AU2001252618A1 - Cell proliferation inhibitors - Google Patents
Cell proliferation inhibitorsInfo
- Publication number
- AU2001252618A1 AU2001252618A1 AU2001252618A AU5261801A AU2001252618A1 AU 2001252618 A1 AU2001252618 A1 AU 2001252618A1 AU 2001252618 A AU2001252618 A AU 2001252618A AU 5261801 A AU5261801 A AU 5261801A AU 2001252618 A1 AU2001252618 A1 AU 2001252618A1
- Authority
- AU
- Australia
- Prior art keywords
- cell proliferation
- proliferation inhibitors
- pthrp
- inhibitors
- proliferation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000004663 cell proliferation Effects 0.000 title 1
- 230000035755 proliferation Effects 0.000 abstract 2
- ZOWOHMFPXMYFKJ-WBTWNKCNSA-N (4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-5-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C1=CN=CN1 ZOWOHMFPXMYFKJ-WBTWNKCNSA-N 0.000 abstract 1
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 abstract 1
- 102000043299 Parathyroid hormone-related Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108010054971 parathyroid hormone-related protein (1-34) Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000131793 | 2000-04-28 | ||
| JP2000-131793 | 2000-04-28 | ||
| JP2000-173834 | 2000-06-09 | ||
| JP2000173834 | 2000-06-09 | ||
| PCT/JP2001/003665 WO2001082968A1 (fr) | 2000-04-28 | 2001-04-26 | Inhibiteurs de proliferation cellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001252618A1 true AU2001252618A1 (en) | 2001-11-12 |
Family
ID=26591317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001252618A Abandoned AU2001252618A1 (en) | 2000-04-28 | 2001-04-26 | Cell proliferation inhibitors |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8029793B2 (de) |
| EP (2) | EP1987842A1 (de) |
| JP (1) | JP4846169B2 (de) |
| AT (1) | ATE420661T1 (de) |
| AU (1) | AU2001252618A1 (de) |
| DE (1) | DE60137417D1 (de) |
| WO (1) | WO2001082968A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841788B1 (fr) | 2002-07-05 | 2006-01-27 | Univ Pasteur | Utilisation d'antagonistes de la pthrp pour traiter le carcinome a cellules renales |
| AU2003262273A1 (en) * | 2002-11-18 | 2004-06-15 | Chugai Seiyaku Kabushiki Kaisha | Remedy for chondroma or chondrosarcoma |
| US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| EP1659918B1 (de) | 2003-08-08 | 2009-01-14 | Amgen Fremont Inc. | Antikörper gegen parath-hormon (pth) und ihre verwendungen |
| US20090041887A1 (en) | 2004-01-26 | 2009-02-12 | Resnessen Llc | High Protein Soybean Meal |
| GB2471693A (en) * | 2009-07-08 | 2011-01-12 | Complix Nv | Parathyroid hormone related protein antagonists |
| WO2014159798A1 (en) * | 2013-03-13 | 2014-10-02 | Avery Dennison Corporation | Improving adhesive properties |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPH0759763B2 (ja) | 1986-03-24 | 1995-06-28 | 株式会社バイオマテリアル・ユニバース | 高強度、高弾性率ポリビニルアルコ−ル繊維およびその製造法 |
| US5001223A (en) * | 1987-05-26 | 1991-03-19 | Merck & Co., Inc. | Parathyroid hormone antagonists with enhanced metabolic properties |
| US4771124A (en) * | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| EP0293130A3 (de) | 1987-05-26 | 1990-06-13 | Merck & Co. Inc. | Dimere von Parathyroid-Hormon-Antagonisten |
| EP0293158A3 (de) | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroide Hormon-Antagonisten |
| JPS6459878A (en) | 1987-08-31 | 1989-03-07 | Matsushita Electric Ind Co Ltd | Semiconductor laser protective circuit |
| DE68908175T2 (de) | 1988-05-27 | 1994-03-03 | Centocor Inc | Gefriergetrocknete formulierung für antikörperprodukte. |
| WO1989011298A1 (en) | 1988-05-27 | 1989-11-30 | Centocor, Inc. | Formulation for antibody reagents |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5217896A (en) * | 1988-12-30 | 1993-06-08 | Oncogene Science, Inc. | Monoclonal antibodies recognizing parathyroid hormone-like protein |
| JPH02207099A (ja) | 1989-02-07 | 1990-08-16 | Tonen Corp | ＰＴＨｒＰ関連ペプチド、その製造法及び用途 |
| CA2035179C (en) | 1990-01-31 | 2001-08-14 | Gerald S. Brenner | Pharmaceutical compositions containing insoluble salts of bisphosphonic acids |
| GB9009548D0 (en) | 1990-04-27 | 1990-06-20 | Celltech Ltd | Chimeric antibody and method |
| JPH04228089A (ja) * | 1990-05-15 | 1992-08-18 | Kanegafuchi Chem Ind Co Ltd | 高カルシウム血症治療・予防剤 |
| AU667662B2 (en) | 1990-07-13 | 1996-04-04 | Regents Of The University Of California, The | Parathyroid hormone analogues modified at positions 3, 6 or 9 |
