AU2001223737A1 - Reaction of carbonyl compounds with organometallic reagents - Google Patents

Reaction of carbonyl compounds with organometallic reagents

Info

Publication number
AU2001223737A1
AU2001223737A1 AU2001223737A AU2373701A AU2001223737A1 AU 2001223737 A1 AU2001223737 A1 AU 2001223737A1 AU 2001223737 A AU2001223737 A AU 2001223737A AU 2373701 A AU2373701 A AU 2373701A AU 2001223737 A1 AU2001223737 A1 AU 2001223737A1
Authority
AU
Australia
Prior art keywords
reaction
carbonyl compounds
organometallic reagents
organometallic
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001223737A
Other languages
English (en)
Inventor
Jurgen Eckstein
Ulrich Koop
Holger Krummradt
Wolfgang Melichar
Michael Schwarz
Joran Stoldt
Stefan Zehner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7627500&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001223737(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2001223737A1 publication Critical patent/AU2001223737A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B49/00—Grignard reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00004—Scale aspects
    • B01J2219/00011—Laboratory-scale plants
    • B01J2219/00013—Miniplants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00058—Temperature measurement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00065—Pressure measurement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00094—Jackets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00177—Controlling or regulating processes controlling the pH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00984—Residence time

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2001223737A 2000-01-14 2001-01-10 Reaction of carbonyl compounds with organometallic reagents Abandoned AU2001223737A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10001317 2000-01-14
DE10001317A DE10001317A1 (de) 2000-01-14 2000-01-14 Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien
PCT/EP2001/000248 WO2001051434A1 (de) 2000-01-14 2001-01-10 Reaktion von carbonylverbindungen mit metallorganischen reagenzien

Publications (1)

Publication Number Publication Date
AU2001223737A1 true AU2001223737A1 (en) 2001-07-24

Family

ID=7627500

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001223737A Abandoned AU2001223737A1 (en) 2000-01-14 2001-01-10 Reaction of carbonyl compounds with organometallic reagents

Country Status (7)

Country Link
US (1) US7098344B2 (de)
EP (1) EP1246784B9 (de)
JP (1) JP2003523960A (de)
AT (1) ATE307101T1 (de)
AU (1) AU2001223737A1 (de)
DE (2) DE10001317A1 (de)
WO (1) WO2001051434A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10108471C1 (de) 2001-02-22 2002-11-21 Boehringer Ingelheim Pharma Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen
US7141681B2 (en) 2001-02-22 2006-11-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Continuous process for preparing dihydropyrones
DE10143189A1 (de) * 2001-09-04 2003-03-20 Clariant Gmbh Verfahren und Vorrichtung zur prozeßbegleitenden Reinigung von Mikro-und Minireaktoren
JP4639042B2 (ja) * 2003-09-29 2011-02-23 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
EP1889849A1 (de) * 2006-07-18 2008-02-20 Lonza Ag Reaktionen vom Grignardtyp in Mikroreaktoren
CA2663615A1 (en) 2006-09-19 2008-03-27 Banyu Pharmaceutical Co., Ltd. Reaction apparatus, and reaction method
CN108002981A (zh) * 2017-12-11 2018-05-08 万华化学集团股份有限公司 一种连续化生产乙烯基-β-紫罗兰醇的方法
CN108164389B (zh) * 2018-01-29 2020-07-10 浙江大学 一种高选择性2-甲基烯丙基氯的合成方法及合成反应器
WO2020164217A1 (en) * 2019-02-15 2020-08-20 Fujian Yongjing Technology Co., Ltd New process for manufacture of fluoroaryl compounds and derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759513A (fr) * 1969-11-29 1971-05-27 Hoffmann La Roche Thiolactone
US5358670A (en) * 1993-07-02 1994-10-25 Ferro Corporation Process for preparing grignard reagents in diethylene glycol dibutyl ether
JP3561938B2 (ja) * 1993-12-27 2004-09-08 住友化学工業株式会社 チオファン誘導体の製造法
DE4411101C2 (de) 1994-03-30 1996-02-01 Merck Patent Gmbh Verfahren zur Herstellung eines D-(+)-Biotin-Zwischenproduktes
CA2193774C (en) * 1995-12-26 2005-02-01 Norihiko Hirata Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid
DE19746583A1 (de) * 1997-10-22 1999-04-29 Merck Patent Gmbh Mikromischer
GB9723260D0 (en) * 1997-11-05 1998-01-07 British Nuclear Fuels Plc A method of performing a chemical reaction
DE19816886C2 (de) * 1998-04-17 2001-06-07 Axiva Gmbh Verfahren und Vorrichtung zur kontinuierlichen Herstellung von Polymerisaten
DE19858856A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Arylmetallverbindungen und deren Umsetzung mit Elektrophilen

Also Published As

Publication number Publication date
US7098344B2 (en) 2006-08-29
ATE307101T1 (de) 2005-11-15
EP1246784A1 (de) 2002-10-09
EP1246784B9 (de) 2006-01-18
WO2001051434A1 (de) 2001-07-19
JP2003523960A (ja) 2003-08-12
DE50107745D1 (de) 2006-03-02
US20030004357A1 (en) 2003-01-02
EP1246784B1 (de) 2005-10-19
DE10001317A1 (de) 2001-07-19

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