ATE85367T1 - Hybridisierungs-test und vorrichtungen zur durchfuehrung dieses tests. - Google Patents

Hybridisierungs-test und vorrichtungen zur durchfuehrung dieses tests.

Info

Publication number
ATE85367T1
ATE85367T1 AT87907035T AT87907035T ATE85367T1 AT E85367 T1 ATE85367 T1 AT E85367T1 AT 87907035 T AT87907035 T AT 87907035T AT 87907035 T AT87907035 T AT 87907035T AT E85367 T1 ATE85367 T1 AT E85367T1
Authority
AT
Austria
Prior art keywords
pct
nucleic acid
nucleotide sequence
rare earth
earth metal
Prior art date
Application number
AT87907035T
Other languages
English (en)
Inventor
Jyrki Ylikoski
Pertti Hurskainen
Patrik Dahlen
Christian Sund
Timo Loevgren
Marek Kwiatkowski
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Application granted granted Critical
Publication of ATE85367T1 publication Critical patent/ATE85367T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT87907035T 1986-10-17 1987-10-16 Hybridisierungs-test und vorrichtungen zur durchfuehrung dieses tests. ATE85367T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8604436A SE454781B (sv) 1986-10-17 1986-10-17 Hybridiseringsforfarande for detektion av polynukleotidsekvens
PCT/SE1987/000474 WO1988002784A1 (en) 1986-10-17 1987-10-16 Hybridization assay and means to be used in the assay
EP87907035A EP0288513B1 (de) 1986-10-17 1987-10-16 Hybridisierungs-test und vorrichtungen zur durchführung dieses tests

Publications (1)

Publication Number Publication Date
ATE85367T1 true ATE85367T1 (de) 1993-02-15

Family

ID=20365979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87907035T ATE85367T1 (de) 1986-10-17 1987-10-16 Hybridisierungs-test und vorrichtungen zur durchfuehrung dieses tests.

Country Status (7)

Country Link
US (1) US5256535A (de)
EP (1) EP0288513B1 (de)
JP (1) JPH01501681A (de)
AT (1) ATE85367T1 (de)
DE (1) DE3784058T2 (de)
SE (1) SE454781B (de)
WO (1) WO1988002784A1 (de)

Families Citing this family (36)

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US6127529A (en) * 1988-06-29 2000-10-03 Wallac Oy Metal-chelating 2,6-disubstituted pyridine compounds and their use
SE8802574D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes
FR2638462B1 (fr) * 1988-10-28 1992-05-22 Oris Ind Complexes tridimensionnels a base de streptavidine (ou avidine) et de composes luminescents polybiotinyles
GB8927503D0 (en) * 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
WO1991010908A1 (en) * 1990-01-17 1991-07-25 Wallac Oy Oligosaccharide derivates linked to lanthanide chelates and to a reactive group
ES2108109T3 (es) * 1991-02-14 1997-12-16 Dade Microscan Inc Nuevos oligonucleotidos conjugados con quelatos de lantanidos.
FI96143C (fi) * 1993-03-16 1996-05-10 Wallac Oy Biospesifinen määritysmenetelmä
FI93781C (fi) * 1993-03-18 1995-05-26 Wallac Oy Biospesifinen multiparametrinen määritysmenetelmä
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
FR2746413B1 (fr) * 1996-03-19 1998-04-24 Bio Merieux Detection d'une sequence nucleotidique avec amplification de signal
WO1998000435A2 (en) * 1996-07-03 1998-01-08 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6030840A (en) * 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
WO2000039335A1 (en) * 1998-12-24 2000-07-06 Aclara Biosciences, Inc. Individually addressable solid surfaces for multiplexed operations
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
US6406851B1 (en) 2000-01-28 2002-06-18 Agilent Technologies, Inc. Method for coating a substrate quickly and uniformly with a small volume of fluid
US6458526B1 (en) 2000-01-28 2002-10-01 Agilent Technologies, Inc. Method and apparatus to inhibit bubble formation in a fluid
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
US20040115692A1 (en) * 2000-04-03 2004-06-17 Cytyc Corporation Methods, compositions and apparatuses for detecting a target in a preservative solution
EP1557422B1 (de) * 2000-08-04 2013-12-25 Senseonics, Incorporated Nachweis von Analyten in wässrigen Medien
US6806051B2 (en) * 2000-09-25 2004-10-19 Picoliter Inc. Arrays of partially nonhybridizing oligonucleotides and preparation thereof using focused acoustic energy
US6927029B2 (en) 2001-12-03 2005-08-09 Agilent Technologies, Inc. Surface with tethered polymeric species for binding biomolecules
US8394944B2 (en) * 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
WO2005044836A2 (de) * 2003-11-05 2005-05-19 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
WO2006039505A2 (en) * 2004-09-30 2006-04-13 Molecular Devices Corporation Luminescent lanthanide complexes
EP1885876A2 (de) * 2005-03-17 2008-02-13 Genovoxx GmbH Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
CN101495867B (zh) * 2006-05-27 2017-09-05 富鲁达加拿大公司 聚合物骨架元素标签
EP2074133A2 (de) * 2006-09-20 2009-07-01 Genovoxx GmbH Komponenten und verfahren zur enzymatischen synthese von nukleinsäuren
CN106964411B (zh) 2012-03-16 2019-12-10 统计诊断与创新有限公司 具有集成传送模块的测试盒
CN111562244B (zh) * 2020-05-25 2023-02-07 赣南师范大学 一种检测柔红霉素的稀土时间分辨荧光探针和试剂盒
CN114062328B (zh) * 2020-08-10 2024-08-27 深圳先进技术研究院 一种基于核酸杂交增强稀土配合物荧光的检测方法

