AU2001241420A1 - Screening assays using intramitochondrial calcium - Google Patents
Screening assays using intramitochondrial calciumInfo
- Publication number
- AU2001241420A1 AU2001241420A1 AU2001241420A AU4142001A AU2001241420A1 AU 2001241420 A1 AU2001241420 A1 AU 2001241420A1 AU 2001241420 A AU2001241420 A AU 2001241420A AU 4142001 A AU4142001 A AU 4142001A AU 2001241420 A1 AU2001241420 A1 AU 2001241420A1
- Authority
- AU
- Australia
- Prior art keywords
- mitochondrial
- agents
- screening assays
- calcium
- detect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
- G01N33/5079—Mitochondria
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17638400P | 2000-01-14 | 2000-01-14 | |
US60176384 | 2000-01-14 | ||
PCT/US2001/001500 WO2001051923A2 (fr) | 2000-01-14 | 2001-01-16 | Tests de criblage utilisant le calcium intramitochondrial |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001241420A1 true AU2001241420A1 (en) | 2001-07-24 |
Family
ID=22644141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001241420A Abandoned AU2001241420A1 (en) | 2000-01-14 | 2001-01-16 | Screening assays using intramitochondrial calcium |
Country Status (6)
Country | Link |
---|---|
US (2) | US6808873B2 (fr) |
EP (1) | EP1247093B1 (fr) |
AT (1) | ATE291737T1 (fr) |
AU (1) | AU2001241420A1 (fr) |
DE (1) | DE60109571D1 (fr) |
WO (1) | WO2001051923A2 (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US8022058B2 (en) * | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
WO2002002816A2 (fr) * | 2000-06-29 | 2002-01-10 | Mitokor | Procedes d'identification de transporteurs de cations divalents mitochondriaux |
EP2383280A1 (fr) | 2002-09-23 | 2011-11-02 | E. I. du Pont de Nemours and Company | Système d'expression pour les canaux d'ion toxiques, par example de récepteurs de la ryanodine |
ATE468114T1 (de) * | 2002-11-08 | 2010-06-15 | High Point Pharmaceuticals Llc | Sichere chemische entkuppler zur behandlung von fettsucht |
GB0228139D0 (en) * | 2002-12-03 | 2003-01-08 | Kozlova Zwinderman Olga | Fungal biosensor for contaminant detection |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
US20090093403A1 (en) | 2007-03-01 | 2009-04-09 | Feng Zhang | Systems, methods and compositions for optical stimulation of target cells |
US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
EP1919497B1 (fr) | 2005-07-22 | 2020-02-12 | The Board of Trustees of the Leland Stanford Junior University | Canaux cationiques activees par la lumiere et leurs utilisations |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
WO2007065080A2 (fr) * | 2005-11-29 | 2007-06-07 | University Of Maryland, College Park | Suppression de l’apoptose par regulation de la propension a la formation de chaine de ceramide |
US8398692B2 (en) | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US8795609B2 (en) | 2007-02-08 | 2014-08-05 | Biokit, S.A. | Magnetic particle washing station |
US8401609B2 (en) | 2007-02-14 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
SG189813A1 (en) | 2008-04-23 | 2013-05-31 | Univ Leland Stanford Junior | Systems, methods and compositions for optical stimulation of target cells |
US8729040B2 (en) | 2008-05-29 | 2014-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | Cell line, system and method for optical control of secondary messengers |
JP5887136B2 (ja) | 2008-06-17 | 2016-03-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 細胞発達を制御するための装置および方法 |
US20110097731A1 (en) * | 2008-06-25 | 2011-04-28 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Mischer Institute for Biomedical Researc | Novel mitochondrial dye |
WO2010006049A1 (fr) | 2008-07-08 | 2010-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Matériaux et approches pour stimulation optique du système nerveux périphérique |
NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
WO2010111208A1 (fr) * | 2009-03-23 | 2010-09-30 | University Of Miami | Inhibiteurs mitochondriaux et utilisations correspondantes |