| EP0546073B1 (de) | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
| JP3464796B2 (ja) | 1991-04-05 | 2003-11-10 | ザ ジェネラル ホスピタル コーポレーション | 副甲状腺ホルモンのレセプターとそれをコードしているｄｎａ |
| US5795965A (en) | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1993013133A1 (en) | 1991-12-20 | 1993-07-08 | Yamanouchi Pharmaceutical Co., Ltd. | HUMAN TYPE ANTIBODY REACTIVE WITH GPIIb/IIIa |
| AU675661B2 (en) | 1992-07-24 | 1997-02-13 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| US5849695A (en) * | 1993-01-13 | 1998-12-15 | The Regents Of The University Of California | Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals |
| JPH08509612A (ja) | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| JP3504697B2 (ja) | 1993-09-30 | 2004-03-08 | 株式会社先端生命科学研究所 | ＰＴＨｒＰアンタゴニスト活性を有するポリペプチド及びそれを含むカルシウム代謝治療薬 |
| JPH07316195A (ja) | 1994-05-25 | 1995-12-05 | Nippon Kayaku Co Ltd | 新規なＰＴＨｒＰ関連ペプチド及びその用途 |
| WO1996002576A1 (fr) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre l'interleukine-8 humaine |
| CO4410206A1 (es) | 1994-07-28 | 1997-01-09 | Sandoz Ag | DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| US5993817A (en) * | 1995-01-23 | 1999-11-30 | Xenotech | Method to ameliorate osteolysis and metastasis |
| US5626845A (en) * | 1995-01-23 | 1997-05-06 | Xenotech Incorporated | Method to ameliorate osteolysis and metastasis |
| KR100528604B1 (ko) * | 1995-01-23 | 2006-03-16 | 제노테크 인코포레이티드 | 골용해와전이를개선하기위한조성물 |
| DE69637104T2 (de) | 1995-02-20 | 2008-01-31 | Yukio Kato | Heilmittel für arthrosis deformans und entzündliche gelenkerkrankungen |
| ATE197250T1 (de) | 1995-03-01 | 2000-11-15 | Stryker Corp | Morphogeninduzierte regenerierung der dentin |
| EP1978033A3 (de) | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Aus immunisiertem Xenomid abgeleitete menschliche Antikörper |
| US5660826A (en) | 1995-06-06 | 1997-08-26 | The Regents Of The University Of California | Therapeutic sepsis treatment using antagonists to PTHrP |
| ATE219374T1 (de) | 1996-02-01 | 2002-07-15 | Chugai Pharmaceutical Co Ltd | Medikamente für die behandlung oder vorbeugung von thrombocytopenie |
| ATE360689T1 (de) | 1996-09-10 | 2007-05-15 | Kocher Theodor Inst | Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung |
| RU2198220C2 (ru) * | 1996-09-26 | 2003-02-10 | Чугаи Сейяку Кабусики Кайся | Антитело против белка, родственного паращитовидному гормону человека, днк, вектор, способ получения и использование антитела |
| JP4372240B2 (ja) | 1997-05-15 | 2009-11-25 | 中外製薬株式会社 | 悪液質治療剤 |
| PL193575B1 (pl) * | 1997-05-15 | 2007-02-28 | Chugai Pharmaceutical Co Ltd | Zastosowanie przeciwciała przeciwko białku pokrewnemu z hormonem przytarczyc (PTHrP) |
| JP4414494B2 (ja) | 1998-02-03 | 2010-02-10 | 旭化成ファーマ株式会社 | 白血球減少症の予防剤および治療剤 |
| US7531621B1 (en) | 1998-05-05 | 2009-05-12 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | PTH2 receptor selective compounds |
| JP2000080100A (ja) * | 1998-06-17 | 2000-03-21 | Japan Tobacco Inc | 副甲状腺ホルモン関連タンパクに対するヒトモノクローナル抗体 |
| TR200003768T2 (tr) | 1998-06-26 | 2001-06-21 | Chugai Seiyaku Kabushiki Kaisha | Hiperkalsemik krizler için terapötik aktif madde. |
| JP2000131793A (ja) | 1998-10-27 | 2000-05-12 | Konica Corp | 熱現像感光材料の製造方法、これにより製造した熱現像感光材料を用いた画像記録方法及び画像形成方法 |
| JP2000173834A (ja) | 1998-12-10 | 2000-06-23 | Mitsubishi Electric Corp | シート巻静止誘導電器 |
-
2001
- 2001-04-26 EP EP08009290A patent/EP1987842A1/de not_active Withdrawn
- 2001-04-26 DE DE60137417T patent/DE60137417D1/de not_active Expired - Lifetime
- 2001-04-26 AT AT01925993T patent/ATE420661T1/de not_active IP Right Cessation
- 2001-04-26 WO PCT/JP2001/003665 patent/WO2001082968A1/ja active Application Filing
- 2001-04-26 JP JP2001579841A patent/JP4846169B2/ja not_active Expired - Fee Related
- 2001-04-26 AU AU2001252618A patent/AU2001252618A1/en not_active Abandoned
- 2001-04-26 US US10/258,477 patent/US8029793B2/en not_active Expired - Fee Related
- 2001-04-26 EP EP01925993A patent/EP1283057B2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60137417D1 (de) | 2009-03-05 |
| EP1283057A1 (de) | 2003-02-12 |
| ATE420661T1 (de) | 2009-01-15 |
| JP4846169B2 (ja) | 2011-12-28 |
| EP1283057B2 (de) | 2012-05-30 |
| US20040001824A1 (en) | 2004-01-01 |
| US8029793B2 (en) | 2011-10-04 |
| EP1987842A1 (de) | 2008-11-05 |
| WO2001082968A1 (fr) | 2001-11-08 |
| EP1283057A4 (de) | 2005-08-03 |
| EP1283057B1 (de) | 2009-01-14 |
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