ATE90343T1 - Verfahren fuer carbapenem-zwischenprodukte. - Google Patents

Verfahren fuer carbapenem-zwischenprodukte.

Info

Publication number
ATE90343T1
ATE90343T1 AT89104433T AT89104433T ATE90343T1 AT E90343 T1 ATE90343 T1 AT E90343T1 AT 89104433 T AT89104433 T AT 89104433T AT 89104433 T AT89104433 T AT 89104433T AT E90343 T1 ATE90343 T1 AT E90343T1
Authority
AT
Austria
Prior art keywords
alkyl
beta
leaving group
intermediate products
substituted
Prior art date
Application number
AT89104433T
Other languages
English (en)
Inventor
Shoichiro Uyeo
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE90343T1 publication Critical patent/ATE90343T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Automobile Manufacture Line, Endless Track Vehicle, Trailer (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT89104433T 1988-03-23 1989-03-13 Verfahren fuer carbapenem-zwischenprodukte. ATE90343T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7076388 1988-03-23
EP89104433A EP0336143B1 (de) 1988-03-23 1989-03-13 Verfahren für Carbapenem-Zwischenprodukte

Publications (1)

Publication Number Publication Date
ATE90343T1 true ATE90343T1 (de) 1993-06-15

Family

ID=13440875

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89104433T ATE90343T1 (de) 1988-03-23 1989-03-13 Verfahren fuer carbapenem-zwischenprodukte.

Country Status (9)

Country Link
US (1) US4960879A (de)
EP (1) EP0336143B1 (de)
KR (1) KR0125932B1 (de)
AT (1) ATE90343T1 (de)
AU (1) AU613724B2 (de)
CA (1) CA1340115C (de)
DE (1) DE68906945T2 (de)
ES (1) ES2017596T3 (de)
GB (1) GB2216525B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0308867B1 (de) * 1987-09-22 1995-07-26 Shionogi Seiyaku Kabushiki Kaisha Alkenylsilylazetidinon-Zwischenprodukte für Carbapeneme
CA2000565C (en) * 1988-10-19 1998-06-23 Masaji Ishiguro Process for the preparation of 4-acyloxy-2-azetidinone derivatives
US4992545A (en) * 1989-09-20 1991-02-12 Eli Lilly And Company Process for preparing 4-substituted azetidinones
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法
FI96311C (fi) * 1989-12-04 1996-06-10 Squibb Bristol Myers Co Menetelmä farmaseuttisesti käyttökelpoisten 6-(1-hydroksietyyli)-3-(substituoitu tio)-7-okso-1-atsabisyklo/3.2.0/hept-2-eeni-2-karboksyylihappojohdannaisten valmistamiseksi
US5672701A (en) * 1990-01-16 1997-09-30 Bristol-Myers Squibb Company 4-substituted alkyl carbapenem antibiotics
US5068232A (en) * 1990-04-10 1991-11-26 American Cyanamid Company Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
EP0695753A1 (de) * 1994-08-05 1996-02-07 Zeneca Limited Carbapenem-Derivate mit einem bicyclischen Substituenten, Verfahren zu ihrer Herstellung und ihre Verwendung
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
US6216687B1 (en) 1996-03-22 2001-04-17 The Majestic Products Company Unvented heating appliance having system for reducing undesirable combustion products
US5973142A (en) * 1997-01-21 1999-10-26 Yasuda; Nobuyoshi Process for synthesizing carbapenem intermediates
AU722405B2 (en) * 1997-01-21 2000-08-03 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
US6346617B1 (en) 1997-08-26 2002-02-12 Merck & Co., Inc. Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof
JP2001514169A (ja) * 1997-08-27 2001-09-11 メルク エンド カムパニー インコーポレーテッド β−メチルカルバペネム中間体の製造
US6143885A (en) * 1997-08-27 2000-11-07 Merck & Co., Inc. Preparation of beta-methyl carbapenem intermediates
US7632828B2 (en) * 2004-06-10 2009-12-15 Fob Synthesis, Inc. Gram-positive carbapenem antibacterials and processes for their preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE10838T1 (de) * 1980-02-28 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. 4-substituierte 2-oxoazetidin-verbindungen, verfahren zu deren herstellung und ihre verwendung zur antibiotika-herstellung.
JPS60158167A (ja) 1984-01-27 1985-08-19 Sumitomo Chem Co Ltd β−ラクタム化合物の製造法
EP0180189B1 (de) * 1984-10-31 1991-01-23 Sumitomo Pharmaceuticals Company, Limited Beta-Lactame und ihre Herstellung
DE3509769A1 (de) * 1985-03-19 1986-09-25 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von carbapenemzwischenprodukten
JPS6229577A (ja) 1985-07-31 1987-02-07 Sumitomo Pharmaceut Co Ltd オキサゾリジン誘導体
JPS62103063A (ja) * 1985-10-29 1987-05-13 Sagami Chem Res Center アゼチジノン誘導体の製造方法

Also Published As

Publication number Publication date
GB2216525A (en) 1989-10-11
GB2216525B (en) 1992-01-02
US4960879A (en) 1990-10-02
AU613724B2 (en) 1991-08-08
DE68906945D1 (de) 1993-07-15
EP0336143B1 (de) 1993-06-09
CA1340115C (en) 1998-11-03
KR0125932B1 (ko) 1997-12-26
ES2017596A4 (es) 1991-03-01
KR890014470A (ko) 1989-10-23
DE68906945T2 (de) 1993-10-14
ES2017596T3 (es) 1994-10-16
EP0336143A1 (de) 1989-10-11
GB8906597D0 (en) 1989-05-04
AU3159989A (en) 1989-09-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time