ATE99298T1 - 1,4,8-triazacyclotridecan-derivate mit prolylendopeptidase-hemmender wirkung. - Google Patents
1,4,8-triazacyclotridecan-derivate mit prolylendopeptidase-hemmender wirkung.Info
- Publication number
- ATE99298T1 ATE99298T1 AT91104163T AT91104163T ATE99298T1 AT E99298 T1 ATE99298 T1 AT E99298T1 AT 91104163 T AT91104163 T AT 91104163T AT 91104163 T AT91104163 T AT 91104163T AT E99298 T1 ATE99298 T1 AT E99298T1
- Authority
- AT
- Austria
- Prior art keywords
- triazacyclotridecan
- prolylene
- derivatives
- inhibitor activity
- endopeptidase inhibitor
- Prior art date
Links
- PUPRMQSYXBJTLN-UHFFFAOYSA-N 1,4,8-triazacyclotridecane Chemical class C1CCNCCCNCCNCC1 PUPRMQSYXBJTLN-UHFFFAOYSA-N 0.000 title 1
- 229940124143 Endopeptidase inhibitor Drugs 0.000 title 1
- LUORGXVDSLVJSV-FTDILOGSSA-N (e)-6-methyl-n-[(3s,7s,10s)-7-methyl-3-(2-methylpropyl)-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl]hept-2-enamide Chemical compound CC(C)CC\C=C\C(=O)N[C@H]1CCCNC(=O)[C@H](CC(C)C)NC(=O)C(=O)[C@H](C)NC1=O LUORGXVDSLVJSV-FTDILOGSSA-N 0.000 abstract 1
- YNIGBMUXBCZRNQ-XYOKQWHBSA-N (e)-6-methyl-n-[7-methyl-3-(2-methylpropyl)-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl]oct-2-enamide Chemical compound CCC(C)CC\C=C\C(=O)NC1CCCNC(=O)C(CC(C)C)NC(=O)C(=O)C(C)NC1=O YNIGBMUXBCZRNQ-XYOKQWHBSA-N 0.000 abstract 1
- 241000187180 Streptomyces sp. Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108010051573 eurystatin A Proteins 0.000 abstract 1
- 108010051571 eurystatin B Proteins 0.000 abstract 1
- 239000003649 prolyl endopeptidase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/497,292 US4999349A (en) | 1990-03-22 | 1990-03-22 | BU-4164E - A and B, prolyl endopeptidase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE99298T1 true ATE99298T1 (de) | 1994-01-15 |
Family
ID=23976256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91104163T ATE99298T1 (de) | 1990-03-22 | 1991-03-18 | 1,4,8-triazacyclotridecan-derivate mit prolylendopeptidase-hemmender wirkung. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4999349A (de) |
| EP (1) | EP0451547B1 (de) |
| JP (1) | JPH06339390A (de) |
| AT (1) | ATE99298T1 (de) |
| CA (1) | CA2038509A1 (de) |
| DE (1) | DE69100865D1 (de) |
| DK (1) | DK0451547T3 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
| GB9024208D0 (en) * | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
| WO1993000361A1 (en) * | 1991-06-20 | 1993-01-07 | Snow Brand Milk Products Co., Ltd. | Novel prolyl endopeptidase inhibitors sna-115 and sna-115t, production thereof, and strain which produces said inhibitors |
| US20030072715A1 (en) * | 2000-08-02 | 2003-04-17 | Benjamin Frydman | Cyclic polyamine compounds for cancer therapy |
| MXPA03000905A (es) * | 2000-08-02 | 2003-06-24 | Slil Biomedical Corp | Compuestos de poliamina ciclicos como tratamiento contra el cancer. |
| ATE462432T1 (de) | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CN1918131B (zh) | 2004-02-05 | 2011-05-04 | 前体生物药物股份公司 | 谷氨酰胺酰基环化酶抑制剂 |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| EA200901140A1 (ru) | 2007-03-01 | 2010-04-30 | Пробиодруг Аг | Новое применение ингибиторов глутаминилциклазы |
| EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
| US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| CN102695546B (zh) | 2009-09-11 | 2014-09-10 | 前体生物药物股份公司 | 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物 |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| SG183229A1 (en) | 2010-03-10 | 2012-09-27 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| EP2560953B1 (de) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Hemmer der glutaminylzyklase |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
| CA1298033C (en) * | 1985-04-16 | 1992-03-24 | Takaharu Tanaka | Dipeptide derivative of fatty acid |
| JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途 |
| US4898940A (en) * | 1985-08-30 | 1990-02-06 | Bristol-Myers Company | Peptide antibiotics |
| JPH0764834B2 (ja) * | 1985-11-29 | 1995-07-12 | サントリー株式会社 | プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途 |
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| JPH08806B2 (ja) * | 1986-11-18 | 1996-01-10 | サントリー株式会社 | プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体 |
| DE3855875T2 (de) * | 1987-02-23 | 1997-08-28 | Ono Pharmaceutical Co | Thiazolidin-Derivate |
| US4857524A (en) * | 1987-08-08 | 1989-08-15 | Kissei Pharmaceutical Co., Ltd. | Thiazolidine compounds and therapeutic method |
-
1990
- 1990-03-22 US US07/497,292 patent/US4999349A/en not_active Expired - Fee Related
-
1991
- 1991-03-18 CA CA002038509A patent/CA2038509A1/en not_active Abandoned
- 1991-03-18 AT AT91104163T patent/ATE99298T1/de not_active IP Right Cessation
- 1991-03-18 DE DE91104163T patent/DE69100865D1/de not_active Expired - Lifetime
- 1991-03-18 EP EP91104163A patent/EP0451547B1/de not_active Expired - Lifetime
- 1991-03-18 DK DK91104163.0T patent/DK0451547T3/da active
- 1991-03-20 JP JP3216761A patent/JPH06339390A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4999349A (en) | 1991-03-12 |
| EP0451547A1 (de) | 1991-10-16 |
| DE69100865D1 (de) | 1994-02-10 |
| JPH06339390A (ja) | 1994-12-13 |
| CA2038509A1 (en) | 1991-09-23 |
| DK0451547T3 (da) | 1993-12-29 |
| EP0451547B1 (de) | 1993-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |