ATE88091T1 - 2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung. - Google Patents
2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung.Info
- Publication number
- ATE88091T1 ATE88091T1 AT88308182T AT88308182T ATE88091T1 AT E88091 T1 ATE88091 T1 AT E88091T1 AT 88308182 T AT88308182 T AT 88308182T AT 88308182 T AT88308182 T AT 88308182T AT E88091 T1 ATE88091 T1 AT E88091T1
- Authority
- AT
- Austria
- Prior art keywords
- alkoxy
- thiobenzamides
- benzamides
- azabicyclo
- oct
- Prior art date
Links
- 229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
- 150000003936 benzamides Chemical class 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 amino, methylamino Chemical group 0.000 abstract 1
- 230000002932 anti-schizophrenic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878720805A GB8720805D0 (en) | 1987-09-04 | 1987-09-04 | 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides |
| EP88308182A EP0306345B1 (de) | 1987-09-04 | 1988-09-05 | 2-Alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und Thiobenzamide mit antischizophrener Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE88091T1 true ATE88091T1 (de) | 1993-04-15 |
Family
ID=10623261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88308182T ATE88091T1 (de) | 1987-09-04 | 1988-09-05 | 2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4877794A (de) |
| EP (1) | EP0306345B1 (de) |
| JP (1) | JPH0269417A (de) |
| AT (1) | ATE88091T1 (de) |
| AU (1) | AU614768B2 (de) |
| CA (1) | CA1318595C (de) |
| DE (1) | DE3880240T2 (de) |
| DK (1) | DK492688A (de) |
| GB (1) | GB8720805D0 (de) |
| IL (1) | IL87662A0 (de) |
| PH (1) | PH25429A (de) |
| ZA (1) | ZA886586B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3878235T2 (de) * | 1988-08-04 | 1993-06-03 | Synthelabo | Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.)oct-3-yl)benzamide und thiobenzamide. |
| KR920700034A (ko) * | 1989-04-21 | 1992-02-19 | 예안 크라메르·한스 루돌프 하우스 | 5-ht₃수용체 길항제의 치료용도 |
| US5236931A (en) * | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
| EP1381603A2 (de) | 2000-08-18 | 2004-01-21 | PHARMACIA & UPJOHN COMPANY | Mit aryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden ) |
| US6486172B2 (en) | 2000-08-18 | 2002-11-26 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
| BR0212123A (pt) * | 2001-08-24 | 2004-07-20 | Upjohn Co | 7-aza[2.2.1]biciclo-heptanos substituìdos com arila para o tratamento de doenças |
| JP2005522456A (ja) | 2002-02-15 | 2005-07-28 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Ｃｎｓ関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド |
| WO2003072578A1 (en) * | 2002-02-20 | 2003-09-04 | Pharmacia & Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| WO2010042799A2 (en) | 2008-10-09 | 2010-04-15 | Howard Hughes Medical Institute | Novel chimeric ligand-gated ion channels and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093734A (en) * | 1975-11-03 | 1978-06-06 | Boehringer Ingelheim Gmbh | Amino-benzoic acid amides |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
| FR2529548A1 (fr) * | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
| US4593034A (en) * | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
| US4605652A (en) * | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| EP0385517B1 (de) * | 1985-03-14 | 1993-04-14 | BEECHAM GROUP plc | Arzneimittel zur Behandlung von Erbrechen |
| GB8511988D0 (en) * | 1985-05-11 | 1985-06-19 | Beecham Group Plc | Compounds |
| EP0272052B1 (de) * | 1986-12-16 | 1992-07-08 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Angstlösende N-(1-Azabicyclo[2.2.2)oct-3-yl)benzamide und -thiobenzamide |
-
1987
- 1987-09-04 GB GB878720805A patent/GB8720805D0/en active Pending
-
1988
- 1988-09-02 IL IL87662A patent/IL87662A0/xx unknown
- 1988-09-05 AT AT88308182T patent/ATE88091T1/de not_active IP Right Cessation
- 1988-09-05 DE DE88308182T patent/DE3880240T2/de not_active Expired - Fee Related
- 1988-09-05 JP JP63220559A patent/JPH0269417A/ja active Pending
- 1988-09-05 AU AU21834/88A patent/AU614768B2/en not_active Ceased
- 1988-09-05 ZA ZA886586A patent/ZA886586B/xx unknown
- 1988-09-05 PH PH37505A patent/PH25429A/en unknown
- 1988-09-05 EP EP88308182A patent/EP0306345B1/de not_active Expired - Lifetime
- 1988-09-05 DK DK492688A patent/DK492688A/da not_active Application Discontinuation
- 1988-09-06 US US07/240,868 patent/US4877794A/en not_active Expired - Fee Related
- 1988-09-06 CA CA000576593A patent/CA1318595C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK492688D0 (da) | 1988-09-05 |
| GB8720805D0 (en) | 1987-10-14 |
| EP0306345A3 (en) | 1989-06-14 |
| CA1318595C (en) | 1993-06-01 |
| US4877794A (en) | 1989-10-31 |
| IL87662A0 (en) | 1989-02-28 |
| PH25429A (en) | 1991-07-01 |
| DK492688A (da) | 1989-03-05 |
| AU614768B2 (en) | 1991-09-12 |
| DE3880240D1 (de) | 1993-05-19 |
| ZA886586B (en) | 1990-05-30 |
| AU2183488A (en) | 1989-03-09 |
| EP0306345B1 (de) | 1993-04-14 |
| EP0306345A2 (de) | 1989-03-08 |
| DE3880240T2 (de) | 1993-10-28 |
| JPH0269417A (ja) | 1990-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0158532A3 (en) | 2-alkoxy-n-(1-azabicycloû2.2.2¨oct-3-yl) benzamides and thiobenzamides | |
| OA09334A (fr) | "Dérivés d'acides aminés". | |
| ATE85217T1 (de) | Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide. | |
| DE3880240D1 (de) | 2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung. | |
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| GB8823605D0 (en) | Therapeutic agents | |
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| NZ235130A (en) | Cephalosporin derivatives; oxygen and carbon analogues thereof; pharmaceutical compositions; methods of preparation and treatment | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |