.Of course, other compositions of cosmetic agents are also possible, the essential being The fact is that it contains nucleosides. The main advantage of this means is that after After months of daily use, the skin is neither irritated nor attacked in any other way. Above all, this appears to be essential, especially in the case of all well-known means for protecting the skin after a long period of time Time an irritation occurred, which could only be remedied by discontinuing the agent. Also no remedy is known which, by directly influencing the cells, can reduce their damage by light. All previously known light stabilizers act as filters and are therefore also washable. The new funds do not need to be constantly reapplied but work over a longer period of time.

309830/1132309830/1132

Claims (5)

Patentansprüche 216 A O 5Claims 216 A O 5 1. Kosmetische Mittel, insbesondere zur Behandlung der menschlichen Haut, mit besonders guter Langzeitverträglichkeit, bestehend aus einer Grundlage mit Zusätzen, gekennzeichnet durch einen Gehalt von mindestens 1% an Cytidin, üridin, Guanosin und/oder Inosin bzw. deren Derivate.1. Cosmetic agents, especially for the treatment of human skin, with particularly good long-term tolerance, consisting of a base with additives, characterized by a content of at least 1% of cytidine, uridine, guanosine and / or inosine or their derivatives. 2. Mittel nach Anspruch 1, gekennzeichnet durch einen Gehalt an entsprechenden Phosphorsäurederivaten, bzw. deren Salzen.2. Means according to claim 1, characterized by a Content of corresponding phosphoric acid derivatives or their salts. 3. Mittel nach Anspruch 1, gekennzeichnet durch einen Gehalt an Ribonucleinsäuren bzw. deren Salze.3. Means according to claim 1, characterized by a Content of ribonucleic acids or their salts. 4. Mittel nach Anspruch 1 dadurch gekennzeichnet, daß eine bei der Spaltung von Hefenucleinsäure anfallende Mischung von Cytidin und Uridin zugesetzt wird.4. Composition according to claim 1, characterized in that one resulting from the cleavage of yeast nucleic acid Mixture of cytidine and uridine is added. 5. Mittel nach Anspruch 1 bis 4 dadurch gekennzeichnet, daß der Wirkstoff in Suspension in der Grundlage vorliegt. 5. Composition according to claim 1 to 4, characterized in that the active ingredient is present in suspension in the base. 309830/1132309830/1132
DE19712164052 1971-12-23 1971-12-23 COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES Pending DE2164052A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BE793306D BE793306A (en) 1971-12-23 COSMETIC PRODUCT
DE19712164052 DE2164052A1 (en) 1971-12-23 1971-12-23 COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES
GB5922072A GB1422642A (en) 1971-12-23 1972-12-21 Cosmetic preparations
IT3348972A IT1054115B (en) 1971-12-23 1972-12-22 COSMETIC PRODUCT INCLUDING AS RAW MATERIALS YEAST CELLULED
FR7247088A FR2164938A1 (en) 1971-12-23 1972-12-22

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712164052 DE2164052A1 (en) 1971-12-23 1971-12-23 COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES

Publications (1)

Publication Number Publication Date
DE2164052A1 true DE2164052A1 (en) 1973-07-26

Family

ID=5828943

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712164052 Pending DE2164052A1 (en) 1971-12-23 1971-12-23 COSMETIC AGENTS WITH NUCLEOSIDE DERIVATIVES

Country Status (5)

Country Link
BE (1) BE793306A (en)
DE (1) DE2164052A1 (en)
FR (1) FR2164938A1 (en)
GB (1) GB1422642A (en)
IT (1) IT1054115B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51139636A (en) * 1975-04-29 1976-12-02 Orlane Toilet article
US4464362A (en) * 1980-06-27 1984-08-07 Estee Lauder Inc. Topical skin repair composition
EP1396497A1 (en) * 2002-09-03 2004-03-10 AMINO GmbH Process for the recovery of uridine from molasses

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374822A (en) * 1981-10-19 1983-02-22 Colgate-Palmolive Oral composition
USRE31954E (en) * 1981-10-19 1985-07-23 Colgate-Palmolive Company Oral composition
JPS61171423A (en) * 1985-01-24 1986-08-02 Advance Res & Dev Co Ltd Drug for alleviating dental caries and periodontosis
FR2620024B1 (en) * 1987-09-09 1991-03-15 Dermatologiques Et COSMETIC COMPOSITION COMPRISING A FREE ANTIRADICAL AGENT, AND CORRESPONDING AGENT
FR2634374B1 (en) * 1988-07-19 1993-10-15 Laboratoires Serobiologiques AGENTS Photoprotective, CYTOPHOTOPROTECTEURS SKIN WITH photoprotective activity CELL COMPONENTS, FUNCTIONAL SKIN, ESPECIALLY CELLS Langerhans, BASED COMPOUNDS NUCLEIC: NUCLEOPROTIDES, ribonucleotides and deoxyribonucleotides, ribonucleosides and deoxyribonucleosides, COSMETIC OR DERMO-PHARMACEUTICAL CONTAINING SUCH AGENT AS WELL AS NEW COMPOUNDS IN ITSELF
US5095007A (en) * 1990-10-24 1992-03-10 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
FR2960426B1 (en) * 2010-05-27 2013-02-15 Oreal USE OF GUANOSINE TO MAINTAIN AND / OR RESTORE THE BIOMECHANICAL PROPERTIES OF THE SKIN
FR2975595B1 (en) * 2011-05-24 2013-08-02 Oreal USE OF GUANOSINE AS ANTI-IRRITATING AGENT.
UA103109C2 (en) * 2012-03-07 2013-09-10 Вадим Алексеевич Козловский Use of methyl silicic acid in hydrogel or xerogel form for treating periodontium tissues
JP6669501B2 (en) * 2013-03-08 2020-03-18 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ Compositions and methods for reducing skin pigmentation
CN116098842B (en) * 2022-10-24 2023-11-21 海南省人民医院 A collutory containing radix Morindae officinalis, and its preparation method

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51139636A (en) * 1975-04-29 1976-12-02 Orlane Toilet article
US4464362A (en) * 1980-06-27 1984-08-07 Estee Lauder Inc. Topical skin repair composition
EP1396497A1 (en) * 2002-09-03 2004-03-10 AMINO GmbH Process for the recovery of uridine from molasses

Also Published As

Publication number Publication date
BE793306A (en) 1973-04-16
IT1054115B (en) 1981-11-10
FR2164938A1 (en) 1973-08-03
GB1422642A (en) 1976-01-28

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