ES2676274T3 (es) | 2010-03-17 | 2018-07-18 | The Board Of Trustees Of The Leland Stanford Junior University | Moléculas sensibles a la luz que permiten el paso de iones |
EP2635346B1 (fr) | 2010-11-05 | 2017-03-29 | The Board of Trustees of the Leland Stanford Junior University | Régulation optogénétique de comportements associés au système de récompense |
EP2635109A4 (fr) | 2010-11-05 | 2014-03-19 | Univ Leland Stanford Junior | Dysfonctionnement du snc contrôlé optiquement |
WO2012061679A2 (fr) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Opsines chimériques activées par la lumière et leurs procédés d'utilisation |
EP2635111B1 (fr) | 2010-11-05 | 2018-05-23 | The Board of Trustees of the Leland Stanford Junior University | Protéines stabilisées de type opsine a fonction discontinue (ssfo) et leurs procédés d'utilisation |
US9522288B2 (en) | 2010-11-05 | 2016-12-20 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light for use in optogenetic methods |
CA2816972C (fr) | 2010-11-05 | 2019-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Controle et caracterisation de la fonction memoire |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
EP2694667B1 (fr) * | 2011-04-08 | 2016-12-07 | Baystate Medical Center, Inc. | Procédés, compositions et nécessaires permettant d'analyser la fonction mitochondriale |
CN104093833B (zh) | 2011-12-16 | 2017-11-07 | 斯坦福大学托管董事会 | 视蛋白多肽及其使用方法 |
ES2628006T3 (es) | 2012-02-21 | 2017-08-01 | Circuit Therapeutics, Inc. | Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico |
WO2014144409A1 (fr) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Contrôle optogénétique de l'état comportemental |
US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
JP6549559B2 (ja) | 2013-04-29 | 2019-07-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 標的細胞における活動電位の光遺伝学的調節のための装置、システム及び方法 |
EP3033427A4 (fr) | 2013-08-14 | 2017-05-31 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Compositions et procédés pour réguler une douleur |
US10568516B2 (en) | 2015-06-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
US12006553B2 (en) | 2017-05-19 | 2024-06-11 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
CA3148248A1 (fr) * | 2019-07-24 | 2021-01-28 | Luca Science Inc. | Procede d'obtention de mitochondries a partir de cellules et mitochondries ainsi obtenues |
CN113069530B (zh) * | 2021-03-31 | 2022-01-25 | 河南大学 | 萘酰亚胺-多胺衍生物联合环孢素a在制备抗肿瘤药物中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5015568A (en) | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
US5049673A (en) | 1987-10-30 | 1991-09-17 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium working at long wavelengths |
US5501980A (en) | 1994-05-20 | 1996-03-26 | Molecular Probes, Inc. | Benzazolylcoumarin-based ion indicators |
US5888498A (en) | 1995-03-03 | 1999-03-30 | Mitokor | Cellular and animal models for diseases associated with mitochondrial defects |
US6183948B1 (en) * | 1998-04-15 | 2001-02-06 | Johns Hopkins University | Methods to identify compounds affecting mitochondria |
-
2001
- 2001-01-16 WO PCT/US2001/001500 patent/WO2001051923A2/fr active IP Right Grant
- 2001-01-16 US US09/765,104 patent/US6808873B2/en not_active Expired - Fee Related
- 2001-01-16 AT AT01912665T patent/ATE291737T1/de not_active IP Right Cessation
- 2001-01-16 AU AU2001241420A patent/AU2001241420A1/en not_active Abandoned
- 2001-01-16 DE DE60109571T patent/DE60109571D1/de not_active Expired - Lifetime
- 2001-01-16 EP EP01912665A patent/EP1247093B1/fr not_active Expired - Lifetime
-
2004
- 2004-10-26 US US10/974,484 patent/US20050170329A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2001051923A3 (fr) | 2002-05-02 |
US6808873B2 (en) | 2004-10-26 |
WO2001051923A2 (fr) | 2001-07-19 |
US20050170329A1 (en) | 2005-08-04 |
EP1247093B1 (fr) | 2005-03-23 |
DE60109571D1 (de) | 2005-04-28 |
US20010046664A1 (en) | 2001-11-29 |
EP1247093A2 (fr) | 2002-10-09 |
ATE291737T1 (de) | 2005-04-15 |
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