ATE291737T1 - Screening-assays unter verwendung von intramitochondrialem kalzium - Google Patents

Screening-assays unter verwendung von intramitochondrialem kalzium

Info

Publication number
ATE291737T1
ATE291737T1 AT01912665T AT01912665T ATE291737T1 AT E291737 T1 ATE291737 T1 AT E291737T1 AT 01912665 T AT01912665 T AT 01912665T AT 01912665 T AT01912665 T AT 01912665T AT E291737 T1 ATE291737 T1 AT E291737T1
Authority
AT
Austria
Prior art keywords
mitochondrial
agents
screening assay
calcium
detect
Prior art date
Application number
AT01912665T
Other languages
English (en)
Inventor
Anne N Murphy
Amy K Stout
Original Assignee
Migenix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Migenix Corp filed Critical Migenix Corp
Application granted granted Critical
Publication of ATE291737T1 publication Critical patent/ATE291737T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria
AT01912665T 2000-01-14 2001-01-16 Screening-assays unter verwendung von intramitochondrialem kalzium ATE291737T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17638400P 2000-01-14 2000-01-14
PCT/US2001/001500 WO2001051923A2 (en) 2000-01-14 2001-01-16 Screening assays using intramitochondrial calcium

Publications (1)

Publication Number Publication Date
ATE291737T1 true ATE291737T1 (de) 2005-04-15

Family

ID=22644141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01912665T ATE291737T1 (de) 2000-01-14 2001-01-16 Screening-assays unter verwendung von intramitochondrialem kalzium

Country Status (6)

Country Link
US (2) US6808873B2 (de)
EP (1) EP1247093B1 (de)
AT (1) ATE291737T1 (de)
AU (1) AU2001241420A1 (de)
DE (1) DE60109571D1 (de)
WO (1) WO2001051923A2 (de)

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US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) * 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
AU2001276846A1 (en) * 2000-06-29 2002-01-14 Mitokor Methods for identifying mitochondrial divalent cation transporters
EP1546183A4 (de) 2002-09-23 2008-06-18 Du Pont Isolierung und verwendung von ryanodinrezeptoren
WO2004041256A2 (en) * 2002-11-08 2004-05-21 Novo Nordisk A/S Safe chemical uncouplers for the treatment of obesity
GB0228139D0 (en) * 2002-12-03 2003-01-08 Kozlova Zwinderman Olga Fungal biosensor for contaminant detection
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2007024391A2 (en) 2005-07-22 2007-03-01 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
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US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7897401B2 (en) * 2005-11-29 2011-03-01 University Of Maryland, College Park Control of apoptosis by controlling the propensity of ceramide channel formation
US8398692B2 (en) 2007-01-10 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8795609B2 (en) 2007-02-08 2014-08-05 Biokit, S.A. Magnetic particle washing station
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WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
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US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
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CA2726128C (en) 2008-05-29 2016-10-18 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
BRPI0915583A2 (pt) 2008-06-17 2016-01-26 Univ Leland Stanford Junior aparelho e métodos para controle do desenvolvimento celular
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NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
WO2010111208A1 (en) * 2009-03-23 2010-09-30 University Of Miami Mitochondrial inhibitors and uses thereof
US9079940B2 (en) 2010-03-17 2015-07-14 The Board Of Trustees Of The Leland Stanford Junior University Light-sensitive ion-passing molecules
CN103298480B (zh) 2010-11-05 2016-10-12 斯坦福大学托管董事会 记忆功能的控制和表征
CN103476456B (zh) 2010-11-05 2017-10-03 斯坦福大学托管董事会 奖赏相关行为的光遗传学控制
JP6145043B2 (ja) 2010-11-05 2017-06-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 光遺伝的方法で使用するための光の上方変換
US8932562B2 (en) 2010-11-05 2015-01-13 The Board Of Trustees Of The Leland Stanford Junior University Optically controlled CNS dysfunction
CN105941328B (zh) 2010-11-05 2019-04-09 斯坦福大学托管董事会 一种鉴定抑制前额叶皮质中的兴奋性或抑制性神经元的去极化的化合物的系统
WO2012061679A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CN103687959B (zh) * 2011-04-08 2016-10-12 贝斯泰医学中心公司 用于测定线粒体功能的方法、组合物和试剂盒
EP3524676A1 (de) 2011-12-16 2019-08-14 The Board of Trustees of The Leland Stanford Junior University Opsin-polypeptide und verfahren zu ihrer verwendung
CN104363961B (zh) 2012-02-21 2017-10-03 斯坦福大学托管董事会 用于治疗盆底神经源性病症的组合物和方法
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
JP6594854B2 (ja) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 行動状態の光遺伝学的制御方法
WO2014179331A2 (en) 2013-04-29 2014-11-06 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
JP6621747B2 (ja) 2013-08-14 2019-12-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛を制御するための組成物及び方法
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CN113069530B (zh) * 2021-03-31 2022-01-25 河南大学 萘酰亚胺-多胺衍生物联合环孢素a在制备抗肿瘤药物中的应用

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US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5049673A (en) 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
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US6183948B1 (en) * 1998-04-15 2001-02-06 Johns Hopkins University Methods to identify compounds affecting mitochondria

Also Published As

Publication number Publication date
AU2001241420A1 (en) 2001-07-24
WO2001051923A3 (en) 2002-05-02
US20050170329A1 (en) 2005-08-04
EP1247093B1 (de) 2005-03-23
US20010046664A1 (en) 2001-11-29
DE60109571D1 (de) 2005-04-28
WO2001051923A2 (en) 2001-07-19
US6808873B2 (en) 2004-10-26
EP1247093A2 (de) 2002-10-09

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