ATE99298T1 - 1,4,8-triazacyclotridecan-derivate mit prolylendopeptidase-hemmender wirkung. - Google Patents
1,4,8-triazacyclotridecan-derivate mit prolylendopeptidase-hemmender wirkung.Info
- Publication number
- ATE99298T1 ATE99298T1 AT91104163T AT91104163T ATE99298T1 AT E99298 T1 ATE99298 T1 AT E99298T1 AT 91104163 T AT91104163 T AT 91104163T AT 91104163 T AT91104163 T AT 91104163T AT E99298 T1 ATE99298 T1 AT E99298T1
- Authority
- AT
- Austria
- Prior art keywords
- triazacyclotridecan
- prolylene
- derivatives
- inhibitor activity
- endopeptidase inhibitor
- Prior art date
Links
- PUPRMQSYXBJTLN-UHFFFAOYSA-N 1,4,8-triazacyclotridecane Chemical class C1CCNCCCNCCNCC1 PUPRMQSYXBJTLN-UHFFFAOYSA-N 0.000 title 1
- 229940124143 Endopeptidase inhibitor Drugs 0.000 title 1
- LUORGXVDSLVJSV-FTDILOGSSA-N (e)-6-methyl-n-[(3s,7s,10s)-7-methyl-3-(2-methylpropyl)-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl]hept-2-enamide Chemical compound CC(C)CC\C=C\C(=O)N[C@H]1CCCNC(=O)[C@H](CC(C)C)NC(=O)C(=O)[C@H](C)NC1=O LUORGXVDSLVJSV-FTDILOGSSA-N 0.000 abstract 1
- YNIGBMUXBCZRNQ-XYOKQWHBSA-N (e)-6-methyl-n-[7-methyl-3-(2-methylpropyl)-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl]oct-2-enamide Chemical compound CCC(C)CC\C=C\C(=O)NC1CCCNC(=O)C(CC(C)C)NC(=O)C(=O)C(C)NC1=O YNIGBMUXBCZRNQ-XYOKQWHBSA-N 0.000 abstract 1
- 241000187180 Streptomyces sp. Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108010051573 eurystatin A Proteins 0.000 abstract 1
- 108010051571 eurystatin B Proteins 0.000 abstract 1
- 239000003649 prolyl endopeptidase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/497,292 US4999349A (en) | 1990-03-22 | 1990-03-22 | BU-4164E - A and B, prolyl endopeptidase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE99298T1 true ATE99298T1 (de) | 1994-01-15 |
Family
ID=23976256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91104163T ATE99298T1 (de) | 1990-03-22 | 1991-03-18 | 1,4,8-triazacyclotridecan-derivate mit prolylendopeptidase-hemmender wirkung. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4999349A (de) |
| EP (1) | EP0451547B1 (de) |
| JP (1) | JPH06339390A (de) |
| AT (1) | ATE99298T1 (de) |
| CA (1) | CA2038509A1 (de) |
| DE (1) | DE69100865D1 (de) |
| DK (1) | DK0451547T3 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
| GB9024208D0 (en) * | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
| CA2089890A1 (en) * | 1991-06-20 | 1992-12-21 | Makoto Yoshihama | Prolyl endopeptidase inhibitors sna-115 and sna-115t, production thereof, and strain which produces said inhibitors |
| WO2002010142A1 (en) * | 2000-08-02 | 2002-02-07 | Slil Biomedical Corporation | Cyclic polyamine compounds for cancer therapy |
| US20030072715A1 (en) * | 2000-08-02 | 2003-04-17 | Benjamin Frydman | Cyclic polyamine compounds for cancer therapy |
| WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| AU2005210004B2 (en) | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| EP2089383B1 (de) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
| WO2008144748A1 (en) * | 2007-05-21 | 2008-11-27 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| SG178953A1 (en) | 2009-09-11 | 2012-04-27 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| EP2542549B1 (de) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Glutaminylcyclase-hemmer |
| WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
| DE3684633D1 (de) * | 1985-04-16 | 1992-05-07 | Suntory Ltd | Dipeptid-derivate von fettsaeure, verfahren zu ihrer herstellung, heilmittel, das sie enthaelt und anwendung. |
| JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途 |
| US4898940A (en) * | 1985-08-30 | 1990-02-06 | Bristol-Myers Company | Peptide antibiotics |
| JPH0764834B2 (ja) * | 1985-11-29 | 1995-07-12 | サントリー株式会社 | プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途 |
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| JPH08806B2 (ja) * | 1986-11-18 | 1996-01-10 | サントリー株式会社 | プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体 |
| ATE151760T1 (de) * | 1987-02-23 | 1997-05-15 | Ono Pharmaceutical Co | Thiazolidin-derivate |
| US4857524A (en) * | 1987-08-08 | 1989-08-15 | Kissei Pharmaceutical Co., Ltd. | Thiazolidine compounds and therapeutic method |
-
1990
- 1990-03-22 US US07/497,292 patent/US4999349A/en not_active Expired - Fee Related
-
1991
- 1991-03-18 DK DK91104163.0T patent/DK0451547T3/da active
- 1991-03-18 EP EP91104163A patent/EP0451547B1/de not_active Expired - Lifetime
- 1991-03-18 AT AT91104163T patent/ATE99298T1/de not_active IP Right Cessation
- 1991-03-18 DE DE91104163T patent/DE69100865D1/de not_active Expired - Lifetime
- 1991-03-18 CA CA002038509A patent/CA2038509A1/en not_active Abandoned
- 1991-03-20 JP JP3216761A patent/JPH06339390A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0451547B1 (de) | 1993-12-29 |
| US4999349A (en) | 1991-03-12 |
| DK0451547T3 (da) | 1993-12-29 |
| CA2038509A1 (en) | 1991-09-23 |
| JPH06339390A (ja) | 1994-12-13 |
| DE69100865D1 (de) | 1994-02-10 |
| EP0451547A1 (de) | 1991-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |