AU2001234174A1 - Phosphonate nucleotide compound - Google Patents

Phosphonate nucleotide compound

Info

Publication number
AU2001234174A1
AU2001234174A1 AU2001234174A AU3417401A AU2001234174A1 AU 2001234174 A1 AU2001234174 A1 AU 2001234174A1 AU 2001234174 A AU2001234174 A AU 2001234174A AU 3417401 A AU3417401 A AU 3417401A AU 2001234174 A1 AU2001234174 A1 AU 2001234174A1
Authority
AU
Australia
Prior art keywords
nucleotide compound
phosphonate nucleotide
phosphonate
compound
nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001234174A
Other languages
English (en)
Inventor
Kouichi Sekiya
Masaru Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Tokyo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tokyo Pharmaceuticals Inc filed Critical Mitsubishi Tokyo Pharmaceuticals Inc
Publication of AU2001234174A1 publication Critical patent/AU2001234174A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001234174A 2000-02-29 2001-02-26 Phosphonate nucleotide compound Abandoned AU2001234174A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-54675 2000-02-29
JP2000054675 2000-02-29
PCT/JP2001/001412 WO2001064693A1 (fr) 2000-02-29 2001-02-26 Compose de nucleotide de phosphonate

Publications (1)

Publication Number Publication Date
AU2001234174A1 true AU2001234174A1 (en) 2001-09-12

Family

ID=18575897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001234174A Abandoned AU2001234174A1 (en) 2000-02-29 2001-02-26 Phosphonate nucleotide compound

Country Status (5)

Country Link
US (1) US6767900B2 (fr)
KR (1) KR20020093824A (fr)
CN (1) CN1426418A (fr)
AU (1) AU2001234174A1 (fr)
WO (1) WO2001064693A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508924A (ja) * 2001-08-30 2005-04-07 三菱ウェルファーマ株式会社 抗ウイルス剤
KR100987815B1 (ko) * 2002-04-26 2010-10-18 길리애드 사이언시즈, 인코포레이티드 Ｈｉｖ 프로테아제 억제제 화합물의 포스포네이트유사체의 세포 축적
US20050239054A1 (en) * 2002-04-26 2005-10-27 Arimilli Murty N Method and compositions for identifying anti-HIV therapeutic compounds
AU2003242428A1 (en) * 2002-05-24 2003-12-12 Mitsubishi Pharma Corporation Drugs improved in tissue selectivity
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US20090247488A1 (en) * 2003-04-25 2009-10-01 Carina Cannizzaro Anti-inflammatory phosphonate compounds
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
KR20060022647A (ko) 2003-04-25 2006-03-10 길리애드 사이언시즈, 인코포레이티드 키나아제 억제 포스포네이트 유사체
WO2005002626A2 (fr) * 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
CA2523083C (fr) 2003-04-25 2014-07-08 Gilead Sciences, Inc. Analogues de phosphonate antiviraux
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
WO2004096285A2 (fr) * 2003-04-25 2004-11-11 Gilead Sciences, Inc. Analogues anti-infectieux du phosphonate
WO2004096287A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
EP1678321A1 (fr) 2003-10-24 2006-07-12 Gilead Sciences, Inc. Procedes et compositions permettant d'identifier des composes therapeutiques
WO2005044308A1 (fr) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Analogues phosphonates d'antimetabolites
US7427624B2 (en) 2003-10-24 2008-09-23 Gilead Sciences, Inc. Purine nucleoside phosphorylase inhibitory phosphonate compounds
US20050153990A1 (en) * 2003-12-22 2005-07-14 Watkins William J. Phosphonate substituted kinase inhibitors
US20080287471A1 (en) * 2003-12-22 2008-11-20 Maria Fardis 4'-Substituted Carbovir And Abacavir-Derivatives As Well As Related Compounds With Hiv And Hcv Antiviral Activity
BRPI0418031A (pt) * 2003-12-22 2007-04-17 Gilead Sciences Inc inibidores de quinase fosfonato-substituìdos
CN100475825C (zh) * 2004-03-19 2009-04-08 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物
PT1778251E (pt) 2004-07-27 2011-06-29 Gilead Sciences Inc Análogos de fosfonato de compostos inibidores de vih
US20080171724A1 (en) * 2004-10-26 2008-07-17 Gilead Sciences, Inc. Phosphonate Derivatives of Mycophenolic Acid
WO2006066074A2 (fr) 2004-12-16 2006-06-22 The Regents Of The University Of California Medicaments destines au poumon
WO2007014491A1 (fr) * 2005-08-03 2007-02-08 Beijing Fu Kang Ren Bio-Pharm Tech.Co.Ltd. Phosphonates de nucléotides acycliques et leur utilisation dans des agents antiviraux
CN1935817B (zh) * 2005-09-19 2011-05-11 北京阜康仁生物制药科技有限公司 新的无环核苷膦酸酯及其医药用途
BRPI0810621A2 (pt) 2007-04-13 2017-06-06 Southern Res Inst métodos de inibição ou redução da angiogênese, do crescimento ou metástase de tumor dependente da mesma e de tratamento de doença ou desordem associada a angiogênese.
US8787221B2 (en) * 2007-10-23 2014-07-22 La Crosse Technology, Ltd. Method of transmitting, receiving, recording, playing and displaying weather radio
CA2729769C (fr) * 2008-07-08 2017-09-05 Gilead Sciences, Inc. Sels de composes inhibiteurs du vih
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
KR101115041B1 (ko) 2011-01-07 2012-03-06 경남과학기술대학교 산학협력단 계육 가수분해물을 포함하는 기능성 조성물 및 이의 제조방법
EP3578563B1 (fr) 2011-12-22 2021-04-14 Geron Corporation Analogues de guanine en tant que substrats de télomérase et d'agents affecteurs de longueur de télomère
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
ES2915381T3 (es) 2014-09-15 2022-06-22 Univ California Análogos de nucleótidos
EP3350191B9 (fr) 2015-09-15 2021-12-22 The Regents of the University of California Analogues nucléotidiques
EP3960740B1 (fr) 2017-08-01 2023-11-15 Gilead Sciences, Inc. Formes crystallines de vanillate de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)méthyl)(phénoxy)phosphoryl)-l-alaninate éthyilique (gs-9131) pour le traitement d'infections virales

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE199906T1 (de) * 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate
CA2195262C (fr) 1996-01-18 2005-08-09 Masaru Ubasawa Composes de phosphonate nucleotidique
KR20020097384A (ko) * 2001-06-20 2002-12-31 미쯔비시 도꾜 세이야꾸 가부시끼가이샤 기존의 약제에 내성변이를 가지는 바이러스에 유효한 약제

Also Published As

Publication number Publication date
WO2001064693A1 (fr) 2001-09-07
KR20020093824A (ko) 2002-12-16
US20030153534A1 (en) 2003-08-14
US6767900B2 (en) 2004-07-27
CN1426418A (zh) 2003-06-25

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