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US4283382A (en) * 1977-12-28 1981-08-11 Eastman Kodak Company Fluorescent labels comprising rare earth chelates
CA1111762A (en) * 1977-12-28 1981-11-03 David S. Frank Fluorescent rare earth chelate in polymeric latex particles
US4259313A (en) * 1978-10-18 1981-03-31 Eastman Kodak Company Fluorescent labels
AT357247B (de) * 1978-12-27 1980-06-25 Vianova Kunstharz Ag Verfahren zur herstellung von selbstver- netzenden bindemitteln fuer kathodisch abscheid- bare elektrotauchlacke
US4434150A (en) * 1981-10-19 1984-02-28 Ortho Diagnostic Systems, Inc. Immunological reagents employing polymeric backbone possessing reactive functional groups
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
FR2570703B1 (fr) * 1984-09-26 1988-07-08 Commissariat Energie Atomique Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
US4795700A (en) * 1985-01-25 1989-01-03 California Institute Of Technology Nucleic acid probes and methods of using same
US4719182A (en) * 1985-03-18 1988-01-12 Eastman Kodak Company Fluorescent labels and labeled species and their use in analytical elements and determinations
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
EP0244471A4 (de) * 1985-10-24 1988-01-28 Siska Diagnostics Inc Mit lanthanidenchelat markierte nukleinsäureproben.
GB8621337D0 (en) * 1986-09-04 1986-10-15 Agricultural Genetics Co Non-radioactive nucleic acid hybridization probes
EP0297373A3 (de) * 1987-06-25 1990-11-07 Colgate-Palmolive Company Mit Fettsäuren überzogenes granuliertes Magnesiummonoperoxyphthalat zur Verhinderung von Farbschäden an gegen Bleichmittel empfindlichen Geweben

Also Published As

Publication number Publication date
DE3784058D1 (de) 1993-03-18
SE454781B (sv) 1988-05-30
EP0288513A1 (de) 1988-11-02
EP0288513B1 (de) 1993-02-03
JPH01501681A (ja) 1989-06-15
US5256535A (en) 1993-10-26
WO1988002784A1 (en) 1988-04-21
DE3784058T2 (de) 1993-05-19
SE8604436L (sv) 1988-04-18
SE8604436D0 (sv) 1986-10-17

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